Journal Information
Vol. 92. Issue 3.
Pages 290-295 (May - June 2016)
Visits
4201
Vol. 92. Issue 3.
Pages 290-295 (May - June 2016)
Original article
Open Access
Critical assessment of the pH of children's soap
Avaliação crítica do pH dos sabonetes infantis
Visits
4201
Bruna Rafaela Mendesa, Danielle Midori Shimabukuroa, Marjorie Ubera, Kerstin Taniguchi Abaggeb,
Corresponding author
kerstinabagge@gmail.com

Corresponding author.
a Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil
b Pediatric Dermatology Unit, Department of Pediatrics, Hospital de Clínicas, Curitiba, PR, Brazil
This item has received

Under a Creative Commons license
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (1)
Table 1. Soaps according to their group, presentation, and potential of hydrogen (pH).
Abstract
Objective

To evaluate the pH value of children's antibacterial soaps and syndets used in children's baths and verify whether there is information regarding pH on the product label.

Methods

Quantitative, cross-sectional, analytical observational study that included ninety soap samples, both in bar and liquid presentations, as follows: 67 children's soap (group 1), 17 antibacterial soaps (group 2), and 6 syndets (group 3). Each sample had its pH measured after 1% dilution. In addition to descriptive statistics, the Pearson–Yates chi-squared test and Student's t-tests were applied, considering the minimal significance level of 5%. The Wilcoxon–Mann–Whitney test, Fisher's exact test, and the Kruskal–Wallis test were used for inferential statistics.

Results

The pH levels varied considerably between liquid and bar presentations, with lower levels (4.4–7.9) found for the liquids (p<0.05). Syndets showed pH levels close to the ideal (slightly acid) and the antibacterial soaps showed the highest pH levels (up to 11.34) (p<0.05). Only two of the soaps included in the study had information about their pH levels on the product packaging.

Conclusions

Knowledge of the pH of children's soap by doctors and users is important, considering the great pH variability found in this study. Moreover, liquid soaps, and especially syndets, are the most recommended for the sensitive skin of neonates and infants, in order to guarantee skin barrier efficacy.

Keywords:
Hydrogen-ion concentration
Soaps
Detergents
Anti-bacterial agents
Childcare
Resumo
Objetivos

Avaliar o pH dos sabonetes infantis, antibacterianos e sindets habitualmente utilizados em crianças; bem como verificar se há no rótulo desses produtos informação sobre seu pH.

Métodos

Estudo observacional, analítico, transversal e quantitativo, que incluiu 90 sabonetes nas apresentações em barra e líquida, sendo 67 infantis (grupo 1), 17 antibacterianos (grupo 2) e 6 sindets (grupo 3). Procedeu-se a mensuração do pH das amostras após diluição a 1%. Além da estatística descritiva, foram usados os testes de Qui quadrado Persons/Yates e teste T de Student,com nível de significância mínimo de 5%. Para a estatística inferencial, foram usados os testes de Wilcoxon–Mann–Whitney, exato de Fisher e Kruskal–Wallis.

Resultados

O pH variou consideravelmente entre as formas líquida e em barra, com pHs menores (de 4,4 a 7,9) nos líquidos (p<0,05). Os sindets mostraram pHs próximos ao ideal (levemente ácidos) e os antibacterianos apresentaram os maiores pHs (até 11,34) (p<0,05). Apenas dois dos sabonetes analisados apresentavam no rótulo a indicação do pH.

Conclusões

A observação do pH dos sabonetes infantis pelos médicos e usuários é importante, haja vista a grande variabilidade de valores de pH encontrados. Além disso, os sabonetes líquidos, e especialmente os sindets, são os mais recomendados para uso em recém-nascidos e lactentes com pele sensível, de forma a garantir a eficácia da barreira cutânea.

