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Vol. 89. Issue 1.
Pages 56-63 (January - February 2013)
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Vol. 89. Issue 1.
Pages 56-63 (January - February 2013)
Original article
Open Access
Hypertriglyceridemic Waist Phenotype: Association with Metabolic Abnormalities in Adolescents
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Maria Ester P. da Conceição-Machadoa,
Corresponding author
, Luciana R. Silvab, Mônica Leila P. Santanac, Elizabete J. Pintod, Rita de Cássia R. Silvae, Lia Terezinha L.P. Moraesf, Ricardo D. Coutog, Ana Marlúcia O. Assish
a PhD Candidate, Postgraduate Program in Medicine and Health, Universidade Federal da Bahia Medical School (FAMED), Salvador, BA, Brazil. Adjunct Professor, Department of Nutritional Science, School of Nutrition, Universidade Federal da Bahia (ENUFBA), Salvador, BA, Brazil
b Full Professor, Pediatric Gastroenterology, Department of Pediatrics, FAMED, Salvador, BA, Brazil. Chief, Pediatric Gastroenterology and Hepatology Unit, Complexo Hospitalar Universitário Professor Edgard Santos (C-HUPES), Salvador, BA, Brazil
c PhD, Adjunct Professor, Department of Nutritional Science, ENUFBA, Salvador, BA, Brazil
d Statistician. MSc, Postgraduate Program in Medicine and Health, FAMED, Salvador, BA, Brazil
e Post-doctorate. Associate Professor, Postgraduate Program in Food and Nutrition, ENUFBA, Salvador, BA, Brazil
f Professor, Department of Statistics, Instituto de Matemática, Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil
g Post-doctorate. Adjunct Professor, Department of Clinical and Toxicological Analysis, Pharmacy School, UFBA, Salvador, BA, Brazil. Professor Chief, Laboratório Central, C-HUPES, Salvador, BA, Brazil
h PhD. Full Professor, Postgraduate Program in Food and Nutrition, Department of Nutritional Science, ENUFBA, Salvador, BA, Brazil
Article information
Abstract
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Abstract
Objective

This study aimed to identify the prevalence of hypertriglyceridemic waist (HTW) phenotype, and to evaluate its association with metabolic abnormalities in adolescents of low socioeconomic status.

Method

This was a cross-sectional study with a random sample of 1,076 adolescents between 11 and 17 years, of both genders, from public schools. The participants underwent anthropometric measurements (weight, height, and waist circumference), and levels of total cholesterol, low-density-lipoprotein cholesterol (LDL-C), high-density-lipoprotein cholesterol (HDL-C), non-HDL cholesterol, triglyceride (TG), and fasting glucose were measured. Information regarding the socioeconomic status of the participants’ families was obtained. The HTW phenotype was defined by the simultaneous presence of increased waist circumference (≥ 90th percentile for age and gender) and serum triglyceride levels (≥ 100mg/dL). A logistic regression analysis was used to evaluate the associations of interest.

Results

The prevalence of HTW phenotype was 7.2% among the adolescents, being higher in the presence of obesity (63.4%) and high levels of non-HDL cholesterol (16.6%) and LDL-C (13.7%). The bivariate analysis indicated that, of the metabolic variables, only blood glucose was not associated with the HTW phenotype. Multivariate analysis adjusted for age and gender indicated that the HTW phenotype was positively associated with high non-HDL cholesterol (odds ratio: 7.0; 95% CI: 3.9-12.6) and low HDL-C levels (odds ratio: 2.7; 95% CI: 1.5-4.8).

Conclusions

This study demonstrated that the HTW phenotype was associated with an atherogenic lipid profile, and this phenotype is suggested as a screening tool to identify adolescents with metabolic alterations.

Keywords:
Hypertriglyceridemic waist
Abdominal obesity
Hypertriglyceridemia
Lipids
Adolescent
Resumo
Objetivo

O presente estudo objetivou identificar a prevalência do fenótipo cintura hiper- trigliceridêmica (CHT) e avaliar sua associação com alterações metabólicas em adoles- centes de baixa condição econômica.

Método

Estudo transversal com amostra probabilística de 1.076 adolescentes entre 11 e 17 anos, de ambos os sexos, estudantes de escolas públicas. Os participantes foram sub- metidos à avaliação antropométrica (peso, altura e circunferência da cintura) e à dosa- gem dos níveis de colesterol total, LDL-C, HDL-C, colesterol não HDL, triglicérides (TG) e glicemia de jejum. Foram obtidas informações referentes às condições econômicas das famílias dos participantes. O fenótipo CHT foi definido pela presença simultânea da cir- cunferência da cintura aumentada (≥ percentil 90 por idade e sexo) e dos níveis séricos de triglicérides elevados (≥ 100mg/dL). A análise de regressão logística foi utilizada para avaliação das associações de interesse.

Resultados

A prevalência do fenótipo CHT foi de 7,2% entre os adolescentes, sendo mais elevada na presença de obesidade (63,4%), do colesterol não HDL (16,6%) e do LDL-C (13,7%) altos. A análise bivariada indicou que, das variáveis metabólicas, apenas a glice- mia não se associou ao fenótipo CHT. A análise multivariada, ajustada por sexo e idade, indicou que o fenótipo CHT se associou positivamente com o colesterol não HDL alto (odds ratio, 7,0; IC95% 3,9-12,6) e com o HDL-C baixo (odds ratio, 2,7; IC95%, 1,5-4,8).

Conclusões

Este estudo mostrou que o fenótipo CHT se associou com um perfil lipídico aterogênico e sugere esse fenótipo como uma ferramenta de screening que pode ser uti- lizada para identificar adolescentes com alterações metabólicas.

Palavras-chave:
Cintura hipertrigliceridêmica
Obesidade abdominal
Hipertrigliceridemia
Lipídios
Adolescente
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Please, cite this article as: Conceição-Machado ME, Silva LR, Santana ML, Pinto EJ, Silva RC, Moraes LT, et al. Hypertriglyceridemic waist phenotype: association with metabolic abnormalities adolescents. J Pediatr (Rio J). 2013;89:56-63.

Copyright © 2013. Sociedade Brasileira de Pediatria
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