Respiratory allergy to moth: the importance of sensitization to Bombyx mori in children with asthma and rhinitis

Araujo, Laura M.L.; Filho, Nelson A. Rosário; Riedi, Carlos A.

doi:10.1016/j.jpedp.2013.08.002

Informação do artigo

Resume

Bibliografia

Baixar PDF

Estatísticas

Abstract

Objective

this study aimed to prepare a silkworm moth (Bombyx mori) antigenic extract and to perform skin prick tests with this extract in patients with allergic respiratory diseases; to evaluate serum specific immunoglobulin E (IgE) to Bombyx mori using ImmunoCAP® system and to compare the frequency of positivity between the two methods and with clinical data.

Methods

this was a cross-sectional study with 99 children and adolescents diagnosed with asthma and/or allergic rhinitis, who had skin reactivity to at least one of the six aeroallergens tested. Clinical data were evaluated, skin prick tests with Bombyx mori in-house extract, and total and specific IgE analysis using ImmunoCAP® were performed.

Results

the frequency of Bombyx mori specific IgE was found to be 52.5% and 60% using the skin prick test and ImmunoCAP®, respectively. An association between a positive skin test for Bombyx mori and the presence of allergic rhinitis, atopic dermatitis, and urticaria was observed, but the same was not true for asthma or allergic conjunctivitis. There was no relation with the severity of asthma or rhinitis symptoms.

Conclusions

a high frequency of sensitization to Bombyx mori was observed in a selected population of patients with respiratory allergic diseases in the city of Curitiba, state of Paraná, Brazil. The extract prepared from the wings of this moth species is effective in demonstrating this sensitivity.

Keywords:

Sensitization

Moth

Asthma

Rhinitis

Resumo

Objetivo

preparar extrato antigênico da mariposa do bicho-da-seda (Bombyx mori) e realizar testes cutâneos com esse extrato em pacientes com doenças respiratórias alér- gicas, avaliar IgE sérica específica para Bombyx mori usando o sistema ImmunoCAP® e comparar a frequência de positividade entre os dois métodos e com dados clínicos.

Métodos

Estudo transversal com 99 crianças e adolescentes com diagnóstico de asma e/ou rinite alérgica, que apresentaram reação cutânea a pelo menos um dos seis aeroa- lérgenos testados. Os dados clínicos foram avaliados; testes cutâneos com extrato de Bombyx mori e análise de IgE total e específica por ImmunoCAP® foram realizados.

Resultados

a frequência de IgE específica para Bombyx mori foi de 52,5% e 60%, res- pectivamente, pelo teste cutâneo e ImmunoCAP®. Foi observada uma associação entre o teste cutâneo positivo para Bombyx mori e a presença de rinite alérgica, dermatite atópica e urticária, mas o mesmo não ocorreu para a asma ou conjuntivite alérgica. Não houve relação com a gravidade dos sintomas de asma ou rinite.

Conclusões

alta frequência de sensibilização à Bombyx mori foi encontrada em uma população selecionada de pacientes com doenças alérgicas respiratórias na cidade de Curitiba, estado do Paraná, Brasil. O extrato preparado a partir das asas dessa espécie de mariposa é eficaz em demonstrar essa sensibilidade.

Palavras-chave:

Sensibilização

Mariposa

Asma

Rinite

O texto completo está disponível em PDF

Referências

[1]

A. Custovic, A. Simpson.

Environmental allergen exposure, sensitisation and asthma: from whole population to individuals atrisk.

Thorax., 59 (2004), pp. 825-827

http://dx.doi.org/10.1136/thx.2004.027334 | Medline

[2]

B.M. Dutra, N.A. Rosário, A.F. Zavadniak.

Alérgenos inaláveis em Curitiba: uma revisão de sua relevância clínica.

Rev Bras Alerg Imunopatol., 24 (2001), pp. 189-195

[3]

F. Perlman.

Insects as inhalant allergens.

J Allergy Clin Immunol., 29 (1958), pp. 302-328

[4]

K.L. Arruda, L.D. Vailes, V.P. Ferriani, A.B. Santos, A. Pommés, M.D. Chapman.

Cockroach allergens and asthma.

