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21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44;72&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44;76&#44; &#40;momento 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>37&#44;12&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>32&#44;31&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#44;87&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44;37&#46; <span class="elsevierStyleBold">B&#46;</span> Associa&#231;&#227;o do volume do Slope 3&#47;corrente entre indiv&#237;duos com FC &#40;1&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; e controles saud&#225;veis &#40;controles&#44; 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&#40;momento 4&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#44; &#40;momento 5&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;1&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#46; <span class="elsevierStyleBold">2&#46;</span> Associa&#231;&#227;o do slope 3 com FC e controles considerando a idade&#46; &#40;momento 1&#41; 11 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;14&#44; 12 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805; 12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#44; 21 &#40;controles<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#44; 22 &#40;controles<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805; 12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#44; &#40;momento 2&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;09&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#44; &#40;momento 3&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#44; &#40;momento 4&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;08&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#44; &#40;momento 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;18&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#46; <span class="elsevierStyleBold">3&#46;</span> Associa&#231;&#227;o do volume do slope 3&#47;corrente com FC e controles considerando o sexo&#46; &#40;momento 1&#41; 11 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>masculino&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;14&#44; 12 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>feminino&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#44; 21 &#40;controles<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>masculino&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#44; 22 &#40;controles<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>feminino&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#44; &#40;momento 2&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;09&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#44; &#40;momento 3&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#44; &#40;momento 4&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;08&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#44; &#40;momento 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;18&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#46; &#40;momentos&#41; 1&#58; momento inicial do SMWT&#59; 2&#58; 1&#176; e 2&#176; minutos do SMWT&#59; 3&#58; 3&#176; e 4&#176; minutos do SMWT&#59; 4&#58; 5&#176; e 6&#176; minutos do SMWT&#59; 5&#58; ap&#243;s o SMWT&#59; SMWT&#58; exerc&#237;cio subm&#225;ximo por seis minutos em esteira&#59; TV&#58; volume corrente&#46; Usamos os testes de Mann&#8208;Whitney&#44; Kruskal&#8208;Wallis e Friedman&#46; Alfa<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; As medianas e o intervalo de confian&#231;a de 95&#37; est&#227;o representados nos gr&#225;ficos&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">A fibrose c&#237;stica &#40;FC&#41; &#40;OMIM&#58; n&#176; 219700&#41; apresenta decl&#237;nio progressivo da fun&#231;&#227;o pulmonar&#44; determinante da mortalidade dos pacientes&#46; Entretanto&#44; recentemente a FC tem apresentado progn&#243;sticos favor&#225;veis em indiv&#237;duos com melhor condicionamento aer&#243;bico e estado nutricional&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1&#44;2</span></a> Por esse motivo&#44; a busca por marcadores que indiquem as limita&#231;&#245;es ao exerc&#237;cio e que avaliem a deteriora&#231;&#227;o pulmonar progressiva tem sido explorada&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A FC apresenta envolvimento progressivo das vias a&#233;reas perif&#233;ricas &#91;zona silenciosa do pulm&#227;o&#93;&#44; considerando que os exames de fun&#231;&#227;o pulmonar convencionais s&#227;o ineficazes para avaliar a regi&#227;o corretamente&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">4&#44;5</span></a> Assim&#44; a capnografia volum&#233;trica &#40;VCap&#41; surge como op&#231;&#227;o para avaliar a press&#227;o parcial de di&#243;xido de carbono &#40;VCO<span class="elsevierStyleInf">2</span>&#41; no g&#225;s que entra e sai dos pulm&#245;es em rela&#231;&#227;o ao tempo e detectar a homogeneiza&#231;&#227;o da periferia pulmonar no in&#237;cio da elimina&#231;&#227;o do g&#225;s&#46; A VCap fornece &#237;ndices de transporte de g&#225;s nas vias a&#233;reas alveolares da periferia pulmonar&#44; ou seja&#44; slope 3&#46; Em suma&#44; a VCap apresenta baixo custo&#44; &#233; de f&#225;cil manuseio&#44; bem tolerada e n&#227;o exige manobras for&#231;adas ou de dif&#237;cil compreens&#227;o&#46; Al&#233;m disso&#44; ela pode detectar altera&#231;&#245;es pulmonares precoces&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Portanto&#44; o objetivo deste estudo &#233; avaliar a din&#226;mica respirat&#243;ria de crian&#231;as e adolescentes controle saud&#225;veis e aquelas com FC em um protocolo de exerc&#237;cio subm&#225;ximo por seis minutos em esteira &#40;SMWT&#41; considerando os par&#226;metros da VCap &#91;slope 3&#44; slope3&#47;volume corrente exalado &#40;slope 3&#47;TV&#41; e slope 2&#93;&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Fizemos um estudo transversal com 128 indiv&#237;duos&#44; 64 portadores de FC e 64 volunt&#225;rios controle saud&#225;veis&#46; Inclu&#237;mos indiv&#237;duos com FC que concordaram em participar do estudo e que atendiam aos crit&#233;rios de inclus&#227;o&#46; O consentimento informado foi obtido de todos os participantes individuais inclu&#237;dos no estudo&#46; O estudo seguiu os crit&#233;rios &#233;ticos da Conven&#231;&#227;o de Helsinque e foi aprovado pelo Comit&#234; de &#201;tica da institui&#231;&#227;o &#40;n&#176; 1182&#47;2009&#41;&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Grupo de indiv&#237;duos com fibrose c&#237;stica</span><p id="par0025" class="elsevierStylePara elsevierViewall">Os crit&#233;rios de inclus&#227;o foram&#58; idade entre seis e 25 anos&#59; diagn&#243;stico de FC por dois testes de suor com concentra&#231;&#245;es de cloreto acima de 60 mEq&#47;L e&#47;ou presen&#231;a de duas muta&#231;&#245;es no gene do Regulador de Condut&#226;ncia Transmembrana da Fibrose C&#237;stica &#40;RTFC&#41;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3&#44;7&#44;8</span></a> e estabilidade cl&#237;nica&#46; A estabilidade cl&#237;nica foi controlada por dois escores cl&#237;nicos&#58; Escore Cl&#237;nico da Funda&#231;&#227;o de Fibrose C&#237;stica e Escore Cl&#237;nico de Fibrose C&#237;stica<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">9&#44;10</span></a> e a gravidade da doen&#231;a foi classificada segundo o escore de Shwachman&#8208;kulczycki&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Grupo de controle</span><p id="par0030" class="elsevierStylePara elsevierViewall">Indiv&#237;duos saud&#225;veis entre seis e 25 anos foram selecionados aleatoriamente entre estudantes de escolas p&#250;blicas e particulares localizadas nas proximidades da universidade&#46; Os participantes responderam um question&#225;rio sobre condi&#231;&#245;es de sa&#250;de e nenhum apresentava doen&#231;a respirat&#243;ria aguda ou modifica&#231;&#227;o nas vari&#225;veis espirom&#233;tricas&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Capnografia volum&#233;trica</span><p id="par0035" class="elsevierStylePara elsevierViewall">Os indiv&#237;duos passaram por VCap em uma esteira&#46; Na VCap&#44; usamos o monitor Co<span class="elsevierStyleInf">2</span>smo Plus Dx&#8208;8100 &#40;Novametrix&#44; Medical Systems&#44; EUA&#41;&#44; que avaliou os participantes quatro minutos antes do SMWT&#44; seis minutos durante o SMWT e quatro minutos depois do teste&#46; O sistema n&#227;o &#233; invasivo e &#233; composto por um monitor que cont&#233;m um capn&#243;grafo&#44; um ox&#237;metro de pulso e um pneumotac&#243;grafo&#46; As medi&#231;&#245;es de VCap e pneumotac&#243;grafo foram obtidas em tempo real pela an&#225;lise do g&#225;s expirado&#46; O Co<span class="elsevierStyleInf">2</span>smo Plus Dx&#8208;8100 foi conectado a um computador equipado com o <span class="elsevierStyleItalic">software</span> para registrar as medidas de fluxo&#44; volume&#44; press&#227;o&#44; press&#227;o&#8208;volume&#44; fluxo de volume&#44; VCap e curvas&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">O sensor do monitor foi conectado a uma mangueira e foi usado um clipe nasal para evitar a sa&#237;da de ar pelo nariz&#46; No fim da coleta&#44; uma sequ&#234;ncia off&#8208;line de ciclos respirat&#243;rios foi selecionada para admitir um coeficiente de varia&#231;&#227;o do TV inferior a 25&#37; do TV m&#233;dio e foi admitido um coeficiente de varia&#231;&#227;o inferior a 10&#37; em mil&#237;metros de merc&#250;rio &#40;mmHg&#41; para tens&#227;o de di&#243;xido de carbono&#160;no fim da&#160;expira&#231;&#227;o&#160;&#40;EtCO<span class="elsevierStyleInf">2</span>&#41;&#46; Os ciclos respirat&#243;rios com valor zero para o slope 3 foram eliminados&#46; O resultado foi obtido da m&#233;dia de vari&#225;veis durante o tempo de monitoramento&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3&#44;5&#44;9</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Neste estudo&#44; analisamos as medidas&#58; &#40;i&#41; TV&#58; volume de ar exalado em uma respira&#231;&#227;o&#44; medido em mililitros &#40;mL&#41;&#59; &#40;ii&#41; Slope da fase II da curva VCap &#40;slope 2&#41;&#58; medido em mil&#237;metros de merc&#250;rio por litro &#40;mmHg&#47;L&#41;&#59; &#40;iii&#41; Slope da fase III da curva VCap &#40;slope 3&#41;&#58; medido em mmHg&#47;L&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Exerc&#237;cio subm&#225;ximo por seis minutos em esteira &#40;SMWT&#41;</span><p id="par0050" class="elsevierStylePara elsevierViewall">Antes de iniciar o SMWT na esteira&#44; foi feita a avalia&#231;&#227;o antropom&#233;trica&#44; que incluiu peso &#40;kg&#41;&#44; altura &#40;cm&#41; e c&#225;lculo do &#237;ndice de massa corporal &#40;IMC&#41;&#46; Os participantes caminharam em uma esteira &#40;Caloi Electronics&#174; Pro CL 5004&#44; SP&#44; Brasil&#41; por seis minutos para analisar o comportamento das vari&#225;veis da VCap&#46; O SMWT come&#231;ou com a esteira parada&#46; Houve um aumento progressivo da velocidade&#44; a cada minuto&#44; de acordo com a toler&#226;ncia do indiv&#237;duo para continuar a caminhar&#44; sem correr e com respeito ao esfor&#231;o subm&#225;ximo de cada um&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3&#44;10</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Imediatamente antes do SMWT&#44; o participante permaneceu em repouso por quatro minutos para avaliar a VCap&#46; Ent&#227;o&#44; o SMWT foi iniciado e os dados da VCap foram medidos durante o teste&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">O exerc&#237;cio foi acompanhado de est&#237;mulos verbais&#44; no primeiro minuto e no fim de cada minuto&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">O protocolo de exerc&#237;cio teve como base o SMWT e protocolos desenvolvidos para esteira&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3&#44;10&#8211;15</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">An&#225;lise estat&#237;stica</span><p id="par0070" class="elsevierStylePara elsevierViewall">Em todo momento da avalia&#231;&#227;o durante os exerc&#237;cios&#44; os dados da VCap s&#227;o apresentados pela m&#233;dia&#44; desvio&#8208;padr&#227;o&#44; mediana&#44; m&#237;nimo&#44; m&#225;ximo e intervalo de confian&#231;a da m&#233;dia&#46; Os momentos avaliados foram&#58; 1&#58; momento inicial do SMWT&#59; 2&#58; 1&#176; e 2&#176; minutos do SMWT&#59; 3&#58; 3&#176; e 4&#176; minutos do SMWT&#59; 4&#58; 5&#176; e 6&#176; minutos do SMWT&#59; 5&#58; ap&#243;s o SMWT&#46; A an&#225;lise estat&#237;stica foi feita no <span class="elsevierStyleItalic">software</span> Statistical Package for the Social Sciences&#44; vers&#227;o 24 &#40;IBM Corp&#46; Lan&#231;ado em 2016&#46; IBM SPSS Statistics for Windows&#44; Vers&#227;o 24&#46;0&#46; Armonk&#44; NY&#58; IBM Corp&#46;&#41; pelos testes de Friedman&#44; Mann&#8208;Whitney e Kruskal&#8208;Wallis&#46; As an&#225;lises consideraram a idade e o sexo dos indiv&#237;duos&#46; Alfa<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Resultados</span><p id="par0075" class="elsevierStylePara elsevierViewall">Nos grupos FC e controle&#44; slope 3&#44; slope 3&#47;TV e slope 2 apresentaram diferen&#231;a entre os momentos analisados &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; O slope 3 apresentou diferen&#231;as entre os valores na FC e nos controles nos momentos 1&#44; 3&#44; 4 e 5 &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#44; ao passo que o slope 3&#47;TV apresentou diferen&#231;a entre os valores na FC e nos controles em todos os momentos &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#59; <a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Considerando os indiv&#237;duos por idade&#44; o slope 3 apresentou diferen&#231;a na FC entre os momentos analisados independentemente da idade&#44; ao passo que os controles apresentaram diferen&#231;a somente nos indiv&#237;duos com idade &#8805; 12 anos &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a> e <a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; O slope 3&#47;TV apresentou diferen&#231;a na FC e nos controles&#44; independentemente da idade&#44; entre os momentos analisados &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a> e <a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; O slope 3&#44; slope 3&#47;TV e slope 2 conseguiram diferenciar os grupos &#40;FC e controles&#41; em todos os momentos e an&#225;lises&#44; quando as faixas et&#225;rias foram atribu&#237;das &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Considerando o sexo&#44; n&#227;o foi observada diferen&#231;a entre os momentos no slope 3 e no slope 3&#47;TV de controles do sexo feminino &#40;p<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#59; <a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; Por outro lado&#44; o slope 2 apresentou diferen&#231;a entre os momentos apenas para FC no sexo feminino &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46; O slope 3 e o slope 3&#47;TV conseguiram diferenciar os grupos &#40;FC e controles&#41; em todos os momentos e an&#225;lises&#44; quando o sexo foi considerado &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discuss&#227;o</span><p id="par0085" class="elsevierStylePara elsevierViewall">Acreditamos que esta &#233; a primeira vez em que a avalia&#231;&#227;o da resposta dos par&#226;metros da VCap &#233; destacada durante o exerc&#237;cio em indiv&#237;duos saud&#225;veis e portadores de FC&#46; O estudo demonstra a possibilidade de se obter marcadores de um modo n&#227;o invasivo e por meio de um protocolo de esfor&#231;o subm&#225;ximo toler&#225;vel pelos participantes&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Especificamente&#44; a VCap obteve v&#225;rios &#237;ndices&#44; como o slope 3&#44; que fornece dados sobre a din&#226;mica do transporte de g&#225;s nas vias a&#233;reas alveolares da periferia pulmonar&#46; A inclina&#231;&#227;o do slope 3 &#233; determinada pela natureza do esvaziamento das unidades alveolares&#58; s&#237;ncrono ou ass&#237;ncrono&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">16&#44;17</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">O esvaziamento de modo s&#237;ncrono acontece quando o g&#225;s &#233; expirado simultaneamente dos alv&#233;olos&#44; resulta em uma curva horizontal na fase III ou com inclina&#231;&#227;o m&#237;nima&#46; Por outro lado&#44; se as unidades alveolares s&#227;o esvaziadas de modo ass&#237;ncrono&#44; ou seja&#44; com constantes de tempo mais longas e elevam o PCO<span class="elsevierStyleInf">2</span>&#44; ocorre o esvaziamento de forma sequencial ou tardia&#44; resulta em uma inclina&#231;&#227;o cada vez maior do slope 3&#46; O slope 3 depende dos v&#225;rios padr&#245;es de esvaziamento dos alv&#233;olos com diferentes raz&#245;es ventila&#231;&#227;o&#47;perfus&#227;o &#40;V&#47;Q&#41;&#44; como a elimina&#231;&#227;o cont&#237;nua de CO<span class="elsevierStyleInf">2</span> nos alv&#233;olos&#44; faz da VCap uma ferramenta &#250;til na detec&#231;&#227;o de anomalias no desajuste entre V&#47;Q&#46;<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">9&#44;18&#44;19</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">O slope 3 apresenta valores maiores na FC&#44; indica heterogeneidade de ventila&#231;&#227;o nos espa&#231;os a&#233;reos distais em compara&#231;&#227;o com os controles&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5&#44;17</span></a> Veronez et al&#46; descreveram que o aumento no slope 3 em indiv&#237;duos com bronquiectasia&#44; relacionada ou n&#227;o &#224; FC&#44; indicava uma doen&#231;a difusa nas pequenas vias a&#233;reas&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">O comportamento do slope 3 durante o exerc&#237;cio f&#237;sico feito nessa pesquisa foi semelhante nos grupos FC e controle&#46; Houve uma queda nos valores do &#237;ndice durante o exerc&#237;cio f&#237;sico&#44; seguida de uma r&#225;pida recupera&#231;&#227;o&#46; Contudo&#44; os valores maiores da inclina&#231;&#227;o do slope 3 provavelmente ocorreram na FC devido &#224; reten&#231;&#227;o maior de di&#243;xido de carbono exalado &#40;VCO<span class="elsevierStyleInf">2</span>&#41;&#44; por&#233;m precisamos considerar outra hip&#243;tese&#44; como esvaziamento precoce das regi&#245;es do espa&#231;o morto alveolar &#40;raz&#227;o V&#47;Q&#41; e varia&#231;&#245;es no d&#233;bito card&#237;aco&#46; Portanto&#44; a FC aumentou os valores do slope 3 durante a avalia&#231;&#227;o&#44; indicou a heterogeneidade da ventila&#231;&#227;o inicialmente&#44; durante o repouso&#46; Esse fato justifica&#8208;se na FC pela produ&#231;&#227;o e reten&#231;&#227;o maiores de CO<span class="elsevierStyleInf">2</span>&#44; pelo aumento na resist&#234;ncia das vias a&#233;reas&#44; pela redu&#231;&#227;o na capacidade residual funcional e pelas altera&#231;&#245;es no d&#233;bito card&#237;aco durante o exerc&#237;cio f&#237;sico &#8211; esses fatores podem afetar a raz&#227;o VQ e influenciar a estatura&#47;slope 3&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">20&#8211;23</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">Ainda considerando o slope 3&#44; alguns autores sugerem a padroniza&#231;&#227;o por TV&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">5&#44;6&#44;9</span></a> Almeida et al&#46; observaram maior slope 3&#47;TV em indiv&#237;duos com asma em compara&#231;&#227;o com os controles&#44; sugeriram a heterogeneidade de ventila&#231;&#227;o nos espa&#231;os a&#233;reos distais e indicaram dist&#250;rbios estruturais cr&#244;nicos das vias a&#233;reas e altera&#231;&#245;es revers&#237;veis agudas observadas no teste de broncoprovoca&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a> Al&#233;m disso&#44; Ribeiro et al&#46;&#44; ao usar espirometria e a VCap para avaliar a fun&#231;&#227;o pulmonar na FC&#44; identificaram um aumento do slope 3&#47;TV&#44; mesmo em indiv&#237;duos com espirometria normal&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> Essa pesquisa corrobora essas discuss&#245;es e identificou maior slope 3&#47;TV durante o exerc&#237;cio f&#237;sico na FC&#44; quando comparado com os controles&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">O slope 3 e&#47;ou o slope 3&#47;TV mostram associa&#231;&#227;o at&#233; mesmo na FC em idade menor do que 12 anos&#46; Assim&#44; desde muito cedo&#44; a FC apresenta altera&#231;&#227;o na din&#226;mica respirat&#243;ria&#44; por&#233;m sem comprometer o desempenho da atividade f&#237;sica&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Foram observadas v&#225;rias caracter&#237;sticas sobre a fisiologia do esfor&#231;o f&#237;sico&#44; considerando a faixa et&#225;ria e o sexo&#46; Nessa linha&#44; constatamos que os valores mais altos de slope 3 ocorreram em FC do sexo masculino&#46; Contudo&#44; ao normalizar para TV &#40;slope 3&#47;TV&#41;&#44; os valores mais altos ocorrem em FC do sexo feminino&#46; Essa observa&#231;&#227;o se deve ao aumento do consumo m&#225;ximo de oxig&#234;nio &#40;VO<span class="elsevierStyleInf">2</span>max&#41; em termos absolutos ao longo do tempo&#44; com maior acelera&#231;&#227;o em meninos do que meninas&#46; Esse evento est&#225; intimamente relacionado ao aumento da massa muscular&#44; de forma que&#44; ao considerar o VO<span class="elsevierStyleInf">2</span>max determinado pelos indicadores de massa muscular&#44; n&#227;o h&#225; aumento com a idade em crian&#231;as e adolescentes do sexo masculino &#40;VO<span class="elsevierStyleInf">2</span>max&#47;kg &#8211; peso corporal constante&#41;&#44; ao passo que h&#225; uma leve redu&#231;&#227;o em meninas &#40;redu&#231;&#227;o no VO<span class="elsevierStyleInf">2</span>max&#47;kg &#8211; peso corporal&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">24&#8211;26</span></a> Assim&#44; a energia anaer&#243;bica n&#227;o difere entre os sexos nos pr&#233;&#8208;p&#250;beres&#44; por&#233;m aumenta proporcionalmente em meninos a partir da puberdade&#46; Tudo isso se deve ao desenvolvimento da massa muscular e ao efeito de matura&#231;&#227;o hormonal sobre as caracter&#237;sticas musculoesquel&#233;ticas funcionais&#46;<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">27&#8211;30</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">Embora a FC tenha apresentado redu&#231;&#227;o da ventila&#231;&#227;o alveolar e varia&#231;&#227;o na raz&#227;o V&#47;Q &#8211; dados comprovados pela inclina&#231;&#227;o na curva do slope 3 &#8211;&#44; eles conseguiram fazer o protocolo de exerc&#237;cio f&#237;sico sem complica&#231;&#245;es&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">A VCap n&#227;o &#233; amplamente usada na pr&#225;tica cl&#237;nica&#44; principalmente devido ao pouco entendimento dos dados obtidos e &#224; exist&#234;ncia de poucos estudos publicados&#46; Neste estudo&#44; foi descrito o comportamento do slope 2 e slope 3 durante o exerc&#237;cio f&#237;sico subm&#225;ximo em pacientes com FC e foi identificado que os pacientes apresentam altera&#231;&#245;es funcionais a partir do per&#237;odo inicial&#44; que se acentuam durante o exerc&#237;cio&#46; Al&#233;m disso&#44; embora n&#227;o tenha sido observada homogeneidade de ventila&#231;&#227;o na periferia pulmonar na FC&#44; os pacientes conseguiram fazer exerc&#237;cios subm&#225;ximos em curtos per&#237;odos&#46; Os dados do slope 2 e slope 3 mostraram que&#44; mesmo em pacientes assintom&#225;ticos&#44; h&#225; altera&#231;&#245;es nas fun&#231;&#245;es pulmonares&#44; que indicam a necessidade de interven&#231;&#227;o precoce para minimizar a degrada&#231;&#227;o pulmonar cr&#244;nica&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Por fim&#44; a an&#225;lise dos par&#226;metros de VCap pode demonstrar que os indiv&#237;duos com FC t&#234;m altera&#231;&#245;es na din&#226;mica respirat&#243;ria durante o exerc&#237;cio f&#237;sico e que essa altera&#231;&#227;o est&#225; relacionada aos espa&#231;os a&#233;reos distais com heterogeneidade de gases liberados&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Financiamento</span><p id="par0140" class="elsevierStylePara elsevierViewall">Funda&#231;&#227;o de Amparo &#224; Pesquisa do Estado de S&#227;o Paulo &#40;Fapesp&#41;&#44; apoio &#224; pesquisa e bolsas de estudo &#40;n&#176; 2011&#47;12939&#8208;4&#44; 2011&#47;18845&#8208;1&#44; 2015&#47;12183&#8208;8 e 2015&#47;12858&#8208;5 para FALM e JDR&#41;&#59; Fundo de Apoio &#224; Pesquisa&#44; ao Ensino e &#224; Extens&#227;o da Universidade Estadual de Campinas&#44; apoio &#224; pesquisa &#40;n&#176; 0648&#47;2015 para FALM&#41;&#46; Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#40;CNPq&#41;&#44; bolsa de estudo para PLFP&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflitos de interesse</span><p id="par0145" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflitos de interesse&#46;</p></span></span>"
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              "titulo" => "Grupo de indiv&#237;duos com fibrose c&#237;stica"
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              "titulo" => "Grupo de controle"
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              "titulo" => "Capnografia volum&#233;trica"
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              "identificador" => "sec0030"
              "titulo" => "Exerc&#237;cio subm&#225;ximo por seis minutos em esteira &#40;SMWT&#41;"
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    "fechaRecibido" => "2017-07-17"
    "fechaAceptado" => "2017-10-20"
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            0 => "Breath"
            1 => "CFTR"
            2 => "Exercise"
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            4 => "Slope 2"
            5 => "Slope 3"
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          "palabras" => array:6 [
            0 => "Respira&#231;&#227;o"
            1 => "CFTR"
            2 => "Exerc&#237;cio"
            3 => "Fun&#231;&#227;o pulmonar"
            4 => "Slope 2"
            5 => "Slope 3"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Volumetric capnography provides the standard CO<span class="elsevierStyleInf">2</span> elimination by the volume expired per respiratory cycle and is a measure to assess pulmonary involvement&#46; Thus&#44; the objective of this study was to evaluate the respiratory dynamics of healthy control subjects and those with cystic fibrosis in a submaximal exercise protocol for six minutes on the treadmill&#44; using volumetric capnography parameters &#40;slope 3 &#91;Slp3&#93;&#44; Slp3&#47;tidal volume &#91;Slp3&#47;TV&#93;&#44; and slope 2 &#91;Slp2&#93;&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This was a cross&#8208;sectional study with 128 subjects &#40;cystic fibrosis&#44; 64 subjects&#59; controls&#44; 64 subjects&#93;&#46; Participants underwent volumetric capnography before&#44; during&#44; and after six minutes on the treadmill&#46; Statistical analysis was performed using the Friedman&#44; Mann&#8211;Whitney&#44; and Kruskal&#8211;Wallis tests&#44; considering age and sex&#46; An alpha<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;05 was considered&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Six minutes on the treadmill evaluation&#58; in cystic fibrosis&#44; volumetric capnography parameters were different before&#44; during&#44; and after six minutes on the treadmill&#59; the same was observed for the controls&#44; except for Slp2&#46; Regarding age&#44; an Slp3 difference was observed in cystic fibrosis patients regardless of age&#44; at all moments&#44; and in controls for age<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>12 years&#59; a difference in Slp3&#47;TV was observed in cystic fibrosis and controls&#44; regardless of age&#59; and an Slp2 difference in the cystic fibrosis&#44; regardless of age&#46; Regarding sex&#44; Slp3 and Slp3&#47;TV differences were observed in cystic fibrosis regardless of sex&#44; and in controls in male participants&#59; an Slp2 difference was observed in the cystic fibrosis and female participants&#46; The analysis between groups &#40;cystic fibrosis and controls&#41; indicated that Slp3 and Slp3&#47;TV has identified the CF&#44; regardless of age and sex&#44; while the Slp2 showed the CF considering age&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Cystic fibrosis showed greater values of the parameters before&#44; during&#44; and after exercise&#44; even when stratified by age and sex&#44; which may indicate ventilation inhomogeneity in the peripheral pathways in the cystic fibrosis&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A capnografia volum&#233;trica fornece o padr&#227;o de elimina&#231;&#227;o do CO<span class="elsevierStyleInf">2</span>&#44; pelo volume expirado por ciclo respirat&#243;rio e avalia o comprometimento pulmonar&#46; O objetivo do estudo foi avaliar a din&#226;mica respirat&#243;ria de indiv&#237;duos controles saud&#225;veis e em indiv&#237;duos com fibrose c&#237;stica&#44; em um protocolo de exerc&#237;cio subm&#225;ximo por seis minutos em esteira&#44; por par&#226;metros da capnografia volum&#233;trica &#91;slope 3&#40;Slp3&#41;&#44; Slp3&#47;volume corrente &#40;Slp3&#47;TV&#41; e slope 2&#40;Slp2&#41;&#93;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudo de corte transversal com 128 indiv&#237;duos &#91;&#40;fibrose c&#237;stica&#41; 64 indiv&#237;duos&#59; &#40;controles&#41; 64 indiv&#237;duos&#93;&#46; Os participantes realizaram capnografia volum&#233;trica antes&#44; durante e ap&#243;s seis minutos em esteira&#46; An&#225;lise estat&#237;stica realizada pelos testes de Friedman&#44; Mann-Whitney e Kruskal-Wallis&#44; considerado a idade e o sexo&#46; Alpha<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Avalia&#231;&#227;o de seis minutos em esteira&#58; na fibrose c&#237;stica&#44; os par&#226;metros da capnografia volum&#233;trica foram diferentes antes&#44; durante e ap&#243;s seis minutos em esteira&#44; o mesmo ocorreu nos controles&#44; exceto para o Slp2&#46; Considerando a idade&#58; &#40;Slp3&#41; diferen&#231;a na FC&#44; independentemente da idade&#44; em todos os momentos e nos controles apenas para &#8805; 12 anos&#59; &#40;Slp3&#47;TV&#41; diferen&#231;a para fibrose c&#237;stica e controles independentemente da idade&#59; &#40;Slp2&#41; diferen&#231;a apenas para o grupo fibrose c&#237;stica&#44; independentemente da idade&#46; Considerando o sexo&#58; &#40;Slp3 e Slp3&#47;TV&#41; diferen&#231;a para fibrose c&#237;stica&#44; independentemente do sexo&#44; e controles apenas no sexo masculino&#59; &#40;Slp2&#41; diferen&#231;a para fibrose c&#237;stica e sexo feminino&#46; An&#225;lise entre grupos &#40;fibrose c&#237;stica <span class="elsevierStyleItalic">versus</span> controles&#41;&#58; Slp3 e Slp3&#47;TV identificou a fibrose c&#237;stica&#44; independentemente da idade e sexo&#44; enquanto o Slp2 evidenciou a fibrose c&#237;stica considerando a idade&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A fibrose c&#237;stica apresentou maiores valores dos par&#226;metros antes&#44; durante e ap&#243;s exerc&#237;cio&#44; inclusive quando se considerou idade e sexo&#44; podendo indicar n&#227;o homogeneidade da distribui&#231;&#227;o da ventila&#231;&#227;o nas vias perif&#233;ricas&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Como citar este artigo&#58; Parazzi PL&#44; Marson FA&#44; Ribeiro MA&#44; Schivinski CI&#44; Ribeiro JD&#46; Evaluation of respiratory dynamics by volumetric capnography during submaximal exercise protocol of six minutes on treadmill in cystic fibrosis patients&#46; J Pediatr &#40;Rio J&#41;&#46; 2019&#59;95&#58;76&#8211;86&#46;</p>"
