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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The first time I heard someone talk about zero tolerance toward death from asthma was at the World Allergy Organization &#40;WAO&#41; International Scientific Conference in Dubai in 2010&#46; I was impressed by the vigor with which Professor Tari Haahtela presented the results obtained with the use of health education plans in the prevention of asthma mortality in Finland&#46; Gary Wong had just affirmed the same concept in a different context&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">1</span></a> Under all the heavens then&#44; including that of Latin America&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">2</span></a> there is no greater cost than the preventable death of a patient&#44; in particular among children&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">After its rise from a rate of 0&#46;45&#47;100&#44;000 in 1974&#47;5 to a peak rate of 0&#46;62&#47;100&#44;000 in 1985&#47;6&#44; the mortality from asthma across the world has declined&#46; In 2004&#47;5&#44; the mortality in developed countries &#8211; including the United States&#44; Canada&#44; New Zealand&#44; Australia&#44; Western Europe&#44; Hong Kong&#44; and Japan &#8211; was reduced to a rate of 0&#46;23&#47;100&#44;000&#46; This reduction was associated to the increasing use of inhaled corticosteroids&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The drop in mortality has coincided with the introduction of increasingly precise guidelines for the management of asthma internationally and in specific countries&#44; with the development of educational plans for practitioners&#44; pharmacists&#44; and other health professions&#44; and with their implementation by the health authorities of each country&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The prototype for models of disease management remains the Finnish asthma management program&#44; which produced a huge effect in reducing asthma mortality and morbidity over the period 1994&#8211;2004&#46; It was centered on early diagnosis&#44; active anti-inflammatory treatment immediately after the diagnosis&#44; information on the disease and its treatment&#44; self-management&#44; and effective networking among specialists&#44; primary care physicians&#44; and pharmacists&#46; This program resulted in a reduction in asthma deaths from 100 to less than 20 per year in the Finnish population of 5 million&#44; which could be largely attributed to early and more effective use of anti-inflammatory medication&#44; especially inhaled corticosteroids &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">4&#44;5</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Other countries &#40;Australia&#44; Ireland&#44; Canada&#44; Poland&#44; Tonga&#44; South Africa&#44; New Zealand&#41; followed the Finnish example&#44; developing their own national asthma reduction strategies with good success&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">2&#44;6</span></a> In Europe&#44; the integrated plan &#8216;European Asthma Research and Innovation Partnership&#8217; &#40;EARIP&#41; has been also put in place to harmonize asthma education activities across the continent&#44; in order to develop a comprehensive approach focused on asthma control&#44; to reduce asthma-related mortality and morbidity&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">7</span></a> Its ambition is to reduce asthma mortality in Europe by 25&#37; within ten years and by 50&#37; within 20 years&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Despite all the progress made with early therapeutic intervention&#44; an incompressible mortality rate remains&#44; even when the possibilities offered by conventional anti-inflammatory drugs have been saturated &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In developed countries&#44; we are now experiencing signals of upward rebound in mortality&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">8</span></a> together with an increase in corticosteroid-induced adverse events in severe asthma patients&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">9</span></a> while the mortality from asthma has not been eliminated anywhere&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">This scenario is applicable to some parts of Brazil&#44; but not to the whole country&#46; The data published in this issue of the <span class="elsevierStyleItalic">Jornal</span><a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">10</span></a> are of particular interest as they arise from a solid reporting system in a young age range&#44; where asthma mortality can be very accurately tracked due to absence of confounding diagnoses&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">11</span></a> In Brazil&#44; the reduction in asthma mortality over 20 years is conspicuous&#44; testifying to the great progress in pediatric pulmonology care in that country&#46; The most important reduction was achieved in the group of children under the age of 4 years&#44; which&#44; however&#44; remains the group that most contributes to asthma mortality in 2015&#46; Indeed&#44; the mortality for asthma in Brazilian children has not reached an optimal low level countrywide&#46; Some areas of higher mortality still persist&#44; in particular among children under 10 years of age and in some geographical areas&#44; such as the North and the Northeast&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The study calls for two areas of possible intervention&#58; adolescents and preschoolers&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Brazilian adolescents with asthma incur the risk of under-hospitalization during attacks&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">10</span></a> perhaps as part of their denial of the disease&#44; noncompliant therapeutic behaviors&#44; smoking&#44; and psychosocial issues&#46; Some of these conditions are ameliorable with specific educational interventions&#44; targeted toward the reasons for poor control of asthmatic symptoms&#58; underestimation by patients and physicians&#44; under-treatment &#8211; especially with anti-inflammatory drugs&#44; overuse of bronchodilators in case of attacks&#44; low compliance to medications&#44; and poor skills in the use of prescribed devices&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">12</span></a> An important part could be the use of the now-available Portuguese version of the Test for Respiratory and Asthma Control in Kids &#40;TRACK&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">13</span></a> A