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and for the mean papule diameter of the immediate reading skin test for: (e) total cow's milk (f), α-lactalbumin, (g) β-lactoglobulin, and (h) casein in the open oral challenge test for cow's milk and its fractions.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jackeline M. 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The advantages of this method are that the internal surface of the organ undergoing endoscopy can be observed directly, pathological sampling from lesions can be performed, and treatment can be administered when necessary. Since its introduction in pediatric patients in 1970, the use of endoscopic procedures has increased dramatically.<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a> Franciosi et al.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a> reported that the number of upper endoscopic procedures increased by 12-fold between 1985 and 2005. As a consequence of this trend, new disorders of the GI tract and new pathologies were described in children.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In parallel to the increased use of EGD among children, numerous studies evaluating the pathologies of the stomach and esophagus in children have been performed.<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3,4</span></a> However, there have been very few studies investigating the association between duodenal endoscopic findings and histologic diagnosis in the pediatric population. Alper et al.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> reported that the prevalence of duodenitis in children undergoing endoscopy was 12.7%, and the correlation between endoscopic appearance and histology was considered to be poor. In another study, Alabd Alrazzak et al.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a> observed an 11% rate of duodenitis prevalence, while in a study of 1000 children undergoing EGD, Sheiko et al.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a> observed endoscopic disorder in the duodenum at a rate of 9.9% and histopathologic disorder at a rate of 10.7%.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The aim of the study was to assess the endoscopic and histopathologic features of duodenal disorders with respect to age groups in children undergoing diagnostic EGD for the first time.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">The authors retrospectively reviewed all upper endoscopic charts of children between the ages of 1 and 17 years who underwent diagnostic EGD at Kanuni Training and Research Hospital Pediatric Gastroenterology Department, Turkey, between September 2014 and September 2016. Clinical data, demographic characteristics, and histopathology findings were also reviewed. Patients with known gastrointestinal disease (such as celiac disease, Crohn's disease, and ulcerative colitis), with neurodevelopmental delay (such as cerebral palsy), and those undergoing endoscopy for therapeutic purposes were excluded. In children undergoing endoscopy more than once, the data of the first EGD was recorded. This study was performed in agreement with the Declaration of Helsinki and following the approval of the Local Ethics Committee. Symptoms were grouped into growth retardation, chronic anemia, chronic diarrhea, chronic abdominal pain, dyspepsia, and reflux symptoms (vomiting, chest pain, regurgitation, and eructation).<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a> Chronic abdominal pain was defined as three or more bouts in at least a three-month period.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a> Chronic diarrhea was defined as that lasting more than 14 days.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a> The patients were stratified into four groups with respect to the growth stages; infants (0–2 years), preschoolers (3–5 years), school-aged children (6–11 years), and adolescents (>12 years).</p><p id="par0025" class="elsevierStylePara elsevierViewall">All procedures were performed by the same experienced gastroenterologist (U.E.A.) on an video gastroscopy device (Olympus, GIF-H180, PA, USA). Mucosal breaks of >5<span class="elsevierStyleHsp" style=""></span>mm observed in endoscopy were defined as ulcers.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> In addition, gross endoscopic findings such as scalloping, nodularity, loss of mucosal folds, or mosaic pattern in the duodenum were regarded as pathological findings.<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">12–14</span></a> Non-specific findings such as hyperemia, increased or decreased vascularity, and pallor were not regarded as pathological.<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">15</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">At least two biopsies were taken from all patients from the esophagus, stomach (antrum), and the second part of the duodenum. All the initial examinations were performed by experienced gastrointestinal pathologists blinded to the patients’ clinical status and endoscopic findings. For cases with a diagnosis of duodenum pathology, all microscopic sections were retrieved and reviewed by two experienced pathologists, and the diagnosis of duodenum pathology was confirmed in all patients. Increased intraepithelial lymphocytes in the duodenum (>30 lymphocytes) and chronic changes involving neutrophilic infiltration or villous/crypt structural changes were regarded as duodenitis.<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">16</span></a> Patients at >stage 2 according to the modified Marsh criteria and with positive serology were diagnosed with celiac disease.<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">17</span></a> The diagnosis of eosinophilic gastroenteritis (EG) was established upon observation of ≥25 eosinophils in one high-power field in the duodenum following the exclusion of parasitic infections, <span class="elsevierStyleItalic">Helicobacter pylori</span> infection, celiac disease, inflammatory bowel disease, hypereosinophilic syndrome, malignity, and connective tissue diseases (such as Churg–Strauss syndrome).<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">18</span></a> Endoscopic and/or histopathological abnormalities in the duodenum were considered as duodenal pathology. The antral biopsy specimens were fixed in 10% formalin and stained with hematoxylin and eosin (H&E). Giemsa staining was used to confirm the presence of <span class="elsevierStyleItalic">H. pylori</span>. Microscopic detection of gastric non-<span class="elsevierStyleItalic">Helicobacter pylori</span> helicobacter (NHPH), either in histologic sections or in smears, is the most widely used diagnostic method and usually allows differentiation between <span class="elsevierStyleItalic">H. pylori</span> and NHPH infections.<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">19</span></a> For example, <span class="elsevierStyleItalic">Helicobacter felis</span> is characterized by the presence of periplasmic fibrils. <span class="elsevierStyleItalic">Helicobacter salomonis</span> is a less tightly coiled bacteria usually with a one periplasmic fibril, whereas long spiral shape is the morphological distinction of <span class="elsevierStyleItalic">Helicobacter heilmannii</span>.<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">19</span></a> Findings such as papillary elongation in the esophagus, basal cell hyperplasia, and an increase in intraepithelial neutrophils were evaluated in favor of reflux esophagitis.