Journal Information
Vol. 95. Issue 3.
Pages 275-281 (May - June 2019)
Vol. 95. Issue 3.
Pages 275-281 (May - June 2019)
Review article
Open Access
Eosinophilic esophagitis—Where are we today?
Esofagite eosinofílica - Qual é a nossa posição atual?
Cristina Targa Ferreiraa,b,
Corresponding author

Corresponding author.
, Mario Cesar Vieirac,d, Glenn T. Furutae,f, Fernando Celso Lopes Fernandes de Barrosg, Mirna Chehadeh
a Universidade Federal de Ciências da Saúde de Porto Alegre, Departamento de Pediatria, Porto Alegre, RS, Brazil
b Hospital Santo Antonio, Porto Alegre, RS, Brazil
c Pontifícia Universidade Católica do Paraná (PUC-PR), Departamento de Pediatria, Curitiba, PR, Brazil
d Hospital Pequeno Príncipe, Centro de Gastroenterologia Pediátrica, Curitiba, PR, Brazil
e Children's Hospital Colorado, Hepatology and Nutrition, Digestive Health Institute, Aurora, United States
f University of Colorado School of Medicine, Department of Pediatrics, Gastrointestinal Eosinophilic Diseases Program, Aurora, United States
g Universidade Católica de Pelotas (UCPel), Curso de Pós-Graduação em Saúde e Comportamento, Pelotas, RS, Brazil
h Icahn School of Medicine at Mount Sinai, Mount Sinai Center for Eosinophilic Disorders, New York, United States
This item has received

Under a Creative Commons license
Article information
Full Text
Download PDF
Tables (1)
Table 1. Additional questions and possible studies in order to identify patients with eosinophilic esophagitis.

The objective of this review is to provide an overview of the practical diagnostic and therapeutic approaches to eosinophilic esophagitis and to increase the visibility of the disease among pediatricians.


A search of the MEDLINE, Embase, and CINAHL databases and recent consensus statements and guidelines were performed.

Summary of the findings

The definition of eosinophilic esophagitis is based on symptoms and histology. It is important to rule out other diseases associated with esophageal eosinophil-predominant inflammation. It is not yet clear whether the increased prevalence is due to a real increase in incidence or a result of increased awareness of the disease. Various options for management have been used in pediatric patients, including proton pump inhibitors, dietary restriction therapies, swallowed topical steroids, and endoscopic dilations. More recently, proton pump inhibitor-responsive esophageal eosinophilia and eosinophilic esophagitis have been contemplated on the same spectrum, and proton pump inhibitors should be considered the initial step in the treatment of these patients.


Eosinophilic esophagitis is a relatively new disease with a remarkable progression of its incidence and prevalence in the past two to three decades, and diagnostic criteria that are constantly evolving. It is important to better understand the pathogenesis of the disease, the predisposing factors, the natural history, and the categorization of varying phenotypes to develop diagnostic and therapeutic strategies that meet the clinical needs of patients.

Eosinophilic esophagitis
Esophageal eosinophilia
Proton pump inhibitors

Fornecer uma visão geral do diagnóstico e do tratamento da esofagite eosinofílica na prática clínica e aumentar a visibilidade da doença entre os pediatras.

Fontes dos dados

Foi feita uma busca na literatura relevante nos bancos de dados Medline, Embase, CINAHL e consensos e diretrizes recentes foram revisados.

Síntese dos dados

A definição de esofagite eosinofílica é baseada nos sintomas e na histologia. É importante excluir outras doenças associadas com inflamação esofágica predominantemente eosinofílica. Ainda não está claro se o aumento na prevalência é devido a um real aumento da incidência ou se é o resultado da maior suspeição diagnóstica. Várias opções para tratamento, inclusive inibidores de bomba de prótons, restrições dietéticas, esteroides tópicos deglutidos e dilatações endoscópicas têm sido usadas em pacientes pediátricos. Mais recentemente a eosinofilia esofágica responsiva a inibidores de bomba de prótons e a esofagite eosinofílica têm sido contempladas no mesmo espectro e os inibidores de bomba de prótons devem ser considerados como opção inicial no tratamento desses pacientes.


A esofagite eosinofílica é uma doença relativamente nova com uma notável progressão da incidência e prevalência nas últimas 2-3 décadas e critérios diagnósticos estão em evolução constante. É importante entender melhor a patogênese dessa doença, os fatores predisponentes, a história natural e a categorização dos diferentes fenótipos para desenvolver estratégias diagnósticas e terapêuticas que vão ao encontro das necessidades clínicas dos pacientes.