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          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Associa&#231;&#227;o da capnografia volum&#233;trica entre indiv&#237;duos com fibrose c&#237;stica&#46; <span class="elsevierStyleBold">A&#46;</span> Associa&#231;&#227;o do slope 3 entre indiv&#237;duos com fibrose c&#237;stica &#40;FC&#44; 1&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; e os controles saud&#225;veis &#40;2&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; considerando a idade e o sexo em diferentes momentos da capnografia volum&#233;trica&#46; <span class="elsevierStyleBold">1&#46;</span> Associa&#231;&#227;o do slope 3 com FC e controles&#46; &#40;momento 1&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>34&#44;5&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#44;15&#44; &#40;momento 2&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#44;29&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#44;75&#44; &#40;momento 3&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>26&#44;41&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44;4&#44; &#40;momento 4&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#44;74&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#44;31&#44; &#40;momento 5&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>33&#44;77&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#44;57&#46; <span class="elsevierStyleBold">2&#46;</span> Associa&#231;&#227;o do slope 3 com FC e controles considerando a idade&#46; &#40;momento 1&#41; 11 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>38&#44;04&#44; 12 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805; 12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>31&#44;6&#44; 21 &#40;controles<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#44;63&#44; 22 &#40;controles<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805; 12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44;05&#44; &#40;momento 2&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>32&#44;01&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&#44;13&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#44;04&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#44;84&#44; &#40;momento 3&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#44;09&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#44;56&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44;5&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44;9&#44; &#40;momento 4&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>28&#44;51&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#44;06&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44;54&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>9&#44;37&#44; &#40;momento 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>36&#44;84&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#44;52&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#44;84&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#44;21&#46; <span class="elsevierStyleBold">3&#46;</span> Associa&#231;&#227;o do slope 3 com FC e controles considerando o sexo&#46; &#40;momento 1&#41; 11 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>masculino&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>34&#44;5&#44; 12 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>feminino&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>34&#44;1&#44; 21 &#40;controles<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>masculino&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>17&#44;25&#44; 22 &#40;controles<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>feminino&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>15&#44;29&#44; &#40;momento 2&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#44;96&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#44;29&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19&#44;67&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#44;32&#44; &#40;momento 3&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#44;97&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#44;32&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#44;96&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44;84&#44; &#40;momento 4&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>24&#44;02&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>23&#44;74&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#44;72&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44;76&#44; &#40;momento 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>37&#44;12&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>32&#44;31&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#44;87&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>11&#44;37&#46; <span class="elsevierStyleBold">B&#46;</span> Associa&#231;&#227;o do volume do Slope 3&#47;corrente entre indiv&#237;duos com FC &#40;1&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; e controles saud&#225;veis &#40;controles&#44; 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&#40;momento 4&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#44; &#40;momento 5&#41; 1<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;1&#44; 2<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#46; <span class="elsevierStyleBold">2&#46;</span> Associa&#231;&#227;o do slope 3 com FC e controles considerando a idade&#46; &#40;momento 1&#41; 11 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;14&#44; 12 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#8805; 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&#40;momento 5&#41; 11<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;18&#44; 12<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#44; 21<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#44; 22<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#46; <span class="elsevierStyleBold">3&#46;</span> Associa&#231;&#227;o do volume do slope 3&#47;corrente com FC e controles considerando o sexo&#46; &#40;momento 1&#41; 11 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>masculino&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;14&#44; 12 &#40;FC<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>feminino&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;07&#44; 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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">1&#44; momento inicial do SMWT&#59; 2&#44; 1&#176; e 2&#176; minutos do SMWT&#59; 3&#44; 3&#176; e 4&#176; minutos do SMWT&#59; 4&#44; 5&#176; e 6&#176; minutos do SMWT&#59; 5&#44; ap&#243;s o SMWT&#59; DP&#44; desvio&#8208;padr&#227;o&#59; IC&#44; intervalo de confian&#231;a&#59; SMWT&#44; exerc&#237;cio subm&#225;ximo por seis minutos em esteira&#46; Alfa<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Usamos os testes de Mann&#8208;Whitney e Friedman&#46; Dados com valores de p positivos apresentados em negrito&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Marcadores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Grupo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Momento</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " rowspan="5" align="left" valign="top">Slope 3</td><td class="td" title="table-entry  " align="left" valign="top">Fibrose c&#237;stica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#44;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#44;98<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#44;05<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001 &#40;1 &#8800; 2&#44; 3 e 4&#59; 4 &#8800; 1 e 5&#59; 5 &#8800; 3 e 4&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#44;5<br>5<br>140&#44;1<br>31&#44;58 a 43&#44;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#44;29<br>6&#44;05<br>246&#44;48<br>26&#44;76 a 44&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#44;41<br>6&#44;24<br>99&#44;47<br>25&#44;71 a 36&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#44;74<br>6&#44;51<br>99&#44;34<br>25&#44;36 a 36&#44;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#44;77<br>6&#44;85<br>170&#44;58<br>30&#44;55 a 45&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#44;95<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#44;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44;49<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#44;55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44;24<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#44;019 &#40;1 &#8800; 3&#44; 4 e 5&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16&#44;15<br>1&#44;5<br>91<br>16&#44;45 a 25&#44;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;75<br>4&#44;63<br>147&#44;71<br>15&#44;13 a 25&#44;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;4<br>4&#44;58<br>97&#44;61<br>13&#44;28 a 23&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;31<br>3&#44;5<br>78&#44;08<br>13&#44;52 a 21&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;57<br>1<br>163&#44;67<br>12&#44;71 a 23&#44;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;052&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="9" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="5" align="left" valign="top">Slope 3&#47;volume corrente</td><td class="td" title="table-entry  " align="left" valign="top">Fibrose c&#237;stica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;15<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;17<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;1 &#8800; 2&#44; 3 e 4&#59; 4 &#8800; 1 e 5&#59; 5 &#8800; 3 e 4&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;13<br>0&#44;01<br>1&#44;4<br>0&#44;11 a 0&#44;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;06<br>0&#44;01<br>3&#44;04<br>0&#44;05 a 0&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;06<br>0<br>0&#44;54<br>0&#44;07 a 0&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;05<br>0<br>0&#44;52<br>0&#44;07 a 0&#44;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;1<br>0&#44;01<br>2&#44;05<br>0&#44;1 a 0&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;05<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;05<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001 &#40;1 &#8800; 3&#44; 4 e 5&#41;</span><br></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;04<br>0<br>0&#44;67<br>0&#44;04 a 0&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<br>0<br>1&#44;74<br>0&#44;01 a 0&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<br>0<br>0&#44;76<br>0&#44;02 a 0&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<br>0<br>0&#44;85<br>0&#44;02 a 0&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<br>0<br>1&#44;41<br>0&#44;02 a 0&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="9" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="5" align="left" valign="top">Slope 2</td><td class="td" title="table-entry  " align="left" valign="top">Fibrose c&#237;stica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">487&#44;55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#44;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">449&#44;93<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">450&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">443&#44;29<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">483&#44;63<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#44;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;1 &#8800; 2&#44; 3 e 4&#59; 4 &#8800; 1 e 5&#59; 5 &#8800; 3 e 4&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">480&#44;63<br>140<br>940&#44;17<br>444&#44;43 a 530&#44;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">439&#44;04<br>147&#44;49<br>1003&#44;17<br>409&#44;39 a 490&#44;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">402&#44;71<br>167&#44;4<br>1070&#44;96<br>407&#44;95 a 493&#44;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">385&#44;18<br>161&#44;66<br>1173&#44;23<br>395&#44;28 a 491&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">462&#44;7<br>139<br>1366&#44;24<br>433&#44;84 a 533&#44;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">455&#44;95<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>21&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">415&#44;73<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#44;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">408&#44;27<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">409&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">428&#44;99<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>19&#44;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#44;101<br></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">440&#44;06<br>225&#44;88<br>1215&#44;58<br>413&#44;64 a 498&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">401&#44;39<br>228&#44;65<br>791&#44;22<br>385&#44;04 a 446&#44;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">380&#44;12<br>207&#44;82<br>816&#44;03<br>374&#44;53 a 442&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">388&#44;58<br>207&#44;76<br>779&#44;63<br>376&#44;75 a 441&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">400&#44;36<br>240&#44;28<br>1184&#44;37<br>389&#44;72 a 468&#44;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;596&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;596&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;216&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;052&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab1943343.png"
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        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Associa&#231;&#227;o do slope 3&#44; slope 3&#47;TV e slope 2 entre os indiv&#237;duos com fibrose c&#237;stica &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; e os controles saud&#225;veis &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; em diferentes momentos da capnografia volum&#233;trica</p>"
        ]
      ]
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        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">1&#44; momento inicial do SMWT&#59; 2&#44; 1&#176; e 2&#176; minutos do SMWT&#59; 3&#44; 3&#176; e 4&#176; minutos do SMWT&#59; 4&#44; 5&#176; e 6&#176; minutos do SMWT&#59; 5&#44; ap&#243;s o SMWT&#59; DP&#44; desvio&#8208;padr&#227;o&#59; IC&#44; intervalo de confian&#231;a&#59; SMWT&#44; exerc&#237;cio subm&#225;ximo por seis minutos em esteira&#46; Alfa<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Usamos os testes de Kruskal&#8208;Wallis e Friedman&#46; Dados com valores de p positivos apresentados em negrito&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Marcadores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Grupo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Momento</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " rowspan="9" align="left" valign="top">Slope 3</td><td class="td" title="table-entry  " align="left" valign="top">Fibrose c&#237;stica<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos de idade<br>&#40;A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44&#44;69<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">45&#44;79<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#44;29<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#44;76<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44&#44;38<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#44;034 &#40;3 &#8800; 1&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#44;04<br>16&#44;38<br>140&#44;1<br>34&#44;59 a 54&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&#44;01<br>15&#44;4<br>246&#44;48<br>27&#44;6 a 63&#44;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#44;09<br>13&#44;25<br>99&#44;47<br>26&#44;95 a 45&#44;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;51<br>12&#44;15<br>99&#44;34<br>28&#44;55 a 46&#44;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#44;84<br>11&#44;71<br>135&#44;6<br>33&#44;9 a 54&#44;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos de idade<br>&#40;B&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#44;57<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">25&#44;32<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#44;35<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#44;63<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22&#44;85<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#44;445</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#44;63<br>1&#44;5<br>91<br>17&#44;43 a 31&#44;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#44;04<br>7&#44;17<br>147&#44;71<br>16&#44;58 a 34&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;5<br>7&#44;52<br>97&#44;61<br>14&#44;62 a 32&#44;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;54<br>6&#44;7<br>78&#44;08<br>15&#44;2 a 28&#44;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#44;84<br>1<br>163&#44;67<br>13&#44;6 a 32&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fibrose c&#237;stica &#8805; 12 anos de idade<br>&#40;C&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&#44;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;51<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#44;49<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#44;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#44;43<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#44;006 &#40;4 &#8800; 1&#44; 2&#44; 3&#44; 5&#41;</span><br></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">31&#44;6<br>5<br>102&#44;12<br>25&#44;11 a 39&#44;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44;13<br>6&#44;05<br>123&#44;5<br>20&#44;10 a 36&#44;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#44;56<br>6&#44;24<br>84&#44;87<br>20&#44;73 a 34&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#44;06<br>6&#44;51<br>85&#44;1<br>19&#44;09 a 32&#44;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#44;52<br>6&#44;85<br>170&#44;58<br>22&#44;80 a 44&#44;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles &#8805; 12 anos de idade<br>&#40;D&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#44;99<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;77<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;89<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;96<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;93<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#44;028 &#40;1 &#8800; 3&#44; 4&#44; 5&#41;</span><br></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;05<br>4&#44;79<br>39&#44;04<br>11&#44;91 a 20&#44;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44;84<br>4&#44;63<br>36&#44;72<br>10&#44;57 a 16&#44;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;9<br>4&#44;58<br>23&#44;6<br>9&#44;77 a 13&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;37<br>3&#44;5<br>36&#44;25<br>8&#44;92 a 15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44;21<br>1&#44;21<br>32&#44;95<br>9&#44;08 a 14&#44;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; B&#44; C&#44; D&#59; C &#8800; A&#44; B&#44; D&#59; B &#8800; A&#44; C&#59; D &#8800; A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#44;004</span><br><span class="elsevierStyleBold">&#40;A &#8800; B&#44; C&#44; D&#59; C &#8800; A&#44; D&#59; B &#8800; A&#44; D&#59; D &#8800; A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; B&#44; C&#44; D&#59; C &#8800; A&#44; D&#59; B &#8800; A&#44; D&#59; D &#8800; A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; B&#44; C&#44; D&#59; C &#8800; A&#44; D&#59; B &#8800; A&#44; D&#59; D &#8800; A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; B&#44; C&#44; D&#59; C &#8800; A&#44; B&#44; D&#59; B &#8800; A&#44; C&#44; D&#59; D &#8800; A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="9" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="9" align="left" valign="top">Slope 3&#47;volume corrente</td><td class="td" title="table-entry  " align="left" valign="top">Fibrose c&#237;stica<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos de idade<br>&#40;A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;21<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;15<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;14<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;1 e 5 &#8800; 2&#44; 3&#44; 4&#59; 2 &#8800; 1&#44; 3&#44; 5&#59; 3 &#8800; 1&#44; 2&#44; 5&#59; 4 &#8800; 1&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;14<br>0&#44;04<br>1&#44;4<br>0&#44;11 a 0&#44;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;09<br>0&#44;02<br>3&#44;04<br>0&#44;02 a 0&#44;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<br>0&#44;02<br>0&#44;54<br>0&#44;09 a 0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;08<br>0&#44;02<br>0&#44;52<br>0&#44;09 a 0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;18<br>0&#44;02<br>0&#44;98<br>0&#44;12 a 0&#44;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos de idade<br>&#40;B&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;09<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;09<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#44;005</span><br><span class="elsevierStyleBold">&#40;1 e 5 &#8800; 3&#44; 4&#59; 2 &#8800; 4&#59; 3 &#8800; 1&#44; 5&#59; 4 &#8800; 1&#44; 2&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;05<br>0<br>0&#44;67<br>0&#44;05 a 0&#44;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;03<br>0&#44;01<br>1&#44;74<br>0&#44;01 a 0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<br>0&#44;01<br>0&#44;76<br>0&#44;03 a 0&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<br>0&#44;01<br>0&#44;85<br>0&#44;02 a 0&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;03<br>0<br>1&#44;41<br>0&#44;02 a 0&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fibrose c&#237;stica &#8805; 12 anos de idade<br>&#40;C&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;08<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;1 e 5 &#8800; 2&#44; 3&#44; 4&#59; 2 e 3 &#8800; 1&#44; 4&#44; 5&#59; 4 &#8800; 1&#44; 2&#44; 3&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<br>0&#44;01<br>0&#44;64<br>0&#44;07 a 0&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;03<br>0&#44;01<br>0&#44;57<br>0&#44;04 a 0&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;03<br>0<br>0&#44;51<br>0&#44;04 a 0&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;03<br>0<br>0&#44;49<br>0&#44;03 a 0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<br>0&#44;01<br>2&#44;05<br>0&#44;04 a 0&#44;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles &#8805; 12 anos de idade<br>&#40;D&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;04<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;1 &#8800; 2&#44; 3&#44; 4&#44; 5&#59; 2 e 5 &#8800; 1&#44; 4&#59; 3 &#8800; 1&#59; 4 &#8800; 1&#44; 2&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<br>0&#44;01<br>0&#44;15<br>0&#44;02 a 0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;01<br>0<br>0&#44;07<br>0&#44;01 a 0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;01<br>0<br>0&#44;04<br>0&#44;01 a 0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;01<br>0<br>0&#44;08<br>0&#44;01 a 0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;01<br>0<br>0&#44;09<br>0&#44;01 a 0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; B&#44; C&#44; D&#59; C &#8800; A&#44; D&#59; B &#8800; A&#44; D&#59; D &#8800; A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; B&#44; C&#44; D&#59; C &#8800; A&#44; D&#59; B &#8800; A&#44; D&#59; D &#8800; A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; B&#44; C&#44; D&#59; C &#8800; A&#44; D&#59; B &#8800; A&#44; D&#59; D &#8800; A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; B&#44; C&#44; D&#59; C &#8800; A&#44; D&#59; B &#8800; A&#44; D&#59; D &#8800; A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; B&#44; C&#44; D&#59; C &#8800; A&#44; D&#59; B &#8800; A&#44; D&#59; D &#8800; A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="9" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="9" align="left" valign="top">Slope 2</td><td class="td" title="table-entry  " align="left" valign="top">Fibrose c&#237;stica<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos de idade<br>&#40;A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">562&#44;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#44;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">537&#44;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#44;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">534<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>32&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">529&#44;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>33&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">551&#44;43<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#44;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#44;017</span><br><span class="elsevierStyleBold">&#40;1 e 5 &#8800; 3&#44; 4&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">548&#44;63<br>332&#44;84<br>940&#44;17<br>503&#44;7 a 620&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">554&#44;58<br>340&#44;24<br>1003&#44;17<br>476&#44;35 a 598&#44;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">549&#44;36<br>279&#44;94<br>1070&#44;96<br>467&#44;59 a 600&#44;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">566&#44;16<br>277&#44;46<br>919&#44;83<br>459&#44;87 a 598&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">553&#44;21<br>304&#44;51<br>871&#44;09<br>492&#44;66 a 610&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>12 anos de idade<br>&#40;B&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">517&#44;42<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>30&#44;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">470&#44;71<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">460&#44;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">462&#44;76<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">490&#44;97<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#44;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#44;497</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">476&#44;5<br>273<br>1215&#44;58<br>455&#44;22 a 579&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">450&#44;06<br>272&#44;59<br>791&#44;22<br>428&#44;58 a 512&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">421&#44;89<br>287&#44;67<br>816&#44;03<br>410&#44;09 a 509&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">427<br>293&#44;25<br>779&#44;63<br>417&#44;23 a 508&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">462&#44;52<br>277&#44;14<br>1184&#44;37<br>432&#44;98 a 548&#44;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fibrose c&#237;stica &#8805; 12 anos de idade<br>&#40;C&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">432&#44;98<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">386&#44;08<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">390&#44;08<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#44;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">380&#44;49<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">434&#44;15<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>35&#44;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#44;003</span><br><span class="elsevierStyleBold">&#40;4 &#8800; 1&#44; 3&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">400&#44;21<br>140<br>833&#44;67<br>376&#44;17 a 489&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">381&#44;25<br>147&#44;49<br>708&#44;09<br>340&#44;18 a 431&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">347&#44;12<br>167&#44;4<br>924<br>340&#44;45 a 439&#44;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">366&#44;42<br>161&#44;66<br>1173&#44;23<br>320&#44;14 a 440&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">430&#44;06<br>139<br>1366&#44;24<br>361&#44;39 a 506&#44;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles &#8805; 12 anos de idade<br>&#40;D&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">371&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">340&#44;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">337&#44;35<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">335&#44;55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">344&#44;05<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#44;244</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">351<br>225&#44;88<br>602&#44;15<br>335&#44;07 a 408&#44;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">334&#44;85<br>228&#44;65<br>464&#44;55<br>314&#44;56 a 366&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">338&#44;1<br>207&#44;82<br>471&#44;01<br>311&#44;99 a 362&#44;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">340&#44;32<br>207&#44;76<br>519&#44;02<br>307&#44;34 a 363&#44;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">341&#44;68<br>240&#44;28<br>501&#44;23<br>315&#44;94 a 372&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; C&#44; D&#59; C &#8800; A&#44; B&#59; B &#8800; C&#44; D&#59; D &#8800; A&#44; B&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; C&#44; D&#59; C &#8800; A&#44; B&#59; B &#8800; C&#44; D&#59; D &#8800; A&#44; B&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; C&#44; D&#59; C &#8800; A&#44; B&#59; B &#8800; C&#44; D&#59; D &#8800; A&#44; B&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; C&#44; D&#59; C &#8800; A&#44; B&#59; B &#8800; C&#44; D&#59; D &#8800; A&#44; B&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A &#8800; C&#44; D&#59; C &#8800; A&#44; B&#44; D&#59; B &#8800; C&#44; D&#59; D &#8800; A&#44; B&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1943342.png"