<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">20</span></a> Eosinophilia in the esophagus was defined as ≥30 eosinophils in one high-power field and/or observation of eosinophilic microabscesses.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> In these cases, EGD was repeated subsequent to the administration of high-dose PPI (lansoprazole 1<span class="elsevierStyleHsp" style=""></span>mg/kg per dose, twice daily) for eight weeks. Persisting eosinophilia in the esophagus was regarded as eosinophilic esophagitis.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> Reflux esophagitis and eosinophilic esophagitis were evaluated under the group of esophagitis. Gastritis is diagnosed by the presence of mixed inflammatory infiltrate.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Data were analyzed using SPSS software (SPSS for Windows, version 13.0, Chicago, USA). Descriptive data were expressed as mean<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>standard deviation (SD), with the Student's <span class="elsevierStyleItalic">t</span>-test for independent paired samples was used to compare normally distributed variables between two groups, and the Mann–Whitney <span class="elsevierStyleItalic">U</span> test, for non-normally distributed variables. The chi-squared test was used to compare categoric variables. Statistical significance was set at <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0040" class="elsevierStylePara elsevierViewall">During the two-year study period, 870 EGDs were performed in total. A total of 123 EGDs were excluded, including repeated EGD procedures (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>67), EGD of patients with previously known gastrointestinal disease (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>18), retarded neuromotor development (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>14), or undergoing procedures for therapeutic purposes (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>24). Finally, 747 patients were enrolled in the study. The patients were aged between 1 and 17 years and the majority was female (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>458, 61.3%). One patient (0.1%) was an infant, 41 (5.5%) were preschoolers, 242 (32.3%) were school-aged children, and 463 patients (62.1%) were adolescents. Duodenal pathology was observed in 226 (30.3%) patients. Pathology was also present in the esophagus in 31.6% of patients and in the stomach in 58.4%. Of the 236 esophageal pathologies, 232 were reflux esophagitis and four were eosinophilic esophagitis.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The mean age of the patients with pathology in the duodenum was 12.9 years (range 4–17 years) and the majority was female (58.4%). The demographic characteristics of patients with gastrointestinal symptoms and accompanying pathologies are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>. The level of chronic diarrhea was higher in patients with duodenal pathology compared to those without duodenal pathology (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.002, OR: 3.91, 95% CI: 1.59–9.57). It was observed that reflux symptoms were more common in preschoolers; dyspeptic complaints, in school-aged children; and chronic anemia, in adolescents (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). <span class="elsevierStyleItalic">H. pylori</span> gastritis and esophagitis were more common in patients with pathology in the duodenum compared to those without pathology (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001, OR: 3.43, 95% CI: 2.48–4.76 <span class="elsevierStyleItalic">vs</span>. <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001, OR: 0.40, 95% CI: 0.29–0.56; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Endoscopy determined ulcer in the bulbus in 59 patients (7.8%), scalloping in eight (1.0%), and nodularity in eight (1.0%). The endoscopic and histopathological characteristics of the duodenum are shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>. Histopathological examination of the duodenum in patients with ulcer in the bulbus revealed nonspecific duodenitis in 96.6%. Normal histopathological findings were observed in one patient. Abdominal pain persisting for 6 months, weight loss and sedimentation elevation were present in a 16-year-old girl with ulcer in the bulbus, in whom granuloma was determined on histopathological examination; this patient was diagnosed with Crohn's disease. <span class="elsevierStyleItalic">H. pylori</span> gastritis was present in 51 (86.4%) of the patients with ulcer in the bulbus. Anti-tissue transglutaminase IgA positivity was present in all patients with scalloping in the duodenum, and these were diagnosed with celiac disease following histopathological examination. Among the patients with nodularity in the duodenum, eosinophilic enteropathy was diagnosed in two (22.2%), giardiasis in two (22.2%), and celiac disease in one (11.1%). Duodenal disorders were more common in the adolescent group when compared with the other groups (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Pathology was identified with histopathological examination in 151 (22.4%) of the 672 patients in whom pathology in the duodenum was not determined with endoscopy. Nonspecific duodenitis was present in 141 patients (93.3%), giardiasis in seven (4.6%), eosinophilic enteritis in two (1.4%), and celiac disease in one (0.7%). Abnormality was identified histopathologically in 74 (98.6%) of the 75 patients in whom pathology was determined at endoscopy (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>).</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">Diagnostic sensitivity for the diagnosis of GIS disorders has increased remarkably with the advances in imaging technology and the increase in the use of EGD. Previous studies have reported an incidence of duodenitis in children undergoing endoscopy of 10.7–12.7%.<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5,6</span></a> Alabd Alrazzak et al.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a> observed a prevalence of duodenitis of 11.0%, while in a study of 1000 children undergoing EGD, Sheiko et al.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a> diagnosed duodenal pathology in 9.9% of their sample when using endoscopy and in 10.7% when using histopathological methods. Recently, Alper et al.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> investigated 2772 children undergoing EGD and diagnosed duodenitis in 12.7%. The incidence of overall duodenal disorders in the present cohort was 30.3%.</p><p id="par0065" class="elsevierStylePara elsevierViewall">In agreement with Alper et al.,<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> the most common indication for EGD in this study was Chronic abdominal pain (CAP). Those authors reported a higher level of CAP in subjects with duodenal pathology than in those without. In the current study, however, no difference was observed between subjects with or without duodenal pathology in terms of the prevalence of CAP. A significantly higher level of chronic diarrhea was observed in subjects with duodenal pathologies compared to those with no such pathology. The American Society for Gastrointestinal Endoscopy recommends EGD in cases of chronic diarrhea, particularly if absorption disorder is suspected.