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Vol. 89. Issue 3.
Pages 263-268 (May - June 2013)
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Vol. 89. Issue 3.
Pages 263-268 (May - June 2013)
ARTIGO ORIGINAL
Open Access
Breast milk fatty acid composition of women living far from the coastal area in Brazil
Composição de ácidos graxos do leite materno em mulheres residentes em área distante da costa litorânea brasileira
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Renata Y. Nishimuraa, Gabriela S.F. de Castrob, Alceu A. Jordão Juniorc, Daniela S. Sartorellid,
Corresponding author
daniss@fmrp.usp.br

Corresponding author.
a Mestre, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), São Paulo, SP, Brasil
b Doutoranda, Departamento de Clínica Médica, FMRP, USP, SP, Brasil
c Doutor. Departamento de Medicina Social, FMRP, USP, SP, Brasil
d Doutora. Departamento de Clínica Médica, FMRP, USP, SP, Brasil
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Under a Creative Commons license
Article information
Abstract
Objectives

To evaluate the fatty acid composition of mature human milk of women living far from the coastal area of Brazil.

Methods

Mature breast milk samples were obtained from 47 lactating women aged between 18 and 35 years, who delivered their babies at term and who exclusively or predominantly breastfed. Milk collection took place after the fifth week postpartum by hand expression. The fatty acid composition of the milk was determined by gas chro- matography.

Results

It was observed that the concentration of eicosapentaenoic acid (0.08%) was higher than that observed in previous studies in Brazil. However, the content of doco- sahexaenoic acid (0.09%) found in human milk was one of the lowest verified in the world. The content of trans fatty acids (2.05%) was similar to that reported in national studies previous to the mandatory declaration of this fatty acid content in food labels, suggesting that this measure had no effect on reducing the content of this fatty acid in the usual diet of women.

Conclusions

Low levels of docosahexaenoic acid and high concentrations of trans fatty acids were observed in mature breast milk of women living far from the coastal area in Brazil.

Keywords:
Fatty acids
Human breast milk
Lactation
Resumo
Objetivos

Avaliar a composição de ácidos graxos do leite humano maduro de mulheres residentes em área distante da costa litorânea brasileira.

Métodos

Amostras de leite materno maduro foram obtidas de 47 mulheres lactantes com idade entre 18 e 35 anos, que tiveram partos a termo e em aleitamento exclusivo ou predominante. A coleta de leite se deu a partir da 5ª semana pós-parto, por meio de ordenha manual. A composição de ácidos graxos do leite foi determinada por cromato- grafia gasosa.

Resultados

Verificou-se que a concentração de eicosapentaenoico (0,08%) foi superior ao observado em estudos brasileiros prévios. Entretanto, o teor de docosahexaenoico (0,09%) encontrado no leite humano foi um dos menores já verificados no mundo. O teor de ácidos graxos trans (2,05%) foi similar ao relatado em estudos nacionais prévios à obrigatoriedade de declaração do teor deste em rótulos de alimentos, sugerindo que esta medida não surtiu efeito na redução de seu teor na dieta habitual das mulheres.

Conclusões

Baixo teor de docosahexaenoico e elevada concentração de ácidos graxos trans foram verificados no leite materno maduro de mulheres residentes em área dis- tante da costa litorânea brasileira.

