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nasal secretions&#44; urine&#44; feces&#44; and fecal enzymes&#41;&#44; dust&#44; and microorganisms&#46;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">1</span></a> According to the World Health Organization &#40;WHO&#41;&#44; it is recommended that the NB be given the first bath 6<span class="elsevierStyleHsp" style=""></span>h after birth&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">9</span></a> It has been suggested that a bath given with only water is the least harmful method of cleaning the NB&#44; which has been adopted in the national postnatal care protocols in many countries&#44; including the United Kingdom&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">9</span></a> However&#44; the buffering capacity of water has been questioned&#44; as it can increase skin pH from 5&#46;5 to 7&#46;5&#46; Moreover&#44; the use of water alone was identified as an ineffective cleaning agent&#44; as it does not remove oily substances such as feces and sebum&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">14&#44;15</span></a> American guidelines recommend the use of lukewarm drinking water&#44; with the option of associating a mild cleaning product with a physiologically adequate pH &#40;5&#46;5&#8211;7&#46;0&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">14</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">It is believed that the repeated use of cleaning agents can alter the skin surface pH in the long term&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">12</span></a> Traditional soaps have an alkaline pH&#44; which can destroy the skin lipid layer<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">9</span></a> and elevate skin pH above 8&#46;0&#44; leading to skin dryness and irritation&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">12&#44;14&#44;16&#8211;19</span></a> A pH of 7&#46;5 is capable of increasing skin protease activity and inhibiting lipid lamellae synthesis&#44; leading to a breakdown of the skin barrier&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">14</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The &#8220;syndets&#8221;&#44; a term derived from &#8220;synthetic detergent&#8221;&#44; are formulated from synthetic surfactants that have good detergent effect&#44; with neutral or slightly acid pH&#44; and cause less irritation&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">9</span></a> Studies show that taking a bath using this type of soap is comparable or even superior to a bath with water only&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">20</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">A good cleaning product for NBs must have a pH close to 5&#46;5 and some buffer capacity to maintain the pH close to that level&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">14</span></a> The cosmetic industries offer a great variety of such products and classify them as &#8220;mild&#8221;&#46; However&#44; there is no international criterion to establish the mildness of cleaning agents&#44; and often&#44; various products advertised as adequate for sensitive skins exhibit significant irritative effects&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">21</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Thus&#44; the aim of this study was to evaluate the pH of children&#39;s soaps&#44; antibacterial soaps&#44; and syndets commonly used to bathe children and infants&#44; in order to verify whether they are slightly acidic and&#44; therefore&#44; consistent with the maintenance of the water&#8211;lipid mantle and barrier function and&#44; secondly&#44; to determine whether the labels of these products have information about their pH&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0040" class="elsevierStylePara elsevierViewall">This was an observational&#44; analytical&#44; cross-sectional&#44; quantitative study&#46; Products from all brands &#40;liquid or bar&#41; of children&#39;s soap were obtained&#44; antibacterial and syndets found at points of purchase &#40;supermarkets&#44; drugstores&#44; and cosmetic stores&#41; located within 7<span class="elsevierStyleHsp" style=""></span>km of Hospital de Cl&#237;nicas&#44; located in downtown Curitiba&#44; state of Parana&#44; Brazil&#46; These samples were paid for using the researchers&#8217; own funds&#44; in order to avoid any conflicts of interest&#46; Ninety types of soaps were analyzed &#40;62 bars and 28 liquid soaps&#41;&#44; divided into three categories&#44; including 67 children&#39;s soaps&#44; 17 antibacterial soaps&#44; and six syndets&#46; These groups were further divided into five categories according to pH ranges&#58; pH<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5&#59; between 5 and 5&#46;9&#59; between 6 and 6&#46;9&#59; between 7 and 7&#46;9&#59; and &#8805;8&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The pH of all the soap samples was measured using a pHmeter<span class="elsevierStyleSup">&#174;</span> &#40;Hanna Instruments&#44; model H19321&#44; TX&#44; USA&#41; at a dilution of 1&#37; in distilled water &#40;pH 9&#46;1&#41;&#46; A comparison between 1&#37; and 10&#37; dilutions was performed and it was verified that pH values remained the same&#46; Thus&#44; due to the fact that smaller volumes are easier to use&#44; the 1&#37; dilution was chosen&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Data were stored in a Microsoft Excel<span class="elsevierStyleSup">&#174;</span> spreadsheet and evaluated using R<span class="elsevierStyleSup">&#174;</span> software&#44; version 3&#46;0&#46;2 &#40;Microsoft<span class="elsevierStyleSup">&#174;</span>&#44; Washington&#44; USA&#41;&#46; Summary measures used in descriptive statistics were mean&#44; standard deviation&#44; median&#44; minimum and maximum values&#44; and frequencies&#44; depending on the type of the studied variable&#46; The Pearson&#8211;Yates chi-squared test and Student&#39;s <span class="elsevierStyleItalic">t</span>-test were applied&#44; considering the significance level of 5&#37;&#46; The tests used for inferential statistics &#40;data comparison&#41; were the Wilcoxon&#8211;Mann&#8211;Whitney test&#44; Fisher&#39;s exact test&#44; and the Kruskal&#8211;Wallis test&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">This study did not require the approval by the ethics committee&#44; as it did not involve human subjects&#44; but only the biochemical analysis of soaps&#59; opinion No&#46; 064&#46;2012&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0060" class="elsevierStylePara elsevierViewall">The pH of the soaps ranged from 4&#46;4 to 11&#46;5&#44; with a median of 10&#46;7&#46; Two &#40;2&#46;2&#37;&#41; had pH<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5&#44; 8 &#40;8&#46;8&#37;&#41; soaps had pH between 5 and 5&#46;9&#44; 9 &#40;10&#37;&#41; had pH between 6 and 6&#46;9&#44; 10 &#40;11&#46;1&#37;&#41; had pH between 7 and 7&#46;9&#44; and 61 &#40;67&#46;7&#37;&#41; had pH<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>8&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">In the group of children&#39;s soaps&#44; 47 were bars and 20 were liquid soaps &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Only one of bar soaps had