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          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Associa&#231;&#227;o do slope 3&#44; slope 3&#47;TV e slope 2 entre os indiv&#237;duos com fibrose c&#237;stica &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; e os controles saud&#225;veis &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; considerando a idade em diferentes momentos da capnografia volum&#233;trica</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">1&#44; momento inicial do SMWT&#59; 2&#44; 1&#176; e 2&#176; minutos do SMWT&#59; 3&#44; 3&#176; e 4&#176; minutos do SMWT&#59; 4&#44; 5&#176; e 6&#176; minutos do SMWT&#59; 5&#44; ap&#243;s o SMWT&#59; DP&#44; desvio&#8208;padr&#227;o&#59; IC&#44; intervalo de confian&#231;a&#59; SMWT&#44; exerc&#237;cio subm&#225;ximo por seis minutos em esteira&#46; Alfa<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p><p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">Usamos os testes de Kruskal&#8208;Wallis e Friedman&#46; Dados com valores de p positivos apresentados em negrito&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Marcadores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Grupo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Momento</th><th class="td" title="table-head  " align="left" valign="top" scope="col">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " rowspan="9" align="left" valign="top">Slope 3</td><td class="td" title="table-entry  " align="left" valign="top">Fibrose c&#237;stica e masculino<br>&#40;A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#44;67<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&#44;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#44;97<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">28&#44;81<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&#44;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#44;008</span><br><span class="elsevierStyleBold">&#40;1 e 5 &#8800; 3&#44; 4&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#44;5<br>6&#44;95<br>140&#44;1<br>28&#44;23 a 47&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#44;96<br>9&#44;15<br>246&#44;48<br>21&#44;88 a 54&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#44;95<br>6&#44;65<br>81&#44;12<br>20&#44;91 a 35&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24&#44;02<br>6&#44;57<br>85&#44;66<br>21&#44;4 a 36&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#44;12<br>6&#44;85<br>84&#44;58<br>28&#44;14 a 42&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles e masculino<br>&#40;B&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#44;36<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#44;88<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#44;51<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#44;93<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#44;89<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#44;04</span><br><span class="elsevierStyleBold">&#40;3 &#8800; 1&#44; 2&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#44;25<br>1&#44;5<br>91<br>15&#44;81 a 30&#44;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19&#44;67<br>4&#44;82<br>147&#44;71<br>16&#44;05 a 37&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;96<br>4&#44;58<br>97&#44;61<br>12&#44;54 a 34&#44;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;72<br>3&#44;5<br>78&#44;08<br>13&#44;87 a 30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#44;87<br>4&#44;17<br>59&#44;21<br>14&#44;27 a 25&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fibrose c&#237;stica e feminino<br>&#40;C&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#44;55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#44;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#44;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#44;14<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40&#44;65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#44;029</span><br><span class="elsevierStyleBold">&#40;1 &#8800; 2&#44; 4&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#44;1<br>5<br>104&#44;26<br>29&#44;5 a 45&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#44;29<br>6&#44;05<br>105&#44;14<br>24&#44;51 a 42&#44;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">27&#44;32<br>6&#44;24<br>99&#44;47<br>25&#44;76 a 43&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&#44;74<br>6&#44;51<br>99&#44;34<br>24&#44;36 a 41&#44;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&#44;31<br>8&#44;14<br>170&#44;58<br>27&#44;13 a 54&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles e feminino<br>&#40;D&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44;83<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#44;77<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#44;06<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16&#44;79<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#44;230</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#44;29<br>4&#44;78<br>90&#44;04<br>13&#44;32 a 24&#44;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;32<br>4&#44;63<br>35&#44;56<br>12&#44;20 a 17&#44;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;84<br>4&#44;75<br>28&#44;5<br>12&#44;2 a 15&#44;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;76<br>4&#44;89<br>36&#44;25<br>11&#44;13 a 16&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;37<br>1<br>163&#44;67<br>7&#44;34 a 26&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A e C &#8800; B&#44; D&#59; B e D &#8800; A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#44;038</span><br><span class="elsevierStyleBold">&#40;A&#44; C&#44; B &#8800; D&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A e C &#8800; B&#44; D&#59; B e D &#8800; A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A e C &#8800; B&#44; D&#59; B e D &#8800; A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A e C &#8800; B&#44; D&#59; B e D &#8800; A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="9" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="9" align="left" valign="top">Slope 3&#47;volume corrente</td><td class="td" title="table-entry  " align="left" valign="top">Fibrose c&#237;stica e masculino<br>&#40;A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;21<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;25<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;15<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;14<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;1 e 5 &#8800; 2&#44; 3&#44; 4&#59; 2 &#8800; 1&#44; 4&#44; 5&#59; 3 &#8800; 1&#44; 5&#59; 4 &#8800; 1&#44; 2&#44; 5&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;14<br>0&#44;04<br>1&#44;4<br>0&#44;11 a 0&#44;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;09<br>0&#44;02<br>3&#44;04<br>0&#44;02 a 0&#44;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<br>0&#44;02<br>0&#44;54<br>0&#44;09 a 0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;08<br>0&#44;02<br>0&#44;52<br>0&#44;09 a 0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;18<br>0&#44;02<br>0&#44;98<br>0&#44;12 a 0&#44;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles e masculino<br>&#40;B&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;09<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;09<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#44;001<br>&#40;1&#44; 2 e 5 &#8800; 3&#44; 4&#41;</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;05<br>0<br>0&#44;67<br>0&#44;05 a 0&#44;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;03<br>0&#44;01<br>1&#44;74<br>0&#44;01 a 0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<br>0&#44;01<br>0&#44;76<br>0&#44;03 a 0&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<br>0&#44;01<br>0&#44;85<br>0&#44;02 a 0&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;03<br>0<br>1&#44;41<br>0&#44;02 a 0&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fibrose c&#237;stica e feminino<br>&#40;C&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;08<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001<br>&#40;1 e 5 &#8800; 2&#44; 3 e 4&#59; 2 &#8800; 1&#44; 4&#44; 5&#59; 3 &#8800; 1&#44; 5&#59; 4 &#8800; 1&#44; 2&#44; 5&#41;</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<br>0&#44;01<br>0&#44;64<br>0&#44;07 a 0&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;03<br>0&#44;01<br>0&#44;57<br>0&#44;04 a 0&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;03<br>0<br>0&#44;51<br>0&#44;04 a 0&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;03<br>0<br>0&#44;49<br>0&#44;03 a 0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;07<br>0&#44;01<br>2&#44;05<br>0&#44;04 a 0&#44;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles e feminino<br>&#40;D&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;04<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;01<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#44;23</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;02<br>0&#44;01<br>0&#44;15<br>0&#44;02 a 0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;01<br>0<br>0&#44;07<br>0&#44;01 a 0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;01<br>0<br>0&#44;04<br>0&#44;01 a 0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;01<br>0<br>0&#44;08<br>0&#44;01 a 0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;01<br>0<br>0&#44;09<br>0&#44;01 a 0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A e C &#8800; B&#44; D&#59; B e D &#8800; A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleBold">0&#44;01</span><br><span class="elsevierStyleBold">&#40;D &#8800; A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A e C &#8800; B&#44; D&#59; B e D &#8800; A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A e C &#8800; B&#44; D&#59; B e D &#8800; A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">&#60;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;A e C &#8800; B&#44; D&#59; B e D &#8800; A&#44; C&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="9" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " rowspan="9" align="left" valign="top">Slope 2</td><td class="td" title="table-entry  " align="left" valign="top">Fibrose c&#237;stica e masculino<br>&#40;A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">562&#44;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#44;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">537&#44;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#44;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">534<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>32&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">529&#44;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>33&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">551&#44;43<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#44;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#44;068</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">548&#44;63<br>332&#44;84<br>940&#44;17<br>503&#44;7 a 620&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">554&#44;58<br>340&#44;24<br>1003&#44;17<br>476&#44;35 a 598&#44;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">549&#44;36<br>279&#44;94<br>1070&#44;96<br>467&#44;59 a 600&#44;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">566&#44;16<br>277&#44;46<br>919&#44;83<br>459&#44;87 a 598&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">553&#44;21<br>304&#44;51<br>871&#44;09<br>492&#44;66 a 610&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles e masculino<br>&#40;B&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">517&#44;42<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>30&#44;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">470&#44;71<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>20&#44;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">460&#44;03<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">462&#44;76<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">490&#44;97<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#44;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#44;238</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">476&#44;5<br>273<br>1215&#44;58<br>455&#44;22 a 579&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">450&#44;06<br>272&#44;59<br>791&#44;22<br>428&#44;58 a 512&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">421&#44;89<br>287&#44;67<br>816&#44;03<br>410&#44;09 a 509&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">427<br>293&#44;25<br>779&#44;63<br>417&#44;23 a 508&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">462&#44;52<br>277&#44;14<br>1184&#44;37<br>432&#44;98 a 548&#44;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fibrose c&#237;stica e feminino<br>&#40;C&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">432&#44;98<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>28&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">386&#44;08<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>22&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">390&#44;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#44;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">380&#44;49<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>29&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">434&#44;15<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>35&#44;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top"><span class="elsevierStyleBold">0&#44;001</span><br><span class="elsevierStyleBold">&#40;1 e 5 &#8800; 3&#44; 4&#41;</span></td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">400&#44;21<br>140<br>833&#44;67<br>376&#44;17 a 489&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">381&#44;25<br>147&#44;49<br>708&#44;09<br>340&#44;18 a 431&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">347&#44;12<br>167&#44;4<br>924<br>340&#44;45 a 439&#44;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">366&#44;42<br>161&#44;66<br>1173&#44;23<br>320&#44;14 a 440&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">430&#44;06<br>139<br>1366&#44;24<br>361&#44;39 a 506&#44;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Controles e feminino<br>&#40;D&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">371&#44;7<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>17&#44;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">340&#44;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">337&#44;35<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">335&#44;55<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">344&#44;05<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>13&#44;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="left" valign="top">0&#44;189</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mediana<br>M&#237;nimo<br>M&#225;ximo<br>IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">351<br>225&#44;88<br>602&#44;15<br>335&#44;07 a 408&#44;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">334&#44;85<br>228&#44;65<br>464&#44;55<br>314&#44;56 a 366&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">338&#44;1<br>207&#44;82<br>471&#44;01<br>311&#44;99 a 362&#44;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">340&#44;32<br>207&#44;76<br>519&#44;02<br>307&#44;34 a 363&#44;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">341&#44;99<br>240&#44;28<br>501&#44;23<br>315&#44;94 a 372&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Valor de p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;222&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;808&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;463&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;801&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;129&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "pt" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Associa&#231;&#227;o do slope 3&#44; slope 3&#47;TV e slope 2 entre os indiv&#237;duos com fibrose c&#237;stica &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; e os controles saud&#225;veis &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>64&#41; considerando o sexo em diferentes momentos da capnografia volum&#233;trica</p>"
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        0 => array:2 [
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          "bibliografiaReferencia" => array:30 [
            0 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pediatric exercise testing&#58; value and implications of peak oxygen uptake"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;T&#46; Pianosi"
                            1 => "R&#46;I&#46; Liem"
                            2 => "R&#46;G&#46; McMurray"
                            3 => "F&#46;J&#46; Cerny"
                            4 => "B&#46; Falk"
                            5 => "H&#46;C&#46; Kemper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Children &#40;Basel&#41;"
                        "fecha" => "2017"
                        "volumen" => "4"
                        "paginaInicial" => "2"
                        "paginaFinal" => "9"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory muscle training improves respiratory muscle endurance but not exercise tolerance in children with cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46; Bieli"
                            1 => "S&#46; Summermatter"
                            2 => "U&#46; Boutellier"
                            3 => "A&#46; Moeller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/ppul.23647"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Pulmonol"
                        "fecha" => "2017"
                        "volumen" => "52"
                        "paginaInicial" => "331"
                        "paginaFinal" => "336"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28114723"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ventilatory abnormalities in subjects with cystic fibrosis undergoing the submaximal treadmill exercise test"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46;L&#46; Parazzi"
                            1 => "F&#46;A&#46; Marson"
                            2 => "M&#46;A&#46; Ribeiro"
                            3 => "C&#46;C&#46; de Almeida"
                            4 => "L&#46;C&#46; Martins"
                            5 => "I&#46;A&#46; Paschoal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12890-015-0056-5"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Pulm Med"
                        "fecha" => "2015"
                        "volumen" => "15"
                        "paginaInicial" => "63"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25985982"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiopulmonary exercise testing in children with cystic fibrosis&#58; one centre&#39;s experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Weir"
                            1 => "P&#46;D&#46; Burns"
                            2 => "A&#46; Devenny"
                            3 => "D&#46; Young"
                            4 => "J&#46;Y&#46; Paton"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/archdischild-2016-310651"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Dis Child"
                        "fecha" => "2017"
                        "volumen" => "102"
                        "paginaInicial" => "440"
                        "paginaFinal" => "444"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27919886"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Volumetric capnography as a tool to detect early peripheric lung obstruction in cystic fibrosis subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; Ribeiro"
                            1 => "M&#46;T&#46; Silva"
                            2 => "J&#46;D&#46; Ribeiro"
                            3 => "M&#46;M&#46; Moreira"
                            4 => "C&#46;C&#46; Almeida"
                            5 => "A&#46;A&#46; Almeida-Junior"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Pediatr &#40;Rio J&#41;"
                        "fecha" => "2012"
                        "volumen" => "88"
                        "paginaInicial" => "509"
                        "paginaFinal" => "517"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Volumetric capnography for the evaluation of pulmonary disease in adult subjects with cystic fibrosis and noncystic fibrosis bronchiectasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Veronez"
                            1 => "M&#46;M&#46; Moreira"
                            2 => "S&#46;T&#46; Soares"
                            3 => "M&#46;C&#46; Pereira"
                            4 => "M&#46;A&#46; Ribeiro"
                            5 => "J&#46;D&#46; Ribeiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00408-009-9213-z"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lung"
                        "fecha" => "2010"
                        "volumen" => "188"
                        "paginaInicial" => "263"
                        "paginaFinal" => "268"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20049470"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystic fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46;P&#46; O&#39;Sullivan"
                            1 => "S&#46;D&#46; Freedman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(09)60327-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2009"
                        "volumen" => "373"
                        "paginaInicial" => "1891"
                        "paginaFinal" => "1904"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19403164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Controversies in cystic fibrosis from pediatrician to specialist"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;D&#46; Ribeiro"
                            1 => "M&#46;A&#46; Ribeiro"
                            2 => "A&#46;F&#46; Ribeiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Pediatr &#40;Rio J&#41;"
                        "fecha" => "2002"
                        "volumen" => "78"
                        "paginaInicial" => "S171"
                        "paginaFinal" => "S186"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Volumetric capnography to detect ventilation inhomogeneity in children and adolescents with controlled persistent asthma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "C&#46;C&#46; Almeida"
                            1 => "A&#46;A&#46; Almeida-Junior"
                            2 => "M&#46;A&#46; Ribeiro"
                            3 => "M&#46;T&#46; Nolasco-Silva"
                            4 => "J&#46;D&#46; Ribeiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Pediatr &#40;Rio J&#41;"
                        "fecha" => "2011"
                        "volumen" => "87"
                        "paginaInicial" => "163"
                        "paginaFinal" => "168"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Statement&#58; Guidelines for the six&#8208;minute walk test"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.166.1.at1102"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2002"
                        "volumen" => "166"
                        "paginaInicial" => "111"
                        "paginaFinal" => "117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12091180"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cystic fibrosis and physiological responses to exercise"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;A&#46; Williams"
                            1 => "Z&#46;L&#46; Saynor"
                            2 => "O&#46;W&#46; Tomlinson"
                            3 => "A&#46;R&#46; Barker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1586/17476348.2014.966693"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Respir Med"
                        "fecha" => "2014"
                        "volumen" => "8"
                        "paginaInicial" => "751"
                        "paginaFinal" => "762"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25395018"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metabolic responses to submaximal treadmill walking and cycle ergometer pedalling in obese adolescents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;L&#46; Lafortuna"
                            1 => "S&#46; Lazzer"
                            2 => "F&#46; Agosti"
                            3 => "C&#46; Busti"
                            4 => "R&#46; Galli"
                            5 => "G&#46; Mazzilli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0838.2009.00975.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Med Sci Sports"
                        "fecha" => "2010"
                        "volumen" => "20"
                        "paginaInicial" => "630"
                        "paginaFinal" => "637"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19706003"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Submaximal treadmill test predicts VO<span class="elsevierStyleInf">2</span> max in overweight children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46;A&#46; Nemeth"
                            1 => "A&#46;L&#46; Carrel"
                            2 => "J&#46; Eickhoff"
                            3 => "R&#46;R&#46; Clark"
                            4 => "S&#46;E&#46; Peterson"
                            5 => "D&#46;B&#46; Allen"
                          ]
                        ]
                      ]
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                    0 => array:1 [
                      "Revista" => array:5 [
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                        "paginaFinal" => "681"
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                      "titulo" => "Validity of cardiorespiratory fitness criterion&#8208;referenced standards for adolescents"
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                        "paginaFinal" => "1229"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19461545"
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                      "titulo" => "Should the 6&#8208;minute walk test be compared when conducted by 2 different assessors in subjects with COPD&#63;"
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                          "etal" => false
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                            1 => "J&#46;F&#46; Arcuri"
                            2 => "A&#46;C&#46; Sentanin"
                            3 => "J&#46;N&#46; Costa"
                            4 => "B&#46;V&#46; Pessoa"
                            5 => "V&#46;A&#46; Di Lorenzo"
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                    0 => array:2 [
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                        "paginaInicial" => "1323"
                        "paginaFinal" => "1330"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27682814"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
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                      "titulo" => "Calculation of the capnographic index based on expiratory molar mass&#8208;volume&#8208;curves a suitable tool to screen for cystic fibrosis lung disease"
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                        0 => array:2 [
                          "etal" => false
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                            2 => "H&#46; Ellemunter"
                            3 => "M&#46; Ballmann"
                            4 => "M&#46; Gappa"
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                        "paginaFinal" => "283"
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                    0 => array:2 [
                      "titulo" => "Volumetric capnography for the evaluation of chronic airways diseases"
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                            5 => "M&#46;M&#46; Moreira"
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                        "tituloSerie" => "Int J Chron Obstruct Pulmon Dis"
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                        "paginaFinal" => "989"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25284998"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Volumetric capnography&#58; lessons from the past and current clinical applications"
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                          "etal" => false
                          "autores" => array:5 [
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                            1 => "P&#46;B&#46; Massion"
                            2 => "F&#46; Verschuren"
                            3 => "P&#46; Damas"
                            4 => "S&#46; Magder"
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                        "tituloSerie" => "Crit Care"
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                        "paginaInicial" => "184"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27334879"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Noninvasive monitoring of lung recruitment maneuvers in morbidly obese subjects&#58; the role of pulse oximetry and volumetric capnography"
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                          "etal" => true
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                            2 => "F&#46;E&#46; Fiolo"
                            3 => "A&#46; Scandurra"
                            4 => "J&#46;M&#46; Arca"
                            5 => "G&#46; Krumrick"
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                        "tituloSerie" => "Anesth Analg"
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                        "paginaFinal" => "144"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24356163"
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                    0 => array:2 [
                      "titulo" => "The physiology of ventilation"
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                            0 => "G&#46; Murias"
                            1 => "L&#46; Blanch"
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                        "paginaInicial" => "1795"
                        "paginaFinal" => "1807"
                        "link" => array:1 [
                          0 => array:2 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Methacholine&#8208;induced variations in airway volume and the slope of the alveolar capnogram are distinctly associated with airflow limitation and airway closure"
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                          "etal" => false
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                            2 => "L&#46; Boyer"
                            3 => "C&#46; Taill&#233;"
                            4 => "C&#46; Delclaux"
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              ]
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              "identificador" => "bib0260"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Multivariate analysis of the volumetric capnograph for PaCO2 estimation"
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                            2 => "A&#46;I&#46; Batchinsky"
                            3 => "S&#46; Mittal"
                            4 => "T&#46; Watkins"
                            5 => "J&#46; Salinas"
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                        ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Burns Trauma"
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                        "volumen" => "5"
                        "paginaInicial" => "66"
                        "paginaFinal" => "74"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26550531"
                            "web" => "Medline"
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                  ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The ability of volumetric capnography to distinguish between chronic obstructive pulmonary disease subjects and normal subjects"
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                            3 => "F&#46; Xi"
                            4 => "H&#46; Wu"
                            5 => "J&#46;M&#46; Liu"
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Vol. 95. Núm. 1.
Páginas 76-86 (janeiro - fevereiro 2019)
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Vol. 95. Núm. 1.
Páginas 76-86 (janeiro - fevereiro 2019)
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Evaluation of respiratory dynamics by volumetric capnography during submaximal exercise protocol of six minutes on treadmill in cystic fibrosis patients
Avaliação da dinâmica respiratória por capnografia volumétrica durante o protocolo de exercício submáximo por seis minutos em esteira em pacientes com fibrose cística
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Paloma L.F. Parazzia,
Autor para correspondência
palomaparazzi@yahoo.com