Esofagite eosinofílica
Eosinofilia esofágica
Inibidores de bomba de prótons
Full Text
Introduction and concepts

Eosinophilic esophagitis (EoE) is defined as a chronic, immune/antigen-mediated, inflammatory esophageal disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation.1,2

The definition of EoE is based on two diagnostic pillars: symptoms and histology. It is important to rule out other diseases associated with esophageal eosinophil-predominant inflammation, such as gastroesophageal reflux disease, esophageal Crohn's disease, achalasia, eosinophilic gastroenteritis, connective tissue disorders, and esophageal infections before EoE can be diagnosed.1–3

Since its first recognition as a distinct disorder approximately 23 years ago, there has been an increase in the prevalence of EoE in many parts of the world recently and a growing number of studies on EoE have been published, including consensus documents and clinical practice guidelines.1–7

While initially described in North America and Europe, EoE is a global phenomenon and has recently been reported in other regions, including South and Central America, Africa, and Asia.8–10

It is yet not clear whether the increased prevalence is due to a real increase in incidence or a result of increased awareness of the disease.8,11–14 Several studies have attempted to define the extent of EoE by estimating its epidemiology in different populations. Different methodological approaches have been employed, ranging from population-based research to studies defining the frequency of EoE in various series of endoscopies and esophageal biopsies. The results of epidemiological studies with varied methodology have shown a gradual increase in the prevalence of EoE in recent years, with a recent estimate of four patients per 100000 population.15 Because diagnosis is frequently deferred due to delayed request for medical care by patients with esophageal symptoms, poor recognition of typical endoscopic appearances of EoE and failed recognition or recording of typical histologic findings in biopsies, these numbers likely underestimate the true prevalence of the disease. Nevertheless, EoE has recently been considered a common cause of chronic or recurrent esophageal symptoms in children and also represents the most prevalent cause of dysphagia among adolescents and young adults worldwide.1–3

Various options for managing EoE, including proton pump inhibitors (PPIs), dietary restriction therapies, swallowed topical steroids, and endoscopic dilations for esophageal strictures have been used in pediatric and adult patients. Recent publications including systematic reviews and meta-analyses support the use of these modalities of treatment.1–4,8 As EoE is a chronic progressive disorder, a long-term maintenance treatment is typically required.

The objective of this review is to provide an overview of the practical diagnostic and therapeutic approaches to EoE and to increase the visibility of the disease among pediatricians and other health-care professionals.

EoE and proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE)

The initial diagnostic criteria of EoE were based on the concept that gastroesophageal reflux disease (GERD) and EoE were mutually exclusive disorders2,3 and consensus guidelines required unresponsiveness to PPI to confirm the diagnosis of EoE.1,4 However, the correlation between GERD and EoE appears to be more complex, because both diseases may respond to treatment with PPIs.1,4

It is intriguing to ponder why an immune-mediated disease would respond to an acid-blocking medication. Multiple studies have reported patients with GERD-like symptoms and significant esophageal eosinophilia that responded to PPI treatment.7,16–22 This may in part be explained by the anti-inflammatory effects of PPIs unrelated to acid suppression, with inhibition of Th2 cytokines and eotaxin-3 production as demonstrated in recent studies.21–24 This mechanism, along with improvement of barrier function, make PPIs an effective form of treatment for some EoE cases.25

It is difficult to predict whether a patient with esophageal eosinophilia will respond to a PPI. In fact, the clinical, endoscopic, and histological phenotypes of PPI responders and non-responders and the results of their esophageal pH monitoring have been shown to be indistinguishable.17,18,20–22 These findings prompted the creation of a new term: PPI-responsive esophageal eosinophilia (PPI-REE). This denomination was used to define a group of patients with typical symptoms of EoE, esophageal eosinophilic infiltration, and a clinical and histological response to PPI.18,20,26–28

A prospective study conducted in 2011 showed that 50% of adult patients with suspected EoE responded to treatment with PPIs and that there were overlapping clinical, endoscopic, and histological characteristics among responders and non-responders.16 This study revealed that 20% of patients did not respond to PPI, even those with abnormal pH monitoring (suggestive of GERD), while 33% of patients with normal pH monitoring were PPI responders.16

Overall, in adults as well as in children, excluding the individual case series, histologic response rates to PPIs ranged from 23 to 83%, and clinical response rates were 23 to 82%.7 These findings suggest that some patients with PPI-REE may in fact have EoE.1,17,20

In 2016, Gutiérrez-Junquera et al.18 published a prospective series with 56 children and adolescents with suspected EoE, evaluating their response to systematic PPI therapy. Almost 70% of these children responded clinically and histologically to PPI therapy. Twenty-four children (47%) presented complete symptomatic remission. Neither clinical, endoscopic, or histological characteristics, nor pH monitoring results were capable of predicting the response to PPI therapy. This was the first prospective series in children demonstrating that, in comparison to adult studies, up to 50% of pediatric patients may achieve clinical and histological remission on PPI therapy. Fourteen children were followed for 12 months with lower doses of PPIs, and clinical and histological sustained response was achieved in 11 of them (78.6%).18 Moreover, the same investigators had very recent preliminary data demonstrating that most PPI-responsive EoE children (70.1%) remain in histological and clinical remission on lower dose maintenance treatment at the 1-year follow-up, with an adequate safety profile.29 Complete histological response to 8 weeks of the PPI trial was associated with higher probability of ongoing histological response.29