pH<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>8 &#40;2&#46;2&#37;&#41;&#46; Among the liquid soaps&#44; 1 &#40;5&#37;&#41; had pH<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5&#46;0&#59; 3 &#40;15&#37;&#41; had pH from 5&#46;0 to 5&#46;9&#59; 9 &#40;45&#37;&#41; had pH from 6&#46;0 to 6&#46;9&#59; and 7 had &#40;35&#37;&#41; pH from 7&#46;0 to 7&#46;9&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">In the group of antibacterial soaps&#44; 14 were bars and three were liquid soaps &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; All bar soaps &#40;100&#37;&#41; had pH<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>8&#46;0&#59; among the liquid soaps&#44; 1 &#40;33&#46;3&#37;&#41; had pH<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5&#46;0&#59; 1 &#40;33&#46;3&#37;&#41; had pH between 5&#46;0 and 5&#46;9 &#40;33&#46;3&#37;&#41;&#44; and 1 had pH<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>8&#46;0&#46; Only two antibacterial liquid soaps had the pH close to the physiological range&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">In group of syndets&#44; two were bar and four were liquid soaps &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; Among the bar soaps&#44; 1 &#40;50&#37;&#41; had pH of 5&#46;0&#8211;5&#46;9&#44; and 1 &#40;50&#37;&#41; had pH<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>8&#46;0&#59; and among the three liquids soaps&#44; 3 &#40;75&#37;&#41; had pH between 5&#46;0 and 5&#46;9&#44; and 1 &#40;25&#37;&#41; had pH between 7&#46;0 and 7&#46;9&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">When comparing the pH values between the liquid and bar soaps using Fisher&#39;s exact test&#44; there was a statistically significant difference &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; with the liquid soaps showing lower pH values &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">When divided by soap category&#58; children&#39;s soaps&#44; antibacterial soaps&#44; and syndets&#44; different pH values were also found between them using the Kruskal&#8211;Wallis test &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0017&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">The multiple comparison test &#40;Fisher&#39;s exact test&#41; was used&#44; which showed a statistically significant difference in pH &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0032&#41; between the children&#39;s soap and syndet groups&#44; and between the antibacterial soap and syndet groups &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0002&#41;&#46; The syndets had significantly lower pH when compared to the others &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#59; <a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Only two of the assessed soaps had information on the label indicating the pH&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0095" class="elsevierStylePara elsevierViewall">Skin pH alterations caused by the use of different types of soaps are well known&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">1&#44;7&#44;9&#44;12&#44;13</span></a> It is also known that skin pH is slightly acidic&#44; and that highly-alkaline pH can damage the acid mantle that acts as an antibacterial barrier&#44; as well as disrupt the lipid lamellae of the epidermis&#44; resulting in skin dryness due to higher transepidermal water loss and allowing the entry of potential irritants and allergens&#46;<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">7&#44;9&#44;12&#44;13</span></a> This occurs because the soap&#44; in contact with water&#44; undergoes a hydrolysis reaction&#44; releasing the alkali contained in these products and increasing the skin pH to 10&#8211;11&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">12</span></a> Based on the results&#44; it can be observed that the soaps in liquid form are the most appropriate for everyday use&#44; especially in children and infants&#44; whose skin is more delicate and sensitive&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">As demonstrated in the present study&#44; Volochtchuk et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">12</span></a> in a study carried out at the same institution&#44; have already shown significant differences in pH between liquid and bar soaps&#44; but the study evaluated both adult and children&#39;s soaps&#46; The bar soaps showed pH<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>6&#44; with most between 9 and 10&#46; As for the liquid soaps&#44; most showed pH between 6 and 6&#46;9&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">11</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Liquid syndets have a pH closer to the physiological range &#40;approximately 5&#41;&#44; and are especially recommended to patients with diseases that alter the skin barrier &#40;such as atopic dermatitis and ichthyosis&#41; or children with sensitive skin&#46; In these individuals&#44; the use of soaps with high pH worsens xerosis and can generate solutions of continuity of the skin&#44; which can be a gateway to pathogens&#46; Syndet action occurs in two ways&#58; first&#44; by reducing the interaction between tensioactive agents and skin proteins and lipids&#59; and second&#44; by restoring lipids and moisturizing agents lost during the washing&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">19</span></a> Thus&#44; the skin does not dry&#44; remaining hydrated&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Antibacterial bar soaps showed the highest pH values of all assessed soaps&#46; This demonstrates that these products can be aggressive to the child&#39;s skin and should not be routinely used&#44; but only in specific situations and for short periods of time&#44; and on restricted parts and not the entire body&#44; preferably in liquid form&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">It was verified that only two of the included soaps had any mention of pH levels on their package&#46; The study by Tarun et al&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">22</span></a> mentioned that the labels of all assessed soaps&#44; except for one&#44; had no information related to the product pH&#46; It was observed that even those products whose packaging contained phrases such as &#8220;neutral pH&#8221;&#44; &#8220;balanced pH&#8221;&#44; or &#8220;dermatologically tested&#8221; had pH above the expected range&#46; Therefore&#44; it was found that many of these products provide information that can confuse the consumer&#44; since the fact that the skin is slightly acidic is not generally known by the public&#44; as well as the importance of maintaining the skin&#39;s barrier function&#46; Only one brand &#40;Eucerin bar and liquid soap&#44; Eucerin<span class="elsevierStyleSup">&#174;</span>&#44; USA&#41; displayed pH specification on the packaging&#44; which makes it difficult to choose or recommend these products&#44; by both the lay population and health professionals&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Most analyzed soaps are manufactured and sold in Brazil&#46; Although some of them represent internationally-renowned brands&#44; it cannot be verified that their chemical composition and hence their pH is the same worldwide&#46; However&#44; as this study