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todos os pacientes (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,006), 2; meninos (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,003) 3; meninas (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,111).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ehsan Valavi, Majid Aminzadeh, Parisa Amouri, Afshin Rezazadeh, Maedeh Beladi‐Mousavi" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Ehsan" "apellidos" => "Valavi" ] 1 => array:2 [ "nombre" => "Majid" "apellidos" => "Aminzadeh" ] 2 => array:2 [ "nombre" => "Parisa" "apellidos" => "Amouri" ] 3 => array:2 [ "nombre" => "Afshin" "apellidos" => "Rezazadeh" ] 4 => array:2 [ "nombre" => "Maedeh" "apellidos" => "Beladi‐Mousavi" ] ] ] ] ] "idiomaDefecto" => "pt" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0021755718303632" "doi" => "10.1016/j.jped.2018.07.014" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0021755718303632?idApp=UINPBA000049" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2255553618302106?idApp=UINPBA000049" "url" => "/22555536/0000009600000001/v1_202001250716/S2255553618302106/v1_202001250716/pt/main.assets" ] ] "itemSiguiente" => array:20 [ "pii" => "S0021755718303735" "issn" => "00217557" "doi" => "10.1016/j.jped.2018.07.012" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "723" "copyright" => "Sociedade Brasileira de Pediatria" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "J Pediatr (Rio J). 2020;96:125-31" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 369 "formatos" => array:3 [ "EPUB" => 59 "HTML" => 158 "PDF" => 152 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "pt" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "125" "paginaFinal" => "131" ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Exposição pré-natal a mofo está associada ao desenvolvimento de dermatite atópica em neonatos por reação alérgica" ] ] "contieneResumen" => array:2 [ "en" => true "pt" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2483 "Ancho" => 3311 "Tamanyo" => 297947 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">(A) Association between levels of total serum IgE according to mold exposure during pregnancy and atopic dermatitis. Data are expressed as the mean<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>standard deviation. (B) Correlation between the log-transformed SCORAD index at 1 year of age and log-transformed total serum IgE levels. 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no-CR, failed to achieve remission.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Suzy Abdelmabood, Ashraf Elsayed Fouda, Fatimah Boujettif, Ahmed Mansour" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Suzy" "apellidos" => "Abdelmabood" ] 1 => array:2 [ "nombre" => "Ashraf Elsayed" "apellidos" => "Fouda" ] 2 => array:2 [ "nombre" => "Fatimah" "apellidos" => "Boujettif" ] 3 => array:2 [ "nombre" => "Ahmed" "apellidos" => "Mansour" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "pt" => array:9 [ "pii" => "S2255553618301927" "doi" => "10.1016/j.jpedp.2018.11.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "pt" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2255553618301927?idApp=UINPBA000049" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0021755718305837?idApp=UINPBA000049" "url" => "/00217557/0000009600000001/v1_202001240658/S0021755718305837/v1_202001240658/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Effect of prednisolone on linear growth in children with nephrotic syndrome" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "117" "paginaFinal" => "124" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ehsan Valavi, Majid Aminzadeh, Parisa Amouri, Afshin Rezazadeh, Maedeh Beladi-Mousavi" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Ehsan" "apellidos" => "Valavi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Majid" "apellidos" => "Aminzadeh" "email" => array:2 [ 0 => "aminzadeh_m@ajums.ac.ir" 1 => "majidaminzadeh77@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Parisa" "apellidos" => "Amouri" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Afshin" "apellidos" => "Rezazadeh" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 4 => array:3 [ "nombre" => "Maedeh" "apellidos" => "Beladi-Mousavi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Ahvaz Jundishapur University of Medical Sciences, Chronic Renal Failure Research Center, Ahvaz, Iran" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Ahvaz Jundishapur University of Medical Sciences, Diabetes Research Center, Ahvaz, Iran" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Ahvaz Jundishapur University of Medical Sciences, Faculty of Medicine, Ahvaz, Iran" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Efeito da prednisolona sobre o crescimento linear em crianças com síndrome nefrótica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3534 "Ancho" => 1511 "Tamanyo" => 257075 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Correlation of height <span class="elsevierStyleItalic">Z</span>-score worsening (post-treatment vs. pre-treatment) with prednisolone cumulative dose (in mg) in 90 children with nephrotic syndrome. 1: all patients (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.001); 2: boys (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.088); 3: girls (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.002).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Prednisolone (PDN) has changed the prognosis of nephrotic syndrome (NS) since 1950. Nearly 12–24% of patients are steroid-resistant and about 70% experience at least one episode of relapse.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">1</span></a> Besides the great benefits, there are many concerns about the disadvantages of PDN, particularly about its negative effects on linear growth. Several mechanisms have been proposed regarding the effects of NS on growth.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Some studies have confirmed the short-time inhibitory effects of PDN on growth by comparing height <span class="elsevierStyleItalic">Z</span>-score (Ht.<span class="elsevierStyleItalic">Z</span>s) before and after treatment between frequent and infrequent relapsers.