substantial part of the causes &#40;for instance&#44; low-income households<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">14&#44;15</span></a>&#41; would require complex interventions&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Of note&#44; 68&#37; of reported deaths happened in children under 4 years of age&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">10</span></a> In this age range&#44; uncertainties remain about the possibility of labeling a child as asthmatic&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">16</span></a> We fully agree with the authors&#8217; opinion that in preschool age asthma must be considered as such&#44; beyond the difficulties of definition&#46; Under its multifaceted phenotypes&#44;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">17</span></a> preschoolers experience severe wheezing episodes resulting in emergency room visits&#44; hospitalization&#44; and oral steroid courses&#46; Preschoolers merit asthma treatment&#44; as an early intervention may decrease the number of exacerbations and promote lung growth&#46; As part of this intervention&#44; educational plans must not be spared&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">A considerable obstacle for the realization of educational plans could be the territorial vastness and the socioeconomic heterogeneity of Brazil&#46; This nation has one of the highest rates of inequality in the world&#44; and the Gini index&#44; measuring economic inequality within countries&#44; has been associated with a high prevalence of allergies and asthma&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">18</span></a> It is also a country with high prevalence of sensitization to perennial allergens&#44; associated with asthma mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">19</span></a> However&#44; Brazil offers opportunities for educational plans&#46; It is the fifth country in smart phone usage in the world&#58; as 54&#37; of Brazilian adults own a smart phone&#44; and families often share one device&#44; it can be estimated that 120 million Brazilians have access to the internet&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">20</span></a> This could offer the infrastructural opportunities for modern&#44; digital health-based interventions&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">21</span></a> An additional effort will be necessary on the part of the Brazilian medical community and health authorities to address&#44; together with the health problems&#44; the social issues that can be glimpsed under the data of the present study&#46; After all&#44; it is a question of facing one of the many aspects of the fragility of children in the preschool age and in adolescence&#44; which recalls the need for recognition&#44; care&#44; and education&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Every asthma death is one too many&#46; The interest of their <span class="elsevierStyleItalic">Jornal</span> shows that Brazilian pediatricians are ready to take up this challenge&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
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Editorial
Zero tolerance for asthma deaths in children
Tolerância zero para mortes por asma em crianças
Alessandro Fiocchi
Corresponding author
, Rocco Valluzzi, Lamia Dahdah
Bambino Gesù Childrens’ Hospital IRCCS, Rome, Italy
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The first time I heard someone talk about zero tolerance toward death from asthma was at the World Allergy Organization &#40;WAO&#41; International Scientific Conference in Dubai in 2010&#46; I was impressed by the vigor with which Professor Tari Haahtela presented the results obtained with the use of health education plans in the prevention of asthma mortality in Finland&#46; Gary Wong had just affirmed the same concept in a different context&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">1</span></a> Under all the heavens then&#44; including that of Latin America&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">2</span></a> there is no greater cost than the preventable death of a patient&#44; in particular among children&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">After its rise from a rate of 0&#46;45&#47;100&#44;000 in 1974&#47;5 to a peak rate of 0&#46;62&#47;100&#44;000 in 1985&#47;6&#44; the mortality from asthma across the world has declined&#46; In 2004&#47;5&#44; the mortality in developed countries &#8211; including the United States&#44; Canada&#44; New Zealand&#44; Australia&#44; Western Europe&#44; Hong Kong&#44; and Japan &#8211; was reduced to a rate of 0&#46;23&#47;100&#44;000&#46; This reduction was associated to the increasing use of inhaled corticosteroids&#46;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The drop in mortality has coincided with the introduction of increasingly precise guidelines for the management of asthma internationally and in specific countries&#44; with the development of educational plans for practitioners&#44; pharmacists&#44; and other health professions&#44; and with their implementation by the health authorities of each country&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The prototype for models of disease management remains the Finnish asthma management program&#44; which produced a huge effect in reducing asthma mortality and morbidity over the period 1994&#8211;2004&#46; It was centered on early diagnosis&#44; active anti-inflammatory treatment immediately after the diagnosis&#44; information on the disease and its treatment&#44; self-management&#44; and effective networking among specialists&#44; primary care physicians&#44; and pharmacists&#46; This program resulted in a reduction in asthma deaths from 100 to less than 20 per year in the Finnish population of 5 million&#44; which could be largely attributed to early and more effective use of anti-inflammatory medication&#44; especially inhaled corticosteroids &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">4&#44;5</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Other countries &#40;Australia&#44; Ireland&#44; Canada&#44; Poland&#44; Tonga&#44; South Africa&#44; New Zealand&#41; followed the Finnish example&#44; developing their own national asthma reduction strategies with good success&#46;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">2&#44;6</span></a> In Europe&#44; the integrated plan &#8216;European Asthma Research and Innovation Partnership&#8217; &#40;EARIP&#41; has been also put in place to harmonize asthma education activities across the continent&#44; in order to develop a