selected product brands that are also available in other countries&#44; in easily accessible and popular stores&#44; and also because as many different brands as possible were acquired&#44; it is believed that the results can be extrapolated to other cities in Brazil and other regions of the world&#44; which should be supported by studies in these locations&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">This study highlights the pH inadequacy of several children&#39;s products freely available in points of purchase&#46; Pediatricians&#44; parents&#44; and caregivers should be aware of the characteristics of products used in pediatric patients&#44; as some may even cause damage to the skin of children and infants&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Based on this fact&#44; it is important that health surveillance institutions that regulate the selling of products for infant use establish stricter criteria for their commercialization&#44; as well as for the information that should be included in their packaging&#44; including the product pH&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conflicts of interest</span><p id="par0135" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To evaluate the pH value of children&#39;s antibacterial soaps and syndets used in children&#39;s baths and verify whether there is information regarding pH on the product label&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Quantitative&#44; cross-sectional&#44; analytical observational study that included ninety soap samples&#44; both in bar and liquid presentations&#44; as follows&#58; 67 children&#39;s soap &#40;group 1&#41;&#44; 17 antibacterial soaps &#40;group 2&#41;&#44; and 6 syndets &#40;group 3&#41;&#46; Each sample had its pH measured after 1&#37; dilution&#46; In addition to descriptive statistics&#44; the Pearson&#8211;Yates chi-squared test and Student&#39;s <span class="elsevierStyleItalic">t</span>-tests were applied&#44; considering the minimal significance level of 5&#37;&#46; The Wilcoxon&#8211;Mann&#8211;Whitney test&#44; Fisher&#39;s exact test&#44; and the Kruskal&#8211;Wallis test were used for inferential statistics&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The pH levels varied considerably between liquid and bar presentations&#44; with lower levels &#40;4&#46;4&#8211;7&#46;9&#41; found for the liquids &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Syndets showed pH levels close to the ideal &#40;slightly acid&#41; and the antibacterial soaps showed the highest pH levels &#40;up to 11&#46;34&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Only two of the soaps included in the study had information about their pH levels on the product packaging&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Knowledge of the pH of children&#39;s soap by doctors and users is important&#44; considering the great pH variability found in this study&#46; Moreover&#44; liquid soaps&#44; and especially syndets&#44; are the most recommended for the sensitive skin of neonates and infants&#44; in order to guarantee skin barrier efficacy&#46;</p></span>"
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      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Avaliar o pH dos sabonetes infantis&#44; antibacterianos e sindets habitualmente utilizados em crian&#231;as&#59; bem como verificar se h&#225; no r&#243;tulo desses produtos informa&#231;&#227;o sobre seu pH&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudo observacional&#44; anal&#237;tico&#44; transversal e quantitativo&#44; que incluiu 90 sabonetes nas apresenta&#231;&#245;es em barra e l&#237;quida&#44; sendo 67 infantis &#40;grupo 1&#41;&#44; 17 antibacterianos &#40;grupo 2&#41; e 6 sindets &#40;grupo 3&#41;&#46; Procedeu-se a mensura&#231;&#227;o do pH das amostras ap&#243;s dilui&#231;&#227;o a 1&#37;&#46; Al&#233;m da estat&#237;stica descritiva&#44; foram usados os testes de Qui quadrado Persons&#47;Yates e teste T de Student&#44;com n&#237;vel de signific&#226;ncia m&#237;nimo de 5&#37;&#46; Para a estat&#237;stica inferencial&#44; foram usados os testes de Wilcoxon&#8211;Mann&#8211;Whitney&#44; exato de Fisher e Kruskal&#8211;Wallis&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">O pH variou consideravelmente entre as formas l&#237;quida e em barra&#44; com pHs menores &#40;de 4&#44;4 a 7&#44;9&#41; nos l&#237;quidos &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Os sindets mostraram pHs pr&#243;ximos ao ideal &#40;levemente &#225;cidos&#41; e os antibacterianos apresentaram os maiores pHs &#40;at&#233; 11&#44;34&#41; &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Apenas dois dos sabonetes analisados apresentavam no r&#243;tulo a indica&#231;&#227;o do pH&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#245;es</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A observa&#231;&#227;o do pH dos sabonetes infantis pelos m&#233;dicos e usu&#225;rios &#233; importante&#44; haja vista a grande variabilidade de valores de pH encontrados&#46; Al&#233;m disso&#44; os sabonetes l&#237;quidos&#44; e especialmente os sindets&#44; s&#227;o os mais recomendados para uso em rec&#233;m-nascidos e lactentes com pele sens&#237;vel&#44; de forma a garantir a efic&#225;cia da barreira cut&#226;nea&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclus&#245;es"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Mendes BR&#44; Shimabukuro DM&#44; Uber M&#44; Abagge KT&#46; Critical assessment of the pH of children&#39;s soap&#46; J Pediatr &#40;Rio J&#41;&#46; 2016&#59;92&#58;290&#8211;5&#46;</p>"
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 904
            "Ancho" => 1601
            "Tamanyo" => 42664
          ]
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        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Potential of hydrogen &#40;pH&#41; variation according to the soap presentation <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>90&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 899
            "Ancho" => 1620
            "Tamanyo" => 52351
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Potential of hydrogen &#40;pH&#41; variation according to the group of soaps &#40;children&#39;s&#44; antibacterial&#44; or syndet&#41; <span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>90&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">pH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Children&#39;s bar soaps</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Baruel Xuxinha amarelo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Baruel Xuxinha camomila&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Baruel Xuxinha Lavanda&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Biocrema The Flintstone&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Botic&#225;rio Baby Boti&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Botic&#225;rio Sophie Fantasy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Botic&#225;rio Sophie Jeans&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Botic&#225;rio Sophie Magic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Botic&#225;rio Spul&#243;kis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cetrilan suave&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cremer