<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">1,3</span></a> Other studies have investigated its negative impact in long-term use,<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">4,5</span></a> some others have followed patients longitudinally to compare their final height with their peers,<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">6,7</span></a> and finally, some have used a combination of methods.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">8</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Theoretically, growth potential can be evaluated using final height prediction in childhood. Several methods have been proposed for this purpose. The chronological age (CA)-based system decreases the prediction as bone age (BA) increases. However, the bone age-based system does not do this. In the BA-based system, the predictions are less affected by bone age discrepancies, but the effect is not symmetrical. Greulich-Pyle (GP) and Tanner-Whitehouse (TW) methods for skeletal age determination can be used for predicting adult height, which is helpful in diagnosing and evaluating the effects of treatment. In this method, the predicted adult height (PAHt.) is compared to the expected adult height (target range of height; target height [THt.], calculated as mid-parental height [MPHt.]).<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">By newer TW Mark systems, the errors of prediction are generally a little smaller than those arising from the Bayley-Pinneau predictions, and considerably smaller in the case of postmenarcheal girls.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">10</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The aim of this study was to evaluate potential short-term and long-term effects of PDN on linear growth by comparing: (a) Ht.<span class="elsevierStyleItalic">Z</span>s before and after treatment, (b) post-treatment predicted final height compared with (potential pre-treatment) mid-parental target height, and (c) low and high total cumulative doses of PDN according to the growth variables.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Method</span><p id="par0030" class="elsevierStylePara elsevierViewall">This cross-sectional study was conducted on all children (>2 yr.) and adolescents with the diagnosis of idiopathic nephrotic syndrome (INS) registered to the pediatric nephrology department at the main tertiary (Abuzar) children's hospital in Southwestern Iran from January 2011 to December 2012. All new admissions and recurrences were treated in the in-patient ward and were followed at the out-patient clinic at the same center.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Definitions: INS was diagnosed if urine protein was >40<span class="elsevierStyleHsp" style=""></span>mg/m<span class="elsevierStyleSup">2</span>/hr., serum protein <2.5<span class="elsevierStyleHsp" style=""></span>g/dL, edema, hyperlipidemia (more than age-appropriate limit) with the absence of gross hematuria, renal failure, prolonged hypertension, and normal complement.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">11</span></a> Relapse was defined as reappearance of proteinuria ≥2+ by dipstick for three consecutive days. Patients who responded during 8 weeks of PDN treatment (and did not relapse frequently before 3 months of drug discontinuation) were defined as SSNS (steroid-sensitive nephrotic syndrome). They were considered as SRNS (steroid-resistant nephrotic syndrome) if there was no response during this period. SDNS (steroid-dependent nephrotic syndrome) was defined if recurrence occurred during the alternate-day treatment or 3 months after discontinuation of treatment.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Inclusion criteria were: age <12 yr. for boys and <10 yr. for girls, more than 6 months having passed the beginning of treatment, receiving at least 152<span class="elsevierStyleHsp" style=""></span>mg/kg – equal to a complete initial course of treatment, and parental agreement. The exclusion criteria were: abnormal blood pressure, chronic kidney disease, any sign of pubertal development, and the presence of any other substantial disease affecting linear growth, such as hypothyroidism and celiac disease (discovered by a full history taking, precise physical examination, and a basic laboratory panel obtained during the first assessment).</p><p id="par0045" class="elsevierStylePara elsevierViewall">All subjects were initially treated with 2<span class="elsevierStyleHsp" style=""></span>mg/kg/d of PDN with a maximum of 80<span class="elsevierStyleHsp" style=""></span>mg/day over 4–6 weeks, followed by 4 weeks of the same steroid dose given on alternate days, and then the dose was tapered over about 3 months. Relapses were treated with PDN 40–60<span class="elsevierStyleHsp" style=""></span>mg/kg/d up to 5 days after disappearance of proteinuria, and then were tapered during the next 8 weeks. SDNS and SRNS patients also received other immunosuppressive drugs, including levamisole, cyclophosphamide, mycophenolate mofetil, and cyclosporine.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The following data were prepared for analysis:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0055" class="elsevierStylePara elsevierViewall">Date of birth, to calculate exact chronological age (CA) at each visit.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0060" class="elsevierStylePara elsevierViewall">Age at diagnosis and the time passed after the diagnosis.</p></li></ul></p><p id="par0065" class="elsevierStylePara elsevierViewall">The first and the last weight and height (before and after treatment) measured by a clinic nurse using instruments with an accuracy of 0.1<span class="elsevierStyleHsp" style=""></span>kg and 0.1<span class="elsevierStyleHsp" style=""></span>cm, respectively (Seca®, SP, USA). Height measurements were expressed as height standard deviation score (Ht.-SDS) based on the Tanner-Whitehouse reference growth curves.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">12</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Parents’ heights at the beginning of treatment were used to calculate MPHt. as pre-treatment Ht. prediction.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Bone age: radiographs of the left hand and wrist were taken and rated according to the GP system.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">13</span></a> All bone X-rays were reviewed by two radiologists separately and the mean values were used as the final report.