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              "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Associa&#231;&#227;o da capnografia volum&#233;trica entre indiv&#237;duos com fibrose c&#237;stica&#46; <span class="elsevierStyleBold">A&#46;</span> Associa&#231;&#227;o do slope 3 entre indiv&#237;duos com fibrose c&#237;stica &#40;FC&#44; 1&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; e os controles saud&#225;veis &#40;2&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; considerando a idade e o sexo em diferentes momentos da capnografia volum&#233;trica&#46; <span class="elsevierStyleBold">1&#46;</span> Associa&#231;&#227;o do slope 3 com FC e controles&#46; &#40;momento 1&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>34&#44;5&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#44;15&#44; 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&#40;momento 1&#41; 11 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>38&#44;04&#44; 12 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805; 12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>31&#44;6&#44; 21 &#40;controles<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#44;63&#44; 22 &#40;controles<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805; 12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44;05&#44; &#40;momento 2&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>32&#44;01&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&#44;13&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#44;04&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#44;84&#44; &#40;momento 3&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#44;09&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#44;56&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44;5&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44;9&#44; 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&#40;momento 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;18&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#46; <span class="elsevierStyleBold">3&#46;</span> Associa&#231;&#227;o do volume do slope 3&#47;corrente com FC e controles considerando o sexo&#46; &#40;momento 1&#41; 11 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>masculino&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;14&#44; 12 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>feminino&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#44; 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&#40;moment 1&#41; 11 &#40;CF<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#60;12 years&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;14&#44; 12 &#40;CF<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805;12 years&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;07&#44; 21 &#40;controls<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#60;12 years&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; 22 &#40;controls<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805;12 years&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#46; &#40;moment 2&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;09&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moment 3&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;07&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moment 4&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;08&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moment 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;18&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;07&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; 3&#46; Association of slope 3&#47;tidal volume with CF and controls considering sex&#46; &#40;moment 1&#41; 11 &#40;CF<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>masculine&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;14&#44; 12 &#40;CF<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>feminine&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;07&#44; 21 &#40;controls<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>masculine&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; 22 &#40;controls<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>feminine&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#46; &#40;moment 2&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;09&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moment 3&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;07&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moment 4&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;08&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moment 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;18&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;07&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moments&#41; 1&#44; baseline time in the SMWT&#59; 2&#44; 1st and 2nd minutes of the SMWT&#59; 3&#44; 3rd and 4th minutes of the SMWT&#59; 4&#44; 5th and 6th minutes of the SMWT&#59; 5&#44; after the SMWT&#59; SMWT&#44; six-minute walk test on the treadmill&#46; TV&#44; tidal volume&#46; We used the Mann&#8211;Whitney&#44; Kruskal&#8211;Wallis and Friedman tests&#46; Alpha<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46; The medians and the 95&#37; confidence interval are represented in the graphs&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">In cystic fibrosis &#40;CF&#59; OMIM&#58; &#35;<a id="intr0010" class="elsevierStyleInterRef" href="omim:219700">219700</a>&#41; there is a progressive decline of lung function that is determinant of patients&#8217; mortality&#46; However&#44; recently&#44; favorable CF prognosis have been demonstrated in subjects with better aerobic conditioning and nutritional status&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1&#44;2</span></a> For this reason&#44; markers that show limitations to exercise and that evaluate progressive pulmonary deterioration have been studied&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">CF shows progressive involvement of peripheral airways &#40;pulmonary silent zone&#41;&#44; and conventional pulmonary function tests are ineffective to correctly assess the region&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">4&#44;5</span></a> Thus&#44; volumetric capnography &#40;VCap&#41; arises as an alternative to assess the partial pressure of carbon dioxide &#40;VCO<span class="elsevierStyleInf">2</span>&#41; in the gas that comes in and out of the lungs over time and to detect homogenization of the pulmonary periphery at the beginning of the gas washout&#46; VCap provides gas transport indexes in the alveolar airways of the lung periphery&#44; slope 3&#46; In summary&#44; VCap is a low cost procedure&#44; easy to administer&#44; that is well tolerated and does not require a maneuver that is forced or hard to understand&#46; In addition&#44; it can detect early pulmonary alterations&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Therefore&#44; the objective of this study was to evaluate the respiratory dynamics of healthy control children and adolescents and those with CF in a submaximal exercise protocol on treadmill for six minutes &#40;SMWT&#41; considering VCap parameters &#40;slope 3&#44; slope 3&#47;exhaled tidal volume &#91;slope 3&#47;TV&#93;&#44; and slope 2&#41;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">This was a cross-sectional study with 128 subjects&#44; 64 with CF and 64 healthy control volunteers&#46; The study included subjects with CF who agreed to participate in the study and who met the inclusion criteria&#46; A signed informed consent was obtained from all participants included in the study&#46; The study followed the ethical criteria of the Helsinki Convention and was approved by the Ethics Committee of the institution &#40;No&#46; 1182&#47;2009&#41;&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">CF group</span><p id="par0025" class="elsevierStylePara elsevierViewall">Inclusion criteria were&#58; age between 6 and 25 years&#59; CF diagnosis by two sweat tests with chloride values above 60 mEq&#47;L and&#47;or presence of two mutations in the cystic fibrosis transmembrane regulator &#40;<span class="elsevierStyleItalic">CFTR</span>&#41; gene<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3&#44;7&#44;8</span></a>&#59; and clinical stability determined by two clinical scores&#58; Cystic Fibrosis Foundation Clinical Score and Cystic Fibrosis Clinical Score&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">9&#44;10</span></a> Disease severity was classified in accordance with the Shwachman-Kulczycki score&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Control group</span><p id="par0030" class="elsevierStylePara elsevierViewall">Healthy subjects aged between 6 and 25 years were randomly selected among students of public and private schools located in the same neighborhood as this university&#46; Participants answered a questionnaire about health conditions and did not present acute respiratory disease or modification in the spirometry variables&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Volumetric capnography</span><p id="par0035" class="elsevierStylePara elsevierViewall">The subjects underwent the VCap on a treadmill&#46; In VCap&#44; the CO<span class="elsevierStyleInf">2</span>smo Plus Dx-8100 monitor &#40;Novametrix&#44; Medical Systems&#44; USA&#41; was used to evaluate the participants four minutes before SMWT&#44; six minutes during it&#44; and four minutes after the test&#46; The system is not invasive and is composed of a monitor containing a capnograph&#44; pulse oximetry&#44; and pneumotachograph&#46; VCap and pneumotachograph measurements were obtained in real time by the expired gas analysis&#46; The CO<span class="elsevierStyleInf">2</span>smo