Autores para correspondência.
, Fernando A.L. Marsona,b,
Autor para correspondência
fernandolimamarson@hotmail.com

Autores para correspondência.
, Maria A.G.O. Ribeiroa, Camila I.S. Schivinskic, José D. Ribeiroa
a Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, Brasil
b Universidade Estadual de Campinas (Unicamp), Faculdade de Ciências Médicas, Departamento de Genética Médica, Campinas, SP, Brasil
c Universidade do Estado de Santa Catarina (Udesc), Centro de Educação Física e Esporte, Florianópolis, SC, Brasil
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Tabelas (3)
Tabela 1. Associação do slope 3, slope 3/TV e slope 2 entre os indivíduos com fibrose cística (n=64) e os controles saudáveis (n=64) em diferentes momentos da capnografia volumétrica
Tabela 2. Associação do slope 3, slope 3/TV e slope 2 entre os indivíduos com fibrose cística (n=64) e os controles saudáveis (n=64) considerando a idade em diferentes momentos da capnografia volumétrica
Tabela 3. Associação do slope 3, slope 3/TV e slope 2 entre os indivíduos com fibrose cística (n=64) e os controles saudáveis (n=64) considerando o sexo em diferentes momentos da capnografia volumétrica
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Abstract
Objectives

Volumetric capnography provides the standard CO2 elimination by the volume expired per respiratory cycle and is a measure to assess pulmonary involvement. Thus, the objective of this study was to evaluate the respiratory dynamics of healthy control subjects and those with cystic fibrosis in a submaximal exercise protocol for six minutes on the treadmill, using volumetric capnography parameters (slope 3 [Slp3], Slp3/tidal volume [Slp3/TV], and slope 2 [Slp2]).