<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">H. pylori</span> infection was present in 59.3% of the current study patients with duodenal pathology. This level is considerably higher than that observed in previous studies. For example, while Alper et al.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> made specific diagnosis in 64% of patients with duodenitis (the majority consisting of celiac disease and inflammatory bowel disease, while <span class="elsevierStyleItalic">H. pylori</span> was observed at the low level of 6%), 36% of patients were diagnosed with nonspecific duodenitis. However, although the prevalence of <span class="elsevierStyleItalic">H. pylori</span> infection ranges from 6.5% to 31.0% in Europe, the reported prevalence is 53.0% to 66.3% in Turkey.<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">22,23</span></a> In a study of 751 children undergoing EGD in Israel, a country with a high prevalence of <span class="elsevierStyleItalic">H. pylori</span> infection alike Turkey, Egbaria et al.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> identified duodenal ulcer in 26 (3.5%) cases and <span class="elsevierStyleItalic">H. pylori</span> in 14 (∼54%) of these. A prospective study of 303 children in Saudi Arabia indicated the presence of <span class="elsevierStyleItalic">H. pylori</span> in 14 (56%) of 25 children with duodenal ulcer.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a> These results show that <span class="elsevierStyleItalic">H. pylori</span> infection bears a high level of responsibility for duodenal pathologies in communities in which this agent is widespread.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Several studies have shown that the prevalence of <span class="elsevierStyleItalic">H. pylori</span> infection increases with age.<a class="elsevierStyleCrossRefs" href="#bib0275"><span class="elsevierStyleSup">25,26</span></a> It has been observed at younger ages in developing countries, whereas the infection is more common in older ages in developed countries.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a> In a recent pediatric study from Turkey, Ozbey et al. reported that the prevalence of <span class="elsevierStyleItalic">H. pylori</span> infection among children reaches its peak between the ages of 13 and 18 years.<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">27</span></a> Similar to that study, in the present study <span class="elsevierStyleItalic">H. pylori</span> infection was more common in the adolescent age group. Parallel to the increase in the incidence of <span class="elsevierStyleItalic">H. pylori</span> infection with age, duodenal pathologies were also observed at a higher rate in the adolescent age group.</p><p id="par0080" class="elsevierStylePara elsevierViewall">In a multicenter study conducted in Europe, the incidence of duodenal ulcer in children undergoing EGD was reported as 2.4%.<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">28</span></a> In Israel, this rate was 3.5%.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> In the present study, the incidence of ulcer in duodenum was 7.8%. The difference in the duodenal ulcer incidence between the studies may be due to the differences in the dietary habits and socio-cultural levels of the communities and use of gastro-protective drugs before endoscopy.</p><p id="par0085" class="elsevierStylePara elsevierViewall">A weak correlation has been observed between endoscopic findings and histopathological results in previous studies.<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5,29,30</span></a> In a study of 75 children, Long et al.<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">29</span></a> reported that endoscopic appearance was 54% sensitive in estimating duodenitis. In a study by Alper et al.,<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> in which a biopsy was performed in all patients, as in the present research, sensitivity was determined at 37%. Studies advocating the performance of routine duodenal biopsies in pediatric populations are lacking, and the practice among pediatric gastroenterologists is diverse. Kori et al.<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> observed histopathological abnormalities in 35 (17.4%) of 201 patients with a normal endoscopic duodenal appearance. Several studies reported that the diagnosis of celiac disease was made and even granulomas, cryptitis and villus structure disorders were detected by histopathological evaluation of duodenal biopsies of some patients with normal duodenum appearance at endoscopy.<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5,30</span></a> Despite the high consensus of pathologists to identify histologic anomalies, there is considerable variability in the identification and classification of endoscopic abnormalities among endoscopists.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a> In the current study, histopathological abnormality was also observed in a significant proportion (22.4%) of patients with a normal endoscopic duodenal appearance. The present findings suggest that a routine biopsy should be performed during EGD regardless of endoscopic appearance and endoscopy indications in children. This may minimize the overlooking of certain GIS disorders that may be clinically significant and can be remedied by appropriate treatment. Moreover, by performing a routine biopsy, the risks related to unjustifiable treatment or those associated with sedation or intervention during a repeat endoscopy procedure could be eliminated; the cost increase would also be avoided.</p><p id="par0090" class="elsevierStylePara elsevierViewall">The present study has some limitations. It was retrospective in design. The number of patients in the infant group was low, therefore the duodenal disorders in that age group could not be evaluated. In addition, it was carried out in a single center; therefore, it may not fully reflect the duodenal disorders in different populations.</p><p id="par0095" class="elsevierStylePara elsevierViewall">In conclusion, a higher level of duodenal pathologies was observed in this study involving both endoscopic and histopathological examination of duodenal pathologies compared to previous studies, and a high level of <span class="elsevierStyleItalic">H. pylori</span> infection was determined to accompany such pathologies. This variation among studies may be due to the fact that they were performed in different societies and patient populations. Further studies involving different communities and larger patient numbers are therefore needed to determine the prevalence, etiology, and clinical characteristics of duodenal pathologies. Another finding of this study was that histopathological abnormalities were observed at a considerable rate even in patients with normal endoscopic appearance. It can be suggested that the inclusion of routine duodenal biopsies as part of upper endoscopy in pediatric patients to be considered favorably. This practice may yield additional pathologic findings that might otherwise have been missed and may have clinical significance. It should be performed regardless of the indication for endoscopy or the general appearance of the mucosa.