Molina-Infante et al.,20 in a review article, suggested that the term PPI-REE is an inappropriate disease descriptor based on a response to a single drug and should therefore be disregarded. According to these authors, patients with PPI responsiveness perhaps should be considered within the same spectrum of EoE. This group is phenotypically indistinguishable from similar patients who do not respond to PPIs.1,17,20

These findings and others provide evidence that patients with PPI-REE exhibit significant overlap with EoE and that these patients represent a continuum of the same pathogenic allergic mechanisms that underlie EoE.17,20 Further supporting this concept is the finding that PPI therapy can reverse gene expression associated with PPI-REE to that associated with classical EoE.30 Taken together, these findings provide new insights into potential disease etiology and management strategies for patients with significant esophageal eosinophilia and the elimination of the term PPI-REE.1,17,20

In accordance with the EoE guidelines, published in 2017, the authors suggest that PPI-REE and EoE are on the same spectrum and that PPIs should be considered the first step in the treatment of patients with symptoms of esophageal dysfunction and esophageal eosinophilia.1

EoE diagnostic criteria are constantly evolving.1,7,17,20 New evidence shows that the correlation between esophageal eosinophilic infiltration and GERD is becoming more and more complex.20

Pediatricians have often taken the lead in conducting EoE studies with topical steroids26,31–33 and various dietary treatments,34–36 but there is a lack of well-conducted studies evaluating the rate of response to PPI therapy in children with EoE.

Diagnosis of EoE

EoE is conceptually defined in the 2011 guideline as a chronic, immune/antigen-mediated esophageal disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation.2 Clinically significant esophageal eosinophilia is defined as ≥15 eos/hpf in the most involved area.

In order to try to identify patients who may have EoE in practice, a more detailed history should be obtained if symptoms such as vomiting, reflux, food sticking, feeding difficulties, heartburn, or abdominal pain are identified. In addition, if these are seen in a child who has a history of atopic disease or a family history of food impaction, esophageal dilation/stretching, or eosinophilic gastrointestinal disease, a higher index of suspicion should be entertained (Table 1).

Table 1.

Additional questions and possible studies in order to identify patients with eosinophilic esophagitis.

Symptoms  Additional questions  Studies prior to referral 
Vomiting, reflux, food sticking, feeding difficulties, heartburn, or abdominal pain  Do you use water or sauces to help food go down?  Esophagram with barium to evaluate for long segment narrowing or stricture 
  Do you avoid going out to eat meals?  CBC with differential to evaluate for peripheral eosinophilia 
  Do mealtimes take an excessive amount of time, i.e., longer than everyone else?   
  Do you avoid highly textured foods such as meat, bread, or rice?   
  Do you prefer to eat certain foods that may be easier to swallow? Soft foods like pasta, pudding, shakes, etc.   
  Are you able to swallow pills?   
  Has anyone had to do the Heimlich maneuver to remove a piece of food?   

At times, when symptoms in children consist of only chronic gastroesophageal reflux symptoms, which are not uncommon in children, it is challenging for the pediatrician to discern EoE from GERD. In addition to looking for history of concurrent atopy and/or IgE-mediated food allergy, assessing for failure to thrive is very helpful, as this indicates a potentially more serious disease than GERD, including EoE. In fact, failure to thrive can occur in up to one-third of children with EoE and is potentially reversible with successful therapy for EoE.

The endoscopist must carefully evaluate for endoscopic signs of EoE (esophageal rings, longitudinal furrows, exudates, edema, strictures, or narrow caliber esophagus) and ideally report the findings using the EoE Endoscopic Reference Score (EREFS).37 Esophageal biopsy specimens should be obtained in all cases where EoE is a clinical possibility (even when the endoscopic appearance is normal).37,38

Since EoE tends to be patchy, multiple biopsies from two or more esophageal levels targeting areas of apparent inflammation are recommended, as this will increase the diagnostic yield. Gastric and duodenal biopsies should be obtained in order to exclude other gastrointestinal eosinophilic disorders (eosinophilic gastritis, duodenitis, or gastroenteritis).1–3

At this stage, a patient would be considered to have suspected EoE if there are symptoms of esophageal dysfunction and at least 15 eos/hpf on biopsy. These patients should also be evaluated for non-EoE disorders that cause or potentially contribute to esophageal eosinophilia. GERD, hypereosinophilic syndrome, non-EoE EGIDs, Crohn's disease, infections, connective tissue disorders, and drug hypersensitivity reactions have been associated with esophageal eosinophilia but are uncommon or are present with clinical features that readily distinguish them from EoE.2,10 In some patients, it may be difficult to ascertain the precise contribution of GERD to esophageal eosinophilia and the clinical evaluation for GERD could be undertaken prior to a definitive diagnosis of EoE.17,39

EoE is finally diagnosed and defined as “confirmed EoE” when there are symptoms of esophageal dysfunction, at least 15 eos/hpf (or ∼60 eos/mm2) on esophageal biopsy, in patients with no other causes of symptoms and/or esophageal eosinophilia.1–3

Clinical treatments

The current clinical treatment of EoE includes the three Ds: drugs, diet and, dilations.