J Allergy ClinImmunol., 107 (2001), pp. 419-428

[5]

A.R. Feinberg, S.M. Feinberg, C. Benaim-Pinto.

Asthma and rhinitisfrom insect allergens.

J Allergy., 27 (1956), pp. 437-444

Medline

[6]

T. Kino, J. Chihara, K. Fukuda, Y. Sasaki, Y. Shogaki, S. Oshima.

Allergy to insects in Japan III High frequency of IgE antibody responses to insects (moth, butterfly, caddis fly, and chironomid) in patients with bronchial asthma immuno-chemical quantitation of the insect related airborne particlessmaller than 10μm in diameter.

J Allergy Clin Immunol., 79 (1987), pp. 857-866

Medline

[7]

Mendes E, Lacaz CS. Alergia a insetos. Em: Alergia nas regiões tropicais. São Paulo: Editora Universidade de São Paulo; 1965. p. 89.

[8]

S. Kobayashi, T. Nakazawa, S. Yoshida.

A study on antigenic substances of asthma in sericiculture.

Part 3 Japan J Allergol., 21 (1972), pp. 107

[9]

M. Inasawa, K. Horikoshi, S. Tomioka.

A study of bronchial asthma related to silkworm culturing.

Japan J Allergol., 22 (1973), pp. 142

[10]

Kobayashi S. Occupational asthma due to inhalation of pharmacological dusts and other chemical agents with some reference to other occupational asthmas in Japan. Allergology. Amsterdan: Excerpta Medica; 1974. p. 53.

[11]

T. Kino, S. Oshima.

Allergy to insects in Japan I The reaginic sensitivity to moth and butterfly in patients with bronchial asthma.

J Allergy Clin Immunol., 61 (1978), pp. 10-16

Medline

[12]

T. Kino, S. Oshima.

Allergy to insects in Japan II The reaginic sensitivity to silkworm in patients with bronchial asthma.

J Allergy Clin Immunol., 64 (1979), pp. 131-138

Medline

[13]

S.R. Wynn, M.C. Swanson, C.E. Reed, N.D. Penny, W.B. Showers, J.M. Smith.

Immunochemical quantitation, size distribution, and cross- reactivity of lepdoptera (moth) aeroallergens in southeastern Minnesota.

J Allergy Clin Immunol., 82 (1988), pp. 47-54

Medline

[14]

N.A. Rosário, M.M. Vilela.

Quantitative skin prick tests and serum IgE antibodies in atopic asthmatics.

J Invest Allergol Clin Immunol., 7 (1997), pp. 40-45

[15]

Global Iniciative for Asthma - GINA. Bethesda: Global Iniciative for Asthma. Global Strategy for Asthma Treatmentand Prevention, 2006 [cited 2012 Feb 10]. Disponível em: http://www.ginasthma.org/pdf/GINA Report 2010.pdf.

[16]

J. Bousquet, N. Khaltaev, A.A. Cruz, J. Denburg, W.J. Fokkens, A. Togias, et al.

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008.

Allergy., 63 (2008), pp. 8-160

http://dx.doi.org/10.1111/j.1398-9995.2007.01620.x | Medline

[17]

M.B. Lierl, M.M. Riordan, T.J. Fischer.

Prevalence of insect allergen- specific IgE in allergic asthmatic children in Cincinnati.

Ohio Ann Allergy., 72 (1994), pp. 45-50

[18]

Nelson HS. In vivo testing for immunoglobulin E-mediated sensitivity. Em: Leung DYM, Sampson HA, Geha R, Szefler SJ, editores. Pediatric allergy - principles and practice. 2nd ed. Oxford: Elsevier; 2011. p. 250-8.

[19]

Método de avaliação de IgE específica e total - Immuno-CAP PHADIA® [cited 2012 Feb 12]. Disponível em: http://www. phadia.com.

[20]

Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis and athopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee Lancet. 1998;351:1225-32.

[21]

C.K. Lai, R. Beasley, J. Cran, S. Foliaski, J. Shah, S. Weiland.

International Study of Asthma and Allergies in Childhood Phase Three S tudy Group Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC).