Methods

This was a cross‐sectional study with 128 subjects (cystic fibrosis, 64 subjects; controls, 64 subjects]. Participants underwent volumetric capnography before, during, and after six minutes on the treadmill. Statistical analysis was performed using the Friedman, Mann–Whitney, and Kruskal–Wallis tests, considering age and sex. An alpha=0.05 was considered.

Results

Six minutes on the treadmill evaluation: in cystic fibrosis, volumetric capnography parameters were different before, during, and after six minutes on the treadmill; the same was observed for the controls, except for Slp2. Regarding age, an Slp3 difference was observed in cystic fibrosis patients regardless of age, at all moments, and in controls for age12 years; a difference in Slp3/TV was observed in cystic fibrosis and controls, regardless of age; and an Slp2 difference in the cystic fibrosis, regardless of age. Regarding sex, Slp3 and Slp3/TV differences were observed in cystic fibrosis regardless of sex, and in controls in male participants; an Slp2 difference was observed in the cystic fibrosis and female participants. The analysis between groups (cystic fibrosis and controls) indicated that Slp3 and Slp3/TV has identified the CF, regardless of age and sex, while the Slp2 showed the CF considering age.

Conclusions

Cystic fibrosis showed greater values of the parameters before, during, and after exercise, even when stratified by age and sex, which may indicate ventilation inhomogeneity in the peripheral pathways in the cystic fibrosis.

Keywords:
Breath
CFTR
Exercise
Pulmonary function
Slope 2
Slope 3
Resumo
Objetivos

A capnografia volumétrica fornece o padrão de eliminação do CO2, pelo volume expirado por ciclo respiratório e avalia o comprometimento pulmonar. O objetivo do estudo foi avaliar a dinâmica respiratória de indivíduos controles saudáveis e em indivíduos com fibrose cística, em um protocolo de exercício submáximo por seis minutos em esteira, por parâmetros da capnografia volumétrica [slope 3(Slp3), Slp3/volume corrente (Slp3/TV) e slope 2(Slp2)].

Métodos

Estudo de corte transversal com 128 indivíduos [(fibrose cística) 64 indivíduos; (controles) 64 indivíduos]. Os participantes realizaram capnografia volumétrica antes, durante e após seis minutos em esteira. Análise estatística realizada pelos testes de Friedman, Mann-Whitney e Kruskal-Wallis, considerado a idade e o sexo. Alpha=0,05.

Resultados

Avaliação de seis minutos em esteira: na fibrose cística, os parâmetros da capnografia volumétrica foram diferentes antes, durante e após seis minutos em esteira, o mesmo ocorreu nos controles, exceto para o Slp2. Considerando a idade: (Slp3) diferença na FC, independentemente da idade, em todos os momentos e nos controles apenas para ≥ 12 anos; (Slp3/TV) diferença para fibrose cística e controles independentemente da idade; (Slp2) diferença apenas para o grupo fibrose cística, independentemente da idade. Considerando o sexo: (Slp3 e Slp3/TV) diferença para fibrose cística, independentemente do sexo, e controles apenas no sexo masculino; (Slp2) diferença para fibrose cística e sexo feminino. Análise entre grupos (fibrose cística versus controles): Slp3 e Slp3/TV identificou a fibrose cística, independentemente da idade e sexo, enquanto o Slp2 evidenciou a fibrose cística considerando a idade.

Conclusão

A fibrose cística apresentou maiores valores dos parâmetros antes, durante e após exercício, inclusive quando se considerou idade e sexo, podendo indicar não homogeneidade da distribuição da ventilação nas vias periféricas.

Palavras‐chave:
Respiração
CFTR
Exercício
Função pulmonar
Slope 2
Slope 3
Texto Completo
Introdução

A fibrose cística (FC) (OMIM: n° 219700) apresenta declínio progressivo da função pulmonar, determinante da mortalidade dos pacientes. Entretanto, recentemente a FC tem apresentado prognósticos favoráveis em indivíduos com melhor condicionamento aeróbico e estado nutricional.1,2 Por esse motivo, a busca por marcadores que indiquem as limitações ao exercício e que avaliem a deterioração pulmonar progressiva tem sido explorada.2,3

A FC apresenta envolvimento progressivo das vias aéreas periféricas [zona silenciosa do pulmão], considerando que os exames de função pulmonar convencionais são ineficazes para avaliar a região corretamente.4,5 Assim, a capnografia volumétrica (VCap) surge como opção para avaliar a pressão parcial de dióxido de carbono (VCO2) no gás que entra e sai dos pulmões em relação ao tempo e detectar a homogeneização da periferia pulmonar no início da eliminação do gás. A VCap fornece índices de transporte de gás nas vias aéreas alveolares da periferia pulmonar, ou seja, slope 3. Em suma, a VCap apresenta baixo custo, é de fácil manuseio, bem tolerada e não exige manobras forçadas ou de difícil compreensão. Além disso, ela pode detectar alterações pulmonares precoces.5,6

Portanto, o objetivo deste estudo é avaliar a dinâmica respiratória de crianças e adolescentes controle saudáveis e aquelas com FC em um protocolo de exercício submáximo por seis minutos em esteira (SMWT) considerando os parâmetros da VCap [slope 3, slope3/volume corrente exalado (slope 3/TV) e slope 2].