PPIs are considered by many to be the first option to treat patients with esophageal eosinophilia and esophageal symptoms.40

In general, the recommended dose is 1mg/kg twice daily up to a maximum adult dose for at least 8–12 weeks.18 After this period, repeat endoscopy is recommended to verify if there is persistence of esophageal eosinophils. If there are more than 15 eos/hpf and symptoms after PPI treatment, diet or steroids are recommended.

If there are less than 15 eosinophils/hpf, it may be possible to reduce the dose and maintain PPIs only once daily. If the patient is clinically stable and has no symptoms, follow-up endoscopy may be performed in 6–12 months. A prospective study in a pediatric cohort demonstrated that patients responding to PPIs (78%) remained in clinicopathologic remission at the 1-year follow-up on maintenance PPI therapy.18 The first long-term follow-up study in 75 adult PPI-REE patients showed that all subjects who discontinued therapy had symptomatic and/or histologic relapse.19 Most patients who relapsed attained histologic remission after dose escalation, which suggests that some patients responding to PPIs might require long-term high-dose therapy.

There are so far no studies on the long-term (more than 1 year) outcomes of PPI treatment for EoE. Thus, patients treated with PPIs should be carefully monitored.


Systemic corticosteroids induce clinical and histological response. However, due to their side-effect profile, they are not recommended for treatment of EoE.1,2,40,41

Swallowed topical corticosteroids including fluticasone and viscous budesonide have been shown to provide good clinical and histological response.30–32,41–43

Budesonide can be administered as an oral viscous slurry (1mg daily for children under the age of 10 years, and 2mg daily for older children and adults). Viscous budesonide can be prepared by mixing with sucralose (1g packet per 1mg of budesonide).33 The dose of topical fluticasone in children can range from 88 to 440mcg/day in divided doses, while the dose in adults can range from 880 to 1760mcg/day in divided doses.26,41

Patients must avoid ingestion of foods and liquids for at least 30min after taking the medication.

The efficacy of topical corticosteroids in treating EoE, as assessed in several trials and summarized in meta-analyses, indicates that budesonide and fluticasone propionate are significantly superior to placebo, both in decreasing esophageal eosinophil mucosal infiltration and in relieving symptoms.44

A meta-analysis showed that topical corticosteroids seem to be effective in inducing histological remission, but may not have a similar significant impact in improving clinical symptoms of EoE.45

Other drugs

Other drugs with a better long-term safety profile have been tested in treating EoE.

Montelukast, a selective leukotriene receptor antagonist, has been evaluated as a therapeutic option, but recent studies have shown that this agent is not effective in reducing esophageal eosinophilic infiltration.46,47

The use of biologic therapies including mepolizumab and reslizumab, two anti-IL-5 antibodies, has been demonstrated to be effective in reducing esophageal and blood eosinophils, but without significant reduction in symptoms.48–50 The use of the anti-IgE antibody omalizumab was shown to improve symptoms in two open-label studies.51,52 As patients were kept on conventional therapies for EoE, the improvement could be a result of a placebo effect.51

Given the increased esophageal epithelial cell TNF-α expression in EoE, infliximab, an anti-TNF-α antibody, was studied in patients with EoE, with lack of success both clinically and histologically.53

None of the biologicals studied in EoE have been highly effective, though many demonstrated some histological benefit, especially those that target the Th2 axis. The future for biologicals is promising, however, as the pathophysiology of EoE is better understood, clinical assessment tools are validated, patient subsets that respond best to biologicals are identified, and dosages of biologicals are optimized.53


There are currently three options for dietary management of EoE.

The first is an elemental diet, consisting of complete elimination of all food allergens and instead consuming an amino acid-based formula for 6–8 weeks. In the event of disease remission, this would be followed by reintroduction of single foods or food groups to identify food culprits. The great majority of patients (>90%) show good clinical and histological response with the elemental diet.34,54,55 The rapid resolution of symptoms with an elemental diet is very encouraging. However, poor palatability, high costs, and the need for large volumes of formula are potential obstacles for this treatment modality. In some patients, the use a nasogastric tube for the administration of the formula may be necessary.55

Another dietary treatment option is a test-directed elimination diet, which consists of using the information from allergy tests (food-specific IgE, skin prick test, and/or atopy patch test) to guide the diet. Only foods identified as potentially allergenic are excluded from the diet.34 Histologic remission has been achieved in 48% of children and 32% of adult patients with this approach.54,56,57