Disney&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cremer Disney Princesas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Davene Beb&#234;vida com extrato natural de aveia e glicerina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dove baby&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dove baby da cabe&#231;a aos p&#233;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Galderma Proderm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Granado Glicerina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Granado Glicerina Erva doce&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Granado Lavanda&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Huggies Ch&#225; de camomila&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Huggies Extra suave&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Huggies Toque de am&#234;ndoas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hydrata Cuidado perfumado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;99&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hydratta Beb&#234; cuidado suave&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hydratta Cuidado delicado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Johnson&#39;s Baby&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Johnson&#39;s Glicerinado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Johnson&#39;s Hora de brincar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Johnson&#39;s &#211;leo de am&#234;ndoas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Johnson&#39;s Glicerinado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Johnson&#39;s Milk&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Johnson&#39;s Hora do sono&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Muriel Baby Menina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Muriel Baby Menino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Natura Cuca fresca glicerinado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Natura Mam&#227;e e Beb&#234; com extrato de Passiflora&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Natura Natur&#233; Bolol&#244;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Natura Natur&#233; Mistureba&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nazca Acqua Kids Extrato de ma&#231;&#227; e Camomila&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nazca Acqua Kids Pele delicada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nazca Acqua Kids Cheirinho de erva doce e hortel&#227;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pom Pom Camomila e erva cidreira&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pom Pom Glicerinado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pom Pom Leite e Mel&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pom Pom Lo&#231;&#227;o hidratante&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pom Pom &#211;leo de am&#234;ndoas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Topz Tom &#38; Jerry Limpeza Suave&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Children&#39;s liquid soap</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Avon Baby Calming&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Beb&#234; Natureza Extrato de algod&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Botic&#225;rio Sophie&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Botic&#225;rio Baby Boti&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cremer Disney&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dove baby da cabe&#231;a aos p&#233;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fisher Price&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fofo Glicerinado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Galinha Pintadinha Extrato de Algod&#227;o e glicerina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Giovanna Baby Orange com Giby Care&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Granado Glicerina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Huggies Turma da M&#244;nica Cream Oil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Huggies Turma da M&#244;nica Extra suave&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Johnson&#39;s Hora de Brincar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Johnson&#39;s Baby rec&#233;m-nascido&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Muriel Baby Menina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Muriel Baby Menino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Natura Mam&#227;e e Beb&#234; Glicerina com &#243;leo de passiflora&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Panvel Baby Club&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Patati Patata Extrato de Aloe Vera&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Antibacterial bar soaps</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dettol Cool&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dettol Cuidado Di&#225;rio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dettol Suave&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lifebuoy Aveia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lifebuoy Care&#38;Clinical 10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lifebuoy Cream&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lifebuoy Fresh&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lifebuoy Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Protex Cream&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Protex Erva doce&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Protex Limpeza profunda&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Protex &#212;mega 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Protex Pr&#243;polis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Protex suave&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Antibacterial liquid soaps</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dettol original&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#46;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Protex Cream&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Lifebuoy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9&#46;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Syndet bars</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Eucerin Ph5 Syndet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>La Roche Posay Lipikar Surgras&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="2" align="left" valign="top"><span class="elsevierStyleItalic">Liquid syndets</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Eucerin Pele Sens&#237;vel pH5 Syndet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>La Roche Posay Lipikar Surgras&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cetaphil Restoraderm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">5&#46;93&nbsp;\t\t\t\t\t\t\n
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Journal Information
Vol. 92. Issue 3.
Pages 290-295 (May - June 2016)
Visits
4154
Vol. 92. Issue 3.
Pages 290-295 (May - June 2016)
Original article
Open Access
Critical assessment of the pH of children's soap
Avaliação crítica do pH dos sabonetes infantis
Visits
4154
Bruna Rafaela Mendesa, Danielle Midori Shimabukuroa, Marjorie Ubera, Kerstin Taniguchi Abaggeb,
Corresponding author
kerstinabagge@gmail.com