Thorax., 64 (2009), pp. 476-483

http://dx.doi.org/10.1136/thx.2008.106609 | Medline

[22]

D. Solé, G.F. Wandalsen, I.C. Camelo-Nunes, C.K. Naspitz.

ISAAC- Brazilian Group Prevalence of symptoms of asthma, rhinitisand atopic eczema among Brazilian children and adolescents identified by the International Study of Asthma and Allergiesin Childhood (ISAAC)- Phase 3.

J Pediatr (Rio J)., 82 (2006), pp. 341-346

[23]

C.K. Naspitz, D. Solé, C.A. Jacob, E. Sarinho, F.J. Soares, V. Dantas, et al.

Sensibilização a alérgenos inalantes e alimentares em crianças brasileiras atópicas, pela determinação in vitro de IgE total e específica - Projeto Alergia (PROAL) Allergy project- PROAL.

J Pediatr (Rio J)., 80 (2004), pp. 203-210

[24]

E. Fernandez-Caldas, R.F. Lockey.

Blomia tropicalis: a mite whose time has come.

Allergy., 59 (2004), pp. 1161-1164

http://dx.doi.org/10.1111/j.1398-9995.2004.00727.x | Medline

[25]

M. Suzuki, H. Itoh, K. Sugiyama, I. Takagi, J. Nishimura, K. Kato, et al.

Causative allergens of allergic rhinitis in Japan with special reference to silkworm moth allergen.

Allergy., 50 (1995), pp. 23-27

Medline

[26]

S.M. Dinehart, M.E. Archer, J.E. Wolf, M.H. Mcgravan, C. Reitz, E.B. Smith.

Caripito itch: dermatitis from contact with moths.

J American Academy Dermatol., 13 (1985), pp. 743-747

[27]

P.L. Ooi, K.T. Goh, H.S. Lee, C.L. Goh.

Tussockosis: an outbreak of dermatitis caused by tussock moths in Singapore.

Contact Dermatitis., 24 (1991), pp. 197-200

Medline

[28]

Y. Komase, M. Sakata, T. Azuma, A. Tanaka, T. Nakagawa.

IgE anti- bodies against midge and moth found in Japanese asthmatic subjects and comparison of allergenicity between these two insects.

Allergy., 52 (1997), pp. 75-81

Medline

[29]

Z. Liu, L. Xia, Y. Wu, Q. Xia, J. Xen, K.H. Roux.

Identification andcharacterization of an arginin kinase as a major allergen from silkworm () larvae.

Int Arch Allergy Clin Immunol., 50 (2008), pp. 8-14

[30]

B.X. Zhong.

Protein databank for several tissues derived from five in star of silk worm.

Yi Chuan Xue Bao., 28 (2001), pp. 217-224

Medline

[31]

R.C. Aalberse.

Allergens from mites: implications of cross-reactivity between invertebrate antigens.

Allergy., 53 (1998), pp. 47-48

Medline

[32]

K.Y. Jeong, J. Lee, I.Y. Lee, H.I. Ree, C.S. Hong, T.S. Yong.

Allerginicity of recombinant Bla g 7.

German cockroach tropomyosin. Allergy., 58 (2003), pp. 1059-1063

[33]

A. Mari.

When does a protein become an allergen? Searching for a dynamic definition based on most advanced technology tools.

Clin Exp Allergy., 38 (2008), pp. 1089-1094

http://dx.doi.org/10.1111/j.1365-2222.2008.03011.x | Medline

[34]

G. Melioli, L. Marcomini, A. Agazzi, G. Bazurro, M. Tosca, G.A. Rossi, et al.

The IgE repertoire in children and adolescents resolved at component level: a cross-sectional study.

Ped Allergy Immunol., 40 (2012), pp. 433-440

☆

Como citar este artigo: Araujo LM, Rosário Filho NA, Riedi CA. Respiratory allergy to moth: the importance of sensitization to Bombyx mori in children with asthma and rhinitis. J Pediatr (Rio J). 2014;90:176-81.

☆☆

Estudo realizado no Serviço de Alergia e Imunologia Pediátrica, Hospital de Clínicas, Universidade Federal do Paraná (UFPR).

Indexada em:

Siga-nos:

Indexada em:

Siga-nos:

Receba a nossa Newsletter