</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Medications, duration, and doses</span><p id="par0080" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><p id="par0085" class="elsevierStylePara elsevierViewall">Number of relapses.</p></li><li class="elsevierStyleListItem" id="lsti0020"><p id="par0090" class="elsevierStylePara elsevierViewall">Total cumulative dose of PDN was considered as the sum of 150<span class="elsevierStyleHsp" style=""></span>mg/kg for initial treatment and 100<span class="elsevierStyleHsp" style=""></span>mg/kg for each relapse for SSNS subjects. For SDNS and SRNS individuals, all doses of PDN used between the relapses were also added to the calculation. Based on this variable, to assess the possible relation of total PDN dose and linear growth, patients were divided into two groups: less than 550<span class="elsevierStyleHsp" style=""></span>mg/kg [150<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>(3<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>100)] equal to three or fewer relapses; and patients with ≥550<span class="elsevierStyleHsp" style=""></span>mg/kg equal to four or more relapses.</p></li></ul></p><p id="par0095" class="elsevierStylePara elsevierViewall">Secondary variables were calculated as follows:<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0100" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Height standard deviation score (Ht.-SDS)</span> was calculated as: Ht.SDS=(x−x¯)/SD, where "x¯" and “SD” are the age-matched population mean height and standard deviation, respectively, and “<span class="elsevierStyleItalic">x</span>” is the patient's height (population data according to Tanner et al.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">12</span></a>). For example, based on CDC charts, the 50th percentiles for boys and girls at 20 years of age (used for parental Ht.-SDS determination) were considered as 177<span class="elsevierStyleHsp" style=""></span>cm and 163.3<span class="elsevierStyleHsp" style=""></span>cm, respectively. The Ht.-SDSs at this age were 7.0<span class="elsevierStyleHsp" style=""></span>cm and 6.5<span class="elsevierStyleHsp" style=""></span>cm, respectively.</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">-</span><p id="par0105" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">MPHt.</span> was calculated as the target height (the potential height range that a child is expected to reach if no postnatal disorder or environmental factor has interacted with the genetic height potential). <span class="elsevierStyleItalic">THt.</span> was calculated as: mean parental height<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>6.5<span class="elsevierStyleHsp" style=""></span>cm in males and mean parental height<span class="elsevierStyleHsp" style=""></span>−<span class="elsevierStyleHsp" style=""></span>6.5<span class="elsevierStyleHsp" style=""></span>cm in females.</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">-</span><p id="par0110" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">PAHt.</span> was calculated using TW mark-2 equations.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">14</span></a> The variables Ht., CA, BA, and MPHt. are used in this equation.</p></li></ul><elsevierMultimedia ident="eq0005"></elsevierMultimedia>where <span class="elsevierStyleItalic">a</span>, height coefficient; <span class="elsevierStyleItalic">b</span>, age coefficient; <span class="elsevierStyleItalic">c</span>, bone age coefficient; <span class="elsevierStyleItalic">d</span>, a constant.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">15</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">The equations permit a prediction of adult height, which, in 95% of instances, is within ±7<span class="elsevierStyleHsp" style=""></span>cm of true adult height in boys aged 4–12 and ±6<span class="elsevierStyleHsp" style=""></span>cm in girls aged 4–11.</p><p id="par0120" class="elsevierStylePara elsevierViewall">With this equation, only two coefficients are provided for each chronological year (<span class="elsevierStyleItalic">i.e.</span>, for 6, 6.5, 7, 7.5, etc.). Therefore, the coefficient of each child referring to the nearest half-year point has been used in this study. This system was limited to the ages more than 6 years. Consequently, their previous coefficients (TW mark-1) were used<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">10</span></a> for younger subjects. In comparison with the 1975 system (TW mark-1) and with the newer version, the standard errors of prediction (actual fewer estimates) are about the same or, on occasion, larger (near half a centimeter). Recent standard errors are therefore preferred.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">14</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">For assessment of short-time side-effects of PDN on linear growth, statistical differences between the first and the last Ht.-SDS were analyzed by comparing 95% confidence intervals.</p><p id="par0130" class="elsevierStylePara elsevierViewall">Finally, predicted adult height (±3.5<span class="elsevierStyleHsp" style=""></span>cm as the standard errors of prediction) and the mid-parental target height of each patient were compared; less values of predicted heights will be expressed as the negative effect of PDN on the potential linear growth.</p><p id="par0135" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleUnderline">Delta Ht.</span><span class="elsevierStyleUnderline"><span class="elsevierStyleItalic">Z</span>-score</span> and <span class="elsevierStyleUnderline">Delta Ht. Prediction</span> were calculated as follow:<elsevierMultimedia ident="eq0010"></elsevierMultimedia><elsevierMultimedia ident="eq0015"></elsevierMultimedia></p><p id="par0140" class="elsevierStylePara elsevierViewall">All variables including numbers of relapses (cumulative PDN dose) were compared between the different types of NS, and between the boys and girls. Student's <span class="elsevierStyleItalic">t</span>-test was used to compare ΔHt.<span class="elsevierStyleItalic">Z</span>s in different groups. Correlation between height changes and prednisolone doses was evaluated by Pearson's correlation test. Data were expressed as mean<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>SD. All <span class="elsevierStyleItalic">p</span>-values were two-sided and considered statistically significant for <0.05.