Plus Dx-8100 monitor was linked to a computer equipped with the software to record flow&#44; volume&#44; pressure&#44; pressure-volume&#44; volume flow&#44; and VCap and curves measurements&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The sensor of the monitor was connected to a nozzle&#44; and a nasal clip was used to avoid air escape through the nose&#46; At the end of collection&#44; an offline sequence of respiratory cycles was selected to admit a coefficient of variation for the TV lower than 25&#37; of the mean TV&#44; and a coefficient of variation lower than 10&#37; in millimeters of mercury &#40;mmHg&#41; was admitted for EtCO<span class="elsevierStyleInf">2</span>&#46; Respiratory cycles with zero value for the slope 3 were eliminated&#46; The result was obtained from the mean of variables during the minutes of monitorization&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3&#44;5&#44;9</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In this study&#44; the following measures were assessed&#58; &#40;i&#41; TV&#58; volume of air exhaled in one breath&#44; measured in milliliters &#40;mL&#41;&#59; &#40;ii&#41; Slope of phase II of the VCap curve &#40;slope 2&#41;&#44; measured in mmHg&#47;L&#59; &#40;iii&#41; Slope of phase III of VCap curve &#40;slope 3&#41;&#58; measured in mmHg&#47;L&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Submaximal exercise of six minutes on the treadmill &#40;SMWT&#41;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Before starting the SMWT on the treadmill&#44; the anthropometric assessment was conducted&#44; which included weight &#40;kg&#41;&#44; height &#40;cm&#41;&#44; and calculation of body mass index &#40;BMI&#41;&#46; Participants walked on a treadmill &#40;Caloi Electronics<span class="elsevierStyleSup">&#174;</span> Pro CL 5004&#44; SP&#44; Brazil&#41; for six minutes to analyze the behavior of the VCap variables&#46; SMWT started with the treadmill paused&#46; The speed was progressively increased every minute according to the individual&#39;s tolerance to walking&#44; without running&#44; and respecting the submaximal effort of each individual&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3&#44;10</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Immediately before the SMWT&#44; the participant remained at rest for four minutes to assess the VCap&#46; Then&#44; the SMWT was started&#44; and the VCap data were measured during the SMWT&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The exercise was accompanied by verbal stimuli&#44; which was provided on the first minute and at the end of each minute&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">The exercise protocol was based on the SMWT and on protocols developed on treadmill&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3&#44;10&#8211;15</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistical analysis</span><p id="par0070" class="elsevierStylePara elsevierViewall">For each moment of evaluation during the exercise&#44; the VCap data are presented by the mean&#44; standard deviation&#44; median&#44; minimum&#44; maximum&#44; and the confidence interval for the mean&#46; The moments evaluated were&#58; &#40;1&#41; baseline&#59; &#40;2&#41; 1st and 2nd minutes of SMWT&#59; &#40;3&#41; 3rd and 4th minutes of SMWT&#59; &#40;4&#41; 5th and 6th minutes of SMWT&#59; and &#40;5&#41; after SMWT&#46; Statistical analysis was performed in the software SPSS&#44; version 24 &#40;IBM Corp&#46; Released 2016&#46; IBM SPSS Statistics for Windows&#44; Version 24 &#8211; Armonk&#44; NY&#58; IBM Corp&#46;&#41; using Friedman&#44; Mann&#8211;Whitney&#44; and Kruskal&#8211;Wallis tests&#46; The analyses considered the age and sex of subjects&#46; An alpha<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05 was considered&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0075" class="elsevierStylePara elsevierViewall">In the CF and control groups&#44; slope 3&#44; slope 3&#47;TV&#44; and slope 2 presented differences among the moments analyzed &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; Slope 3 showed higher values in the CF than control groups at moments 1&#44; 3&#44; 4&#44; and 5 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#44; while slope 3&#47;TV showed higher values in the CF than control groups for all the moments &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#59; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Considering the subjects by age group&#44; the slope 3 showed difference in CF between the analyzed moments regardless of age&#44; whereas the controls only showed difference in subjects aged<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>12 years &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#59; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The slope 3&#47;TV showed difference in the CF and control groups regardless of age&#44; between all the moments analyzed &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> and <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; However&#44; for the slope 2&#44; only the CF was different between the moments for the age groups &#40;<span class="elsevierStyleItalic">p<span class="elsevierStyleHsp" style=""></span></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46; When stratified by age group&#44; slope 3&#44; slope 3&#47;TV&#44; and slope 2 were able to differentiate the groups &#40;CF and controls&#41;&#44; at all moments and in all the analyses &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Regarding sex&#44; no differences were observed between the moments in the parameters slope 3 and slope 3&#47;TV for the controls of the female sex &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#59; <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; In turn&#44; slope 2 only showed differences between the moments for the females from the CF group &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#59; <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; The slope 3 and slope 3&#47;TV were able to differentiate the groups &#40;CF and controls&#41;&#44; at all moment and in all the analyses&#44; when sex was considered &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors believe that this is the first time the VCap parameters during exercise are compared in healthy subjects and CF subjects&#46; The study demonstrated the possibility of obtaining markers in a non-invasive way and through a submaximal effort protocol that is tolerable by participants&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Specifically&#44; VCap presented numerous indexes&#44; such as the slope 3&#44; which provides data about the dynamics of gas transport in the alveolar airways of the lung periphery&#46; The inclination of slope 3 is determined by the emptying nature of the alveolar units&#58; synchronous or asynchronous&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">16&#44;17</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Emptying is synchronous when the gas simultaneously expires from the alveoli&#44; resulting in phase III horizontal or with minimal tilt&#46; In turn&#44; sequential&#47;late emptying occurs when the alveolar units are emptied in an asynchronous manner&#44; i&#46;e&#46;&#44; with longer time constants&#44; making the PCO<span class="elsevierStyleInf">2</span> higher&#44; resulting in a growing inclination of slope 3&#46; Slope 3 depends on the numerous alveoli emptying patterns with different ventilation&#47;perfusion ratios &#40;V&#47;Q&#41;&#44; as the continuous elimination of CO<span class="elsevierStyleInf">2</span> in the alveoli&#44; making the VCap a useful tool to detect anomalies in the maladjustment between V&#47;Q&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">9&#44;18&#44;19</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Slope 3 presented higher values in the CF&#44; indicating a ventilation inhomogeneity in the distal airspaces in comparison with controls&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5&#44;17</span></a> Veronez et al&#46; described that the increase in slope 3 in subjects with bronchiectasis&#44; related or not to the CF&#44; indicated diffuse disease of small airways&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">The behavior of slope 3 during physical exercise observed in this research was similar in the CF and control groups&#46; A decrease in the values of the index was noted during the physical exercise&#44; followed by a quick recovery&#46; However&#44; higher values of slope 3 inclination probably occurred in the CF due to greater retention of exhaled carbon dioxide &#40;VCO<span class="elsevierStyleInf">2</span>&#41;&#44; but it is necessary to consider other hypothesis&#44; such as earlier emptying of alveolar dead space regions &#40;V&#47;Q relationships&#41; and variations in cardiac output&#46; Therefore&#44; the CF group presented increased values of slope 3 during the evaluation&#44; indicating initial ventilation inhomogeneity during the rest&#46; This fact is justified in the CF by the largest CO<span class="elsevierStyleInf">2</span> production and retention&#44; increase in airway resistance&#44; decreased functional residual capacity&#44; and changes in cardiac debit during physical activity &#8211; these factors can affect the V&#47;Q ratio and influence the height&#47;slope 3&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">20&#8211;23</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Still considering the slope 3&#44; some authors suggest that it should be standardized by TV&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5&#44;6&#44;9</span></a> Almeida et al&#46; noted increased slope3&#47;TV in subjects with asthma&#44; in comparison with