Corresponding author.
a Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil
b Pediatric Dermatology Unit, Department of Pediatrics, Hospital de Clínicas, Curitiba, PR, Brazil
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Abstract
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Tables (1)
Table 1. Soaps according to their group, presentation, and potential of hydrogen (pH).
Abstract
Objective

To evaluate the pH value of children's antibacterial soaps and syndets used in children's baths and verify whether there is information regarding pH on the product label.

Methods

Quantitative, cross-sectional, analytical observational study that included ninety soap samples, both in bar and liquid presentations, as follows: 67 children's soap (group 1), 17 antibacterial soaps (group 2), and 6 syndets (group 3). Each sample had its pH measured after 1% dilution. In addition to descriptive statistics, the Pearson–Yates chi-squared test and Student's t-tests were applied, considering the minimal significance level of 5%. The Wilcoxon–Mann–Whitney test, Fisher's exact test, and the Kruskal–Wallis test were used for inferential statistics.

Results

The pH levels varied considerably between liquid and bar presentations, with lower levels (4.4–7.9) found for the liquids (p<0.05). Syndets showed pH levels close to the ideal (slightly acid) and the antibacterial soaps showed the highest pH levels (up to 11.34) (p<0.05). Only two of the soaps included in the study had information about their pH levels on the product packaging.

Conclusions

Knowledge of the pH of children's soap by doctors and users is important, considering the great pH variability found in this study. Moreover, liquid soaps, and especially syndets, are the most recommended for the sensitive skin of neonates and infants, in order to guarantee skin barrier efficacy.

Keywords:
Hydrogen-ion concentration
Soaps
Detergents
Anti-bacterial agents
Childcare
Resumo
Objetivos

Avaliar o pH dos sabonetes infantis, antibacterianos e sindets habitualmente utilizados em crianças; bem como verificar se há no rótulo desses produtos informação sobre seu pH.

Métodos

Estudo observacional, analítico, transversal e quantitativo, que incluiu 90 sabonetes nas apresentações em barra e líquida, sendo 67 infantis (grupo 1), 17 antibacterianos (grupo 2) e 6 sindets (grupo 3). Procedeu-se a mensuração do pH das amostras após diluição a 1%. Além da estatística descritiva, foram usados os testes de Qui quadrado Persons/Yates e teste T de Student,com nível de significância mínimo de 5%. Para a estatística inferencial, foram usados os testes de Wilcoxon–Mann–Whitney, exato de Fisher e Kruskal–Wallis.

Resultados

O pH variou consideravelmente entre as formas líquida e em barra, com pHs menores (de 4,4 a 7,9) nos líquidos (p<0,05). Os sindets mostraram pHs próximos ao ideal (levemente ácidos) e os antibacterianos apresentaram os maiores pHs (até 11,34) (p<0,05). Apenas dois dos sabonetes analisados apresentavam no rótulo a indicação do pH.

Conclusões

A observação do pH dos sabonetes infantis pelos médicos e usuários é importante, haja vista a grande variabilidade de valores de pH encontrados. Além disso, os sabonetes líquidos, e especialmente os sindets, são os mais recomendados para uso em recém-nascidos e lactentes com pele sensível, de forma a garantir a eficácia da barreira cutânea.