</p><p id="par0145" class="elsevierStylePara elsevierViewall">This study was approved by the research ethics committee of Ahvaz Jundishapur University of Medical Sciences (U-91156).</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Results</span><p id="par0150" class="elsevierStylePara elsevierViewall">Ninety-seven patients were enrolled (68% male; male/female ratio<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2.1). The patients were aged 1–11 yr. (3.9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.0 yr.) at the onset of disease and 2.5–11.8 yr. (6.95<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>2.41 yr.) at the end of the study (only one pre-pubertal 14-year-old boy was included). Mean duration of the follow-up was 2.87 years (ranging from 8 months to 9.9 years). This mean was 3.9<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>1.8 yr. for SDNS and SRNS patients. All collected and calculated data are shown in <a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0155" class="elsevierStylePara elsevierViewall">In the SSNS group, 26 patients had several episodes of relapses and the remaining 37 patients had none (six were new cases and before 10-month follow up). The median for relapse rate was two (1–6 relapses) in the SSNS group and five (3–24 relapses) in the SDNS group.</p><p id="par0160" class="elsevierStylePara elsevierViewall">The mean PDN cumulative dosage was 452.6<span class="elsevierStyleHsp" style=""></span>mg/kg and the median was 350<span class="elsevierStyleHsp" style=""></span>mg/kg. The mean PDN cumulative dosages in SSNS, SDNS, and SRNS groups were 272, 757, and 793<span class="elsevierStyleHsp" style=""></span>mg/kg, respectively. Thirty-six patients (36.3%) needed other immunosuppressive drugs, such as steroid sparing agents (SSA): levamisole (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>25), cyclophosphamide (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>8), MMF (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>11), and cyclosporine (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>8).</p><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Effect of cumulative dosage of prednisolone on height</span><p id="par0165" class="elsevierStylePara elsevierViewall">Seventy-one (66%) of all 97 patients had less than four relapses (<550<span class="elsevierStyleHsp" style=""></span>mg/kg PDN; group 1) and the remaining 33 subjects, group 2, had four or more relapses. The second group (frequent relapsers) showed more decrease in mean Ht.<span class="elsevierStyleItalic">Z</span>s compared to the first group (−0.84 <span class="elsevierStyleItalic">vs.</span> −0.28; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.04).</p><p id="par0170" class="elsevierStylePara elsevierViewall">The cumulative dosage of PDN had a meaningful relationship (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.001) with the deterioration of ΔHt.<span class="elsevierStyleItalic">Z</span>s (the difference between post- and pre-treatment Ht.<span class="elsevierStyleItalic">Z</span>s). This deterioration was larger in female patients (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0175" class="elsevierStylePara elsevierViewall">Compared to the mean of target Ht.<span class="elsevierStyleItalic">Z</span>s (pre-treatment predicted height), the mean of post-treatment predicted Ht.<span class="elsevierStyleItalic">Z</span>s was increased to almost 0.4 SD, but again more PDN cumulative dosages were associated with greater decrease in the post-treatment prediction compared to the pre-treatment level. However, statistical significance was found only in male patients (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.006; <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0180" class="elsevierStylePara elsevierViewall">As is clear in the figures, these two variables (ΔHt.<span class="elsevierStyleItalic">Z</span>s and ΔHt. prediction) differed by sex. Pearson's test revealed a higher correlation of prednisolone cumulative dose (PCD) and ΔHt.<span class="elsevierStyleItalic">Z</span> score in girls than boys; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.002 <span class="elsevierStyleItalic">vs</span>. 0.088. Regarding the Δprediction, there was higher correlation in boys than girls; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.003 <span class="elsevierStyleItalic">vs</span>. 0.111.</p><p id="par0185" class="elsevierStylePara elsevierViewall">Patients who needed other immunosuppressive drugs had lower values of ΔHt.<span class="elsevierStyleItalic">Z</span>s (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.047), and this effect was more significant in the group of four or more relapses (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.03). In those with less than four relapses, the cumulative dosage of PDN did not have any meaningful relationship with the outcome measures.</p><p id="par0190" class="elsevierStylePara elsevierViewall">Deterioration of the mean <span class="elsevierStyleItalic">Z</span>-score had no meaningful relationship with the type of nephrotic syndrome (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.05), allergy (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.05), family history of renal and non-renal diseases (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.05), presence of hypertension (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.05), and parental consanguinity (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.05).</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0195" class="elsevierStylePara elsevierViewall">This study was designed to assess the possible short- and long-term effects of steroids on the linear growth of pre-pubertal children with nephrotic syndrome. Results showed its negative effect on patients with SDNS and four or more relapses. While the effect was more noticeable in girls over the short term, it was more noticeable in boys over the long term. The results of this study were similar to previous ones in many aspects. This study showed that the post-treatment Ht.<span class="elsevierStyleItalic">Z</span>s of patients receiving PDN ≥550<span class="elsevierStyleHsp" style=""></span>mg/kg had reduced significantly, and that the deterioration of Ht.<span class="elsevierStyleItalic">Z</span>s was associated with an increase in cumulative PDN dose.