The empiric dietary elimination of the four (milk, wheat, soy, and egg) or six (milk, wheat, soy, egg, nuts, seafood) common allergenic foods has been shown to be effective.56–58 Histologic remission rates of 73% in children and 71% in adults have been reported with the six-food elimination diet (SFED).57 Studies with the four-food elimination diet have reported remission rates of 64% in children and 54% in adults.50–52

The use of single-food elimination diet (cow's milk elimination) has demonstrated encouraging results by some investigators, but further prospective studies are needed to assess the effectiveness of this approach.59

These alternatives may be more easily accepted than elemental diets and compliance is higher. The choice of dietary management should be discussed with the patient or family, to consider factors that may influence treatment adherence (e.g., age, financial resources, feeding difficulties, psychological impact on dietary restrictions, etc.).60

Endoscopic dilation

Endoscopic dilation with through-the-scope balloons or wire-guided bougies is a safe and effective procedure for the management of esophageal strictures in patients with EoE. A high complication rate was reported in small case series continuing until 2006, but recent studies have demonstrated a low risk of perforations (<1%) when the usual precautions are taken, including slow and gradual dilatation.61,62 Concomitant medical treatment (PPIs, steroids, diet) is recommended to reduce the chance of stricture recurrence by treating the underlying esophageal inflammation.62

Future directions

EoE is a relatively new disease with a remarkable progression of the incidence and prevalence in the past two to three decades.

It is important to better understand the molecular pathogenesis of EoE, the predisposing environmental and individual factors for some patients to develop the disease, the natural history and the categorization of varying phenotypes, and their association with genotypes.

Since EoE accounts for significant health-related costs,63 it will be critical to assess the best diagnostic criteria, the least invasive diagnostic modality for assessment of disease activity, and the best treatment strategies, with an emphasis on the development of new easy and inexpensive therapeutic approaches. Collaboration among health-care professionals and researchers is crucial to meet the clinical needs of patients.

Conflicts of interest

C.T.F. is a lecturer, developed scientific and educational and/or support material in research projects for Danone, FQM. M.C.V. is a lecturer, developed scientific and educational and/or support material in research projects for Danone, Nestlé Nutrition Institute and Aché Laboratories. G.T.F. is the founder of EnteroTrack and a consultant for Shire, Copyrights - UpToDate. M. C. is a consultant for Actelion, Shire, Allakos; and the recipient of research funding from - Nutricia, Shire, Regeneron. F.C.B. declares no conflicts of interest.