controls&#44; suggesting ventilation inhomogeneity in the distal airspaces and indicating chronic airway structural disorders and acute reversible changes observed in the bronchial challenge test&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a> Moreover&#44; Ribeiro et al&#46;&#44; when using spirometry and the VCap to assess lung function in CF&#44; identified an increase in slope 3&#47;TV&#44; even in subjects with normal spirometry&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> The present study corroborates those findings and identified an increased slope 3&#47;TV during physical exercise in the CF when compared with controls&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">The slope 3 and&#47;or slope 3&#47;TV show association even in the CF with age younger than 12 years&#46; Thus&#44; since a young age&#44; the CF group present alterations in the respiratory dynamics&#44; but does not compromise the physical activity performance&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Numerous features on the physiology of physical effort considering the age group and sex were observed&#46; In this line&#44; the higher values of slope 3 were observed in male participants from the CF group &#40;moments 1&#44; 4 and 5&#41;&#46; Also&#44; when normalizing by TV &#40;slope 3&#47;TV&#41;&#44; the higher values were observed in male participants from the CF group&#46; This observation is due to the increase of maximal oxygen consumption &#40;VO<span class="elsevierStyleInf">2</span>max&#41; in absolute terms throughout the age groups&#44; with greater acceleration in boys than in girls&#46; This event is closely related to the increase in muscle mass&#44; in a way that when considering the VO<span class="elsevierStyleInf">2</span>max fixed by indicators of muscle mass&#44; there is no increase with age in male children and adolescents &#40;VO<span class="elsevierStyleInf">2</span>max&#47;kg &#8211; body weight remains constant&#41;&#44; while there is a progressive decline in girls &#40;decrease in VO<span class="elsevierStyleInf">2</span>max&#47;kg-body weight&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">24&#8211;26</span></a> Thus&#44; the anaerobic power does not differ between sexes in prepubescent individuals&#44; but it increase proportionally in males from puberty onwards&#46; All of that is due to the development of muscle mass and effect of hormonal maturation on the functional musculoskeletal characteristics&#46;<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">27&#8211;30</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Although the CF group presented reduction of the alveolar ventilation and change in the V&#47;Q ratio&#44; as evidenced by the curve of slope 3&#44; the patients in this group were able to perform the physical exercise protocol without complications&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">VCap is not widely used in clinical practice mainly due to little understanding of the data obtained&#44; as well as the scarcity of published studies&#46; This study described the behavior of slope 2 and slope 3 during submaximal physical exercise in CF patients&#59; it was observed that patients show functional alterations from the baseline period&#44; which are accentuated during exercise&#46; In addition&#44; although no ventilation homogeneity was observed in the pulmonary periphery in the CF group&#44; patients were able to perform submaximal exercises for short periods of time&#46; Data from slope 2 and slope 3 showed that even asymptomatic patients presented changes in lung function&#44; which indicates the need for earlier intervention to minimize chronic lung degradation&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">In conclusion&#44; the VCap parameters analysis demonstrated that CF subjects present alterations in respiratory dynamics during physical exercise and that these alterations are related to the distal airspaces with heterogeneity of emptying gases&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Funding</span><p id="par0145" class="elsevierStylePara elsevierViewall">Funda&#231;&#227;o de Amparo &#224; Pesquisa do Estado de S&#227;o Paulo &#40;<span class="elsevierStyleGrantSponsor" id="gs1">FAPESP</span>&#41; for research support and scholarships &#40;&#35;<span class="elsevierStyleGrantNumber" refid="gs1">2011&#47;12939-4</span>&#44; &#35;<span class="elsevierStyleGrantNumber" refid="gs1">2011&#47;18845-1</span>&#44; &#35;<span class="elsevierStyleGrantNumber" refid="gs1">2015&#47;12183-8</span> and &#35;<span class="elsevierStyleGrantNumber" refid="gs1">2015&#47;12858-5</span> to FALM and JDR&#41;&#59; <span class="elsevierStyleGrantSponsor" id="gs2">Fundo de Apoio &#224; Pesquisa&#44; ao Ensino e &#224; Extens&#227;o da Universidade Estadual de Campinas</span> for research support &#40;&#35;<span class="elsevierStyleGrantNumber" refid="gs2">0648&#47;2015</span> to FALM&#41;&#46; <span class="elsevierStyleGrantSponsor" id="gs3">Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico</span> for scholarship to PLFP&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflicts of interest</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Volumetric capnography provides the standard CO<span class="elsevierStyleInf">2</span> elimination by the volume expired per respiratory cycle and is a measure to assess pulmonary involvement&#46; Thus&#44; the objective of this study was to evaluate the respiratory dynamics of healthy control subjects and those with cystic fibrosis in a submaximal exercise protocol for six minutes on the treadmill&#44; using volumetric capnography parameters &#40;slope 3 &#91;Slp3&#93;&#44; Slp3&#47;tidal volume &#91;Slp3&#47;TV&#93;&#44; and slope 2 &#91;Slp2&#93;&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This was a cross-sectional study with 128 subjects &#40;cystic fibrosis&#44; 64 subjects&#59; controls&#44; 64 subjects&#93;&#46; Participants underwent volumetric capnography before&#44; during&#44; and after six minutes on the treadmill&#46; Statistical analysis was performed using the Friedman&#44; Mann&#8211;Whitney&#44; and Kruskal&#8211;Wallis tests&#44; considering age and sex&#46; An alpha<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05 was considered&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Six minutes on the treadmill evaluation&#58; in cystic fibrosis&#44; volumetric capnography parameters were different before&#44; during&#44; and after six minutes on the treadmill&#59; the same was observed for the controls&#44; except for Slp2&#46; Regarding age&#44; an Slp3 difference was observed in cystic fibrosis patients regardless of age&#44; at all moments&#44; and in controls for age<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>12 years&#59; a difference in Slp3&#47;TV was observed in cystic fibrosis and controls&#44; regardless of age&#59; and an Slp2 difference in the cystic fibrosis&#44; regardless of age&#46; Regarding sex&#44; Slp3 and Slp3&#47;TV differences were observed in cystic fibrosis regardless of sex&#44; and in controls in male participants&#59; an Slp2 difference was observed in the cystic fibrosis and female participants&#46; The analysis between groups &#40;cystic fibrosis and controls&#41; indicated that Slp3 and Slp3&#47;TV has identified the CF&#44; regardless of age and sex&#44; while the Slp2 showed the CF considering age&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Cystic fibrosis showed greater values of the parameters before&#44; during&#44; and after exercise&#44; even when stratified by age and sex&#44; which may indicate ventilation inhomogeneity in the peripheral pathways in the cystic fibrosis&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A capnografia volum&#233;trica fornece o padr&#227;o de elimina&#231;&#227;o do CO<span class="elsevierStyleInf">2</span>&#44; pelo volume expirado por ciclo respirat&#243;rio&#44; e avalia o comprometimento pulmonar&#46; O objetivo do estudo foi avaliar a din&#226;mica respirat&#243;ria de indiv&#237;duos controles saud&#225;veis e em indiv&#237;duos com fibrose c&#237;stica&#44; em um protocolo de exerc&#237;cio subm&#225;ximo por seis minutos em esteira&#44; por par&#226;metros da capnografia volum&#233;trica &#91;slope 3&#40;Slp3&#41;&#44; Slp3&#47;volume corrente &#40;Slp3&#47;TV&#41; e slope 2&#40;Slp2&#41;&#93;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudo de corte transversal com 128 indiv&#237;duos &#91;&#40;fibrose c&#237;stica&#41; 64 &#40;controles&#41; 64&#93;&#46; Os participantes realizaram capnografia volum&#233;trica antes&#44; durante e ap&#243;s seis minutos em esteira&#46; An&#225;lise estat&#237;stica foi realizada pelos testes de Friedman&#44; Mann-Whitney e Kruskal-Wallis&#44; considerado a idade e o sexo&#46; Alpha<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Avalia&#231;&#227;o de seis minutos em esteira&#58; na fibrose c&#237;stica&#44; os par&#226;metros da capnografia volum&#233;trica foram diferentes antes&#44; durante e ap&#243;s seis minutos em esteira&#44; o mesmo ocorreu nos controles&#44; exceto para o Slp2&#46; Considerando a idade&#58; &#40;Slp3&#41; diferen&#231;a na FC&#44; independentemente da idade&#44; em todos os momentos e nos controles apenas para &#8805;12 anos&#59; &#40;Slp3&#47;TV&#41; diferen&#231;a para fibrose c&#237;stica e controles independentemente da idade&#59; &#40;Slp2&#41; diferen&#231;a apenas para o grupo fibrose c&#237;stica&#44; independentemente da idade&#46; Considerando o sexo&#58; &#40;Slp3 e Slp3&#47;TV&#41; diferen&#231;a para fibrose c&#237;stica&#44; independentemente do sexo&#44; e controles apenas no sexo masculino&#59; &#40;Slp2&#41; diferen&#231;a para fibrose c&#237;stica e sexo feminino&#46; An&#225;lise entre grupos &#40;fibrose c&#237;stica versus controles&#41;&#58; Slp3 e Slp3&#47;TV identificou a fibrose c&#237;stica&#44; independentemente da idade e sexo&#44; enquanto o Slp2 evidenciou a fibrose c&#237;stica considerando a idade&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A fibrose c&#237;stica apresentou maiores valores dos par&#226;metros antes&#44; durante e ap&#243;s exerc&#237;cio&#44; inclusive quando se considerou idade e sexo&#44; podendo indicar n&#227;o homogeneidade da distribui&#231;&#227;o da ventila&#231;&#227;o nas vias perif&#233;ricas&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Parazzi PL&#44; Marson FA&#44; Ribeiro MA&#44; Schivinski CI&#44; Ribeiro JD&#46; Evaluation of respiratory dynamics by volumetric capnography during submaximal exercise protocol of six minutes on treadmill in cystic fibrosis patients&#46; J Pediatr &#40;Rio J&#41;&#46; 2019&#59;95&#58;76&#8211;86&#46;</p>"