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conflicts of interest</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1027090" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec984696" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1027091" "titulo" => "Resumo" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec984697" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-02-06" "fechaAceptado" => "2017-04-17" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec984696" "palabras" => array:3 [ 0 => "Duodenitis" 1 => "Endoscopy" 2 => "Children" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec984697" "palabras" => array:3 [ 0 => "Duodenite" 1 => "Endoscopia" 2 => "Crianças" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Several studies have been performed concerning pathologies of the stomach and esophagus in the pediatric age group. However, there have been very few studies of duodenal pathologies in children. The authors aimed to examine the clinical, endoscopic, and histopathological characteristics, as well as the etiology of duodenal pathologies in children.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patients aged between 1 and 17 years undergoing esophagogastroduodenoscopy during two years at this unit, were investigated retrospectively. Demographic, clinical, endoscopic data, and the presence of duodenal pathologies, gastritis, and esophagitis were recorded in all of the children.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Out of 747 children who underwent endoscopy, duodenal pathology was observed in 226 (30.3%) patients. Pathology was also present in the esophagus in 31.6% of patients and in the stomach in 58.4%. The level of chronic diarrhea was higher in patients with duodenal pathology when compared with those without duodenal pathology (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.002, OR: 3.91, 95% CI: 1.59–9.57). <span class="elsevierStyleItalic">Helicobacter pylori</span> infection was more common in patients with pathology in the duodenum (59.3%).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Duodenal pathology was detected in 30.3% of the present patients. A significantly higher level of chronic diarrhea was observed in subjects with duodenal pathologies compared to those with no such pathology. The rate of <span class="elsevierStyleItalic">Helicobacter pylori</span> infection was considerably higher than that in previous studies. In addition, there is a weak correlation between endoscopic appearance and histology of duodenitis.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Foram realizados vários estudos com relação a patologias do estômago e esôfago na faixa etária pediátrica. Contudo, poucos estudos das patologias duodenais em crianças. Visamos examinar as características clínicas, endoscópicas e histopatológicas juntamente com a etiologia das patologias duodenais em crianças.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Foram investigados retrospectivamente pacientes com idades entre 1 e 17 anos submetidos a esofagogastroduodenoscopia durante dois anos em nossa unidade. Os dados demográficos, clínicos e endoscópicos e a presença de patologias duodenais, gastrite e esofagite foram registrados com relação a todas as crianças.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Das 747 crianças submetidas a endoscopia, 226 (30,3%) pacientes apresentaram patologia duodenal. A patologia também esteve presente no esôfago de 31,6% dos pacientes e no estômago de 58,4% deles. O nível de diarreia crônica foi maior nos pacientes com patologia duodenal, em comparação aos pacientes sem patologia duodenal (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,002, RC: 3,91, IC de 95%: 1,59-9,57). Infecção por <span class="elsevierStyleItalic">Helicobacter pylori</span> foi mais comum em pacientes com patologia no duodeno (59,3%).</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusão</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Foi detectada patologia duodenal em 30,3% de nossos pacientes. Um nível significativamente maior de diarreia crônica foi observado em indivíduos com patologias duodenais, em comparação aos sem nenhuma patologia. A infecção por <span class="elsevierStyleItalic">Helicobacter pylori</span> esteve presente consideravelmente maior que em estudos anteriores. Além disso, há uma fraca correlação entre a imagem endoscópica e a histologia de duodenite.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Please cite this article as: Akbulut UE, Fidan S, Emeksiz HC, Ors OP. Duodenal pathologies in children: a single-center experience. J Pediatr (Rio J). 2018;94:273–8.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patients with duodenal pathology (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>226) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patients without duodenal pathology (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>521) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-value<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Female, n (%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">132 (58.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">326 (62.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.284 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Age groups, n (%)</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Infant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " rowspan="4" align="char" valign="middle"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">0.001</span></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Preschoolers \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11 (4.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">30 (5.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Schoolchildren \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">53 (23.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">189 (36.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Adolescent \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">162 (71.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">301 (57.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Symptoms, n (%)</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Chronic abdominal pain \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">150 (66.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">337 (64.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.656 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Failure to thrive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26 (11.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">57 (10.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.821 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Reflux symptoms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26 (11.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">65 (12.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.373 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Chronic diarrhea \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 (5.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (1.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">0.002</span></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dyspepsia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (5.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28 (5.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.971 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Chronic anemia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (4.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 (3.