A.J. Lucendo, J. Molina-Infante, A. Arias, U. von Arnim, A.J. Bredenoord, C. Bussmann, et al.
Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults.
United Eur Gastroenterol J, 5 (2017), pp. 335-358
C.A. Liacouras, G.T. Furuta, I. Hirano, D. Atkins, S.E. Attwood, P.A. Bonis, et al.
Eosinophilic esophagitis: updated consensus recommendations for children and adults.
J Allergy Clin Immunol, 128 (2011), pp. 3-20
G.T. Furuta, C.A. Liacouras, M.H. Collins, S.K. Gupta, C. Justinich, P.E. Putnam, et al.
Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment.
Gastroenterology, 133 (2007), pp. 1342-1363
R.T. Landres, G.G. Kuster, W.B. Strum.
Eosinophilic esophagitis in a patient with vigorous achalasia.
Gastroenterology, 74 (1978), pp. 1298-1301
S.E. Attwood, T.C. Smyrk, T.R. Demeester, J.B. Jones.
Esophageal eosinophilia with dysphagia: a distinct clinicopathologic syndrome.
Dig Dis Sci, 38 (1993), pp. 109-116
C. Blanchard, N. Wang, M.E. Rothenberg.
Eosinophilic esophagitis: pathogenesis, genetics, and therapy.
J Allergy Clin Immunol, 118 (2006), pp. 1054-1059
A. Arias, I. Perez-Martinez, J.M. Tenias, A.J. Lucendo.
Systematic review with meta-analysis: the incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies.
Aliment Pharmacol Ther, 43 (2016), pp. 3-15
G.T. Furuta, A. Straumann.
Review article: the pathogenesis and management of eosinophilic oesophagitis.
Aliment Pharmacol Ther, 24 (2006), pp. 173-182
C.T. Ferreira, M.C. Vieira, S.M. Vieira, G.S. Silva, D.R. Yamamoto, T.R. Silveira.
Eosinophilic esophagitis in 29 pediatric patients.
Arq Gastroenterol, 45 (2008), pp. 141-146
D. Simon, H. Marti, P. Heer, H.U. Simon, L.R. Braathen, A. Straumann.
Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases.
J Allergy Clin Immunol, 115 (2005), pp. 1090-1092
M.E. Rothenberg.
Eosinophilic gastrointestinal disorders (EGID).
J Allergy Clin Immunol, 113 (2004), pp. 11-28
C.W. DeBrosse, J.W. Case, P.E. Putnam, M.H. Collins, M.E. Rothenberg.
Quantity and distribution of eosinophils in the gastrointestinal tract of children.
Pediatr Dev Pathol, 9 (2006), pp. 210-218
C.W. DeBrosse, M.E. Rothenberg.
Allergy and eosinophil-associated gastrointestinal disorders (EGID).
Curr Opin Immunol, 20 (2008), pp. 703-708
A. Cianferoni, J. Spergel.
Eosinophilic esophagitis: a comprehensive review.
Clin Rev Allergy Immunol, 50 (2016), pp. 159-174
F.J. Moawad.
Eosinophilic esophagitis: incidence and prevalence.
Gastrointest Endosc Clin N Am, 28 (2018), pp. 15-25
J. Molina-Infante, L. Ferrando-Lamana, C. Ripoll, M. Hernandez-Alonso, J.M. Mateos, M. Fernandez-Bermejo, et al.
Esophageal eosinophilic infiltration responds to proton pump inhibition in most adults.
Clin Gastroenterol Hepatol, 9 (2011), pp. 110-117
J. Molina-Infante, A.J. Bredenoord, E. Cheng, E.S. Dellon, G.T. Furuta, S.K. Gupta, et al.
Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis.
C. Gutiérrez-Junquera, S. Fernandez-Fernandez, M.L. Cilleruelo, A. Rayo, L. Echeverria, B. Borrell, et al.
High prevalence of response to proton-pump inhibitor treatment in children with esophageal eosinophilia.
J Pediatr Gastroenterol Nutr, 62 (2016), pp. 704-710
J. Molina-Infante, J. Rodriguez-Sanchez, J. Martinek, B.D. van Rhijn, J. Krajciova, M.D. Rivas, et al.
Long-term loss of response in proton pump inhibitor-responsive esophageal eosinophilia is uncommon and influenced by CYP2C19 genotype and rhinoconjunctivitis.
Am J Gastroenterol, 110 (2015), pp. 1567-1575
J. Molina-Infante, P.L. Gonzalez-Cordero, A.J. Lucendo.
Proton pump inhibitor-responsive esophageal eosinophilia: still a valid diagnosis?.
Curr Opin Gastroenterol, 33 (2017), pp. 285-292
F.J. Moawad, A.M. Schoepfer, E. Safroneeva, M.R. Ally, Y.J. Chen, C.L. Maydonovitch, et al.
Eosinophilic oesophagitis and proton pump inhibitor-responsive oesophageal eosinophilia have similar clinical, endoscopic and histological findings.
Aliment Pharmacol Ther, 39 (2014), pp. 603-608
E.S. Dellon, O. Speck, K. Woodward, J.H. Gebhart, R.D. Madanick, S. Levinson, et al.
Clinical and endoscopic characteristics do not reliably differentiate PPI-responsive esophageal eosinophilia and eosinophilic esophagitis in patients undergoing upper endoscopy: a prospective cohort study.
Am J Gastroenterol, 108 (2013), pp. 1854-1860
E. Cheng, X. Zhang, X. Huo, C. Yu, Q. Zhang, D.H. Wang, et al.
Omeprazole blocks eotaxin-3 expression by oesophageal squamous cells from patients with eosinophilic oesophagitis and GORD.
X. Zhang, E. Cheng, X. Huo, C. Yu, Q. Zhang, T.H. Pham, et al.
Omeprazole blocks STAT6 binding to the eotaxin-3 promoter in eosinophilic esophagitis cells.
S. Durrani, M. Rothenberg.
Recent advances in eosinophilic esophagitis.
F1000 Res, 6 (2017), pp. 1775
E.S. Dellon, N. Gonsalves, I. Hirano, G.T. Furuta, C.A. Liacouras, D.A. Katzka.
ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE).
Am J Gastroenterol, 108 (2013), pp. 679-692
A. Straumann, H.P. Spichtin, L. Grize, K.A. Bucher, C. Beglinger, H.U. Simon.
Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years.
Gastroenterology, 125 (2003), pp. 1660-1669
F. Rea, T. Caldaro, R. Tambucci, E.F. Romeo, C. Caloisi, F. Torroni, et al.
Eosinophilic esophagitis: is it also a surgical disease?.
J Pediatr Surg, 48 (2013), pp. 304-308
C. Gutierrez-Junquera, S. Fernandez-Fernandez, M.L. Cilleruelo, A. Rayo, L. Echeverria, B. Borrell, et al.
Long-term treatment with proton-pump inhibitors is effective in children with eosinophilic esophagitis.
J Pediatr Gastroenterol Nutr, 67 (2018), pp. 210-216
T. Wen, E.S. Dellon, F.J. Moawad, G.T. Furuta, S.S. Aceves, M.E. Rothenberg.
Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation.
J Allergy Clin Immunol, 135 (2015), pp. 187-197
S.S. Aceves, R. Dohil, R.O. Newbury, J.F. Bastian.
Topical viscous budesonide suspension for treatment of eosinophilic esophagitis.
J Allergy Clin Immunol, 116 (2005), pp. 705-706
S.S. Aceves, J.F. Bastian, R.O. Newbury, R. Dohil.
Oral viscous budesonide: a potential new therapy for eosinophilic esophagitis in children.
Am J Gastroenterol, 102 (2007), pp. 2271-2279
R. Dohil, R. Newburry, L. Fox, J. Bastian, S. Aceves.
Oral viscous budesonide is effective in children with eosinophilic esophagitis in a randomized placebo-controlled trial.