Métodos

Fizemos um estudo transversal com 128 indivíduos, 64 portadores de FC e 64 voluntários controle saudáveis. Incluímos indivíduos com FC que concordaram em participar do estudo e que atendiam aos critérios de inclusão. O consentimento informado foi obtido de todos os participantes individuais incluídos no estudo. O estudo seguiu os critérios éticos da Convenção de Helsinque e foi aprovado pelo Comitê de Ética da instituição (n° 1182/2009).

Grupo de indivíduos com fibrose cística

Os critérios de inclusão foram: idade entre seis e 25 anos; diagnóstico de FC por dois testes de suor com concentrações de cloreto acima de 60 mEq/L e/ou presença de duas mutações no gene do Regulador de Condutância Transmembrana da Fibrose Cística (RTFC)3,7,8 e estabilidade clínica. A estabilidade clínica foi controlada por dois escores clínicos: Escore Clínico da Fundação de Fibrose Cística e Escore Clínico de Fibrose Cística9,10 e a gravidade da doença foi classificada segundo o escore de Shwachman‐kulczycki.11

Grupo de controle

Indivíduos saudáveis entre seis e 25 anos foram selecionados aleatoriamente entre estudantes de escolas públicas e particulares localizadas nas proximidades da universidade. Os participantes responderam um questionário sobre condições de saúde e nenhum apresentava doença respiratória aguda ou modificação nas variáveis espirométricas.

Capnografia volumétrica

Os indivíduos passaram por VCap em uma esteira. Na VCap, usamos o monitor Co2smo Plus Dx‐8100 (Novametrix, Medical Systems, EUA), que avaliou os participantes quatro minutos antes do SMWT, seis minutos durante o SMWT e quatro minutos depois do teste. O sistema não é invasivo e é composto por um monitor que contém um capnógrafo, um oxímetro de pulso e um pneumotacógrafo. As medições de VCap e pneumotacógrafo foram obtidas em tempo real pela análise do gás expirado. O Co2smo Plus Dx‐8100 foi conectado a um computador equipado com o software para registrar as medidas de fluxo, volume, pressão, pressão‐volume, fluxo de volume, VCap e curvas.

O sensor do monitor foi conectado a uma mangueira e foi usado um clipe nasal para evitar a saída de ar pelo nariz. No fim da coleta, uma sequência off‐line de ciclos respiratórios foi selecionada para admitir um coeficiente de variação do TV inferior a 25% do TV médio e foi admitido um coeficiente de variação inferior a 10% em milímetros de mercúrio (mmHg) para tensão de dióxido de carbono no fim da expiração (EtCO2). Os ciclos respiratórios com valor zero para o slope 3 foram eliminados. O resultado foi obtido da média de variáveis durante o tempo de monitoramento.3,5,9

Neste estudo, analisamos as medidas: (i) TV: volume de ar exalado em uma respiração, medido em mililitros (mL); (ii) Slope da fase II da curva VCap (slope 2): medido em milímetros de mercúrio por litro (mmHg/L); (iii) Slope da fase III da curva VCap (slope 3): medido em mmHg/L.

Exercício submáximo por seis minutos em esteira (SMWT)

Antes de iniciar o SMWT na esteira, foi feita a avaliação antropométrica, que incluiu peso (kg), altura (cm) e cálculo do índice de massa corporal (IMC). Os participantes caminharam em uma esteira (Caloi Electronics® Pro CL 5004, SP, Brasil) por seis minutos para analisar o comportamento das variáveis da VCap. O SMWT começou com a esteira parada. Houve um aumento progressivo da velocidade, a cada minuto, de acordo com a tolerância do indivíduo para continuar a caminhar, sem correr e com respeito ao esforço submáximo de cada um.3,10

Imediatamente antes do SMWT, o participante permaneceu em repouso por quatro minutos para avaliar a VCap. Então, o SMWT foi iniciado e os dados da VCap foram medidos durante o teste.

O exercício foi acompanhado de estímulos verbais, no primeiro minuto e no fim de cada minuto.

O protocolo de exercício teve como base o SMWT e protocolos desenvolvidos para esteira.3,10–15

Análise estatística

Em todo momento da avaliação durante os exercícios, os dados da VCap são apresentados pela média, desvio‐padrão, mediana, mínimo, máximo e intervalo de confiança da média. Os momentos avaliados foram: 1: momento inicial do SMWT; 2: 1° e 2° minutos do SMWT; 3: 3° e 4° minutos do SMWT; 4: 5° e 6° minutos do SMWT; 5: após o SMWT. A análise estatística foi feita no software Statistical Package for the Social Sciences, versão 24 (IBM Corp. Lançado em 2016. IBM SPSS Statistics for Windows, Versão 24.0. Armonk, NY: IBM Corp.) pelos testes de Friedman, Mann‐Whitney e Kruskal‐Wallis. As análises consideraram a idade e o sexo dos indivíduos. Alfa=0,05.

Resultados

Nos grupos FC e controle, slope 3, slope 3/TV e slope 2 apresentaram diferença entre os momentos analisados (p<0,05). O slope 3 apresentou diferenças entre os valores na FC e nos controles nos momentos 1, 3, 4 e 5 (p<0,05), ao passo que o slope 3/TV apresentou diferença entre os valores na FC e nos controles em todos os momentos (p<0,05) (tabela 1; fig. 1). Considerando os indivíduos por idade, o slope 3 apresentou diferença na FC entre os momentos analisados independentemente da idade, ao passo que os controles apresentaram diferença somente nos indivíduos com idade ≥ 12 anos (p<0,05) (tabela 2 e fig. 1). O slope 3/TV apresentou diferença na FC e nos controles, independentemente da idade, entre os momentos analisados (tabela 2 e fig. 1). O slope 3, slope 3/TV e slope 2 conseguiram diferenciar os grupos (FC e controles) em todos os momentos e análises, quando as faixas etárias foram atribuídas (tabela 2).

Tabela 1.

Associação do slope 3, slope 3/TV e slope 2 entre os indivíduos com fibrose cística (n=64) e os controles saudáveis (n=64) em diferentes momentos da capnografia volumétrica

Marcadores  Grupo    MomentoValor de p 
       
Slope 3Fibrose cística  Média±DP  37,61±3,01  35,8±4,52  31,2±2,75  30,98±2,8  38,05±3,75  <0,001 (1 ≠ 2, 3 e 4; 4 ≠ 1 e 5; 5 ≠ 3 e 4)
  Mediana
Mínimo
Máximo
IC 95% 
34,5
5
140,1
31,58 a 43,64 
27,29
6,05
246,48
26,76 a 44,84 
26,41
6,24
99,47
25,71 a 36,7 
23,74
6,51
99,34
25,36 a 36,59 
33,77
6,85
170,58
30,55 a 45,55 
Controles  Média±DP  20,95±2,25  20,44±2,65  18,49±2,6  17,55±2,01  18,24±2,77  0,019 (1 ≠ 3, 4 e 5)
  Mediana
Mínimo
Máximo
IC 95% 
16,15
1,5
91
16,45 a 25,45 
12,75
4,63
147,71
15,13 a 25,76 
13,4
4,58
97,61
13,28 a 23,7 
12,31
3,5
78,08
13,52 a 21,58 
12,57
1
163,67
12,71 a 23,78 
  Valor de p  <0,001  0,052  <0,001  <0,001  <0,001   
Slope 3/volume correnteFibrose cística  Média±DP  0,16±0,02  0,15±0,04  0,1±0,01  0,1±0,01  0,17±0,03  <0,001
(1 ≠ 2, 3 e 4; 4 ≠ 1 e 5; 5 ≠ 3 e 4)
  Mediana
Mínimo
Máximo
IC 95% 
0,13
0,01
1,4
0,11 a 0,21 
0,06
0,01
3,04
0,05 a 0,25 
0,06
0
0,54
0,07 a 0,14 
0,05
0
0,52
0,07 a 0,13 
0,1
0,01
2,05
0,1 a 0,25 
Controles  Média±DP  0,07±0,01  0,07±0,02  0,05±0,01  0,05±0,01  0,07±0,02  <0,001 (1 ≠ 3, 4 e 5)
  Mediana
Mínimo
Máximo
IC 95% 
0,04
0
0,67
0,04 a 0,09 
0,02
0
1,74
0,01 a 0,12 
0,02
0
0,76
0,02 a 0,09 
0,02
0
0,85
0,02 a 0,08 
0,02
0
1,41
0,02 a 0,11 
  Valor de p  <0,001  0,003  <0,001  <0,001  <0,001   
Slope 2Fibrose cística  Média±DP  487,55±21,57  449,93±20,28  450,8±21,44  443,29±24,02  483,63±24,91  <0,001
(1 ≠ 2, 3 e 4; 4 ≠ 1 e 5; 5 ≠ 3 e 4)
  Mediana
Mínimo
Máximo
IC 95% 
480,63
140
940,17
444,43 a 530,68 
439,04
147,49
1003,17
409,39 a 490,48 
402,71
167,4
1070,96
407,95 a 493,65 
385,18
161,66
1173,23
395,28 a 491,3 
462,7
139
1366,24
433,84 a 533,42 
Controles  Média±DP  455,95±21,17  415,73±15,35  408,27±16,88  409,1±16,18  428,99±19,65  0,101
  Mediana
Mínimo
Máximo
IC 95% 
440,06
225,88
1215,58
413,64 a 498,25 
401,39
228,65
791,22
385,04 a 446,41 
380,12
207,82
816,03
374,53 a 442,02 
388,58
207,76
779,63
376,75 a 441,44 
400,36
240,28
1184,37
389,72 a 468,26 
  Valor de p  0,596  0,596  0,216  0,86  0,052   

1, momento inicial do SMWT; 2, 1° e 2° minutos do SMWT; 3, 3° e 4° minutos do SMWT; 4, 5° e 6° minutos do SMWT; 5, após o SMWT; DP, desvio‐padrão; IC, intervalo de confiança; SMWT, exercício submáximo por seis minutos em esteira. Alfa=0,05.

Usamos os testes de Mann‐Whitney e Friedman. Dados com valores de p positivos apresentados em negrito.

Figura 1.

Associação da capnografia volumétrica entre indivíduos com fibrose cística. A. Associação do slope 3 entre indivíduos com fibrose cística (FC, 1) (n=64) e os controles saudáveis (2) (n=64) considerando a idade e o sexo em diferentes momentos da capnografia volumétrica. 1. Associação do slope 3 com FC e controles. (momento 1) 1=34,5, 2=16,15, (momento 2) 1=27,29, 2=12,75, (momento 3) 1=26,41, 2=13,4, (momento 4) 1=23,74, 2=12,31, (momento 5) 1=33,77, 2=12,57. 2. Associação do slope 3 com FC e controles considerando a idade. (momento 1) 11 (FC+<12 anos)=38,04, 12 (FC+≥ 12 anos)=31,6, 21 (controles+<12 anos)=17,63, 22 (controles+≥ 12 anos)=13,05, (momento 2) 11=32,01, 12=18,13, 21=19,04, 22=10,84, (momento 3) 11=27,09, 12=24,56, 21=13,5, 22=11,9, (momento 4) 11=28,51, 12=20,06, 21=13,54, 22=9,37, (momento 5) 11=36,84, 12=27,52, 21=14,84, 22=10,21. 3. Associação do slope 3 com FC e controles considerando o sexo. (momento 1) 11 (FC+masculino)=34,5, 12 (FC+feminino)=34,1, 21 (controles+masculino)=17,25, 22 (controles+feminino)=15,29, (momento 2) 11=24,96, 12=27,29, 21=19,67, 22=12,32, (momento 3) 11=27,97, 12=27,32, 21=12,96, 22=13,84, (momento 4) 11=24,02, 12=23,74, 21=13,72, 22=11,76, (momento 5) 11=37,12, 12=32,31, 21=14,87, 22=11,37. B. Associação do volume do Slope 3/corrente entre indivíduos com FC (1) (n=64) e controles saudáveis (controles, 2) (n=64) considerado a idade e o sexo em diferentes momentos da capnografia volumétrica. 1. Associação do slope 3 com FC e controles. (momento 1) 1=0,13, 2=0,04, (momento 2) 1=0,06, 2=0,02, (momento 3) 1=0,06, 2=0,02, (momento 4) 1=0,05, 2=0,02, (momento 5) 1=0,1, 2=0,02. 2. Associação do slope 3 com FC e controles considerando a idade. (momento 1) 11 (FC+<12 anos)=0,14, 12 (FC+≥ 12 anos)=0,07, 21 (controles+<12 anos)=0,05, 22 (controles+≥ 12 anos)=0,02, (momento 2) 11=0,09, 12=0,03, 21=0,03, 22=0,01, (momento 3) 11=0,07, 12=0,03, 21=0,02, 22=0,01, (momento 4) 11=0,08, 12=0,03, 21=0,02, 22=0,01, (momento 5) 11=0,18, 12=0,07, 21=0,03, 22=0,01. 3. Associação do volume do slope 3/corrente com FC e controles considerando o sexo. (momento 1) 11 (FC+masculino)=0,14, 12 (FC+feminino)=0,07, 21 (controles+masculino)=0,05, 22 (controles+feminino)=0,02, (momento 2) 11=0,09, 12=0,03, 21=0,03, 22=0,01, (momento 3) 11=0,07, 12=0,03, 21=0,02, 22=0,01, (momento 4) 11=0,08, 12=0,03, 21=0,02, 22=0,01, (momento 5) 11=0,18, 12=0,07, 21=0,02, 22=0,01. (momentos) 1: momento inicial do SMWT; 2: 1° e 2° minutos do SMWT; 3: 3° e 4° minutos do SMWT; 4: 5° e 6° minutos do SMWT; 5: após o SMWT; SMWT: exercício submáximo por seis minutos em esteira; TV: volume corrente. Usamos os testes de Mann‐Whitney, Kruskal‐Wallis e Friedman. Alfa=0,05. As medianas e o intervalo de confiança de 95% estão representados nos gráficos.

(0.31MB).
Tabela 2.