Palavras-chave:
Concentração de íons de hidrogênio
Sabões
Detergentes
Antibacterianos
Cuidado da criança
Full Text
Introduction

The skin of newborns (NBs) has indispensable functions for their development: it acts as a protective barrier,1 helps thermoregulation, exchanges gases, maintains hydration, and contributes to innate immunity.2 Additionally, its mildly acidic pH provides additional protection against pathogens.1 The disruption of this natural barrier allows opportunistic microorganisms to affect infants with bloodstream dissemination, especially in premature infants due to immunological system immaturity.3 Studies indicate that the infant's skin continues to develop for up to 12 months after birth4,5 and that it differs from the adult skin in several aspects, such as composition, structure, function, and its susceptibility to infections.4,6,7

The potential of hydrogen (pH) of the slightly acid skin is an important factor in the protection against microorganisms – it is essential for the epidermal barrier maturation and repair processes.8 In adults and adolescents, skin pH is <5 (pH<5). In the thinner skin, especially in preterm infants, the pH tends toward neutral, resulting in significant loss of defense against microbial proliferation, as well as higher transepidermal water loss.9 At birth, a full-term NB's skin has a pH ranging from 6.3 to 7.5.10,11 Within the first 2 weeks of life, the pH drops to approximately 5.11 Between the second and fourth weeks of life, the pH becomes gradually acid, ranging from 4.2 to 5.9, depending on the area of the body, with higher values found in the axillary, genital, and interdigital areas.12

Bath time is a moment of relaxation and mother–child interaction, in addition to being indispensable for the maintenance of skin hygiene and health.13 The bath keeps the skin free of irritants (saliva, nasal secretions, urine, feces, and fecal enzymes), dust, and microorganisms.1 According to the World Health Organization (WHO), it is recommended that the NB be given the first bath 6h after birth.9 It has been suggested that a bath given with only water is the least harmful method of cleaning the NB, which has been adopted in the national postnatal care protocols in many countries, including the United Kingdom.9 However, the buffering capacity of water has been questioned, as it can increase skin pH from 5.5 to 7.5. Moreover, the use of water alone was identified as an ineffective cleaning agent, as it does not remove oily substances such as feces and sebum.14,15 American guidelines recommend the use of lukewarm drinking water, with the option of associating a mild cleaning product with a physiologically adequate pH (5.5–7.0).14

It is believed that the repeated use of cleaning agents can alter the skin surface pH in the long term.12 Traditional soaps have an alkaline pH, which can destroy the skin lipid layer9 and elevate skin pH above 8.0, leading to skin dryness and irritation.12,14,16–19 A pH of 7.5 is capable of increasing skin protease activity and inhibiting lipid lamellae synthesis, leading to a breakdown of the skin barrier.14

The “syndets”, a term derived from “synthetic detergent”, are formulated from synthetic surfactants that have good detergent effect, with neutral or slightly acid pH, and cause less irritation.9 Studies show that taking a bath using this type of soap is comparable or even superior to a bath with water only.20

A good cleaning product for NBs must have a pH close to 5.5 and some buffer capacity to maintain the pH close to that level.14 The cosmetic industries offer a great variety of such products and classify them as “mild”. However, there is no international criterion to establish the mildness of cleaning agents, and often, various products advertised as adequate for sensitive skins exhibit significant irritative effects.21

Thus, the aim of this study was to evaluate the pH of children's soaps, antibacterial soaps, and syndets commonly used to bathe children and infants, in order to verify whether they are slightly acidic and, therefore, consistent with the maintenance of the water–lipid mantle and barrier function and, secondly, to determine whether the labels of these products have information about their pH.

Methods

This was an observational, analytical, cross-sectional, quantitative study. Products from all brands (liquid or bar) of children's soap were obtained, antibacterial and syndets found at points of purchase (supermarkets, drugstores, and cosmetic stores) located within 7km of Hospital de Clínicas, located in downtown Curitiba, state of Parana, Brazil. These samples were paid for using the researchers’ own funds, in order to avoid any conflicts of interest. Ninety types of soaps were analyzed (62 bars and 28 liquid soaps), divided into three categories, including 67 children's soaps, 17 antibacterial soaps, and six syndets. These groups were further divided into five categories according to pH ranges: pH<5; between 5 and 5.9; between 6 and 6.9; between 7 and 7.9; and ≥8.

The pH of all the soap samples was measured using a pHmeter® (Hanna Instruments, model H19321, TX, USA) at a dilution of 1% in distilled water (pH 9.1). A comparison between 1% and 10% dilutions was performed and it was verified that pH values remained the same. Thus, due to the fact that smaller volumes are easier to use, the 1% dilution was chosen.