Gastroenterology, 139 (2010), pp. 418-429
J.E. Markowitz, J.M. Spergel, E. Ruchelli, C.A. Liacouras.
Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents.
Am J Gastroenterol, 98 (2003), pp. 777-782
J.M. Spergel, T. Andrews, T.F. Brown-Whitehorn, J.L. Beausoleil, C.A. Liacouras.
Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests.
Ann Allergy Asthma Immunol, 95 (2005), pp. 336-343
A.F. Kagalwalla, T.A. Sentongo, S. Ritz, T. Hess, S.P. Nelson, K.M. Emerick, et al.
Effect of six-food elimination diet on clinical and histological outcomes in eosinophilic esophagitis.
Clin Gastroenterol Hepatol, 4 (2006), pp. 1097-1102
I. Hirano, N. Moy, M.G. Heckman, C.S. Thomas, N. Gonsalves, S.R. Achem.
Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system.
E.S. Dellon, C.C. Cotton, J.H. Gebhart, L.L. Higgins, R. Beitia, J.T. Woosley, et al.
Accuracy of the eosinophilic esophagitis endoscopic reference score in diagnosis and determining response to treatment.
Clin Gastroenterol Hepatol, 14 (2016), pp. 31-39
H.P. Kim, R.B. Vance, N.J. Shaheen, E.S. Dellon.
The prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis.
Clin Gastroenterol Hepatol, 10 (2012), pp. 988-996
J. Molina-Infante, A.J. Lucendo.
Proton pump inhibitor therapy for eosinophilic esophagitis: a paradigm shift.
Am J Gastroenterol, 112 (2017), pp. 1770-1773
E.T. Schaefer, J.F. Fitzgerald, J.P. Molleston, J.M. Croffie, M.D. Pfefferkorn, M.R. Corkins, et al.
Comparison of oral prednisone and topical fluticasone in the treatment of eosinophilic esophagitis: a randomized trial in children.
Clin Gastroenterol Hepatol, 6 (2008), pp. 165-173
J.E. Teitelbaum, V.L. Fox, F.J. Twarog, S. Nurko, D. Antonioli, G. Gleich, et al.
Eosinophilic esophagitis in children: immunopathological analysis and response to fluticasone propionate.
Gastroenterology, 122 (2002), pp. 1216-1225
M.R. Konikoff, R.J. Noel, C. Blanchard, C. Kirby, S.C. Jameson, B.K. Buckmeier, et al.
A randomized, double-blind, placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis.
Gastroenterology, 131 (2006), pp. 1381-1391
M. Munoz-Persy, A.J. Lucendo.
Treatment of eosinophilic esophagitis in the pediatric patient: an evidence-based approach.
Eur J Pediatr, 177 (2018), pp. 649-663
A.R. Murali, A. Gupta, B.M. Attar, V. Ravi, P. Koduro.
Topical steroids in eosinophilic esophagitis: systematic review and meta-analysis of placebo-controlled randomized clinical trials.
J Gastroenterol Hepatol, 31 (2016), pp. 1111-1119
J.A. Alexander, K. Ravi, F.T. Enders, D.M. Geno, L.A. Kryzer, K.C. Mara, et al.
Montelukast does not maintain symptom remission after topical steroid therapy for eosinophilic esophagitis.
Clin Gastroenterol Hepatol, 15 (2017), pp. 214-221
A.J. Lucendo, L.C. De Rezende, S. Jiménez-Contreras, J.L. Yagüe-Compadre, J. González-Cervera, T. Mota-Huertas, et al.
Montelukast was inefficient in maintaining steroid-induced remission in adult eosinophilic esophagitis.
Dig Dis Sci, 56 (2011), pp. 3551-3558
M.L. Stein, M.H. Collins, J.M. Villanueva, J.P. Kushner, P.E. Putnam, P.K. Buckmeier, et al.
Anti-IL-5 (mepolizumab) therapy for eosinophilic esophagitis.
J Allergy Clin Immunol, 118 (2006), pp. 1312-1319
A. Straumann, S. Conus, P. Grzonka, H. Kita, G. Kephart, C. Bussmann, et al.
Anti-interleukin-5 antibody treatment (mepolizumab) in active eosinophilic oesophagitis: a randomised, placebo-controlled, double-blind trial.
Gut, 59 (2010), pp. 21-30
J.M. Spergel, M.E. Rothenberg, M.H. Collins, G.T. Furuta, J.E. Markowitz, G. Fuchs, et al.
Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial.
J Allergy Clin Immunol, 129 (2012), pp. 456-463
D. Loizou, B. Enav, E. Komlodi-Pasztor, P. Hider, J. Kim-Chang, L. Noonan, et al.
A pilot study of omalizumab in eosinophilicesophagitis.
PLoS ONE, 10 (2015), pp. e0113483
S. Foroughi, B. Foster, N. Kim, L.B. Bernardino, L.M. Scott, R.G. Hamilton, et al.
Anti-IgE treatment of eosinophil-associated gastrointestinal disorders.
J Allergy Clin Immunol, 120 (2007), pp. 594-660
E. Ko, M. Chehade.
Biological therapies for eosinophilic esophagitis: where do we stand?.
Clin Rev Allergy Immunol, 55 (2018), pp. 205-216
C.J. Henderson, J.P. Abonia, E.C. King, P.E. Putnam, M.H. Collins, J.P. Franciosi, et al.
Comparative dietary therapy effectiveness in remission of pediatric eosinophilic esophagitis.
J Allergy Clin Immunol, 129 (2012), pp. 1570-1578
K.A. Peterson, K.R. Byrne, L.A. Vinson, J. Ying, K.K. Boynton, J.C. Fang, et al.
Elemental diet induces histologic response in adult eosinophilic esophagitis.
Am J Gastroenterol, 108 (2013), pp. 759-766
J. Molina-Infante, A. Arias, J. Barrio, J. Rodrıguez-Sanchez, M. Sanchez-Cazalilla, A.J. Lucendo.
Four-food group elimination diet for adult eosinophilic esophagitis: a prospective multicenter study.
J Allergy Clin Immunol, 134 (2014), pp. 1093-1099
A. Arias, J. Gonzalez-Cervera, J.M. Tenias, A.J. Lucendo.
Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: a systematic review and meta-analysis.
Gastroenterology, 146 (2014), pp. 1639-1648
A.F. Kagalwalla, J.B. Wechsler, K. Amsden, S. Schwartz, M. Makhija, A. Olive, et al.
Efficacy of a 4-food elimination diet for children with eosinophilic esophagitis.
Clin Gastroenterol Hepatol, 15 (2017), pp. 1698-1707
A.F. Kagalwalla, K. Amsden, A. Shah, S. Ritz, M. Manuel-Rubio, K. Dunne, et al.
Cow's milk elimination: a novel dietary approach to treat eosinophilic esophagitis.
J Pediatr Gastroenterol Nutr, 55 (2012), pp. 711-716
M. Chehade, E. Sher.
Medical therapy versus dietary avoidance in eosinophilic esophagitis: which approach is better?.
Allergy Asthma Proc, 38 (2017), pp. 170-176
S.S. Aceves, R.O. Newbury, R. Dohil, J.F. Bastian, D.H. Broide.
Esophageal remodeling in pediatric eosinophilic esophagitis.
J Allergy Clin Immunol, 119 (2007), pp. 206-212
F.J. Moawad, J.G. Cheatham, K.J. DeZee.
Meta-analysis: the safety and efficacy of dilation in eosinophilic oesophagitis.
Aliment Pharmacol Ther, 38 (2013), pp. 713-720
V. Mukkada, G.W. Falk, C.S. Eichinger, D. King, L. Todorova, N.J. Shaheen.
Health-related quality of life and costs associated with eosinophilic esophagitis: a systematic review.
Clin Gastroenterol Hepatol, 16 (2018), pp. 495-503