Palavras-chave:
Ácidos graxos
Leite materno
Lactação
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Referências
[1]
C.S. Boccolini, M.L. Carvalho, M.I. Oliveira, M. Boccolini Pde.
Breastfeeding can prevent hospitalization for pneumonia among children under 1 year old.
J Pediatr (Rio J)., 87 (2011), pp. 399-404
[2]
L.M. Arterburn, E.B. Hall, H. Oken.
Distribution, interconversion, and dose response of n-3 fatty acids in humans.
Am J Clin Nutr., 83 (2006), pp. 1467-1476
[3]
B.L. Schmeits, J.A. Cook, D.J. VanderJagt, M.A. Magnussen, S.K. Bhatt, E.G. Bobik, et al.
Fatty acid composition of the milk lipids of women in Nepal.
Nutr Res., 19 (1999), pp. 1339-1348
[4]
M.H. Silva, M.T. Silva, S.C. Brandão, J.C. Gomes, L.A. Peternelli, S.C. Franceschini.
Fatty acid composition of mature breast milk in Brazilian women.
Food Chem., 93 (2005), pp. 297-303
[5]
S.M. Tinoco, R. Sichieri, A.S. Moura, F.S. Santos, M.G. do Carmo.
Importância dos ácidos graxos essenciais e os efeitos dos ácidos graxos trans do leite materno para o desenvolvimento fetal e neonatal.
Cad Saúde Pública., 23 (2007), pp. 525-534
[6]
F. Meneses, A.G. Torres, N.M. Trugo.
Essential and long-chain polyunsaturated fatty acid status and fatty acid composition of breast milk of lactating adolescents.
Br J Nutr., 100 (2008), pp. 1029-1037
[7]
S.M. Innis.
Fatty acids and early development.
Earl Hum Dev., 83 (2007), pp. 761-766
[8]
P.C. Calder, L.S. Kremmyda, M. Vlachava, P.S. Noakes, A. Elizabeth, E.A. Miles.
Is there a role for fatty acids in early life programming of the immune system?.
Proc Nutr Soc., 69 (2010), pp. 373-380
[9]
S.M. Tinoco, R. Sichieri, C.L. Setta, A.S. Moura, Md. do Carmo.
Trans fatty acids from milk of Brazilian mothers of premature infants.
J Paediatr Child Health., 44 (2008), pp. 50-56
[10]
S.M. Innis.
Trans fatty acids during pregnancy, infancy and early childhood.
[11]
J.M. Griimari, B.A. Corl, S.H. Lacy, P.Y. Chouinard, K.V. Nurmela, D.E. Bauman.
Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Delta(9)-desaturase.
J Nutr., 130 (2000), pp. 2285-2291
[12]
A.B. Feitoza, A.F. Pereira, N. Ferreira da Costa, B. Gonçalves Ribeiro.
Conjugated linoleic acid (CLA): Effect modulation of body composition and lipid profile.
Nutr Hosp., 24 (2009), pp. 422-428
[13]
M.W. Pariza, Y. Park, M.E. Cook.
Conjugated linoleic acid and the control of cancer and obesity.
Toxicol Sci., 52 (1999), pp. 107-110
[14]
J. da Cunha, T.H. Macedo da Costa, M.K. Ito.
Influences of maternal dietary intake and suckling on breast milk lipid and fatty acid composition in low-income women from Brasilia.
Brazil. Early Hum Dev., 81 (2005), pp. 303-311
[15]
A.G. Torres, J.G. Ney, F. Meneses, N.M. Trugo.
Polyunsaturated fatty acids and conjugated linoleic acid isomers in breast milk are associated with plasma non-esterified and erythrocyte membrane fatty acid composition in lactating women.
Br J Nutr., 95 (2006), pp. 517-524
[16]
H. Demmelmair, M. Baumheuer, B. Koletzko, K. Dokoupil, G. Kratl.
Metabolism of U13C-labeled linoleic acid in lactating women.
J Lipid Res., 39 (1998), pp. 1389-1396
[17]
J. Cade, R. Thompson, V. Burley, D. Warm.
Development, validation and utilization of food-frequency questionnaires – a review.
Public Health Nutr., 5 (2002), pp. 567-587
[18]
E.G. Bligh, W.J. Dyer.
A rapid method of total lipid extraction and purification.
Can J Biochem Physiol., 37 (1959), pp. 911-917
[19]
A.G. Torres, N.M. Trugo.
Evidence of inadequate docosahexaenoic acid status in Brazilian pregnant and lactating women.
Rev Saúde Pública., 43 (2009), pp. 359-368
[20]
R.A. Gibson, B. Muhlhausler, M. Makrides.
Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life.
Matern Child Nutr., 7 (2011), pp. 17-26
[21]
Instituto Brasileiro de Geografia e Estatística (Brasil). Pesquisa de Orçamentos Familiares 2008-2009: Análise do Consumo Alimentar Pessoal no Brasil. Rio de Janeiro: IBGE; 2011.
[22]
R.A. Gibson, G.M. Kneebone.
Fatty acid composition of human colostrum and mature breast milk.
Am J Clin Nutr., 34 (1981), pp. 252-257
[23]
G. Harzer, M. Haug, I. Dieterich, P.R. Gentner.
Changing patterns of human milk lipids in the course of the lactation and during the day.
Am J Clin Nutr., 37 (1983), pp. 612-621
[24]
E.E. Mosley, A.L. Wright, M.K. McGuire, M.A. McGuire.
trans Fatty acids in milk produced by women in the United States.
Am J Clin Nutr., 82 (2005), pp. 1292-1297
[25]
S.M. Innis, D.J. King.
Trans fatty acids in human milk are inversely associated with concentrations of essential all-cis n-6 and n-3 fatty acids and determine trans, but not n-6 and n-3, fatty acids in plasma lipids of breast-fed infants.
Am J Clin Nutr., 70 (1999), pp. 383-390
[26]
D. Precht, J. Molkentin.
C18:1, C18:2 and C18:3 trans and cis fatty acid isomers including conjugated cis delta 9, trans delta 11 linoleic acid (CLA) as well as total fat composition of German human milk lipids.
[27]
J.M. Chardigny, R.L. Wolff, E. Mager, J.L. Sébédio, L. Martine, P. Juanéda.
Trans mono- and polyunsaturated fatty acids in human milk.
Eur J Clin Nutr., 49 (1995), pp. 523-531
[28]
D. Precht, J. Molkentin.
Effect of feeding on conjugated cis delta 9, trans delta 11-octadecadienoic acid and other isomers of linoleic acid in bovine milk fats.
Nahrung., 41 (1997), pp. 330-335
[29]
Y. Wang, P.J. Jones.
Dietary conjugated linoleic acid and body composition.
Am J Clin Nutr., 79 (2004), pp. 1153S-1158S

Nishimura RY, Castro GS, Junior AA, Sartorelli DS. Breast milk fatty acid composition of women living far from the coastal area in Brazil. J Pediatr (Rio J). 2013;89:263-8.

Copyright © 2013. Sociedade Brasileira de Pediatria
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