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.525 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Accompanying pathologies, n (%)</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">H. pylori</span> (+) gastritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">134 (59.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">155 (29.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><span class="elsevierStyleBold"><0.001</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Non-helicobacter gastritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">54 (23.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">93 (17.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.057 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Esophagitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">103 (45.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">133 (25.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><span class="elsevierStyleBold"><0.001</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1747484.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Chi-squared test.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Demographic characteristics of patients with gastrointestinal symptoms and accompanying pathologies.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Preschoolers (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>41) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Schoolchildren (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>242) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Adolescent (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>463) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-value<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Gastrointestinal symptoms, n (%)</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Chronic abdominal pain \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 (56.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">156 (64.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">307 (66.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.478 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Failure to thrive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (4.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">35 (14.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">46 (9.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.069 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Reflux symptoms \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">13 (31.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">27 (11.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51 (11.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">0.004</span></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Chronic diarrhea \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (4.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (2.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (2.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.750 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Dyspepsia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17 (7.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 (5.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">0.050</span></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Chronic anemia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (2.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 (5.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">0.001</span></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Endoscopic pathologies, n (%)</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nonspecific duodenitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (17.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">44 (18.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">150 (32.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold"><0.001</span></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Celiac disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (4.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5 (2.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N.A. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Giardiasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (4.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (1.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (0.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N.A. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Eosinophilic enteropathy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0 (0.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (0.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">N.A. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">H. pylori</span> (+) gastritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12 (29.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">75 (31.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">202 (43.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">0.001</span></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Non-helicobacter gastritis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (9.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">46 (19.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">97 (21.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.151 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Esophagitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 (39.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">72 (29.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">148 (32.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.546 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1747486.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0010" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Chi-squared test.</p> <p class="elsevierStyleNotepara" id="npar0015">N.A., not applicable.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Comparison of gastrointestinal symptoms according to age groups.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col">Endoscopic appearance, <span class="elsevierStyleItalic">n</span></th><th class="td" title="table-head " colspan="6" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Histopathological findings</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Nonspecific duodenitis, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Celiac disease, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Giardiasis, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Eosinophilic enteropathy, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Crohn's disease, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Normal, <span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ulcer in the bulbus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">57 (96.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (1.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (1.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Scalloping \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 (100) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Nodularity \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3 (44.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (11.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (22.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (22.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Normal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">672 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">141 (20.