Palavras-chave:
Concentração de íons de hidrogênio
Sabões
Detergentes
Antibacterianos
Cuidado da criança
Full Text
Introduction

The skin of newborns (NBs) has indispensable functions for their development: it acts as a protective barrier,1 helps thermoregulation, exchanges gases, maintains hydration, and contributes to innate immunity.2 Additionally, its mildly acidic pH provides additional protection against pathogens.1 The disruption of this natural barrier allows opportunistic microorganisms to affect infants with bloodstream dissemination, especially in premature infants due to immunological system immaturity.3 Studies indicate that the infant's skin continues to develop for up to 12 months after birth4,5 and that it differs from the adult skin in several aspects, such as composition, structure, function, and its susceptibility to infections.4,6,7

The potential of hydrogen (pH) of the slightly acid skin is an important factor in the protection against microorganisms – it is essential for the epidermal barrier maturation and repair processes.8 In adults and adolescents, skin pH is <5 (pH<5). In the thinner skin, especially in preterm infants, the pH tends toward neutral, resulting in significant loss of defense against microbial proliferation, as well as higher transepidermal water loss.9 At birth, a full-term NB's skin has a pH ranging from 6.3 to 7.5.10,11 Within the first 2 weeks of life, the pH drops to approximately 5.11 Between the second and fourth weeks of life, the pH becomes gradually acid, ranging from 4.2 to 5.9, depending on the area of the body, with higher values found in the axillary, genital, and interdigital areas.12

Bath time is a moment of relaxation and mother–child interaction, in addition to being indispensable for the maintenance of skin hygiene and health.13 The bath keeps the skin free of irritants (saliva, nasal secretions, urine, feces, and fecal enzymes), dust, and microorganisms.1 According to the World Health Organization (WHO), it is recommended that the NB be given the first bath 6h after birth.9 It has been suggested that a bath given with only water is the least harmful method of cleaning the NB, which has been adopted in the national postnatal care protocols in many countries, including the United Kingdom.9 However, the buffering capacity of water has been questioned, as it can increase skin pH from 5.5 to 7.5. Moreover, the use of water alone was identified as an ineffective cleaning agent, as it does not remove oily substances such as feces and sebum.14,15 American guidelines recommend the use of lukewarm drinking water, with the option of associating a mild cleaning product with a physiologically adequate pH (5.5–7.0).14

It is believed that the repeated use of cleaning agents can alter the skin surface pH in the long term.12 Traditional soaps have an alkaline pH, which can destroy the skin lipid layer9 and elevate skin pH above 8.0, leading to skin dryness and irritation.12,14,16–19 A pH of 7.5 is capable of increasing skin protease activity and inhibiting lipid lamellae synthesis, leading to a breakdown of the skin barrier.14

The “syndets”, a term derived from “synthetic detergent”, are formulated from synthetic surfactants that have good detergent effect, with neutral or slightly acid pH, and cause less irritation.9 Studies show that taking a bath using this type of soap is comparable or even superior to a bath with water only.20

A good cleaning product for NBs must have a pH close to 5.5 and some buffer capacity to maintain the pH close to that level.14 The cosmetic industries offer a great variety of such products and classify them as “mild”. However, there is no international criterion to establish the mildness of cleaning agents, and often, various products advertised as adequate for sensitive skins exhibit significant irritative effects.21

Thus, the aim of this study was to evaluate the pH of children's soaps, antibacterial soaps, and syndets commonly used to bathe children and infants, in order to verify whether they are slightly acidic and, therefore, consistent with the maintenance of the water–lipid mantle and barrier function and, secondly, to determine whether the labels of these products have information about their pH.

Methods

This was an observational, analytical, cross-sectional, quantitative study. Products from all brands (liquid or bar) of children's soap were obtained, antibacterial and syndets found at points of purchase (supermarkets, drugstores, and cosmetic stores) located within 7km of Hospital de Clínicas, located in downtown Curitiba, state of Parana, Brazil. These samples were paid for using the researchers’ own funds, in order to avoid any conflicts of interest. Ninety types of soaps were analyzed (62 bars and 28 liquid soaps), divided into three categories, including 67 children's soaps, 17 antibacterial soaps, and six syndets. These groups were further divided into five categories according to pH ranges: pH<5; between 5 and 5.9; between 6 and 6.9; between 7 and 7.9; and ≥8.

The pH of all the soap samples was measured using a pHmeter® (Hanna Instruments, model H19321, TX, USA) at a dilution of 1% in distilled water (pH 9.1). A comparison between 1% and 10% dilutions was performed and it was verified that pH values remained the same. Thus, due to the fact that smaller volumes are easier to use, the 1% dilution was chosen.

Data were stored in a Microsoft Excel® spreadsheet and evaluated using R® software, version 3.0.2 (Microsoft®, Washington, USA). Summary measures used in descriptive statistics were mean, standard deviation, median, minimum and maximum values, and frequencies, depending on the type of the studied variable. The Pearson–Yates chi-squared test and Student's t-test were applied, considering the significance level of 5%. The tests used for inferential statistics (data comparison) were the Wilcoxon–Mann–Whitney test, Fisher's exact test, and the Kruskal–Wallis test.

This study did not require the approval by the ethics committee, as it did not involve human subjects, but only the biochemical analysis of soaps; opinion No. 064.2012.

Results

The pH of the soaps ranged from 4.4 to 11.5, with a median of 10.7. Two (2.2%) had pH<5, 8 (8.8%) soaps had pH between 5 and 5.9, 9 (10%) had pH between 6 and 6.9, 10 (11.1%) had pH between 7 and 7.9, and 61 (67.7%) had pH>8.

