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Vol. 90. Núm. 1.
Páginas 28-34 (Janeiro - Fevereiro 2014)
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Vol. 90. Núm. 1.
Páginas 28-34 (Janeiro - Fevereiro 2014)
ARTIGO ORIGINAL
Open Access
Effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in children with metabolic syndrome: a triple-masked controlled trial
Efeitos da suplementação de vitamina D sobre a resistência à insulina e fatores de risco cardiometabólico em crianças com síndrome metabólica: ensaio clínico triplo- cego controlado
Visitas
...
Roya Kelishadia,
Autor para correspondência
kelishadi@med.mui.ac.ir

Corresponding author.
, Shadi Saleka, Mehdi Saleka, Mahin Hashemipoura, Mahsa Movahedianb
a Departamento de Pediatria, Centro de Pesquisa de Crescimento e Desenvolvimento Infantil e Faculdade de Medicina, Isfahan University of Medical Sciences, Isfahan, Irã
b Departamento de Linguística Inglesa, The University of Isfahan, Isfahan, Irã
Informação do artigo
Abstract

This triple-masked controlled trial aimed to assess the effects of vitamin D supple- mentation on insulin resistance and cardiometabolic risk factors in obese children and adolescents.

The study comprised 50 participants, aged 10 to 16 years, who were randomly assigned into two groups of equal number. In this 12-week trial, one group received oral vitamin D (300,000 IU) and the other group received placebo. Cardiometabolic risk factors, insulin resistance, and a continuous value of metabolic syndrome (cMetS) were determined. Statistical analysis was conducted after adjustment for covariate interactions.

Overall, 21 patients in the vitamin D group and 22 in the placebo group completed the trial. No significant difference was observed in the baseline characteristics of the two groups. After the trial, in the vitamin D group, serum insulin and triglyceride concentrations, as well as HOM-IR and C-MetS decreased significantly, both when compared with the baseline and with the placebo group. No significant difference was observed when comparing total cholesterol, LDL-C, HDL-C, fasting blood glucose, and blood pressure.

The present findings support the favorable effects of vitamin D supplementation on reducing insulin resistance and cardiometabolic risk factors in obese children.

Keywords:
Vitamin D
Metabolic syndrome
Insulin resistance
Children and adolescents
Resumo

Este ensaio clínico triplo-cego controlado visa investigar os efeitos da suplementação de vitamina D sobre a resistência à insulina e os fatores de risco cardiometabólico em crianças e adolescentes obesos.

O estudo contou com 50 participantes com idade entre 10 e 16 anos, aleatoriamente divididos em dois grupos de igual número de participantes. Neste ensaio clínico de 12 semanas, um grupo recebeu vitamina D via oral (300000 IU) e o outro grupo recebeu placebo. Foram determinados fatores de risco cardiometabólico, resistência à insulina e valor contínuo da síndrome metabólica (cMetS). A análise estatística foi conduzida após o ajuste das interações covariáveis.

No todo, 21 pacientes no grupo vitamina D e 22 no grupo placebo concluíram o ensaio clí- nico. Nenhuma diferença significativa foi encontrada nas características de base dos dois grupos estudados. Após o ensaio clinico, no grupo vitamina D, as concentrações séricas de insulina e triglicerídeos, bem como HOMA-RI e cMetS caíram significativamente em comparação ao início do estudo; e também em comparação ao grupo placebo. Nenhuma diferença significativa foi vista ao comparar o colesterol total, LDL-C, HDL-C, glicemia de jejum e pressão sanguínea.

Nossas conclusões indicam efeitos favoráveis da suplementação de vitamina D sobre a redução da resistência à insulina e de fatores de risco cardiometabólico em crianças obesas.

Palavras-chave:
Vitamina D
Síndrome metabólica
Resistência à insulina
Crianças e adolescents
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Como citar este artigo: Kelishadi R, Salek S, Salek M, Hashemipour M, Effects of vitamin D supplementation on insulin resistance and cardiometabolic risk factors in children with metabolic syndrome: a triple-masked controlled trial. J Pediatr (Rio J). 2014;90:28-34.

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