</p><p id="par0200" class="elsevierStylePara elsevierViewall">The study by Donatti et al. on 85 SSNS patients, over all, did not show any significant alterations in the Ht.<span class="elsevierStyleItalic">Z</span>s and the mean height percentile between the first and last visit; by dividing patients into two groups, however, if they had improved Ht.<span class="elsevierStyleItalic">Z</span>s, the total dose and duration of PDN, and the chronological age were higher in the last group. This group also had retarded growth and puberty.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">16</span></a></p><p id="par0205" class="elsevierStylePara elsevierViewall">In an opposite direction, Adhikari et al., in a study on an African/Indian population, did not found any significant difference between treated and untreated (symptomatically managed) children in mean Ht.-SDS. They then concluded that courses of daily steroids or persistent proteinuria did not inhibit linear growth.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">17</span></a> That study had not considered the effect of cumulative PDN dose or relapse rate in their evaluation.</p><p id="par0210" class="elsevierStylePara elsevierViewall">Non-uniform results seen in previous studies could mostly be due to differences in their methodologies, and since a cut-off has been used for high- <span class="elsevierStyleItalic">vs.</span> low-dose PDN exposures in this study, it is hard to compare this study with the previous ones.</p><p id="par0215" class="elsevierStylePara elsevierViewall">The suppression of osteoblastogenesis in bone marrow and the promotion of osteocyte and osteoblast apoptosis are consequences of steroids, which lead to a decrease in bone formation. The accumulation of apoptotic osteocytes could account for some definitions, such as osteonecrosis, aseptic necrosis, or avascular necrosis. The negative effect of steroid use on bone mass and short-term growth depends on the type and dose of steroid, and occurs mostly during the first 6 months of treatment. The common belief is that trabecular bones are affected more than cortical ones. However, a recent study in patients with acute lymphoblastic leukemia found a high incidence of cortical bone involvement after glucocorticoid treatment.</p><p id="par0220" class="elsevierStylePara elsevierViewall">However, there is some evidence indicating that steroids induce bone resorption by prolonging osteoclast lifespan. Besides, they promote calcium loss through the kidneys and intestine, producing a negative balance in calcium metabolism that induces more osteoclastic activity due to secondary hyperparathyroidism.<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">2,18</span></a></p><p id="par0225" class="elsevierStylePara elsevierViewall">The effect of PDN cumulative dose on linear growth is shown better with longitudinal studies. For example, the study by Emma et al. on children with SDNS (mean follow up<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>11.7<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>3.5 years) showed loss of almost 0.5 SD of Ht.-SDS during the pre-pubertal period, and 0.7 SD of their target Ht. (only in male subjects) when they reached their final height. More prolonged treatment was associated with higher risk of Ht.-SDS loss.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">6</span></a> These findings were similar to the present results in that this study also discovered long-term negative effects (lower values for Ht. prediction after treatment) limited to boys. In comparison with the study by Emma et al., using a cut off makes the present approach different, but looking at PDN impact on ΔHt.<span class="elsevierStyleItalic">Z</span>s and height prediction using MPHt.<span class="elsevierStyleItalic">Z</span> could be a point of strength in the present study. It was also shown in the study by Ribeiro et al.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">4</span></a> that long-term PDN, particularly in higher doses, affects height SDS as well as spinal bone density. A longitudinal study by Rees et al. on 41 patients (29 boys) with SSNS also showed a decrease in Ht.-SDS in boys (only after 10 years, and it was associated with delay in puberty) but not in girls.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">3</span></a> This finding requires further research for explanation.</p><p id="par0230" class="elsevierStylePara elsevierViewall">Simmonds et al. determined a cut-off point in which lower cumulative PDN dose was compatible with normal growth. By calculating daily PDN dose and Ht.-SDS velocity between clinics, they found no negative effect on growth at doses of PDN <0.75<span class="elsevierStyleHsp" style=""></span>mg/kg/day; with higher doses, there was a small decline in Ht. SDS velocity.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">19</span></a> In the present study, a similar relationship with the cumulative doses of PDN ≥550<span class="elsevierStyleHsp" style=""></span>mg/kg was found.</p><p id="par0235" class="elsevierStylePara elsevierViewall">Under high-dose steroid treatment, the physiological secretion of growth hormone may be reduced or mediated by somatostatin and, in some cases, growth hormone stimulation tests are unable to produce an appropriate response.<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">20</span></a></p><p id="par0240" class="elsevierStylePara elsevierViewall">Attainment of peak bone mass and growth may also be impaired by steroid use because of an altered pituitary-gonadal axis. A reversible hypo-gonadotropic hypogonadism is shown in studies in adults using steroid therapy. Adrenal insufficiency following chronic glucocorticoid therapy may also be associated with depressed levels of other sex steroids, such as androstenedione and estrogen. Steroids may also impair FSH and cause reduction in estrogen secretion.