Data were stored in a Microsoft Excel® spreadsheet and evaluated using R® software, version 3.0.2 (Microsoft®, Washington, USA). Summary measures used in descriptive statistics were mean, standard deviation, median, minimum and maximum values, and frequencies, depending on the type of the studied variable. The Pearson–Yates chi-squared test and Student's t-test were applied, considering the significance level of 5%. The tests used for inferential statistics (data comparison) were the Wilcoxon–Mann–Whitney test, Fisher's exact test, and the Kruskal–Wallis test.

This study did not require the approval by the ethics committee, as it did not involve human subjects, but only the biochemical analysis of soaps; opinion No. 064.2012.

Results

The pH of the soaps ranged from 4.4 to 11.5, with a median of 10.7. Two (2.2%) had pH<5, 8 (8.8%) soaps had pH between 5 and 5.9, 9 (10%) had pH between 6 and 6.9, 10 (11.1%) had pH between 7 and 7.9, and 61 (67.7%) had pH>8.

In the group of children's soaps, 47 were bars and 20 were liquid soaps (Table 1). Only one of bar soaps had pH<8 (2.2%). Among the liquid soaps, 1 (5%) had pH<5.0; 3 (15%) had pH from 5.0 to 5.9; 9 (45%) had pH from 6.0 to 6.9; and 7 had (35%) pH from 7.0 to 7.9.

Table 1.

Soaps according to their group, presentation, and potential of hydrogen (pH).

  pH 
Children's bar soaps
Baruel Xuxinha amarelo  10.72 
Baruel Xuxinha camomila  11.16 
Baruel Xuxinha Lavanda  11.18 
Biocrema The Flintstone  8.86 
Boticário Baby Boti  9.66 
Boticário Sophie Fantasy  11.20 
Boticário Sophie Jeans  10.74 
Boticário Sophie Magic  10.54 
Boticário Spulókis  9.82 
Cetrilan suave  10.65 
Cremer Disney  11.37 
Cremer Disney Princesas  11.19 
Davene Bebêvida com extrato natural de aveia e glicerina  10.83 
Dove baby  8.61 
Dove baby da cabeça aos pés  7.88 
Galderma Proderm  7.41 
Granado Glicerina  10.62 
Granado Glicerina Erva doce  10.90 
Granado Lavanda  10.95 
Huggies Chá de camomila  10.87 
Huggies Extra suave  10.77 
Huggies Toque de amêndoas  10.73 
Hydrata Cuidado perfumado  10.99 
Hydratta Bebê cuidado suave  10.59 
Hydratta Cuidado delicado  11.23 
Johnson's Baby  10.25 
Johnson's Glicerinado  11.04 
Johnson's Hora de brincar  11.36 
Johnson's Óleo de amêndoas  11.41 
Johnson's Glicerinado  9.79 
Johnson's Milk  11.28 
Johnson's Hora do sono  11.34 
Muriel Baby Menina  11.38 
Muriel Baby Menino  11.38 
Natura Cuca fresca glicerinado  10.72 
Natura Mamãe e Bebê com extrato de Passiflora  10.22 
Natura Naturé Bololô  11.19 
Natura Naturé Mistureba  10.08 
Nazca Acqua Kids Extrato de maçã e Camomila  11.24 
Nazca Acqua Kids Pele delicada  11.55 
Nazca Acqua Kids Cheirinho de erva doce e hortelã  11.30 
Pom Pom Camomila e erva cidreira  10.80 
Pom Pom Glicerinado  10.44 
Pom Pom Leite e Mel  11.16 
Pom Pom Loção hidratante  10.85 
Pom Pom Óleo de amêndoas  10.97 
Topz Tom & Jerry Limpeza Suave  11.24 
Children's liquid soap
Avon Baby Calming  6.10 
Bebê Natureza Extrato de algodão  7.38 
Boticário Sophie  6.94 
Boticário Baby Boti  7.76 
Cremer Disney  7.90 
Dove baby da cabeça aos pés  7.48 
Fisher Price  7.45 
Fofo Glicerinado  6.44 
Galinha Pintadinha Extrato de Algodão e glicerina  6.52 
Giovanna Baby Orange com Giby Care  6.60 
Granado Glicerina  6.98 
Huggies Turma da Mônica Cream Oil  5.60 
Huggies Turma da Mônica Extra suave  5.86 
Johnson's Hora de Brincar  4.40 
Johnson's Baby recém-nascido  5.86 
Muriel Baby Menina  6.87 
Muriel Baby Menino  7.20 
Natura Mamãe e Bebê Glicerina com óleo de passiflora  7.83 
Panvel Baby Club  6.64 
Patati Patata Extrato de Aloe Vera  6.07 
Antibacterial bar soaps
Dettol Cool  11.26 
Dettol Cuidado Diário  11.34 
Dettol Suave  11.34 
Lifebuoy Aveia  11.22 
Lifebuoy Care&Clinical 10  11.07 
Lifebuoy Cream  11.10 
Lifebuoy Fresh  11.25 
Lifebuoy Total  11.24 
Protex Cream  10.96 
Protex Erva doce  11.05 
Protex Limpeza profunda  10.28 
Protex Ômega 3  11.00 
Protex Própolis  10.93 
Protex suave  10.91 
Antibacterial liquid soaps
Dettol original  4.40 
Protex Cream  5.90 
Lifebuoy  9.50 
Syndet bars
Eucerin Ph5 Syndet  5.81 
La Roche Posay Lipikar Surgras  10.35 
Liquid syndets
Eucerin Pele Sensível pH5 Syndet  5.30 
La Roche Posay Lipikar Surgras  5.40 
Cetaphil Restoraderm  5.93 
Fisiogel Sabonete Líquido Hidratante  7.36 