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7 (1.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2 (0.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">521 (77.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Total patients \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">747 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">201 (26.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10 (1.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9 (1.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4 (0.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 (0.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">522 (70.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1747485.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Endoscopic and histopathological characteristics of the duodenum.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0155" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Design of predictive models for positive outcomes of upper and lower gastrointestinal endoscopies in children and adolescents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.J. Noble" 1 => "E. Drouin" 2 => "R. Tamblyn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MPG.0b013e3181565e3c" "Revista" => array:7 [ "tituloSerie" => "J Pediatr Gastroenterol Nutr" "fecha" => "2008" "volumen" => "46" "paginaInicial" => "409" "paginaFinal" => "413" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18367953" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S019096221631009X" "estado" => "S300" "issn" => "01909622" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0160" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changing indications for upper endoscopy in children during a 20-year period" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.P. Franciosi" 1 => "K. Fiorino" 2 => "E. Ruchelli" 3 => "J. Shults" 4 => "J. Spergel" 5 => "C.A. Liacouras" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MPG.0b013e3181d67bee" "Revista" => array:7 [ "tituloSerie" => "J Pediatr Gastroenterol Nutr" "fecha" => "2010" "volumen" => "51" "paginaInicial" => "443" "paginaFinal" => "447" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20562722" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1542356508001559" "estado" => "S300" "issn" => "15423565" ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0165" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chemical gastropathy: a distinct histopathologic entity in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.S. Pashankar" 1 => "W.P. Bishop" 2 => "F.A. Mitros" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr Gastroenterol Nutr" "fecha" => "2002" "volumen" => "35" "paginaInicial" => "653" "paginaFinal" => "657" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12454581" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0170" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management guidelines of eosinophilic esophagitis in childhood" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Papadopoulou" 1 => "S. Koletzko" 2 => "R. Heuschkel" 3 => "J.A. Dias" 4 => "K.J. Allen" 5 => "S.H. Murch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MPG.0b013e3182a80be1" "Revista" => array:6 [ "tituloSerie" => "J Pediatr Gastroenterol Nutr" "fecha" => "2014" "volumen" => "58" "paginaInicial" => "107" "paginaFinal" => "118" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24378521" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0175" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and clinical, endoscopic, and pathological features of duodenitis in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Alper" 1 => "S. Hardee" 2 => "D. Rojas-Velasquez" 3 => "S. Escalera" 4 => "R.A. Morotti" 5 => "D.S. Pashankar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MPG.0000000000000942" "Revista" => array:6 [ "tituloSerie" => "J Pediatr Gastroenterol Nutr" "fecha" => "2016" "volumen" => "62" "paginaInicial" => "314" "paginaFinal" => "316" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26252915" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0180" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Upper endoscopy in children: do symptoms predict positive findings?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. Alabd Alrazzak" 1 => "T. Husien" 2 => "D.L. Preston" 3 => "Y. Elitsur" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Pediatr (Phila)" "fecha" => "2014" "volumen" => "53" "paginaInicial" => "474" "paginaFinal" => "478" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0185" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic yield of EGD in children: a retrospective single-center study of 1000 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.A. Sheiko" 1 => "J.A. Feinstein" 2 => "K.E. Capocelli" 3 => "R.E. Kramer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.gie.2013.03.168" "Revista" => array:6 [ "tituloSerie" => "Gastrointest Endosc" "fecha" => "2013" "volumen" => "78" "paginaInicial" => "47" "paginaFinal" => "54" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23669024" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0190" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Vandenplas" 1 => "C.D. Rudolph" 2 => "C. Di Lorenzo" 3 => "E. Hassall" 4 => "G. Liptak" 5 => "L. Mazur" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MPG.0b013e3181b7f563" "Revista" => array:6 [ "tituloSerie" => "J Pediatr Gastroenterol Nutr" "fecha" => "2009" "volumen" => "49" "paginaInicial" => "498" "paginaFinal" => "547" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19745761" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0195" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recurrent abdominal pains: a field survey of 1000 school children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Apley" 1 => "N. Naish" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dis Child" "fecha" => "1958" "volumen" => "33" "paginaInicial" => "165" "paginaFinal" => "170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13534750" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0200" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic diarrhoea in children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Guarino" 1 => "A. Lo Vecchio" 2 => "R. Berni Canani" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.bpg.2012.11.004" "Revista" => array:7 [ "tituloSerie" => "Best Pract Res Clin Gastroenterol" "fecha" => "2012" "volumen" => "26" "paginaInicial" => "649" "paginaFinal" => "661" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23384809" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0190962216300147" "estado" => "S300" "issn" => "01909622" ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0205" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Peptic ulcers and erosions are common in Israeli children undergoing upper endoscopy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Egbaria" 1 => "A. Levine" 2 => "A. Tamir" 3 => "R. Shaoul" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1523-5378.2008.00570.x" "Revista" => array:6 [ "tituloSerie" => "Helicobacter" "fecha" => "2008" "volumen" => "13" "paginaInicial" => "62" "paginaFinal" => "68" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18205668" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0210" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Celiac disease for the endoscopist" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Olds" 1 => "R. McLoughlin" 2 => "C. O’Morian" 3 => "M.V. Sivak Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastrointest Endosc" "fecha" => "2002" "volumen" => "56" "paginaInicial" => "407" "paginaFinal" => "415" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12196781" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0215" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is esophagoscopy alone sufficient for patients with reflux symptoms?