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          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Volumetric capnography association among subjects with cystic fibrosis&#46; A&#46; Slope 3 association among subjects with cystic fibrosis &#40;CF&#44; 1&#41; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; and healthy controls &#40;2&#41; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; considering age and sex in different moments of volumetric capnography&#46; 1&#46; Association of slope 3 with CF and controls&#46; &#40;moment 1&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>34&#46;5&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#46;15&#44; &#40;moment 2&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#46;29&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#46;75&#46; &#40;moment 3&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>26&#46;41&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#46;4&#46; &#40;moment 4&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#46;74&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#46;31&#46; &#40;moment 5&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>33&#46;77&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#46;57&#46; 2&#46; Association of slope 3 with CF and controls considering age&#46; &#40;moment 1&#41; 11 &#40;CF<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#60;12 years&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>38&#46;04&#44; 12 &#40;CF<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805;12 years&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>31&#46;6&#44; 21 &#40;controls<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#60;12 years&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#46;63&#44; 22 &#40;controls<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805;12 years&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#46;05&#46; &#40;moment 2&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>32&#46;01&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&#46;13&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#46;04&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#46;84&#46; &#40;moment 3&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#46;09&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#46;56&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#46;5&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#46;9&#46; &#40;moment 4&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>28&#46;51&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#46;06&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#46;54&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#46;37&#46; &#40;moment 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>36&#46;84&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#46;52&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#46;84&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#46;21&#46; 3&#46; Association of slope 3 with CF and controls considering sex&#46; &#40;moment 1&#41; 11 &#40;CF<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>masculine&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>34&#46;5&#44; 12 &#40;CF<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>feminine&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>34&#46;1&#44; 21 &#40;controls<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>masculine&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#46;25&#44; 22 &#40;controls<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>feminine&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#46;29&#46; &#40;moment 2&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#46;96&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#46;29&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#46;67&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#46;32&#46; &#40;moment 3&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#46;97&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#46;32&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#46;96&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#46;84&#46; &#40;moment 4&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#46;02&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#46;74&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#46;72&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#46;76&#46; &#40;moment 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>37&#46;12&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>32&#46;31&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#46;87&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#46;37&#46; B&#46; Slope 3&#47;tidal volume association among subjects with CF &#40;1&#41; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; and healthy controls &#40;controls&#44; 2&#41; &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; considering the age and sex in different moments of volumetric capnography&#46; 1&#46; Association of slope 3 with CF and controls&#46; &#40;moment 1&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;13&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;04&#44; &#40;moment 2&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;06&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#46; &#40;moment 3&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;06&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#46; &#40;moment 4&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#46; &#40;moment 5&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;1&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#46; 2&#46; Association of slope 3 with CF and controls considering age&#46; &#40;moment 1&#41; 11 &#40;CF<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#60;12 years&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;14&#44; 12 &#40;CF<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805;12 years&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;07&#44; 21 &#40;controls<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#60;12 years&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; 22 &#40;controls<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805;12 years&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#46; &#40;moment 2&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;09&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moment 3&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;07&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moment 4&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;08&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moment 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;18&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;07&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; 3&#46; Association of slope 3&#47;tidal volume with CF and controls considering sex&#46; &#40;moment 1&#41; 11 &#40;CF<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>masculine&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;14&#44; 12 &#40;CF<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>feminine&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;07&#44; 21 &#40;controls<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>masculine&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#44; 22 &#40;controls<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>feminine&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#46; &#40;moment 2&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;09&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moment 3&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;07&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moment 4&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;08&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moment 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;18&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;07&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#46; &#40;moments&#41; 1&#44; baseline time in the SMWT&#59; 2&#44; 1st and 2nd minutes of the SMWT&#59; 3&#44; 3rd and 4th minutes of the SMWT&#59; 4&#44; 5th and 6th minutes of the SMWT&#59; 5&#44; after the SMWT&#59; SMWT&#44; six-minute walk test on the treadmill&#46; TV&#44; tidal volume&#46; We used the Mann&#8211;Whitney&#44; Kruskal&#8211;Wallis and Friedman tests&#46; Alpha<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46; The medians and the 95&#37; confidence interval are represented in the graphs&#46;</p>"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">SD&#44; standard deviation&#59; CI&#44; confidence interval&#59; 1&#44; baseline&#59; 2&#44; 1st and 2nd minutes of the SMWT&#59; 3&#44; 3rd and 4th minutes of the SMWT&#59; 4&#44; 5th and 6th minutes of the SMWT&#59; 5&#44; after the SMWT&#59; SMWT&#44; six-minute walk test on the