<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">21,22</span></a></p><p id="par0245" class="elsevierStylePara elsevierViewall">Puberty occurs between childhood and the time when final height is obtained. Its beginning time varies according to the ethnic and familial genetic basis, and it may last 2–6 years to complete. For each family and sibling, it has an individual pattern of progress regarding the overall rate and stages intervals. Even in a healthy child, the exact prediction of pubertal onset and its growth spurt is not possible. With steroid exposure and its negative effects on pubertal process and bone formation, such predictions become more difficult. Accordingly, the present study completely excluded pubertal stages from follow-up analysis. Longitudinal follow-up of patients after completion of puberty can solve this problem when they have reached the final height. Finding a sex difference in short-term and long-term negative PDN impacts (in girls and boys, respectively) matches with the shorter pre-pubertal years in girls than in the boys.</p><p id="par0250" class="elsevierStylePara elsevierViewall">Finally, it was better to compare pre-treatment and post-treatment PAHt.<span class="elsevierStyleItalic">Z</span>, but because pre-treatment bone ages were not available in subjects, MPHt.<span class="elsevierStyleItalic">Z</span> was used as the basic potential target height, which, theoretically, must not change from childhood to adolescence. Comparing different items before and after treatment to evaluate PDN side effects can cause some errors. Although the number of patients in this study was greater than in the previous ones, a much larger population in a multicenter study for longer period would give better results. Short duration (<2.5 yr.) of follow-up in more than half of the patients may affect the results.</p><p id="par0255" class="elsevierStylePara elsevierViewall">Moreover, the equations used in this study were obtained based on data from a British population. However, they have been checked in a Japanese population. Still, they need to match with the raw data of each population to assess applicability.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">14</span></a></p><p id="par0260" class="elsevierStylePara elsevierViewall">Finally, the authors were more familiar with the GP system for bone age assessment, and then it was used as a part of TW mark-2 system for height prediction. In fact, the original method for bone age rating in TW formula is their own system, and not that of GP.</p><p id="par0265" class="elsevierStylePara elsevierViewall">This study showed the negative effect of cumulative PDN dose on linear growth in nephrotic syndrome; fortunately, it happened mostly in prolonged disease with four or more relapses. This finding is important for giving parental assurance about relative safety of this lifesaving drug. Finally, the importance of earlier growth intervention in frequent relapses is warranted.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Funding</span><p id="par0270" class="elsevierStylePara elsevierViewall">This study was supported by Vice chancellor for research of the Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicts of interest</span><p id="par0275" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1290496" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1192226" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1290495" "titulo" => "Resumo" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1192227" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Method" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Medications, duration, and doses" ] ] ] 6 => array:3 [ "identificador" => "sec0020" "titulo" => "Results" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Effect of cumulative dosage of prednisolone on height" ] ] ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0035" "titulo" => "Funding" ] 9 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-03-20" "fechaAceptado" => "2018-07-30" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1192226" "palabras" => array:4 [ 0 => "Prednisolone" 1 => "Linear growth" 2 => "Children" 3 => "Nephrotic syndrome" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec1192227" "palabras" => array:4 [ 0 => "Prednisolona" 1 => "Crescimento linear" 2 => "Crianças" 3 => "Síndrome nefrótica" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">This study aims at determining the relationship between prednisolone cumulative dose and linear growth in pre-pubertal children with idiopathic nephrotic syndrome.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This cross-sectional study was conducted on all children with idiopathic nephrotic syndrome registered to the pediatric nephrology department at the main referral children's hospital in Southwestern Iran. Inclusion criteria included age (males <12 years; females <10 years), >6 months of use, and the minimum prednisolone cumulative dose of 152<span class="elsevierStyleHsp" style=""></span>mg/kg. The exclusion criteria were individuals who had entered puberty or had other diseases affecting linear growth. Based on the prednisolone cumulative dose of ≥550<span class="elsevierStyleHsp" style=""></span>mg/kg (four or more relapses), the children were divided into two groups. All data regarding age, height, and weight at disease onset and the last visit, bone age, and the parents’ height were collected. Secondary variables including mid-parental target height and predicted adult height were also calculated. Height data were compared between the different rates of relapse.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A total of 97 children (68% male) were enrolled. Their post-treatment mean height <span class="elsevierStyleItalic">Z</span>-score was less than that obtained before treatment (−0.584 <span class="elsevierStyleItalic">vs.</span> −0.158; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.001). Subjects with higher prednisolone cumulative doses were found to have more reduction in height <span class="elsevierStyleItalic">Z</span>-score (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.001). Post-treatment height prediction also showed less growth potential compared to pre-treatment target height (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.006). Thirty-three children (34.4%) had four or more relapses, among whom more mean-height <span class="elsevierStyleItalic">Z</span>-score decreases were found compared to those with less-frequent relapses (−0.84 <span class="elsevierStyleItalic">vs.</span> −0.28; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.04).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">This study showed the negative effect of cumulative dosages of prednisolone on linear growth, which was greater in children with four or more relapses.