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Vol. 89. Issue 2.
Pages 112-115 (March - April 2013)
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Vol. 89. Issue 2.
Pages 112-115 (March - April 2013)
Open Access
Advancing and prioritizing research on oral clefts in Brazil
Avançando e priorizando a pesquisa sobre fissuras orais no Brasil
George L. Wehby
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Corresponding author.
MPH, PhD, Associate Professor, Department of Health Management and Policy, College of Public Health, University of Iowa, Iowa, USA
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M.M. Yazdy, M.A. Honein, S.A. Rasmussen, J.L. Frias.
Priorities for future public health research in orofacial clefts.
Cleft Palate Craniofac J., 44 (2007), pp. 351-357
J. Souza, S. Raskin.
Clinical and epidemiological study of orofacial clefts.
J Pediatr (Rio J)., 89 (2013), pp. 137-144
M. Shi, G.L. Wehby, J.C. Murray.
Review on genetic variants and maternal smoking in the etiology of oral clefts and other birth defects.
Birth Defects Res C Embryo Today., 84 (2008), pp. 16-29
G.L. Wehby, R.L. Ohsfeldt, J.C. Murray.
‘Mendelian randomization’ equals instrumental variable analysis with genetic instruments.
Stat Med., 27 (2008), pp. 2745-2749
G. Wehby, A. Jugessur, J.C. Murray, L. Moreno, A. Wilcox, R.T. Lie.
Genes as instruments for studying risk behavior effects: an application to maternal smoking and orofacial clefts.
Health Serv Outcomes Res Methodol., 11 (2011), pp. 54-78
G.L. Wehby, J.M. Fletcher, S.F. Lehrer, L.M. Moreno, J.C. Murray, A. Wilcox, R.T. Lie.
A genetic instrumental variables analysis of the effects of maternal smoking during pregnancy on birth weight.
Biodemography Soc Biol., 57 (2011), pp. 3-32
G.L. Wehby, J.C. Murray, A. Wilcox, R.T. Lie.
Smoking and body weight: evidence using genetic instruments.
Econ Hum Biol., 10 (2012), pp. 113-126
Wehby GL, Wilcox A, Lie RT. The impact of cigarette quitting during pregnancy on other prenatal health behaviors. Rev Econ Household. [in press] DOI: 10.1007/s11150-012-9163-8.
Tyler M, Wehby GL, Robbins J, Damiano P. Separation anxiety in children ages 4 through 9 with oral clefts. Cleft Palate Craniofac Jl. [in press] DOI:
K. Christensen, K. Juel, A.M. Herskind, J.C. Murray.
Long term follow up study of survival associated with cleft lip and palate at birth.
G.L. Wehby, M.C. Tyler, S. Lindgren, P. Romitti, J. Robbins, P. Damiano.
Oral clefts and behavioral health of young children.
G.L. Wehby, D.A. Pedersen, J.C. Murray, K. Christensen.
The effects of oral clefts on hospital use throughout the lifespan.
BMC Health Serv Res., 12 (2012), pp. 58
G.L. Wehby, C.H. Cassell.
The impact of orofacial clefts on quality of life and healthcare use and costs.
A. Dietz, D.A. Pedersen, R. Jacobsen, G.L. Wehby, J.C. Murray, K. Christensen.
Risk of breast cancer in families with cleft lip and palate.
Ann Epidemiol., 22 (2012), pp. 37-42
G.L. Wehby, R.L. Ohsfeldt, J.C. Murray.
Health professionals’ assessment of health-related quality of life values for oral clefting by age using a visual analogue scale method.
Cleft Palate Craniofac J., 43 (2006), pp. 383-391
Wehby GL, Castilla EE, Goco N, Rittler M, Cosentino V, Javois L, et al. Description of the methodology used in an ongoing pediatric care interventional study of children born with cleft lip and palate in South America [NCT00097149]. BMC Pediatr. 2006;6:9.
G.L. Wehby, E.E. Castilla, N. Goco, M. Rittler, V. Cosentino, L. Javois, et al.
The effect of systematic pediatric care on neonatal mortality and hospitalizations of infants born with oral clefts.
BMC Pediatr., 11 (2011), pp. 121
K.A. Nyarko, J. Lopez-Camelo, E.E. Castilla, G.L. Wehby.
Does the relationship between prenatal care and birth weight vary by oral clefts? Evidence using South American and United States samples.
J Pediatr., 162 (2013), pp. 42-49
Wehby GL, Nyarko K, Lopez-Camelo JS. Fetal health shocks and early inequalities in health capital accumulation. Health Econ. [in press] DOI: 10.1002/hec.2901.
G.L. Wehby, J.C. Murray.
Folic acid and orofacial clefts: a review of the evidence.
R.G. Munger, H.E. Sauberlich, C. Corcoran, B. Nepomuceno, S. Daack- Hirsch, F.S. Solon.
Maternal vitamin B-6 and folate status and risk of oral cleft birth defects in the Philippines.
Birth Defects Res A Clin Mol Teratol., 70 (2004), pp. 464-471
D. Grosen, C. Chevrier, A. Skytthe, C. Bille, K. Mølsted, A. Sivertsen, et al.
A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance.
J Med Genet., 47 (2010), pp. 162-168
H. Chakraborty, G. Wehby, N. Goco, J. Moore, M. Kindem, C. Vila- Nova, et al.
Challenges and implemented solutions for the oral cleft prevention trial in Brazil.
Int J Med Public Health., 1 (2011), pp. 9-16
G.L. Wehby, N. Goco, D. Moretti-Ferreira, T. Felix, A. Richieri-Costa, C. Padovani, et al.
Oral cleft prevention program (OCPP).
BMC Pediatr., 12 (2012), pp. 184
G.L. Wehby, N. Goco, T. Felix, H. Chakraborty, C. Padovani, R. Pereira, et al.
High dosage folic acid supplementation, oral cleft recurrence and fetal growth.
Int J Environ Res Public Health., 10 (2013), pp. 590-605

Please, cite this article as: Wehby GL. Advancing and prioritizing research on oral clefts in Brazil. J Pediatr (Rio J). 2013;89:112−5.

See paper by Souza J et al. in pages 137−44.

Copyright © 2013. Sociedade Brasileira de Pediatria
Jornal de Pediatria (English Edition)
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