treadmill&#46; Alpha<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">The Mann-Whitney and Friedman tests were used&#46; Data with positive <span class="elsevierStyleItalic">p</span>-values are presented in bold&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Markers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Moment</th><th class="td" title="table-head  " align="left" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " rowspan="5" align="center" valign="top">Slope 3</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#46;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#46;98<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#46;05<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001 &#40;1</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">2&#44; 3 and 4&#59; 4</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1 and 5&#59; 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">3 and 4&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#46;5<br>5<br>140&#46;1<br>31&#46;58&#8211;43&#46;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;29<br>6&#46;05<br>246&#46;48<br>26&#46;76&#8211;44&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#46;41<br>6&#46;24<br>99&#46;47<br>25&#46;71&#8211;36&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#46;74<br>6&#46;51<br>99&#46;34<br>25&#46;36&#8211;36&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#46;77<br>6&#46;85<br>170&#46;58<br>30&#46;55&#8211;45&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#46;95<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#46;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#46;49<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#46;55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#46;24<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;019 &#40;1</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">3&#44; 4 and 5&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16&#46;15<br>1&#46;5<br>91<br>16&#46;45&#8211;25&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;75<br>4&#46;63<br>147&#46;71<br>15&#46;13&#8211;25&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;4<br>4&#46;58<br>97&#46;61<br>13&#46;28&#8211;23&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;31<br>3&#46;5<br>78&#46;08<br>13&#46;52&#8211;21&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;57<br>1<br>163&#46;67<br>12&#46;71&#8211;23&#46;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;052&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="9" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="5" align="center" valign="top">Slope 3&#47;tidal volume</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;15<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;17<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;1</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">2&#44; 3 and 4&#59; 4</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1 and 5&#59; 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">3 and 4&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;13<br>0&#46;01<br>1&#46;4<br>0&#46;11&#8211;0&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;06<br>0&#46;01<br>3&#46;04<br>0&#46;05&#8211;0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;06<br>0<br>0&#46;54<br>0&#46;07&#8211;0&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;05<br>0<br>0&#46;52<br>0&#46;07&#8211;0&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;1<br>0&#46;01<br>2&#46;05<br>0&#46;1&#8211;0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;05<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;05<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001 &#40;1</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">3&#44; 4 and 5&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;04<br>0<br>0&#46;67<br>0&#46;04&#8211;0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<br>0<br>1&#46;74<br>0&#46;01&#8211;0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<br>0<br>0&#46;76<br>0&#46;02&#8211;0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<br>0<br>0&#46;85<br>0&#46;02&#8211;0&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<br>0<br>1&#46;41<br>0&#46;02&#8211;0&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#46;003</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="9" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="5" align="center" valign="top">Slope 2</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">487&#46;55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">449&#46;93<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">450&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">443&#46;29<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">483&#46;63<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;1</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">2&#44; 3 and 4&#59; 4</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1 and 5&#59; 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">3 and 4&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">480&#46;63<br>140<br>940&#46;17<br>444&#46;43&#8211;530&#46;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">439&#46;04<br>147&#46;49<br>1003&#46;17<br>409&#46;39&#8211;490&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">402&#46;71<br>167&#46;4<br>1070&#46;96<br>407&#46;95&#8211;493&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">385&#46;18<br>161&#46;66<br>1173&#46;23<br>395&#46;28&#8211;491&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">462&#46;7<br>139<br>1366&#46;24<br>433&#46;84&#8211;533&#46;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">455&#46;95<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">415&#46;73<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">408&#46;27<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">409&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">428&#46;99<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#46;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;101</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">440&#46;06<br>225&#46;88<br>1215&#46;58<br>413&#46;64&#8211;498&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">401&#46;39<br>228&#46;65<br>791&#46;22<br>385&#46;04&#8211;446&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">380&#46;12<br>207&#46;82<br>816&#46;03<br>374&#46;53&#8211;442&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">388&#46;58<br>207&#46;76<br>779&#46;63<br>376&#46;75&#8211;441&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">400&#46;36<br>240&#46;28<br>1184&#46;37<br>389&#46;72&#8211;468&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;596&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;596&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;216&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;052&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Association of slope 3&#44; slope 3&#47;TV&#44; and slope 2 among subjects with cystic fibrosis &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; and healthy controls &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; in different moments of the volumetric capnography&#46;</p>"
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          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">SD&#44; standard deviation&#59; CI&#44; confidence interval&#59; 1&#44; baseline&#59; 2&#44; 1st and 2nd minutes of the SMWT&#59; 3&#44; 3rd and 4th minutes of the SMWT&#59; 4&#44; 5th and 6th minutes of the SMWT&#59; 5&#44; after the SMWT&#59; SMWT&#44; six-minute walk test on the treadmill&#46; Alpha<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46; The Kruskal&#8211;Wallis and Friedman tests were used&#46; Data with positive <span class="elsevierStyleItalic">p</span>-values are presented in bold&#46;</p>"
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Markers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Moment</th><th class="td" title="table-head  " align="left" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " rowspan="9" align="center" valign="top">Slope 3</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis &#60;12 years old<br>&#40;A&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44&#46;69<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45&#46;79<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#46;29<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#46;76<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44&#46;38<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;034 &#40;3</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#46;04<br>16&#46;38<br>140&#46;1<br>34&#46;59&#8211;54&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&#46;01<br>15&#46;4<br>246&#46;48<br>27&#46;6&#8211;63&#46;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;09<br>13&#46;25<br>99&#46;47<br>26&#46;95&#8211;45&#46;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#46;51<br>12&#46;15<br>99&#46;34<br>28&#46;55&#8211;46&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#46;84<br>11&#46;71<br>135&#46;6<br>33&#46;9&#8211;54&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls &#60;12 years old<br>&#40;B&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#46;57<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&#46;32<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#46;35<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#46;63<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&#46;85<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;445</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#46;63<br>1&#46;5<br>91<br>17&#46;43&#8211;31&#46;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#46;04<br>7&#46;17<br>147&#46;71<br>16&#46;58&#8211;34&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;5<br>7&#46;52<br>97&#46;61<br>14&#46;62&#8211;32&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;54<br>6&#46;7<br>78&#46;08<br>15&#46;2&#8211;28&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#46;84<br>1<br>163&#46;67<br>13&#46;6&#8211;32&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis &#8805;12 years old<br>&#40;C&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&#46;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#46;51<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;49<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#46;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#46;43<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;006 &#40;4</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 2&#44; 3&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#46;6<br>5<br>102&#46;12<br>25&#46;11&#8211;39&#46;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#46;13<br>6&#46;05<br>123&#46;5<br>20&#46;10&#8211;36&#46;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#46;56<br>6&#46;24<br>84&#46;87<br>20&#46;73&#8211;34&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#46;06<br>6&#46;51<br>85&#46;1<br>19&#46;09&#8211;32&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;52<br>6&#46;85<br>170&#46;58<br>22&#46;80&#8211;44&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls &#8805;12 years old<br>&#40;D&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#46;99<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;77<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#46;89<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#46;96<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#46;93<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;028 &#40;1</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">3&#44; 4&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;05<br>4&#46;79<br>39&#46;04<br>11&#46;91&#8211;20&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;84<br>4&#46;63<br>36&#46;72<br>10&#46;57&#8211;16&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#46;9<br>4&#46;58<br>23&#46;6<br>9&#46;77&#8211;13&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#46;37<br>3&#46;5<br>36&#46;25<br>8&#46;92&#8211;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;21<br>1&#46;21<br>32&#46;95<br>9&#46;08&#8211;14&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; D&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; C&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#46;004</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; D&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; C&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="9" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="9" align="center" valign="top">Slope 3&#47;tidal volume</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis &#60;12 years old<br>&#40;A&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;21<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;15<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;14<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;1 and 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">2&#44; 3&#44; 4&#59; 2</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 3&#44; 5&#59; 3</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 2&#44; 5&#59; 4</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;14<br>0&#46;04<br>1&#46;4<br>0&#46;11&#8211;0&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;09<br>0&#46;02<br>3&#46;04<br>0&#46;02&#8211;0&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<br>0&#46;02<br>0&#46;54<br>0&#46;09&#8211;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;08<br>0&#46;02<br>0&#46;52<br>0&#46;09&#8211;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;18<br>0&#46;02<br>0&#46;98<br>0&#46;12&#8211;0&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls &#60;12 years old<br>&#40;B&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;09<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;09<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;005</span><br><span class="elsevierStyleBold">&#40;1 and 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">3&#44; 4&#59; 2</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">4&#59; 3</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 5&#59; 4</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 2&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;05<br>0<br>0&#46;67<br>0&#46;05&#8211;0&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03<br>0&#46;01<br>1&#46;74<br>0&#46;01&#8211;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<br>0&#46;01<br>0&#46;76<br>0&#46;03&#8211;0&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<br>0&#46;01<br>0&#46;85<br>0&#46;02&#8211;0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03<br>0<br>1&#46;41<br>0&#46;02&#8211;0&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis &#8805;12 years old<br>&#40;C&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;08<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;1 and 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">2&#44; 3&#44; 4&#59; 2 and 3</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 4&#44; 5&#59; 4</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 2&#44; 3&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<br>0&#46;01<br>0&#46;64<br>0&#46;07&#8211;0&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03<br>0&#46;01<br>0&#46;57<br>0&#46;04&#8211;0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03<br>0<br>0&#46;51<br>0&#46;04&#8211;0&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03<br>0<br>0&#46;49<br>0&#46;03&#8211;0&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<br>0&#46;01<br>2&#46;05<br>0&#46;04&#8211;0&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls &#8805;12 years old<br>&#40;D&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;04<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;001</span><br><span class="elsevierStyleBold">&#40;1</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">2&#44; 3&#44; 4&#44; 5&#59; 2 and 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 4&#59; 3</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#59; 4</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 2&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<br>0&#46;01<br>0&#46;15<br>0&#46;02&#8211;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<br>0<br>0&#46;07<br>0&#46;01&#8211;0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<br>0<br>0&#46;04<br>0&#46;01&#8211;0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<br>0<br>0&#46;08<br>0&#46;01&#8211;0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<br>0<br>0&#46;09<br>0&#46;01&#8211;0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="9" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="9" align="center" valign="top">Slope 2</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis &#60;12 years old<br>&#40;A&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">562&#46;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#46;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">537&#46;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">534<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>32&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">529&#46;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>33&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">551&#46;43<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;017</span><br><span class="elsevierStyleBold">&#40;1 and 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">3&#44; 4&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">548&#46;63<br>332&#46;84<br>940&#46;17<br>503&#46;7&#8211;620&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">554&#46;58<br>340&#46;24<br>1003&#46;17<br>476&#46;35&#8211;598&#46;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">549&#46;36<br>279&#46;94<br>1070&#46;96<br>467&#46;59&#8211;600&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">566&#46;16<br>277&#46;46<br>919&#46;83<br>459&#46;87&#8211;598&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">553&#46;21<br>304&#46;51<br>871&#46;09<br>492&#46;66&#8211;610&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls &#60;12 years old<br>&#40;B&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">517&#46;42<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>30&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">470&#46;71<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">460&#46;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">462&#46;76<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">490&#46;97<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;497</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">476&#46;5<br>273<br>1215&#46;58<br>455&#46;22&#8211;579&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">450&#46;06<br>272&#46;59<br>791&#46;22<br>428&#46;58&#8211;512&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">421&#46;89<br>287&#46;67<br>816&#46;03<br>410&#46;09&#8211;509&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">427<br>293&#46;25<br>779&#46;63<br>417&#46;23&#8211;508&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">462&#46;52<br>277&#46;14<br>1184&#46;37<br>432&#46;98&#8211;548&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis &#8805;12 years old<br>&#40;C&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">432&#46;98<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">386&#46;08<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">390&#46;08<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">380&#46;49<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">434&#46;15<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>35&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;003</span><br><span