Please cite this article as: Ferreira CT, Vieira MC, Furuta GT, Barros FC, Chehade M. Eosinophilic esophagitis—Where are we today? J Pediatr (Rio J). 2019;95:275–81.

Study carried out at Departamento de Pediatria of the Universidade Federal de Porto Alegre and the Hospital Pediátrico Santo Antônio, Porto Alegre, RS, Brazil.

Copyright © 2018. Sociedade Brasileira de Pediatria
Jornal de Pediatria (English Edition)
Article options
en pt
Taxa de publicaçao Publication fee
Os artigos submetidos a partir de 1º de setembro de 2018, que forem aceitos para publicação no Jornal de Pediatria, estarão sujeitos a uma taxa para que tenham sua publicação garantida. O artigo aceito somente será publicado após a comprovação do pagamento da taxa de publicação. Ao submeterem o manuscrito a este jornal, os autores concordam com esses termos. A submissão dos manuscritos continua gratuita. Para mais informações, contate Articles submitted as of September 1, 2018, which are accepted for publication in the Jornal de Pediatria, will be subject to a fee to have their publication guaranteed. The accepted article will only be published after proof of the publication fee payment. By submitting the manuscript to this journal, the authors agree to these terms. Manuscript submission remains free of charge. For more information, contact
Cookies policy Política de cookies
To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.