Associação do slope 3, slope 3/TV e slope 2 entre os indivíduos com fibrose cística (n=64) e os controles saudáveis (n=64) considerando a idade em diferentes momentos da capnografia volumétrica

Marcadores  Grupo    MomentoValor de p 
       
Slope 3Fibrose cística<12 anos de idade
(A) 
Média±DP  44,69±4,91  45,79±8,84  36,29±4,54  37,76±4,47  44,38±5,1  0,034 (3 ≠ 1, 5)
  Mediana
Mínimo
Máximo
IC 95% 
38,04
16,38
140,1
34,59 a 54,8 
32,01
15,4
246,48
27,6 a 63,98 
27,09
13,25
99,47
26,95 a 45,64 
28,51
12,15
99,34
28,55 a 46,96 
36,84
11,71
135,6
33,9 a 54,87 
Controles<12 anos de idade
(B) 
Média±DP  24,57±3,51  25,32±4,3  23,35±4,3  21,63±3,16  22,85±4,56  0,445
  Mediana
Mínimo
Máximo
IC 95% 
17,63
1,5
91
17,43 a 31,71 
19,04
7,17
147,71
16,58 a 34,05 
13,5
7,52
97,61
14,62 a 32,07 
13,54
6,7
78,08
15,2 a 28,06 
14,84
1
163,67
13,6 a 32,1 
Fibrose cística ≥ 12 anos de idade
(C) 
Média±DP  32,44±3,61  28,51±4,15  27,49±3,33  26,03±3,41  33,43±5,24  0,006 (4 ≠ 1, 2, 3, 5)
  Mediana
Mínimo
Máximo
IC 95% 
31,6
5
102,12
25,11 a 39,78 
18,13
6,05
123,5
20,10 a 36,93 
24,56
6,24
84,87
20,73 a 34,25 
20,06
6,51
85,1
19,09 a 32,96 
27,52
6,85
170,58
22,80 a 44,07 
Controles ≥ 12 anos de idade
(D) 
Média±DP  15,99±1,98  13,77±1,55  11,89±11,96±1,48  11,93±1,38  0,028 (1 ≠ 3, 4, 5)
  Mediana
Mínimo
Máximo
IC 95% 
13,05
4,79
39,04
11,91 a 20,07 
10,84
4,63
36,72
10,57 a 16,96 
11,9
4,58
23,6
9,77 a 13,9 
9,37
3,5
36,25
8,92 a 15 
10,21
1,21
32,95
9,08 a 14,77 
  Valor de p  <0,001
(A ≠ B, C, D; C ≠ A, B, D; B ≠ A, C; D ≠ A, C) 
0,004
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C) 
<0,001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C) 
<0,001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C) 
<0,001
(A ≠ B, C, D; C ≠ A, B, D; B ≠ A, C, D; D ≠ A, B, C) 
 
Slope 3/volume correnteFibrose cística<12 anos de idade
(A) 
Média±DP  0,21±0,04  0,25±0,11  0,15±0,02  0,14±0,02  0,2±0,03  <0,001
(1 e 5 ≠ 2, 3, 4; 2 ≠ 1, 3, 5; 3 ≠ 1, 2, 5; 4 ≠ 1, 5)
  Mediana
Mínimo
Máximo
IC 95% 
0,14
0,04
1,4
0,11 a 0,32 
0,09
0,02
3,04
0,02 a 0,48 
0,07
0,02
0,54
0,09 a 0,2 
0,08
0,02
0,52
0,09 a 0,2 
0,18
0,02
0,98
0,12 a 0,27 
Controles<12 anos de idade
(B) 
Média±DP  0,09±0,02  0,1±0,04  0,09±0,02  0,07±0,02  0,1±0,04  0,005
(1 e 5 ≠ 3, 4; 2 ≠ 4; 3 ≠ 1, 5; 4 ≠ 1, 2, 5)
  Mediana
Mínimo
Máximo
IC 95% 
0,05
0
0,67
0,05 a 0,13 
0,03
0,01
1,74
0,01 a 0,2 
0,02
0,01
0,76
0,03 a 0,14 
0,02
0,01
0,85
0,02 a 0,12 
0,03
0
1,41
0,02 a 0,18 
Fibrose cística ≥ 12 anos de idade
(C) 
Média±DP  0,12±0,02  0,08±0,02  0,07±0,01  0,07±0,01  0,16±0,05  <0,001
(1 e 5 ≠ 2, 3, 4; 2 e 3 ≠ 1, 4, 5; 4 ≠ 1, 2, 3, 5)
  Mediana
Mínimo
Máximo
IC 95% 
0,07
0,01
0,64
0,07 a 0,16 
0,03
0,01
0,57
0,04 a 0,12 
0,03
0
0,51
0,04 a 0,11 
0,03
0
0,49
0,03 a 0,1 
0,07
0,01
2,05
0,04 a 0,27 
Controles ≥ 12 anos de idade
(D) 
Média±DP  0,04±0,02±0,01±0,01±0,02±0,001
(1 ≠ 2, 3, 4, 5; 2 e 5 ≠ 1, 4; 3 ≠ 1; 4 ≠ 1, 2, 5)
  Mediana
Mínimo
Máximo
IC 95% 
0,02
0,01
0,15
0,02 a 0,05 
0,01
0
0,07
0,01 a 0,03 
0,01
0
0,04
0,01 a 0,02 
0,01
0
0,08
0,01 a 0,02 
0,01
0
0,09
0,01 a 0,03 
  Valor de p  <0,001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C) 
<0,001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C) 
<0,001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C) 
<0,001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C) 
<0,001
(A ≠ B, C, D; C ≠ A, D; B ≠ A, D; D ≠ A, B, C) 
 
Slope 2Fibrose cística<12 anos de idade
(A) 
Média±DP  562,34±28,52  537,44±29,71  534±32,3  529,34±33,79  551,43±28,59  0,017
(1 e 5 ≠ 3, 4)
  Mediana
Mínimo
Máximo
IC 95% 
548,63
332,84
940,17
503,7 a 620,97 
554,58
340,24
1003,17
476,35 a 598,52 
549,36
279,94
1070,96
467,59 a 600,41 
566,16
277,46
919,83
459,87 a 598,8 
553,21
304,51
871,09
492,66 a 610,2 
Controles<12 anos de idade
(B) 
Média±DP  517,42±30,66  470,71±20,77  460,03±24,62  462,76±22,44  490,97±28,59  0,497
  Mediana
Mínimo
Máximo
IC 95% 
476,5
273
1215,58
455,22 a 579,62 
450,06
272,59
791,22
428,58 a 512,84 
421,89
287,67
816,03
410,09 a 509,97 
427
293,25
779,63
417,23 a 508,29 
462,52
277,14
1184,37
432,98 a 548,96 
Fibrose cística ≥ 12 anos de idade
(C) 
Média±DP  432,98±28,01  386,08±22,62  390,08±24,47  380,49±29,75  434,15±35,87  0,003
(4 ≠ 1, 3, 5)
  Mediana
Mínimo
Máximo
IC 95% 
400,21
140
833,67
376,17 a 489,79 
381,25
147,49
708,09
340,18 a 431,97 
347,12
167,4
924
340,45 a 439,72 
366,42
161,66
1173,23
320,14 a 440,84 
430,06
139
1366,24
361,39 a 506,92 
Controles ≥ 12 anos de idade
(D) 
Média±DP  371,7±17,82  340,37±12,55  337,35±12,33  335,55±13,72  344,05±13,67  0,244
  Mediana
Mínimo
Máximo
IC 95% 
351
225,88
602,15
335,07 a 408,33 
334,85
228,65
464,55
314,56 a 366,18 
338,1
207,82
471,01
311,99 a 362,71 
340,32
207,76
519,02
307,34 a 363,76 
341,68
240,28
501,23
315,94 a 372,17 
  Valor de p  <0,001
(A ≠ C, D; C ≠ A, B; B ≠ C, D; D ≠ A, B) 
<0,001
(A ≠ C, D; C ≠ A, B; B ≠ C, D; D ≠ A, B) 
<0,001
(A ≠ C, D; C ≠ A, B; B ≠ C, D; D ≠ A, B) 
<0,001
(A ≠ C, D; C ≠ A, B; B ≠ C, D; D ≠ A, B) 
<0,001
(A ≠ C, D; C ≠ A, B, D; B ≠ C, D; D ≠ A, B, C) 
 

1, momento inicial do SMWT; 2, 1° e 2° minutos do SMWT; 3, 3° e 4° minutos do SMWT; 4, 5° e 6° minutos do SMWT; 5, após o SMWT; DP, desvio‐padrão; IC, intervalo de confiança; SMWT, exercício submáximo por seis minutos em esteira. Alfa=0,05.

Usamos os testes de Kruskal‐Wallis e Friedman. Dados com valores de p positivos apresentados em negrito.

Considerando o sexo, não foi observada diferença entre os momentos no slope 3 e no slope 3/TV de controles do sexo feminino (p>0,05) (tabela 3; fig. 1). Por outro lado, o slope 2 apresentou diferença entre os momentos apenas para FC no sexo feminino (p<0,05) (tabela 3). O slope 3 e o slope 3/TV conseguiram diferenciar os grupos (FC e controles) em todos os momentos e análises, quando o sexo foi considerado (tabela 3).

Tabela 3.

Associação do slope 3, slope 3/TV e slope 2 entre os indivíduos com fibrose cística (n=64) e os controles saudáveis (n=64) considerando o sexo em diferentes momentos da capnografia volumétrica

Marcadores  Grupo    MomentoValor de p 
       
Slope 3Fibrose cística e masculino
(A) 
Média±DP  37,67±4,62  38,16±7,98  27,97±3,46  28,81±3,63  35,45±3,58  0,008
(1 e 5 ≠ 3, 4)
  Mediana
Mínimo
Máximo
IC 95% 
34,5
6,95
140,1
28,23 a 47,11 
24,96
9,15
246,48
21,88 a 54,44 
19,95
6,65
81,12
20,91 a 35,02 
24,02
6,57
85,66
21,4 a 36,23 
37,12
6,85
84,58
28,14 a 42,75 
Controles e masculino
(B) 
Média±DP  23,36±3,69  26,88±5,29  23,51±5,36  21,93±3,94  19,89±2,74  0,04
(3 ≠ 1, 2)
  Mediana
Mínimo
Máximo
IC 95% 
17,25
1,5
91
15,81 a 30,91 
19,67
4,82
147,71
16,05 a 37,7 
12,96
4,58
97,61
12,54 a 34,48 
13,72
3,5
78,08
13,87 a 30 
14,87
4,17
59,21
14,27 a 25,51 
Fibrose cística e feminino
(C) 
Média±DP  37,55±3,94  33,44±4,37  34,44±4,25  33,14±4,3  40,65±6,63  0,029
(1 ≠ 2, 4)
  Mediana
Mínimo
Máximo
IC 95% 
34,1
5
104,26
29,5 a 45,6 
27,29
6,05
105,14
24,51 a 42,37 
27,32
6,24
99,47
25,76 a 43,12 
23,74
6,51
99,34
24,36 a 41,92 
32,31
8,14
170,58
27,13 a 54,18 
Controles e feminino
(D) 
Média±DP  18,83±2,7  14,77±1,25  14,06±0,91  13,68±1,25  16,79±4,64  0,230
  Mediana
Mínimo
Máximo
IC 95% 
15,29
4,78
90,04
13,32 a 24,34 
12,32
4,63
35,56
12,20 a 17,33 
13,84
4,75
28,5
12,2 a 15,92 
11,76
4,89
36,25
11,13 a 16,23 
11,37
1
163,67
7,34 a 26,24 
  Valor de p  <0,001
(A e C ≠ B, D; B e D ≠ A, C) 
0,038
(A, C, B ≠ D) 
<0,001
(A e C ≠ B, D; B e D ≠ A, C) 
<0,001
(A e C ≠ B, D; B e D ≠ A, C) 
<0,001
(A e C ≠ B, D; B e D ≠ A, C) 
 
Slope 3/volume correnteFibrose cística e masculino
(A) 
Média±DP  0,21±0,04  0,25±0,11  0,15±0,02  0,14±0,02  0,2±0,03  <0,001
(1 e 5 ≠ 2, 3, 4; 2 ≠ 1, 4, 5; 3 ≠ 1, 5; 4 ≠ 1, 2, 5)
  Mediana
Mínimo
Máximo
IC 95% 
0,14
0,04
1,4
0,11 a 0,32 
0,09
0,02
3,04
0,02 a 0,48 
0,07
0,02
0,54
0,09 a 0,2 
0,08
0,02
0,52
0,09 a 0,2 
0,18
0,02
0,98
0,12 a 0,27 
Controles e masculino
(B) 
Média±DP  0,09±0,02  0,1±0,04  0,09±0,02  0,07±0,02  0,1±0,04  0,001
(1, 2 e 5 ≠ 3, 4)
  Mediana
Mínimo
Máximo
IC 95% 
0,05
0
0,67
0,05 a 0,13 
0,03
0,01
1,74
0,01 a 0,2 
0,02
0,01
0,76
0,03 a 0,14 
0,02
0,01
0,85
0,02 a 0,12 
0,03
0
1,41
0,02 a 0,18 
Fibrose cística e feminino
(C) 
Média±DP  0,12±0,02  0,08±0,02  0,07±0,01  0,07±0,01  0,16±0,05  <0,001
(1 e 5 ≠ 2, 3 e 4; 2 ≠ 1, 4, 5; 3 ≠ 1, 5; 4 ≠ 1, 2, 5)
  Mediana
Mínimo
Máximo
IC 95% 
0,07
0,01
0,64
0,07 a 0,16 
0,03
0,01
0,57
0,04 a 0,12 
0,03
0
0,51
0,04 a 0,11 
0,03
0
0,49
0,03 a 0,1 
0,07
0,01
2,05
0,04 a 0,27 
Controles e feminino
(D) 
Média±DP  0,04±0,02±0,01±0,01±0,02±0,23
  Mediana
Mínimo
Máximo
IC 95% 
0,02
0,01
0,15
0,02 a 0,05 
0,01
0
0,07
0,01 a 0,03 
0,01
0
0,04
0,01 a 0,02 
0,01
0
0,08
0,01 a 0,02 
0,01
0
0,09
0,01 a 0,03 
  Valor de p  <0,001
(A e C ≠ B, D; B e D ≠ A, C) 
0,01
(D ≠ A, C) 
<0,001
(A e C ≠ B, D; B e D ≠ A, C) 
<0,001
(A e C ≠ B, D; B e D ≠ A, C) 
<0,001
(A e C ≠ B, D; B e D ≠ A, C) 
 
Slope 2Fibrose cística e masculino
(A) 
Média±DP  562,34±28,52  537,44±29,71  534±32,3  529,34±33,79  551,43±28,59  0,068
  Mediana
Mínimo
Máximo
IC 95% 
548,63
332,84
940,17
503,7 a 620,97 
554,58
340,24
1003,17
476,35 a 598,52 
549,36
279,94
1070,96
467,59 a 600,41 
566,16
277,46
919,83
459,87 a 598,8 
553,21
304,51
871,09
492,66 a 610,2 
Controles e masculino
(B) 
Média±DP  517,42±30,66  470,71±20,77  460,03±24,62  462,76±22,44  490,97±28,59  0,238
  Mediana
Mínimo
Máximo
IC 95% 
476,5
273
1215,58
455,22 a 579,62 
450,06
272,59
791,22
428,58 a 512,84 
421,89
287,67
816,03
410,09 a 509,97 
427
293,25
779,63
417,23 a 508,29 
462,52
277,14
1184,37
432,98 a 548,96 
Fibrose cística e feminino
(C) 
Média±DP  432,98±28,01  386,08±22,62  390,45±24,47  380,49±29,75  434,15±35,87  0,001
(1 e 5 ≠ 3, 4)
  Mediana
Mínimo
Máximo
IC 95% 
400,21
140
833,67
376,17 a 489,79 
381,25
147,49
708,09
340,18 a 431,97 
347,12
167,4
924
340,45 a 439,72 
366,42
161,66
1173,23
320,14 a 440,84 
430,06
139
1366,24
361,39 a 506,92 
Controles e feminino
(D) 
Média±DP  371,7±17,82  340,37±12,55  337,35±12,33  335,55±13,72  344,05±13,67  0,189
  Mediana
Mínimo
Máximo
IC 95% 
351
225,88
602,15
335,07 a 408,33 
334,85
228,65
464,55
314,56 a 366,18 
338,1
207,82
471,01
311,99 a 362,71 
340,32
207,76
519,02
307,34 a 363,76 
341,99
240,28
501,23
315,94 a 372,17 
  Valor de p  0,222  0,808  0,463  0,801  0,129   

1, momento inicial do SMWT; 2, 1° e 2° minutos do SMWT; 3, 3° e 4° minutos do SMWT; 4, 5° e 6° minutos do SMWT; 5, após o SMWT; DP, desvio‐padrão; IC, intervalo de confiança; SMWT, exercício submáximo por seis minutos em esteira. Alfa=0,05.