comprehensive approach focused on asthma control&#44; to reduce asthma-related mortality and morbidity&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">7</span></a> Its ambition is to reduce asthma mortality in Europe by 25&#37; within ten years and by 50&#37; within 20 years&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Despite all the progress made with early therapeutic intervention&#44; an incompressible mortality rate remains&#44; even when the possibilities offered by conventional anti-inflammatory drugs have been saturated &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In developed countries&#44; we are now experiencing signals of upward rebound in mortality&#44;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">8</span></a> together with an increase in corticosteroid-induced adverse events in severe asthma patients&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">9</span></a> while the mortality from asthma has not been eliminated anywhere&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">This scenario is applicable to some parts of Brazil&#44; but not to the whole country&#46; The data published in this issue of the <span class="elsevierStyleItalic">Jornal</span><a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">10</span></a> are of particular interest as they arise from a solid reporting system in a young age range&#44; where asthma mortality can be very accurately tracked due to absence of confounding diagnoses&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">11</span></a> In Brazil&#44; the reduction in asthma mortality over 20 years is conspicuous&#44; testifying to the great progress in pediatric pulmonology care in that country&#46; The most important reduction was achieved in the group of children under the age of 4 years&#44; which&#44; however&#44; remains the group that most contributes to asthma mortality in 2015&#46; Indeed&#44; the mortality for asthma in Brazilian children has not reached an optimal low level countrywide&#46; Some areas of higher mortality still persist&#44; in particular among children under 10 years of age and in some geographical areas&#44; such as the North and the Northeast&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The study calls for two areas of possible intervention&#58; adolescents and preschoolers&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Brazilian adolescents with asthma incur the risk of under-hospitalization during attacks&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">10</span></a> perhaps as part of their denial of the disease&#44; noncompliant therapeutic behaviors&#44; smoking&#44; and psychosocial issues&#46; Some of these conditions are ameliorable with specific educational interventions&#44; targeted toward the reasons for poor control of asthmatic symptoms&#58; underestimation by patients and physicians&#44; under-treatment &#8211; especially with anti-inflammatory drugs&#44; overuse of bronchodilators in case of attacks&#44; low compliance to medications&#44; and poor skills in the use of prescribed devices&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">12</span></a> An important part could be the use of the now-available Portuguese version of the Test for Respiratory and Asthma Control in Kids &#40;TRACK&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">13</span></a> A substantial part of the causes &#40;for instance&#44; low-income households<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">14&#44;15</span></a>&#41; would require complex interventions&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Of note&#44; 68&#37; of reported deaths happened in children under 4 years of age&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">10</span></a> In this age range&#44; uncertainties remain about the possibility of labeling a child as asthmatic&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">16</span></a> We fully agree with the authors&#8217; opinion that in preschool age asthma must be considered as such&#44; beyond the difficulties of definition&#46; Under its multifaceted phenotypes&#44;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">17</span></a> preschoolers experience severe wheezing episodes resulting in emergency room visits&#44; hospitalization&#44; and oral steroid courses&#46; Preschoolers merit asthma treatment&#44; as an early intervention may decrease the number of exacerbations and promote lung growth&#46; As part of this intervention&#44; educational plans must not be spared&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">A considerable obstacle for the realization of educational plans could be the territorial vastness and the socioeconomic heterogeneity of Brazil&#46; This nation has one of the highest rates of inequality in the world&#44; and the Gini index&#44; measuring economic inequality within countries&#44; has been associated with a high prevalence of allergies and asthma&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">18</span></a> It is also a country with high prevalence of sensitization to perennial allergens&#44; associated with asthma mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">19</span></a> However&#44; Brazil offers opportunities for educational plans&#46; It is the fifth country in smart phone usage in the world&#58; as 54&#37; of Brazilian adults own a smart phone&#44; and families often share one device&#44; it can be estimated that 120 million Brazilians have access to the internet&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">20</span></a> This could offer the infrastructural opportunities for modern&#44; digital health-based interventions&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">21</span></a> An additional effort will be necessary on the part of the Brazilian medical community and health authorities to address&#44; together with the health problems&#44; the social issues that can be glimpsed under the data of the present study&#46; After all&#44; it is a question of facing one of the many aspects of the fragility of children in the preschool age and in adolescence&#44; which recalls the need for recognition&#44; care&#44; and education&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Every asthma death is one too many&#46; The interest of their <span class="elsevierStyleItalic">Jornal</span> shows that Brazilian pediatricians are ready to take up this challenge&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
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Article information
ISSN: 00217557
Original language: English
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