In the group of children's soaps, 47 were bars and 20 were liquid soaps (Table 1). Only one of bar soaps had pH<8 (2.2%). Among the liquid soaps, 1 (5%) had pH<5.0; 3 (15%) had pH from 5.0 to 5.9; 9 (45%) had pH from 6.0 to 6.9; and 7 had (35%) pH from 7.0 to 7.9.

Table 1.

Soaps according to their group, presentation, and potential of hydrogen (pH).

  pH 
Children's bar soaps
Baruel Xuxinha amarelo  10.72 
Baruel Xuxinha camomila  11.16 
Baruel Xuxinha Lavanda  11.18 
Biocrema The Flintstone  8.86 
Boticário Baby Boti  9.66 
Boticário Sophie Fantasy  11.20 
Boticário Sophie Jeans  10.74 
Boticário Sophie Magic  10.54 
Boticário Spulókis  9.82 
Cetrilan suave  10.65 
Cremer Disney  11.37 
Cremer Disney Princesas  11.19 
Davene Bebêvida com extrato natural de aveia e glicerina  10.83 
Dove baby  8.61 
Dove baby da cabeça aos pés  7.88 
Galderma Proderm  7.41 
Granado Glicerina  10.62 
Granado Glicerina Erva doce  10.90 
Granado Lavanda  10.95 
Huggies Chá de camomila  10.87 
Huggies Extra suave  10.77 
Huggies Toque de amêndoas  10.73 
Hydrata Cuidado perfumado  10.99 
Hydratta Bebê cuidado suave  10.59 
Hydratta Cuidado delicado  11.23 
Johnson's Baby  10.25 
Johnson's Glicerinado  11.04 
Johnson's Hora de brincar  11.36 
Johnson's Óleo de amêndoas  11.41 
Johnson's Glicerinado  9.79 
Johnson's Milk  11.28 
Johnson's Hora do sono  11.34 
Muriel Baby Menina  11.38 
Muriel Baby Menino  11.38 
Natura Cuca fresca glicerinado  10.72 
Natura Mamãe e Bebê com extrato de Passiflora  10.22 
Natura Naturé Bololô  11.19 
Natura Naturé Mistureba  10.08 
Nazca Acqua Kids Extrato de maçã e Camomila  11.24 
Nazca Acqua Kids Pele delicada  11.55 
Nazca Acqua Kids Cheirinho de erva doce e hortelã  11.30 
Pom Pom Camomila e erva cidreira  10.80 
Pom Pom Glicerinado  10.44 
Pom Pom Leite e Mel  11.16 
Pom Pom Loção hidratante  10.85 
Pom Pom Óleo de amêndoas  10.97 
Topz Tom & Jerry Limpeza Suave  11.24 
Children's liquid soap
Avon Baby Calming  6.10 
Bebê Natureza Extrato de algodão  7.38 
Boticário Sophie  6.94 
Boticário Baby Boti  7.76 
Cremer Disney  7.90 
Dove baby da cabeça aos pés  7.48 
Fisher Price  7.45 
Fofo Glicerinado  6.44 
Galinha Pintadinha Extrato de Algodão e glicerina  6.52 
Giovanna Baby Orange com Giby Care  6.60 
Granado Glicerina  6.98 
Huggies Turma da Mônica Cream Oil  5.60 
Huggies Turma da Mônica Extra suave  5.86 
Johnson's Hora de Brincar  4.40 
Johnson's Baby recém-nascido  5.86 
Muriel Baby Menina  6.87 
Muriel Baby Menino  7.20 
Natura Mamãe e Bebê Glicerina com óleo de passiflora  7.83 
Panvel Baby Club  6.64 
Patati Patata Extrato de Aloe Vera  6.07 
Antibacterial bar soaps
Dettol Cool  11.26 
Dettol Cuidado Diário  11.34 
Dettol Suave  11.34 
Lifebuoy Aveia  11.22 
Lifebuoy Care&Clinical 10  11.07 
Lifebuoy Cream  11.10 
Lifebuoy Fresh  11.25 
Lifebuoy Total  11.24 
Protex Cream  10.96 
Protex Erva doce  11.05 
Protex Limpeza profunda  10.28 
Protex Ômega 3  11.00 
Protex Própolis  10.93 
Protex suave  10.91 
Antibacterial liquid soaps
Dettol original  4.40 
Protex Cream  5.90 
Lifebuoy  9.50 
Syndet bars
Eucerin Ph5 Syndet  5.81 
La Roche Posay Lipikar Surgras  10.35 
Liquid syndets
Eucerin Pele Sensível pH5 Syndet  5.30 
La Roche Posay Lipikar Surgras  5.40 
Cetaphil Restoraderm  5.93 
Fisiogel Sabonete Líquido Hidratante  7.36 

In the group of antibacterial soaps, 14 were bars and three were liquid soaps (Table 1). All bar soaps (100%) had pH>8.0; among the liquid soaps, 1 (33.3%) had pH<5.0; 1 (33.3%) had pH between 5.0 and 5.9 (33.3%), and 1 had pH>8.0. Only two antibacterial liquid soaps had the pH close to the physiological range.