In the group of antibacterial soaps, 14 were bars and three were liquid soaps (Table 1). All bar soaps (100%) had pH>8.0; among the liquid soaps, 1 (33.3%) had pH<5.0; 1 (33.3%) had pH between 5.0 and 5.9 (33.3%), and 1 had pH>8.0. Only two antibacterial liquid soaps had the pH close to the physiological range.

In group of syndets, two were bar and four were liquid soaps (Table 1). Among the bar soaps, 1 (50%) had pH of 5.0–5.9, and 1 (50%) had pH>8.0; and among the three liquids soaps, 3 (75%) had pH between 5.0 and 5.9, and 1 (25%) had pH between 7.0 and 7.9.

When comparing the pH values between the liquid and bar soaps using Fisher's exact test, there was a statistically significant difference (p<0.0001), with the liquid soaps showing lower pH values (Fig. 1).

Figure 1.

Potential of hydrogen (pH) variation according to the soap presentation n=90.

(0.04MB).

When divided by soap category: children's soaps, antibacterial soaps, and syndets, different pH values were also found between them using the Kruskal–Wallis test (p=0.0017).

The multiple comparison test (Fisher's exact test) was used, which showed a statistically significant difference in pH (p=0.0032) between the children's soap and syndet groups, and between the antibacterial soap and syndet groups (p=0.0002). The syndets had significantly lower pH when compared to the others (p<0.05; Fig. 2). Only two of the assessed soaps had information on the label indicating the pH.

Figure 2.

Potential of hydrogen (pH) variation according to the group of soaps (children's, antibacterial, or syndet) n=90.

(0.05MB).
Discussion

Skin pH alterations caused by the use of different types of soaps are well known.1,7,9,12,13 It is also known that skin pH is slightly acidic, and that highly-alkaline pH can damage the acid mantle that acts as an antibacterial barrier, as well as disrupt the lipid lamellae of the epidermis, resulting in skin dryness due to higher transepidermal water loss and allowing the entry of potential irritants and allergens.7,9,12,13 This occurs because the soap, in contact with water, undergoes a hydrolysis reaction, releasing the alkali contained in these products and increasing the skin pH to 10–11.12 Based on the results, it can be observed that the soaps in liquid form are the most appropriate for everyday use, especially in children and infants, whose skin is more delicate and sensitive.

As demonstrated in the present study, Volochtchuk et al.,12 in a study carried out at the same institution, have already shown significant differences in pH between liquid and bar soaps, but the study evaluated both adult and children's soaps. The bar soaps showed pH>6, with most between 9 and 10. As for the liquid soaps, most showed pH between 6 and 6.9.11

Liquid syndets have a pH closer to the physiological range (approximately 5), and are especially recommended to patients with diseases that alter the skin barrier (such as atopic dermatitis and ichthyosis) or children with sensitive skin. In these individuals, the use of soaps with high pH worsens xerosis and can generate solutions of continuity of the skin, which can be a gateway to pathogens. Syndet action occurs in two ways: first, by reducing the interaction between tensioactive agents and skin proteins and lipids; and second, by restoring lipids and moisturizing agents lost during the washing.19 Thus, the skin does not dry, remaining hydrated.