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.M. Wildi" 1 => "T.F. Glenn" 2 => "R.F. Woolson" 3 => "W. Wang" 4 => "R.H. Hawes" 5 => "M.B. Wallace" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Gastrointest Endosc" "fecha" => "2004" "volumen" => "59" "paginaInicial" => "349" "paginaFinal" => "354" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14997130" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0190962214018751" "estado" => "S300" "issn" => "01909622" ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0220" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Esophageal, gastric, and duodenal manifestations of IBD and the role of upper endoscopy in IBD diagnosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Turner" 1 => "A.M. Griffiths" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Gastroenterol Rep" "fecha" => "2007" "volumen" => "9" "paginaInicial" => "475" "paginaFinal" => "478" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18377798" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0225" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcomes of children after esophagogastroduodenoscopy for chronic abdominal pain" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Thakkar" 1 => "L. Chen" 2 => "M.E. Tessier" 3 => "M.A. Gilger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cgh.2013.08.041" "Revista" => array:6 [ "tituloSerie" => "Clin Gastroenterol Hepatol" "fecha" => "2014" "volumen" => "12" "paginaInicial" => "963" "paginaFinal" => "969" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24016631" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0230" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The diagnostic value of the duodenal biopsy: a clinico-pathologic analysis of 28,000 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.W. Carmack" 1 => "R.M. Genta" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.dld.2009.11.010" "Revista" => array:6 [ "tituloSerie" => "Dig Liver Dis" "fecha" => "2010" "volumen" => "42" "paginaInicial" => "485" "paginaFinal" => "489" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20036203" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0235" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic approach and management of cow's-milk protein allergy in infants and children: ESPGHAN GI Committee practical guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Koletzko" 1 => "B. Niggemann" 2 => "A. Arato" 3 => "J.A. Dias" 4 => "R. Heuschkel" 5 => "S. Husby" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MPG.0b013e31825c9482" "Revista" => array:6 [ "tituloSerie" => "J Pediatr Gastroenterol Nutr" "fecha" => "2012" "volumen" => "55" "paginaInicial" => "221" "paginaFinal" => "229" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22569527" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0240" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased prevalence of eosinophilic disorders in pediatric PTEN hamartoma tumor syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.J. Henderson" 1 => "J. Ngeow" 2 => "M.H. Collins" 3 => "L.J. Martin" 4 => "P.E. Putnam" 5 => "J.P. Abonia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MPG.0000000000000253" "Revista" => array:6 [ "tituloSerie" => "J Pediatr Gastroenterol Nutr" "fecha" => "2014" "volumen" => "58" "paginaInicial" => "553" "paginaFinal" => "560" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24345843" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0245" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Non-<span class="elsevierStyleItalic">Helicobacter pylori</span> helicobacters detected in the stomach of humans comprise several naturally occurring Helicobacter species in animals" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Baele" 1 => "F. Pasmans" 2 => "B. Flahou" 3 => "K. Chiers" 4 => "R. Ducatelle" 5 => "F. Haesebrouck" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1574-695X.2009.00535.x" "Revista" => array:6 [ "tituloSerie" => "FEMS Immunol Med Microbiol" "fecha" => "2009" "volumen" => "55" "paginaInicial" => "306" "paginaFinal" => "313" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19243435" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0250" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reassessment of the diagnostic value of histology in patients with GERD, using multiple biopsy sites and an appropriate control group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Zentilin" 1 => "V. Savarino" 2 => "L. Mastracci" 3 => "P. Spaggiari" 4 => "P. Dulbecco" 5 => "P. Ceppa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1572-0241.2005.50209.x" "Revista" => array:6 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2005" "volumen" => "100" "paginaInicial" => "2299" "paginaFinal" => "2306" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16181384" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0255" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of endoscopy in the management of patients with diarrhea" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "ASGE Standards of Practice Committee" 1 => "B. Shen" 2 => "K. Khan" 3 => "S.O. Ikenberry" 4 => "M.A. Anderson" 5 => "S. Banerjee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.gie.2009.11.025" "Revista" => array:7 [ "tituloSerie" => "Gastrointest Endosc" "fecha" => "2010" "volumen" => "71" "paginaInicial" => "887" "paginaFinal" => "892" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20346452" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0190962216300147" "estado" => "S300" "issn" => "01909622" ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0260" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of <span class="elsevierStyleItalic">Helicobacter pylori</span> in children and their family members in a district in Turkey" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Ceylan" 1 => "E. Kirimi" 2 => "O. Tuncer" 3 => "K. Turkdoğan" 4 => "S. Ariyuca" 5 => "N. Ceylan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Health Popul Nutr" "fecha" => "2007" "volumen" => "25" "paginaInicial" => "422" "paginaFinal" => "427" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18402185" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0265" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Seroepidemiology of <span class="elsevierStyleItalic">Helicobacter pylori</span> infection in children living in eastern Turkey" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.A. Selimoglu" 1 => "V. Ertekin" 2 => "T. Inandi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatr Int" "fecha" => "2002" "volumen" => "44" "paginaInicial" => "666" "paginaFinal" => "669" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12421267" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0270" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and risk factors of <span class="elsevierStyleItalic">Helicobacter pylori</span> infection in Saudi children: a