Usamos os testes de Kruskal‐Wallis e Friedman. Dados com valores de p positivos apresentados em negrito.

Discussão

Acreditamos que esta é a primeira vez em que a avaliação da resposta dos parâmetros da VCap é destacada durante o exercício em indivíduos saudáveis e portadores de FC. O estudo demonstra a possibilidade de se obter marcadores de um modo não invasivo e por meio de um protocolo de esforço submáximo tolerável pelos participantes.

Especificamente, a VCap obteve vários índices, como o slope 3, que fornece dados sobre a dinâmica do transporte de gás nas vias aéreas alveolares da periferia pulmonar. A inclinação do slope 3 é determinada pela natureza do esvaziamento das unidades alveolares: síncrono ou assíncrono.16,17

O esvaziamento de modo síncrono acontece quando o gás é expirado simultaneamente dos alvéolos, resulta em uma curva horizontal na fase III ou com inclinação mínima. Por outro lado, se as unidades alveolares são esvaziadas de modo assíncrono, ou seja, com constantes de tempo mais longas e elevam o PCO2, ocorre o esvaziamento de forma sequencial ou tardia, resulta em uma inclinação cada vez maior do slope 3. O slope 3 depende dos vários padrões de esvaziamento dos alvéolos com diferentes razões ventilação/perfusão (V/Q), como a eliminação contínua de CO2 nos alvéolos, faz da VCap uma ferramenta útil na detecção de anomalias no desajuste entre V/Q.9,18,19

O slope 3 apresenta valores maiores na FC, indica heterogeneidade de ventilação nos espaços aéreos distais em comparação com os controles.5,17 Veronez et al. descreveram que o aumento no slope 3 em indivíduos com bronquiectasia, relacionada ou não à FC, indicava uma doença difusa nas pequenas vias aéreas.6

O comportamento do slope 3 durante o exercício físico feito nessa pesquisa foi semelhante nos grupos FC e controle. Houve uma queda nos valores do índice durante o exercício físico, seguida de uma rápida recuperação. Contudo, os valores maiores da inclinação do slope 3 provavelmente ocorreram na FC devido à retenção maior de dióxido de carbono exalado (VCO2), porém precisamos considerar outra hipótese, como esvaziamento precoce das regiões do espaço morto alveolar (razão V/Q) e variações no débito cardíaco. Portanto, a FC aumentou os valores do slope 3 durante a avaliação, indicou a heterogeneidade da ventilação inicialmente, durante o repouso. Esse fato justifica‐se na FC pela produção e retenção maiores de CO2, pelo aumento na resistência das vias aéreas, pela redução na capacidade residual funcional e pelas alterações no débito cardíaco durante o exercício físico – esses fatores podem afetar a razão VQ e influenciar a estatura/slope 3.20–23

Ainda considerando o slope 3, alguns autores sugerem a padronização por TV.5,6,9 Almeida et al. observaram maior slope 3/TV em indivíduos com asma em comparação com os controles, sugeriram a heterogeneidade de ventilação nos espaços aéreos distais e indicaram distúrbios estruturais crônicos das vias aéreas e alterações reversíveis agudas observadas no teste de broncoprovocação.9 Além disso, Ribeiro et al., ao usar espirometria e a VCap para avaliar a função pulmonar na FC, identificaram um aumento do slope 3/TV, mesmo em indivíduos com espirometria normal.5 Essa pesquisa corrobora essas discussões e identificou maior slope 3/TV durante o exercício físico na FC, quando comparado com os controles.

O slope 3 e/ou o slope 3/TV mostram associação até mesmo na FC em idade menor do que 12 anos. Assim, desde muito cedo, a FC apresenta alteração na dinâmica respiratória, porém sem comprometer o desempenho da atividade física.

Foram observadas várias características sobre a fisiologia do esforço físico, considerando a faixa etária e o sexo. Nessa linha, constatamos que os valores mais altos de slope 3 ocorreram em FC do sexo masculino. Contudo, ao normalizar para TV (slope 3/TV), os valores mais altos ocorrem em FC do sexo feminino. Essa observação se deve ao aumento do consumo máximo de oxigênio (VO2max) em termos absolutos ao longo do tempo, com maior aceleração em meninos do que meninas. Esse evento está intimamente relacionado ao aumento da massa muscular, de forma que, ao considerar o VO2max determinado pelos indicadores de massa muscular, não há aumento com a idade em crianças e adolescentes do sexo masculino (VO2max/kg – peso corporal constante), ao passo que há uma leve redução em meninas (redução no VO2max/kg – peso corporal).24–26 Assim, a energia anaeróbica não difere entre os sexos nos pré‐púberes, porém aumenta proporcionalmente em meninos a partir da puberdade. Tudo isso se deve ao desenvolvimento da massa muscular e ao efeito de maturação hormonal sobre as características musculoesqueléticas funcionais.27–30

Embora a FC tenha apresentado redução da ventilação alveolar e variação na razão V/Q – dados comprovados pela inclinação na curva do slope 3 –, eles conseguiram fazer o protocolo de exercício físico sem complicações.

A VCap não é amplamente usada na prática clínica, principalmente devido ao pouco entendimento dos dados obtidos e à existência de poucos estudos publicados. Neste estudo, foi descrito o comportamento do slope 2 e slope 3 durante o exercício físico submáximo em pacientes com FC e foi identificado que os pacientes apresentam alterações funcionais a partir do período inicial, que se acentuam durante o exercício. Além disso, embora não tenha sido observada homogeneidade de ventilação na periferia pulmonar na FC, os pacientes conseguiram fazer exercícios submáximos em curtos períodos. Os dados do slope 2 e slope 3 mostraram que, mesmo em pacientes assintomáticos, há alterações nas funções pulmonares, que indicam a necessidade de intervenção precoce para minimizar a degradação pulmonar crônica.

Por fim, a análise dos parâmetros de VCap pode demonstrar que os indivíduos com FC têm alterações na dinâmica respiratória durante o exercício físico e que essa alteração está relacionada aos espaços aéreos distais com heterogeneidade de gases liberados.

Financiamento

Fundação de Amparo à Pesquisa do Estado de São Paulo (Fapesp), apoio à pesquisa e bolsas de estudo (n° 2011/12939‐4, 2011/18845‐1, 2015/12183‐8 e 2015/12858‐5 para FALM e JDR); Fundo de Apoio à Pesquisa, ao Ensino e à Extensão da Universidade Estadual de Campinas, apoio à pesquisa (n° 0648/2015 para FALM). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), bolsa de estudo para PLFP.

Conflitos de interesse

Os autores declaram não haver conflitos de interesse.

Agradecimentos

Adyléia Aparecida Contrera Dalbo Toro, Arthur Kmit, Roberto José Negrão Nogueira, Kátia Cristina Alberto Aguiar, Aléthea Guimarães Farias, Taís Daiene Russo Hortêncio, Aline Gonçalves, Gabriel Hessel, Renan Marrichi Mauch, Andressa de Oliveira Peixoto, Luciana Cardoso Bonadia, Carmen Sílvia Bertuzzo, Stéphanie Villa‐Nova Pereira, Antônio Fernando Ribeiro, Carla Cristina de Souza Gomez, Silvana Dalge Severino, que contribuíram para os estudos de fibrose cística em nosso centro de referência. Projeto Espaço da Escrita/Coordenadoria Geral da Unicamp pela tradução deste artigo para o inglês.

Referências
[1]
P.T. Pianosi, R.I. Liem, R.G. McMurray, F.J. Cerny, B. Falk, H.C. Kemper.
Pediatric exercise testing: value and implications of peak oxygen uptake.
Children (Basel), 4 (2017), pp. 2-9
[2]
C. Bieli, S. Summermatter, U. Boutellier, A. Moeller.
Respiratory muscle training improves respiratory muscle endurance but not exercise tolerance in children with cystic fibrosis.
Pediatr Pulmonol, 52 (2017), pp. 331-336
[3]
P.L. Parazzi, F.A. Marson, M.A. Ribeiro, C.C. de Almeida, L.C. Martins, I.A. Paschoal, et al.
Ventilatory abnormalities in subjects with cystic fibrosis undergoing the submaximal treadmill exercise test.
BMC Pulm Med, 15 (2015), pp. 63
[4]
E. Weir, P.D. Burns, A. Devenny, D. Young, J.Y. Paton.
Cardiopulmonary exercise testing in children with cystic fibrosis: one centre's experience.
Arch Dis Child, 102 (2017), pp. 440-444
[5]
M.A. Ribeiro, M.T. Silva, J.D. Ribeiro, M.M. Moreira, C.C. Almeida, A.A. Almeida-Junior, et al.
Volumetric capnography as a tool to detect early peripheric lung obstruction in cystic fibrosis subjects.
J Pediatr (Rio J), 88 (2012), pp. 509-517
[6]
L. Veronez, M.M. Moreira, S.T. Soares, M.C. Pereira, M.A. Ribeiro, J.D. Ribeiro, et al.
Volumetric capnography for the evaluation of pulmonary disease in adult subjects with cystic fibrosis and noncystic fibrosis bronchiectasis.
[7]
B.P. O'Sullivan, S.D. Freedman.
Cystic fibrosis.
Lancet, 373 (2009), pp. 1891-1904
[8]
J.D. Ribeiro, M.A. Ribeiro, A.F. Ribeiro.
Controversies in cystic fibrosis from pediatrician to specialist.
J Pediatr (Rio J), 78 (2002), pp. S171-S186
[9]
C.C. Almeida, A.A. Almeida-Junior, M.A. Ribeiro, M.T. Nolasco-Silva, J.D. Ribeiro.
Volumetric capnography to detect ventilation inhomogeneity in children and adolescents with controlled persistent asthma.
J Pediatr (Rio J), 87 (2011), pp. 163-168
[10]
ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories.
Statement: Guidelines for the six‐minute walk test.
Am J Respir Crit Care Med, 166 (2002), pp. 111-117
[11]
C.A. Williams, Z.L. Saynor, O.W. Tomlinson, A.R. Barker.
Cystic fibrosis and physiological responses to exercise.
Expert Rev Respir Med, 8 (2014), pp. 751-762
[12]
C.L. Lafortuna, S. Lazzer, F. Agosti, C. Busti, R. Galli, G. Mazzilli, et al.
Metabolic responses to submaximal treadmill walking and cycle ergometer pedalling in obese adolescents.
Scand J Med Sci Sports, 20 (2010), pp. 630-637
[13]
B.A. Nemeth, A.L. Carrel, J. Eickhoff, R.R. Clark, S.E. Peterson, D.B. Allen.
Submaximal treadmill test predicts VO2 max in overweight children.
J Pediatr (Rio J), 154 (2009), pp. 677-681
[14]
F. Lobelo, R.R. Pate, M. Dowda, A.D. Liese, J.R. Ruiz.
Validity of cardiorespiratory fitness criterion‐referenced standards for adolescents.
Med Sci Sports Exerc, 41 (2009), pp. 1222-1229
[15]
I.G. Labadessa, J.F. Arcuri, A.C. Sentanin, J.N. Costa, B.V. Pessoa, V.A. Di Lorenzo.
Should the 6‐minute walk test be compared when conducted by 2 different assessors in subjects with COPD?.
Respir Care, 61 (2016), pp. 1323-1330
[16]
S.I. Fuchs, S. Junge, H. Ellemunter, M. Ballmann, M. Gappa.
Calculation of the capnographic index based on expiratory molar mass‐volume‐curves a suitable tool to screen for cystic fibrosis lung disease.
J Cyst Fibros, 12 (2013), pp. 277-283
[17]
L. Veronez, M.C. Pereira, S.M. da Silva, L.A. Barcaui, E.M. De Capitani, M.M. Moreira, et al.
Volumetric capnography for the evaluation of chronic airways diseases.
Int J Chron Obstruct Pulmon Dis, 9 (2014), pp. 983-989
[18]
S. Verscheure, P.B. Massion, F. Verschuren, P. Damas, S. Magder.
Volumetric capnography: lessons from the past and current clinical applications.
[19]
G. Tusman, I. Groisman, F.E. Fiolo, A. Scandurra, J.M. Arca, G. Krumrick, et al.
Noninvasive monitoring of lung recruitment maneuvers in morbidly obese subjects: the role of pulse oximetry and volumetric capnography.
Anesth Analg, 118 (2014), pp. 137-144
[20]
G. Murias, L. Blanch, U. Lucangelo.
The physiology of ventilation.
Respir Care, 59 (2014), pp. 1795-1807
[21]
L. Plantier, S. Marchand-Adam, L. Boyer, C. Taillé, C. Delclaux.
Methacholine‐induced variations in airway volume and the slope of the alveolar capnogram are distinctly associated with airflow limitation and airway closure.
PLOS ONE, 10 (2015), pp. e0143550
[22]
S.M. Belenkiy, W.L. Baker, A.I. Batchinsky, S. Mittal, T. Watkins, J. Salinas, et al.
Multivariate analysis of the volumetric capnograph for PaCO2 estimation.
Int J Burns Trauma, 5 (2015), pp. 66-74
[23]
G.S. Qi, W.C. Gu, W.L. Yang, F. Xi, H. Wu, J.M. Liu.
The ability of volumetric capnography to distinguish between chronic obstructive pulmonary disease subjects and normal subjects.
[24]
P.T. Pianosi, R.I. Liem, R.G. McMurray, F.J. Cerny, B. Falk, H.C. Kemper.
Pediatric exercise testing: value and implications of peak oxygen uptake.
Children (Basel), 4 (2017), pp. E6
[25]
P.X. Hommerding, R.R. Baptista, G.T. Makarewicz, C.S. Schindel, M.V. Donadio, L.A. Pinto, et al.
Effects of an educational intervention of physical activity for children and adolescents with cystic fibrosis: a randomized controlled trial.
Respir Care, 60 (2015), pp. 81-87
[26]
J. Pastré, A. Prévotat, C. Tardif, C. Langlois, A. Duhamel, B. Wallaert.
Determinants of exercise capacity in cystic fibrosis subjects with mild‐to‐moderate lung disease.
BMC Pulm Med, 14 (2014), pp. 74
[27]
S. Stanojevic, S.D. Davis, G. Retsch-Bogart, H. Webster, M. Davis, R.C. Johnson, et al.
Progression of lung disease in preschool subjects with cystic fibrosis.
Am J Respir Crit Care Med., 195 (2016), pp. 1216-1225
[28]
T. Lahiri, S.E. Hempstead, C. Brady, C.L. Cannon, K. Clark, M.E. Condren, et al.
Clinical practice guidelines from the cystic fibrosis foundation for preschoolers with cystic fibrosis.
Pediatrics, 137 (2016), pp. e20151784
[29]
M.S. Stalvey, J. Pace, M. Niknian, M.N. Higgins, V. Tarn, J. Davis, et al.
Growth in prepubertal children with cystic fibrosis treated with Ivacaftor.
Pediatrics, 139 (2017), pp. e20162522
[30]
I.R. Del Ciampo, L.A. Del Ciampo, R. Sawamura, L.R. de Oliveira, M.I. Fernandes.
Nutritional status of adolescents with cystic fibrosis treated at a reference center in the southeast region of Brazil.
Ital J Pediatr, 41 (2015), pp. 51

Como citar este artigo: Parazzi PL, Marson FA, Ribeiro MA, Schivinski CI, Ribeiro JD. Evaluation of respiratory dynamics by volumetric capnography during submaximal exercise protocol of six minutes on treadmill in cystic fibrosis patients. J Pediatr (Rio J). 2019;95:76–86.

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