Antibacterial bar soaps showed the highest pH values of all assessed soaps. This demonstrates that these products can be aggressive to the child's skin and should not be routinely used, but only in specific situations and for short periods of time, and on restricted parts and not the entire body, preferably in liquid form.

It was verified that only two of the included soaps had any mention of pH levels on their package. The study by Tarun et al.22 mentioned that the labels of all assessed soaps, except for one, had no information related to the product pH. It was observed that even those products whose packaging contained phrases such as “neutral pH”, “balanced pH”, or “dermatologically tested” had pH above the expected range. Therefore, it was found that many of these products provide information that can confuse the consumer, since the fact that the skin is slightly acidic is not generally known by the public, as well as the importance of maintaining the skin's barrier function. Only one brand (Eucerin bar and liquid soap, Eucerin®, USA) displayed pH specification on the packaging, which makes it difficult to choose or recommend these products, by both the lay population and health professionals.

Most analyzed soaps are manufactured and sold in Brazil. Although some of them represent internationally-renowned brands, it cannot be verified that their chemical composition and hence their pH is the same worldwide. However, as this study selected product brands that are also available in other countries, in easily accessible and popular stores, and also because as many different brands as possible were acquired, it is believed that the results can be extrapolated to other cities in Brazil and other regions of the world, which should be supported by studies in these locations.

This study highlights the pH inadequacy of several children's products freely available in points of purchase. Pediatricians, parents, and caregivers should be aware of the characteristics of products used in pediatric patients, as some may even cause damage to the skin of children and infants.

Based on this fact, it is important that health surveillance institutions that regulate the selling of products for infant use establish stricter criteria for their commercialization, as well as for the information that should be included in their packaging, including the product pH.

Conflicts of interest

The authors declare no conflicts of interest.

Acknowledgements

The authors would like to thank Prof. Dr. Ana Lucia Tararthuch and Prof. Dr. Ricardo Perez for allowing the use of the facilities, machinery, and equipment of the Renal Physiology Laboratory of UFPR for measuring the pH of the products and UFPR statistician, Ricardo Petterle, for his contribution to the statistical analysis.