three-year prospective controlled study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Hasosah" 1 => "M. Satti" 2 => "A. Shehzad" 3 => "A. Alsahafi" 4 => "G. Sukkar" 5 => "A. Alzaben" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/hel.12172" "Revista" => array:6 [ "tituloSerie" => "Helicobacter" "fecha" => "2015" "volumen" => "20" "paginaInicial" => "56" "paginaFinal" => "63" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25495104" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0275" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Using enzyme immunoassay to detect <span class="elsevierStyleItalic">Helicobacter pylori</span> stool antigen for investigating the prevalence of Helicobacter pylori infection in children and adolescents in Changhua" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.T. Cheng" 1 => "K.L. Hwang" 2 => "L.Y. Tsao" 3 => "C.H. Wang" 4 => "W.T. Chaou" 5 => "Y.J. Chang" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Acta Paediatr Taiwan" "fecha" => "2002" "volumen" => "43" "paginaInicial" => "133" "paginaFinal" => "139" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12148962" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0280" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of <span class="elsevierStyleItalic">Helicobacter pylori</span> infection in children from an urban community in North-East Brazil and risk factors for infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.N. Rodrigues" 1 => "D.M. Queiroz" 2 => "J.G. Bezerra Filho" 3 => "L.K. Pontes" 4 => "R.T. Rodrigues" 5 => "L.L. Braga" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur J Gastroenterol Hepatol" "fecha" => "2004" "volumen" => "16" "paginaInicial" => "201" "paginaFinal" => "205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15075995" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S019096221401874X" "estado" => "S300" "issn" => "01909622" ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0285" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of <span class="elsevierStyleItalic">Helicobacter pylori</span> in children in eastern Turkey and molecular typing of isolates" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Ozbey" 1 => "Y. Dogan" 2 => "K. Demiroren" 3 => "I.H. Ozercan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/S1517-838246220140234" "Revista" => array:6 [ "tituloSerie" => "Braz J Microbiol" "fecha" => "2015" "volumen" => "46" "paginaInicial" => "505" "paginaFinal" => "511" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26273266" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0290" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Frequency and risk factors of gastric and duodenal ulcers or erosions in children: a prospective 1-month European multicenter study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Kalach" 1 => "P. Bontems" 2 => "S. Koletzko" 3 => "P. Mourad-Baars" 4 => "P. Shcherbakov" 5 => "D. Celinska-Cedro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MEG.0b013e32833d36de" "Revista" => array:6 [ "tituloSerie" => "Eur J Gastroenterol Hepatol" "fecha" => "2010" "volumen" => "22" "paginaInicial" => "1174" "paginaFinal" => "1181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20634700" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0295" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Duodenitis in children: correlation of radiologic findings with endoscopic and pathologic findings" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F.R. Long" 1 => "S.S. Kramer" 2 => "R.I. Markowitz" 3 => "C.A. Liacouras" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/radiology.206.1.9423658" "Revista" => array:6 [ "tituloSerie" => "Radiology" "fecha" => "1998" "volumen" => "206" "paginaInicial" => "103" "paginaFinal" => "108" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9423658" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0300" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The significance of routine duodenal biopsies in pediatric patients undergoing upper intestinal endoscopy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Kori" 1 => "V. Gladish" 2 => "N. Ziv-Sokolovskaya" 3 => "M. Huszar" 4 => "M. Beer-Gabel" 5 => "R. Reifen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Gastroenterol" "fecha" => "2003" "volumen" => "37" "paginaInicial" => "39" "paginaFinal" => "41" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12811207" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00217557/0000009400000003/v2_201805190418/S0021755717301031/v2_201805190418/en/main.assets" "Apartado" => array:4 [ "identificador" => "10179" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/00217557/0000009400000003/v2_201805190418/S0021755717301031/v2_201805190418/en/main.pdf?idApp=UINPBA000049&text.app=https://jped.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0021755717301031?idApp=UINPBA000049" ]
Year/Month | Html | Total | |
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2024 November | 8 | 4 | 12 |
2024 October | 26 | 30 | 56 |
2024 September | 48 | 36 | 84 |
2024 August | 50 | 31 | 81 |
2024 July | 65 | 29 | 94 |
2024 June | 69 | 30 | 99 |
2024 May | 50 | 6 | 56 |
2024 April | 53 | 25 | 78 |
2024 March | 38 | 22 | 60 |
2024 February | 33 | 21 | 54 |
2024 January | 23 | 31 | 54 |
2023 December | 16 | 19 | 35 |
2023 November | 38 | 34 | 72 |
2023 October | 38 | 34 | 72 |
2023 September | 37 | 39 | 76 |
2023 August | 27 | 21 | 48 |
2023 July | 18 | 11 | 29 |
2023 June | 21 | 15 | 36 |
2023 May | 29 | 17 | 46 |
2023 April | 21 | 14 | 35 |
2023 March | 55 | 22 | 77 |
2023 February | 28 | 19 | 47 |
2023 January | 37 | 14 | 51 |
2022 December | 54 | 31 | 85 |
2022 November | 34 | 31 | 65 |
2022 October | 54 | 49 | 103 |
2022 September | 29 | 32 | 61 |
2022 August | 40 | 28 | 68 |
2022 July | 27 | 38 | 65 |
2022 June | 29 | 32 | 61 |
2022 May | 21 | 22 | 43 |
2022 April | 47 | 33 | 80 |
2022 March | 35 | 38 | 73 |
2022 February | 22 | 30 | 52 |
2022 January | 22 | 13 | 35 |
2021 December | 20 | 25 | 45 |
2021 November | 8 | 15 | 23 |
2021 October | 10 | 17 | 27 |
2021 September | 12 | 13 | 25 |
2021 August | 7 | 8 | 15 |
2021 July | 6 | 1 | 7 |
2021 June | 3 | 8 | 11 |
2021 May | 17 | 15 | 32 |
2021 April | 11 | 10 | 21 |
2021 March | 12 | 15 | 27 |
2021 February | 7 | 6 | 13 |
2021 January | 7 | 10 | 17 |
2020 December | 14 | 9 | 23 |
2020 November | 11 | 12 | 23 |
2020 October | 8 | 13 | 21 |
2020 September | 15 | 11 | 26 |
2020 August | 5 | 3 | 8 |
2020 July | 6 | 5 | 11 |
2020 June | 7 | 5 | 12 |
2020 May | 7 | 3 | 10 |
2020 April | 12 | 10 | 22 |
2020 March | 9 | 3 | 12 |
2020 February | 16 | 16 | 32 |
2020 January | 15 | 16 | 31 |
2019 December | 14 | 9 | 23 |
2019 November | 26 | 13 | 39 |
2019 October | 14 | 11 | 25 |
2019 September | 18 | 10 | 28 |
2019 August | 23 | 10 | 33 |
2019 July | 24 | 12 | 36 |
2019 June | 18 | 59 | 77 |
2019 May | 27 | 7 | 34 |
2019 April | 27 | 3 | 30 |
2019 March | 23 | 9 | 32 |
2019 February | 17 | 6 | 23 |
2019 January | 17 | 6 | 23 |
2018 December | 26 | 10 | 36 |
2018 November | 24 | 3 | 27 |
2018 October | 45 | 13 | 58 |
2018 September | 29 | 9 | 38 |
2018 August | 37 | 10 | 47 |
2018 July | 36 | 7 | 43 |
2018 June | 30 | 12 | 42 |
2018 May | 26 | 20 | 46 |
2018 April | 2 | 4 | 6 |
2018 March | 4 | 10 | 14 |
2018 February | 0 | 4 | 4 |
2018 January | 1 | 3 | 4 |
2017 December | 1 | 3 | 4 |
2017 November | 0 | 2 | 2 |
2017 October | 1 | 11 | 12 |
2017 September | 0 | 2 | 2 |