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Determinar a relação entre a dose cumulativa de prednisolona e o crescimento linear em crianças pré-púberes com síndrome nefrótica idiopática.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudo transversal conduzido em todas as crianças com síndrome nefrótica idiopática registradas no departamento de nefrologia pediátrica no principal hospital infantil para encaminhamento no sudoeste do Irã. Os critérios de inclusão incluíram idade (meninos<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>12 anos; meninas<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>10 anos), >6 meses e a dose cumulativa de prednisolona mínima de 152<span class="elsevierStyleHsp" style=""></span>mg/kg. Os critérios de exclusão foram indivíduos que entraram na puberdade ou tinham outras doenças que afetam o crescimento linear. Com base na dose cumulativa de prednisolona de ≥550<span class="elsevierStyleHsp" style=""></span>mg/kg (≥4 recidivas), as crianças foram divididas em dois grupos. Foram coletados todos os dados relacionados a idade, estatura e peso no início da doença e na última visita, idade óssea e estatura dos pais. Também foram calculadas as variáveis secundárias, inclusive estatura-alvo e estatura adulta prevista. Os dados de estatura foram comparados entre as diferentes taxas de recidivas.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Foram inscritas 97 crianças (68% do sexo masculino). Seu escore z de estatura média pós-tratamento foi inferior ao obtido antes do tratamento (−0,584 em comparação com −0,158; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,001). Os indivíduos com maiores doses cumulativas de prednisolona mostraram maior redução no escore z para estatura (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,001). A estatura pós-tratamento também foi preditiva de menor potencial de crescimento em comparação com a estatura-alvo pré-tratamento (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,006); 33 crianças (34,4%) apresentaram ≥4 recidivas, entre as quais foram encontradas mais reduções médias no escore z para estatura em comparação com as recidivas menos frequentes (−0,84 em comparação com −0,28; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,04).</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusão</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Este estudo mostrou o efeito negativo das doses cumulativas de prednisolona sobre o crescimento linear, que foi maior em crianças com ≥4 recidivas.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0025">Please cite this article as: Valavi E, Aminzadeh M, Amouri P, Rezazadeh A, Beladi-Mousavi M. Effect of prednisolone on linear growth in children with nephrotic syndrome. J Pediatr (Rio J). 2020;96:117–24.</p>" ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3534 "Ancho" => 1511 "Tamanyo" => 257075 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Correlation of height <span class="elsevierStyleItalic">Z</span>-score worsening (post-treatment vs. pre-treatment) with prednisolone cumulative dose (in mg) in 90 children with nephrotic syndrome. 1: all patients (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.001); 2: boys (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.088); 3: girls (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.002).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 3588 "Ancho" => 1502 "Tamanyo" => 248721 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Correlation of height prediction <span class="elsevierStyleItalic">Z</span>-score worsening (post-treatment vs. pre-treatment) with prednisolone cumulative dose (in mg) in 90 children with nephrotic syndrome. 1: all patients (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.006); 2: boys (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.003); 3: girls (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.111).</p>" ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">PCD, prednisolone cumulative dose.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean dif.<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">R</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">All subjects \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Boys \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.500 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Girls \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.270 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.231 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><550<span class="elsevierStyleHsp" style=""></span>mg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.302 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.022 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">≥550<span class="elsevierStyleHsp" style=""></span>mg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.686 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.011 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="5" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Correlation with PCD</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ht. Zs all \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.426 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.337 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Boys \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.500 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.220 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.088 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Girls \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.270 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.559 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.002 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ht. pred. all \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.402 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.282 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.006 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Boys \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.360 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.368 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Girls \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.476 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.297 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.111 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2210066.