References
[1]
L.S. Telofski, A.P. Morello, M.C. Correa, G.N. Stamatas.
The infant skin barrier: can we preserve, protect, and enhance the barrier?.
Dermatol Res Pract, 2012 (2012), pp. 1-18
[2]
P.M. Elias.
The skin barrier as an innate immune element.
Semin Immunopathol, 29 (2007), pp. 3-14
[3]
R.M. Romanelli, L.M. Anchieta, M.V. Mourão, F.A. Campos, F.C. Loyola, P.H. Mourão, et al.
Risk factors and lethality of laboratory-confirmed bloodstream infection caused by non-skin contaminant pathogens in neonates.
J Pediatr (Rio J), 89 (2013), pp. 189-196
[4]
G.N. Stamatas, J. Nikolovski, M.C. Mack, N. Kollias.
Infant skin physiology and development during the first years of life: a review of recent findings based on in vivo studies.
Int J Cosmet Sci, 33 (2011), pp. 17-24
[5]
J. Nikolovski, G.N. Stamatas, N. Kollias, B.C. Wiegand.
Barrier function and water-holding and transport properties of infant stratum corneum are different from adult and continue to develop through the first year of life.
J Investig Dermatol, 128 (2008), pp. 1728-1736
[6]
Y.B. Chiou, U. Blume-Peytavi.
Stratumcorneum maturation. A review of neonatal skin function.
Skin Pharmacol Physiol, 17 (2004), pp. 57-66
[7]
G.N. Stamatas, J. Nikolovski, M.A. Luedtke, N. Kollias, B.C. Wiegand.
Infant skin microstructure assessed in vivo differs from adult skin in organization and at the cellular level.
Pediatr Dermatol, 27 (2010), pp. 125-131
[8]
J.W. Fluhr, R. Darlenski, A. Taleb, J.P. Hacherm, C. Baudouin, P. Msika, et al.
Functional skin adaptation in infancy – almost complete but not fully competent.
Exp Dermatol, 19 (2010), pp. 483-492
[9]
J.D. Fernandes, M.C. Machado, Z.N. Oliveira.
Children and newborn skin care and prevention.
An Bras Dermatol, 86 (2011), pp. 102-110
[10]
G. Yosipovitch, M.I. Duque, T.S. Patel, Y. Ishiuji, D.A. Guzman-Sanchez, A.G. Dawn, et al.
Skin barrier structure and function and their relationship to pruritus in end-stage renal disease.
Nephrol Dial Transplant, 22 (2007), pp. 3268-3272
[11]
C. Lund, J. Kuller, A. Lane, J.W. Lott, D.A. Raines.
Neonatal skin care: the scientific basis for practice.
Neonatal Netw, 18 (1999), pp. 15-27
[12]
O.M. Volochtchuk, A.P. Fadel, T. Almeida, E.M. Fujita, M.P. Auada, L.P. Marinoni.
Variations in the pH of soaps and indications for its use in normal and diseased skin.
An Bras Dermatol, 75 (2000), pp. 697-703
[13]
V.O. Carvalho.
Banho: cuidados a partir dos 30 dias.
pp. 2-7
[14]
T. Lavender, C. Bedwell, E. O’Brien, M.J. Cork, M. Turner, A. Hart.
Infant skin-cleansing product versus water: a pilot randomized, assessor-blinded controlled trial.
BMC Pediatr, 11 (2011), pp. 35
[15]
U. Blume-Peytavi, M.J. Clork, J. Faergemann, J. Szczapa, F. Vanaclocha, C. Gelmetti.
Bathing and cleansing in newborns from day 1 to first year of life: recommendations from a European round table meeting.
J Eur Acad Dermatol Venereol, 23 (2009), pp. 751-759
[16]
F.S. Afsar.
Skin care for preterm and term neonates.
Clin Exp Dermatol, 34 (2009), pp. 855-858
[17]
R. Gfatter, P. Hackl, F. Braun.
Effects of soap and detergents on skin surface pH, stratum corneum hydration and fat content in infants.
Dermatology, 195 (1997), pp. 258-262
[18]
G.L. Darmstadt, J.G. Dinulos.
Neonatal skin care.
Pediatr Clin N Am, 47 (2000), pp. 757-782
[19]
K.P. Ananthapadmanabhan, D.J. Moore, K. Subramanyan, M. Misra, F. Meyer.
Cleansing without compromise: the impact of cleansers on the skin barrier and the technology of mild cleansing.
Dermatol Ther, 17 (2004), pp. 16-25
[20]
U. Blume-Peytavi, M. Hauser, G.N. Stamatas, D. Pathirana, N.G. Bartels.
Skin care practices for newborns and infants: review of the clinical evidence for best practices.
Pediatr Dermatol, 29 (2012), pp. 1-14
[21]
M. Corazza, M.M. Lauriola, A. Bianchi, M. Zappaterra, A. Virgili.
Irritant and sensitizing potential of eight surfactants commonly used in skin cleansers: an evaluation of 105 patients.
Dermatitis, 21 (2010), pp. 262-268
[22]
J. Tarun, J. Susan, J. Suria, V.J. Susan, S. Criton.
Evaluation of pH of bathing soaps and shampoos for skin and hair care.
Indian J Dermatol, 59 (2014), pp. 442-444

Please cite this article as: Mendes BR, Shimabukuro DM, Uber M, Abagge KT. Critical assessment of the pH of children's soap. J Pediatr (Rio J). 2016;92:290–5.

Copyright © 2016. Sociedade Brasileira de Pediatria
Download PDF
Idiomas
Jornal de Pediatria (English Edition)
Article options
Tools
en pt
Taxa de publicaçao Publication fee
Os artigos submetidos a partir de 1º de setembro de 2018, que forem aceitos para publicação no Jornal de Pediatria, estarão sujeitos a uma taxa para que tenham sua publicação garantida. O artigo aceito somente será publicado após a comprovação do pagamento da taxa de publicação. Ao submeterem o manuscrito a este jornal, os autores concordam com esses termos. A submissão dos manuscritos continua gratuita. Para mais informações, contate assessoria@jped.com.br. Articles submitted as of September 1, 2018, which are accepted for publication in the Jornal de Pediatria, will be subject to a fee to have their publication guaranteed. The accepted article will only be published after proof of the publication fee payment. By submitting the manuscript to this journal, the authors agree to these terms. Manuscript submission remains free of charge. For more information, contact assessoria@jped.com.br.
Cookies policy Política de cookies
To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.