In group of syndets, two were bar and four were liquid soaps (Table 1). Among the bar soaps, 1 (50%) had pH of 5.0–5.9, and 1 (50%) had pH>8.0; and among the three liquids soaps, 3 (75%) had pH between 5.0 and 5.9, and 1 (25%) had pH between 7.0 and 7.9.

When comparing the pH values between the liquid and bar soaps using Fisher's exact test, there was a statistically significant difference (p<0.0001), with the liquid soaps showing lower pH values (Fig. 1).

Figure 1.

Potential of hydrogen (pH) variation according to the soap presentation n=90.

(0.04MB).

When divided by soap category: children's soaps, antibacterial soaps, and syndets, different pH values were also found between them using the Kruskal–Wallis test (p=0.0017).

The multiple comparison test (Fisher's exact test) was used, which showed a statistically significant difference in pH (p=0.0032) between the children's soap and syndet groups, and between the antibacterial soap and syndet groups (p=0.0002). The syndets had significantly lower pH when compared to the others (p<0.05; Fig. 2). Only two of the assessed soaps had information on the label indicating the pH.

Figure 2.

Potential of hydrogen (pH) variation according to the group of soaps (children's, antibacterial, or syndet) n=90.

(0.05MB).
Discussion

Skin pH alterations caused by the use of different types of soaps are well known.1,7,9,12,13 It is also known that skin pH is slightly acidic, and that highly-alkaline pH can damage the acid mantle that acts as an antibacterial barrier, as well as disrupt the lipid lamellae of the epidermis, resulting in skin dryness due to higher transepidermal water loss and allowing the entry of potential irritants and allergens.7,9,12,13 This occurs because the soap, in contact with water, undergoes a hydrolysis reaction, releasing the alkali contained in these products and increasing the skin pH to 10–11.12 Based on the results, it can be observed that the soaps in liquid form are the most appropriate for everyday use, especially in children and infants, whose skin is more delicate and sensitive.

As demonstrated in the present study, Volochtchuk et al.,12 in a study carried out at the same institution, have already shown significant differences in pH between liquid and bar soaps, but the study evaluated both adult and children's soaps. The bar soaps showed pH>6, with most between 9 and 10. As for the liquid soaps, most showed pH between 6 and 6.9.11

Liquid syndets have a pH closer to the physiological range (approximately 5), and are especially recommended to patients with diseases that alter the skin barrier (such as atopic dermatitis and ichthyosis) or children with sensitive skin. In these individuals, the use of soaps with high pH worsens xerosis and can generate solutions of continuity of the skin, which can be a gateway to pathogens. Syndet action occurs in two ways: first, by reducing the interaction between tensioactive agents and skin proteins and lipids; and second, by restoring lipids and moisturizing agents lost during the washing.19 Thus, the skin does not dry, remaining hydrated.

Antibacterial bar soaps showed the highest pH values of all assessed soaps. This demonstrates that these products can be aggressive to the child's skin and should not be routinely used, but only in specific situations and for short periods of time, and on restricted parts and not the entire body, preferably in liquid form.

It was verified that only two of the included soaps had any mention of pH levels on their package. The study by Tarun et al.22 mentioned that the labels of all assessed soaps, except for one, had no information related to the product pH. It was observed that even those products whose packaging contained phrases such as “neutral pH”, “balanced pH”, or “dermatologically tested” had pH above the expected range. Therefore, it was found that many of these products provide information that can confuse the consumer, since the fact that the skin is slightly acidic is not generally known by the public, as well as the importance of maintaining the skin's barrier function. Only one brand (Eucerin bar and liquid soap, Eucerin®, USA) displayed pH specification on the packaging, which makes it difficult to choose or recommend these products, by both the lay population and health professionals.

Most analyzed soaps are manufactured and sold in Brazil. Although some of them represent internationally-renowned brands, it cannot be verified that their chemical composition and hence their pH is the same worldwide. However, as this study selected product brands that are also available in other countries, in easily accessible and popular stores, and also because as many different brands as possible were acquired, it is believed that the results can be extrapolated to other cities in Brazil and other regions of the world, which should be supported by studies in these locations.

This study highlights the pH inadequacy of several children's products freely available in points of purchase. Pediatricians, parents, and caregivers should be aware of the characteristics of products used in pediatric patients, as some may even cause damage to the skin of children and infants.

Based on this fact, it is important that health surveillance institutions that regulate the selling of products for infant use establish stricter criteria for their commercialization, as well as for the information that should be included in their packaging, including the product pH.

Conflicts of interest

The authors declare no conflicts of interest.

Acknowledgements

The authors would like to thank Prof. Dr. Ana Lucia Tararthuch and Prof. Dr. Ricardo Perez for allowing the use of the facilities, machinery, and equipment of the Renal Physiology Laboratory of UFPR for measuring the pH of the products and UFPR statistician, Ricardo Petterle, for his contribution to the statistical analysis.

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Please cite this article as: Mendes BR, Shimabukuro DM, Uber M, Abagge KT. Critical assessment of the pH of children's soap. J Pediatr (Rio J). 2016;92:290–5.

Copyright © 2016. Sociedade Brasileira de Pediatria
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