Journal Information
Vol. 96. Issue 1.
Pages 132-133 (January - February 2020)
Share
Share
Download PDF
More article options
Vol. 96. Issue 1.
Pages 132-133 (January - February 2020)
Letter to the Editor
DOI: 10.1016/j.jped.2019.09.002
Open Access
TyG in insulin resistance prediction
TyG na predição da resistência à insulina
Visits
...
Wendell Arthur Lopes
Corresponding author
warthurlopes@gmail.com

Corresponding author.
, Gustavo Henrique de Oliveira, João Carlos Locateli, Caroline Ferraz Simões
Universidade Estadual de Maringá (UEM), Centro de Ciências da Saúde, Departamento de Educação Física, Curitiba, PR, Brazil
Related content
J Pediatr (Rio J). 2019;95:217-2310.1016/j.jped.2017.12.012
Sarah A. Vieira-Ribeiro, Poliana C.A. Fonseca, Cristiana S. Andreoli, Andréia Q. Ribeiro, Helen H.M. Hermsdorff, Patrícia F. Pereira, Silvia E. Priore, Sylvia C.C. Franceschini
J Pediatr (Rio J). 2020;96:133-410.1016/j.jped.2019.09.003
Sarah A. Vieira-Ribeiro, Poliana C.A. Fonseca, Cristiana S. Andreoli, Andréia Q. Ribeiro, Helen H.M. Hermsdorff, Patrícia F. Pereira, Silvia E. Priore, Sylvia C.C. Franceschini
Article information
Full Text
Bibliography
Download PDF
Statistics
Tables (1)
Full Text
Dear Editor,

We read with interest the article “The TyG index cutoff point and its association with body adiposity and lifestyle in children” by Vieira-Ribeiro et al.,1 published in the Jornal de Pediatria, which proposes TyG (triglyceride-glucose índex) cutoff points for the prediction of insulin resistance (IR) in school-aged children and preschoolers. The study makes an important contribution to the topic, considering the need to establish cutoff points to use this tool in the Brazilian pediatric population.

From this perspective, we believe it is very important to warn the authors about a probable mistake in the calculation of TyG. Although the calculation error does not impair the predictive capacity of this method, the proposed cutoff points are significantly altered. This method was proposed by Guerrero-Romero in an article published in 2010,2 and the calculation is described as follows: [ln(fasting triglycerides) (mg/dL)×fasting glucose (mg/dL)/2], and the values found by the authors was 3.7 (values for healthy adults). However, in another publication by the same authors in 2016,3 we can verify that the indicated calculation is as follows:[ln(fasting triglycerides (mg/dL)×fasting glucose (mg/dL)]/2, and the values shown by the authors in this article was 4.5 (values for healthy adult men and women).

The chart below shows that, according to the formula used, different TyG values will be obtained, since the first formula divides by 2 before performing the logarithmic operation and the second formula divides by 2 after the logarithmic operation of the serum triglyceride and glucose product.

Formula  TG  Glucose  TyG 
1st [ln(fasting triglycerides) (mg/dL)×fasting glucose (mg/dL)/2]  168.3  88.3  8.91 
2nd [ln(fasting triglycerides (mg/dL)×fasting glucose (mg/dL)]/2  168.3  88.3  4.80 

Therefore, it is likely that the formula used by the authors who proposed the method is the latter of the two, since the values presented in both articles are between 3.7 and 4.5.

This error in the formula presentation led other authors,4–6 including Vieira-Ribeiro et al.,1 to use the first formula to obtain the TyG, achieving much higher values than those shown by the method’s proponents.

Therefore, we suggest to the authors Vieira-Ribeiro et al.1 that they recalculate the values of TyG based on the second formula, aiming to present more appropriate cutoffs to the original proposal and to allow an appropriate comparison with future studies, which also must adhere to the proper calculation of this index.

Conflicts of interest

The authors declare no conflicts of interest.

References
[1]
S.A. Vieira-Ribeiro, P.C. Fonseca, C.S. Andreoli, A.Q. Ribeiro, H.H. Hermsdorff, P.F. Pereira, et al.
The TyG index cutoff point and its association with body adiposity and lifestyle in children.
J Pediatr (Rio J), 95 (2019), pp. 217-223
[2]
F. Guerrero-Romero, L.E. Simental-Mendía, M. González-Ortiz, E. Martínez-Abundis, M.G. Ramos-Zavala, S.O. Hernández-González, et al.
The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp.
J Clin Endocrinol Metab, 95 (2010), pp. 3347-3351
[3]
F. Guerrero-Romero, R. Villalobos-Molina, Jiménez-Flores, L.E. Simental-Mendía, R. Méndez-Cruz, M. Murguía-Romero, et al.
Fasting triglycerides and glucose index as a diagnostic test for insulin resistance in young adults.
Arch Med Res, 47 (2016), pp. 382-387
[4]
B. Kang, Y. Yang, E.Y. Lee, H.K. Yang, H.S. Kim, S.Y. Lim, et al.
Triglycerides/glucose index is a useful surrogate marker of insulin resistance among adolescents.
Int J Obes, 41 (2017), pp. 789-792
[5]
S. Moon, J.S. Park, Y. Ahn.
The cut-off values of triglycerides and glucose index for metabolic syndrome in American and Korean adolescents.
J Korean Med Sci, 32 (2017), pp. 427-433
[6]
P. Angoorani, R. Heshmat, H.S. Ejtahed, M.E. Motlagh, H. Ziaodini, M. Taheri, et al.
Validity of triglyceride–glucose index as an indicator for metabolic syndrome in children and adolescents: the CASPIAN-V study.
Eat Weight Disord, 23 (2018), pp. 877-883

Please cite this article as: Lopes WA, Oliveira GH, Locateli JC, Simões CF. TyG in insulin resistance prediction. J Pediatr (Rio J). 2020;96:132–3.

Idiomas
Jornal de Pediatria (English Edition)

Subscribe to our newsletter

Article options
Tools
en pt
Taxa de publicaçao Publication fee
Os artigos submetidos a partir de 1º de setembro de 2018, que forem aceitos para publicação no Jornal de Pediatria, estarão sujeitos a uma taxa para que tenham sua publicação garantida. O artigo aceito somente será publicado após a comprovação do pagamento da taxa de publicação. Ao submeterem o manuscrito a este jornal, os autores concordam com esses termos. A submissão dos manuscritos continua gratuita. Para mais informações, contate assessoria@jped.com.br. Articles submitted as of September 1, 2018, which are accepted for publication in the Jornal de Pediatria, will be subject to a fee to have their publication guaranteed. The accepted article will only be published after proof of the publication fee payment. By submitting the manuscript to this journal, the authors agree to these terms. Manuscript submission remains free of charge. For more information, contact assessoria@jped.com.br.
Cookies policy Política de cookies
To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.