class="elsevierStyleBold">&#40;4</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 3&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">400&#46;21<br>140<br>833&#46;67<br>376&#46;17&#8211;489&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">381&#46;25<br>147&#46;49<br>708&#46;09<br>340&#46;18&#8211;431&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">347&#46;12<br>167&#46;4<br>924<br>340&#46;45&#8211;439&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">366&#46;42<br>161&#46;66<br>1173&#46;23<br>320&#46;14&#8211;440&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">430&#46;06<br>139<br>1366&#46;24<br>361&#46;39&#8211;506&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls &#8805;12 years old<br>&#40;D&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">371&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#46;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">340&#46;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">337&#46;35<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">335&#46;55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">344&#46;05<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;244</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">351<br>225&#46;88<br>602&#46;15<br>335&#46;07&#8211;408&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">334&#46;85<br>228&#46;65<br>464&#46;55<br>314&#46;56&#8211;366&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">338&#46;1<br>207&#46;82<br>471&#46;01<br>311&#46;99&#8211;362&#46;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">340&#46;32<br>207&#46;76<br>519&#46;02<br>307&#46;34&#8211;363&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">341&#46;68<br>240&#46;28<br>501&#46;23<br>315&#46;94&#8211;372&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">C&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">C&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">C&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">C&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">C&#44; D&#59; C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; D&#59; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">C&#44; D&#59; D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Association of slope 3&#44; slope 3&#47;TV&#44; and slope 2 among subjects with cystic fibrosis &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; and healthy controls &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; considering the age in different moments of volumetric capnography&#46;</p>"
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          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">SD&#44; standard deviation&#59; CI&#44; confidence interval&#59; 1&#44; baseline&#59; 2&#44; 1st and 2nd minutes of the SMWT&#59; 3&#44; 3rd and 4th minutes of the SMWT&#59; 4&#44; 5th and 6th minutes of the SMWT&#59; 5&#44; after the SMWT&#59; SMWT&#44; six-minute walk test on the treadmill&#46; Alpha<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46; The Kruskal&#8211;Wallis and Friedman tests were used&#46; Data with positive <span class="elsevierStyleItalic">p</span>-values are presented in bold&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Markers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Group&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Moment</th><th class="td" title="table-head  " align="left" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " rowspan="9" align="center" valign="top">Slope 3</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis and masculine<br>&#40;A&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#46;67<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#46;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;97<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#46;81<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&#46;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;008</span><br><span class="elsevierStyleBold">&#40;1 and 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">3&#44; 4&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#46;5<br>6&#46;95<br>140&#46;1<br>28&#46;23&#8211;47&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#46;96<br>9&#46;15<br>246&#46;48<br>21&#46;88&#8211;54&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#46;95<br>6&#46;65<br>81&#46;12<br>20&#46;91&#8211;35&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#46;02<br>6&#46;57<br>85&#46;66<br>21&#46;4&#8211;36&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#46;12<br>6&#46;85<br>84&#46;58<br>28&#46;14&#8211;42&#46;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls and masculine<br>&#40;B&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#46;36<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#46;88<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#46;51<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#46;93<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#46;89<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;04</span><br><span class="elsevierStyleBold">&#40;3</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 2&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#46;25<br>1&#46;5<br>91<br>15&#46;81&#8211;30&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#46;67<br>4&#46;82<br>147&#46;71<br>16&#46;05&#8211;37&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;96<br>4&#46;58<br>97&#46;61<br>12&#46;54&#8211;34&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;72<br>3&#46;5<br>78&#46;08<br>13&#46;87&#8211;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#46;87<br>4&#46;17<br>59&#46;21<br>14&#46;27&#8211;25&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis and feminine<br>&#40;C&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#46;55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#46;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#46;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#46;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#46;14<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40&#46;65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;029</span><br><span class="elsevierStyleBold">&#40;1</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">2&#44; 4&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#46;1<br>5<br>104&#46;26<br>29&#46;5&#8211;45&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;29<br>6&#46;05<br>105&#46;14<br>24&#46;51&#8211;42&#46;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#46;32<br>6&#46;24<br>99&#46;47<br>25&#46;76&#8211;43&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#46;74<br>6&#46;51<br>99&#46;34<br>24&#46;36&#8211;41&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&#46;31<br>8&#46;14<br>170&#46;58<br>27&#46;13&#8211;54&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls and feminine<br>&#40;D&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#46;83<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#46;77<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#46;06<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16&#46;79<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;230</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#46;29<br>4&#46;78<br>90&#46;04<br>13&#46;32&#8211;24&#46;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;32<br>4&#46;63<br>35&#46;56<br>12&#46;20&#8211;17&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;84<br>4&#46;75<br>28&#46;5<br>12&#46;2&#8211;15&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#46;76<br>4&#46;89<br>36&#46;25<br>11&#46;13&#8211;16&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#46;37<br>1<br>163&#46;67<br>7&#46;34&#8211;26&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A and C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; D&#59; B and D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#46;038</span><br><span class="elsevierStyleBold">&#40;A&#44; C&#44; B</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">D&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A and C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; D&#59; B and D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A and C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; D&#59; B and D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A and C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; D&#59; B and D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="9" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="9" align="center" valign="top">Slope 3&#47;tidal volume</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis and masculine<br>&#40;A&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;21<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;15<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;14<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;1 and 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">2&#44; 3&#44; 4&#59; 2</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 4&#44; 5&#59; 3</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 5&#59; 4</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 2&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;14<br>0&#46;04<br>1&#46;4<br>0&#46;11&#8211;0&#46;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;09<br>0&#46;02<br>3&#46;04<br>0&#46;02&#8211;0&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<br>0&#46;02<br>0&#46;54<br>0&#46;09&#8211;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;08<br>0&#46;02<br>0&#46;52<br>0&#46;09&#8211;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;18<br>0&#46;02<br>0&#46;98<br>0&#46;12&#8211;0&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls and masculine<br>&#40;B&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;09<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;09<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;001</span><br><span class="elsevierStyleBold">&#40;1&#44; 2 and 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">3&#44; 4&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;05<br>0<br>0&#46;67<br>0&#46;05&#8211;0&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03<br>0&#46;01<br>1&#46;74<br>0&#46;01&#8211;0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<br>0&#46;01<br>0&#46;76<br>0&#46;03&#8211;0&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<br>0&#46;01<br>0&#46;85<br>0&#46;02&#8211;0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03<br>0<br>1&#46;41<br>0&#46;02&#8211;0&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis and feminine<br>&#40;C&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;08<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;1 and 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">2&#44; 3 and 4&#59; 2</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 4&#44; 5&#59; 3</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 5&#59; 4</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">1&#44; 2</span>&#44; 5&#41;</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<br>0&#46;01<br>0&#46;64<br>0&#46;07&#8211;0&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03<br>0&#46;01<br>0&#46;57<br>0&#46;04&#8211;0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03<br>0<br>0&#46;51<br>0&#46;04&#8211;0&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;03<br>0<br>0&#46;49<br>0&#46;03&#8211;0&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;07<br>0&#46;01<br>2&#46;05<br>0&#46;04&#8211;0&#46;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls and feminine<br>&#40;D&#41;</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;04<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;23</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;02<br>0&#46;01<br>0&#46;15<br>0&#46;02&#8211;0&#46;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<br>0<br>0&#46;07<br>0&#46;01&#8211;0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<br>0<br>0&#46;04<br>0&#46;01&#8211;0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<br>0<br>0&#46;08<br>0&#46;01&#8211;0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01<br>0<br>0&#46;09<br>0&#46;01&#8211;0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">p</span>-Value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A and C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; D&#59; B and D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#46;01</span><br><span class="elsevierStyleBold">&#40;D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A and C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; D&#59; B and D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A and C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; D&#59; B and D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">&#60;0&#46;001</span><br><span class="elsevierStyleBold">&#40;A and C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">B&#44; D&#59; B and D</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="9" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="9" align="center" valign="top">Slope 2</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis and masculine</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">562&#46;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#46;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">537&#46;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">534<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>32&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">529&#46;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>33&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">551&#46;43<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;068</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">548&#46;63<br>332&#46;84<br>940&#46;17<br>503&#46;7&#8211;620&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">554&#46;58<br>340&#46;24<br>1003&#46;17<br>476&#46;35&#8211;598&#46;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">549&#46;36<br>279&#46;94<br>1070&#46;96<br>467&#46;59&#8211;600&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">566&#46;16<br>277&#46;46<br>919&#46;83<br>459&#46;87&#8211;598&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">553&#46;21<br>304&#46;51<br>871&#46;09<br>492&#46;66&#8211;610&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls and masculine</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">517&#46;42<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>30&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">470&#46;71<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">460&#46;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">462&#46;76<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">490&#46;97<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#46;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#46;238</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">476&#46;5<br>273<br>1215&#46;58<br>455&#46;22&#8211;579&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">450&#46;06<br>272&#46;59<br>791&#46;22<br>428&#46;58&#8211;512&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">421&#46;89<br>287&#46;67<br>816&#46;03<br>410&#46;09&#8211;509&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">427<br>293&#46;25<br>779&#46;63<br>417&#46;23&#8211;508&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">462&#46;52<br>277&#46;14<br>1184&#46;37<br>432&#46;98&#8211;548&#46;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Cystic fibrosis and feminine</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">432&#46;98<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">386&#46;08<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">390&#46;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">380&#46;49<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#46;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">434&#46;15<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>35&#46;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#46;001</span><br><span class="elsevierStyleBold">&#40;1 and 5</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#8800;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">3&#44; 4&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Median<br>Minimum<br>Maximum<br>95&#37; CI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">400&#46;21<br>140<br>833&#46;67<br>376&#46;17&#8211;489&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">381&#46;25<br>147&#46;49<br>708&#46;09<br>340&#46;18&#8211;431&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">347&#46;12<br>167&#46;4<br>924<br>340&#46;45&#8211;439&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">366&#46;42<br>161&#46;66<br>1173&#46;23<br>320&#46;14&#8211;440&#46;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">430&#46;06<br>139<br>1366&#46;24<br>361&#46;39&#8211;506&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">Controls and feminine</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">371&#46;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#46;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">340&#46;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;55&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">335&#46;55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">344&#46;05<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#46;67&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">351<br>225&#46;88<br>602&#46;15<br>335&#46;07&#8211;408&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">334&#46;85<br>228&#46;65<br>464&#46;55<br>314&#46;56&#8211;366&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">338&#46;1<br>207&#46;82<br>471&#46;01<br>311&#46;99&#8211;362&#46;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">340&#46;32<br>207&#46;76<br>519&#46;02<br>307&#46;34&#8211;363&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">341&#46;99<br>240&#46;28<br>501&#46;23<br>315&#46;94&#8211;372&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;222&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;808&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;463&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;801&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;129&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Association of slope 3&#44; slope 3&#47;TV&#44; and slope 2 among subjects with cystic fibrosis &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41;&#44; and healthy controls &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; considering the sex in different moments of volumetric capnography&#46;</p>"
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        "texto" => "<p id="par0155" class="elsevierStylePara elsevierViewall">The authors would like to thank Adyl&#233;ia Aparecida Contrera Dalbo Toro&#44; Arthur Kmit&#44; Roberto Jos&#233; Negr&#227;o Nogueira&#44; K&#225;tia Cristina Alberto Aguiar&#44; Al&#233;thea Guimar&#227;es Farias&#44; Ta&#237;s Daiene Russo Hort&#234;ncio&#44; Aline Gon&#231;alves&#44; Gabriel Hessel&#44; Renan Marrichi Mauch&#44; Andressa de Oliveira Peixoto&#44; Luciana Cardoso Bonadia&#44; Carmen S&#237;lvia Bertuzzo&#44; St&#233;phanie Villa-Nova Pereira&#44; Ant&#244;nio Fernando Ribeiro&#44; Carla Cristina de Souza Gomez&#44; and Silvana Dalge Severino&#44; who contributed to the studies on cystic fibrosis in this reference center&#46; They would also like to thank the Espa&#231;o da Escrita project&#47;General Coordination of Unicamp for the English translation of this article&#46;</p>"
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