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Post-treatment Ht. <span class="elsevierStyleItalic">Z</span> score mean<span class="elsevierStyleHsp" style=""></span>−<span class="elsevierStyleHsp" style=""></span>Pre-treatment.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Mean difference of growth indices and their values in 90 children with nephrotic syndrome before and after treatment with prednisolone.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">SSNS, steroid-sensitive nephrotic syndrome; sDNS, steroid-dependent nephrotic syndrome; SRNS, steroid-resistant nephrotic syndrome.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Frequency % \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Male % \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mean age (yr) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Follow up duration \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PDN cumulative dose (mg) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">PrimaryHt <span class="elsevierStyleItalic">Z</span><a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">b</span></a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">CurrentHt <span class="elsevierStyleItalic">Z</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">ΔHt <span class="elsevierStyleItalic">Z</span><a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">c</span></a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Predicted Ht <span class="elsevierStyleItalic">Z</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SSNS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">63.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">74.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.74(2.5)<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.24(1.87) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">272(136) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.17(1.33) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.42(0.99) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.2(0.99) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.6(1.24) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SDNS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.52(2.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.19(1.95) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">757(503) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.7(1.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.44(0.96) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.33(1.36) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.7(1.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SRNS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.5(2.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.4(1.38) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">793(405) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.4(1.26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1.59(1.34) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1.1(1.31) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.03(0.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">All cases \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">68.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.9(2.42) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.87(2.02) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">452(385) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.3(1.28) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.5(1.07) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.18(1.17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0.3(1.39) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2210065.png" ] ] ] "notaPie" => array:3 [ 0 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Values in parenthesis indicate the standard deviation.</p>" ] 1 => array:3 [ "identificador" => "tblfn0015" "etiqueta" => "b" "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Height <span class="elsevierStyleItalic">Z</span>-score.</p>" ] 2 => array:3 [ "identificador" => "tblfn0020" "etiqueta" => "c" "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Δ; 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Year/Month | Html | Total | |
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2024 November | 4 | 1 | 5 |
2024 October | 39 | 26 | 65 |
2024 September | 26 | 31 | 57 |
2024 August | 42 | 54 | 96 |
2024 July | 86 | 66 | 152 |
2024 June | 27 | 31 | 58 |
2024 May | 30 | 24 | 54 |
2024 April | 38 | 30 | 68 |
2024 March | 36 | 18 | 54 |
2024 February | 25 | 36 | 61 |
2024 January | 31 | 29 | 60 |
2023 December | 17 | 24 | 41 |
2023 November | 29 | 38 | 67 |
2023 October | 37 | 98 | 135 |
2023 September | 36 | 41 | 77 |
2023 August | 28 | 18 | 46 |
2023 July | 25 | 18 | 43 |
2023 June | 16 | 9 | 25 |
2023 May | 31 | 26 | 57 |
2023 April | 46 | 16 | 62 |
2023 March | 47 | 20 | 67 |
2023 February | 21 | 19 | 40 |
2023 January | 40 | 20 | 60 |
2022 December | 55 | 30 | 85 |
2022 November | 28 | 31 | 59 |
2022 October | 57 | 33 | 90 |
2022 September | 24 | 25 | 49 |
2022 August | 29 | 41 | 70 |
2022 July | 32 | 23 | 55 |
2022 June | 29 | 32 | 61 |
2022 May | 79 | 24 | 103 |
2022 April | 61 | 35 | 96 |
2022 March | 63 | 125 | 188 |
2022 February | 22 | 27 | 49 |
2022 January | 25 | 20 | 45 |
2021 December | 23 | 19 | 42 |
2021 November | 12 | 16 | 28 |
2021 October | 21 | 11 | 32 |
2021 September | 11 | 7 | 18 |
2021 August | 14 | 9 | 23 |
2021 July | 7 | 4 | 11 |
2021 June | 20 | 8 | 28 |
2021 May | 32 | 14 | 46 |
2021 April | 69 | 36 | 105 |
2021 March | 50 | 25 | 75 |
2021 February | 15 | 10 | 25 |
2021 January | 22 | 12 | 34 |
2020 December | 30 | 9 | 39 |
2020 November | 36 | 15 | 51 |
2020 October | 14 | 8 | 22 |
2020 September | 16 | 9 | 25 |
2020 August | 14 | 6 | 20 |
2020 July | 11 | 8 | 19 |
2020 June | 15 | 4 | 19 |
2020 May | 33 | 8 | 41 |
2020 April | 43 | 9 | 52 |
2020 March | 47 | 5 | 52 |
2020 February | 63 | 31 | 94 |
2020 January | 25 | 27 | 52 |
2019 December | 20 | 11 | 31 |
2019 November | 7 | 3 | 10 |
2019 October | 15 | 8 | 23 |
2019 September | 13 | 7 | 20 |
2019 August | 7 | 10 | 17 |
2019 July | 8 | 11 | 19 |
2019 June | 30 | 20 | 50 |
2019 May | 8 | 18 | 26 |
2019 April | 20 | 7 | 27 |
2019 March | 6 | 35 | 41 |
2019 February | 3 | 4 | 7 |
2019 January | 11 | 6 | 17 |
2018 December | 12 | 6 | 18 |
2018 November | 15 | 2 | 17 |
2018 October | 6 | 9 | 15 |