Pharmacokinetics of vancomycin depends on many factors and one of them is the age of the patient. It is better known in adults and there are few studies in children. Therefore, we studied the serum concentrations in 22 children with multi-resistant bacteria infections that received vancomycin. The doses administered followed the recommended rules for its utilization. This study was made at the equilibrium phase and immunofluorescence was the method utilized, The peak serum concentrations varied from 23 to 99mcg/ml and only in 8 children (36%) they varied from 30 to 40mcg/ml. In 10 cases (45%) we found valley serum concentration between 5 to 10mcg/ml. These observations confirm the imprevisibility of serum concentrations obtained from one single recommended dose. Therefore, due to the complexity of vancomycin pharmacokinetics, the monitorization of blood levels is recommended in order to obtain therapeutic success.
Impact factor
The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years.
© Clarivate Analytics, Journal Citation Reports 2022
Impact factor 2023
2.8
Citescore 2023
5.6
SJR
SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.
See moreSJR 2023
0.76
SNIP
SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field.
See moreSNIP 2023
1.09
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