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    "titulo" => "Advancing pediatric healthcare in Brazil&#58; establishing reliable reference intervals for serum immunoglobulins"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0001" class="elsevierStylePara elsevierViewall">The determination of accurate reference intervals &#40;RI&#41; for serum immunoglobulins is indispensable for effective clinical decision-making in pediatric healthcare&#46; These intervals provide vital benchmarks for assessing immune function and diagnosing immune-related disorders in children&#46; However&#44; the process of establishing reliable RI is complex and often constrained by methodological limitations&#44; particularly in pediatric populations&#46; Addressing this gap&#44; a recent population-based study conducted in Cuiab&#225;&#44; MT&#44; Brazil&#44;<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a> aimed to define RI for serum immunoglobulins G&#44; M&#44; and E in Brazilian children aged 1 to 10 years&#46; This editorial discusses the significance of this study and its implications for pediatric healthcare in Brazil while incorporating relevant citations from the scientific literature to support key points&#46;</p><span id="sec0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Significance of reference intervals in pediatric healthcare</span><p id="para0002" class="elsevierStylePara elsevierViewall">Reference intervals play a pivotal role in pediatric healthcare by providing clinicians with essential guidance for interpreting laboratory results and making informed clinical decisions&#46; In the context of immunoglobulins&#44; reference intervals enable clinicians to assess immune function&#44; monitor disease progression&#44; and guide therapeutic interventions in pediatric patients with immune-related disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> Accurate reference intervals&#44; tailored to specific age and sex groups&#44; are essential for ensuring the validity and reliability of clinical assessments in children&#46;<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a></p><p id="para0003" class="elsevierStylePara elsevierViewall">Challenges in Establishing Reliable Reference Intervals&#58; Despite their importance&#44; establishing reliable reference intervals for serum immunoglobulins presents numerous challenges in pediatric populations&#46; These challenges include limited sample sizes&#44; demographic variability&#44; methodological discrepancies&#44; and the influence of external factors such as ethnicity and geographic location&#46;<a class="elsevierStyleCrossRef" href="#bib0004"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a> Inadequate representation of diverse populations and insufficient adherence to standardized methodologies can compromise the accuracy and generalizability of reference intervals&#44; undermining their utility in clinical practice&#46;</p><p id="para0004" class="elsevierStylePara elsevierViewall">The Canadian Laboratory Initiative on Pediatric Reference Intervals &#40;CALIPER&#41; represents a landmark effort in advancing pediatric healthcare globally&#46; By leveraging a vast dataset comprising samples from ethnically diverse pediatric populations&#44; the CALIPER project has contributed significantly to the establishment of comprehensive reference intervals for various analytes&#44; including immunoglobulins&#44; in children&#46;<a class="elsevierStyleCrossRefs" href="#bib0002"><span class="elsevierStyleSup">2&#8211;4</span></a> However&#44; while the CALIPER database offers valuable insights&#44; its applicability to specific populations&#44; such as Brazilian children&#44; may be limited due to variations in demographics and environmental factors&#46;<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a></p><p id="para0005" class="elsevierStylePara elsevierViewall">The recent study conducted in Cuiab&#225;&#44; MT&#44; represents a significant milestone in Brazilian pediatric healthcare&#46; Utilizing a rigorous methodology endorsed by the Clinical Laboratory Standards Institute &#40;CLSI&#41;&#44; the study aimed to establish accurate and population-specific reference intervals for serum immunoglobulins G&#44; M&#44; and E in Brazilian children aged 1 to 10 years&#46;<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a> By including a diverse sample population representative of the Brazilian demographic landscape&#44; the study sought to address existing gaps in pediatric reference intervals and enhance the quality of clinical care for Brazilian children&#46;</p><p id="para0006" class="elsevierStylePara elsevierViewall">Implications for Clinical Practice and Future Research&#58; The establishment of robust reference intervals for serum immunoglobulins holds profound implications for clinical practice in Brazil&#46; Clinicians can now rely on accurate and population-specific reference values to interpret laboratory results&#44; diagnose immune-related disorders&#44; and guide therapeutic interventions with confidence&#46;<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a> Moreover&#44; the availability of comprehensive reference intervals facilitates the standardization of clinical assessments and promotes consistency in pediatric healthcare delivery across different healthcare settings&#46;</p><p id="para0007" class="elsevierStylePara elsevierViewall">Moving forward&#44; further research is warranted to expand our understanding of immunoglobulin dynamics in Brazilian children and optimize pediatric healthcare outcomes nationwide&#46; Longitudinal studies tracking immunoglobulin levels across different age groups&#44; geographical regions&#44; and ethnicities can provide valuable insights into developmental trends&#44; environmental influences&#44; and disease susceptibility&#46;<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> Collaborative efforts involving multiple research institutions and healthcare stakeholders are essential to ensure the continued advancement of pediatric healthcare in Brazil and address the evolving needs of the pediatric population&#46;</p><p id="para0008" class="elsevierStylePara elsevierViewall">In conclusion&#44; the establishment of reliable reference intervals for serum immunoglobulins in Brazilian children represents a significant advancement in pediatric healthcare&#46; By adhering to a rigorous methodology and incorporating diverse sample populations&#44; the study conducted in Cuiab&#225; has provided clinicians with invaluable tools for assessing immune function and optimizing clinical decision-making in pediatric patients&#46; As Brazil continues to strive for excellence in pediatric healthcare&#44; continued research efforts and collaborative initiatives will be essential to further enhance our understanding of immunoglobulin dynamics and improve healthcare outcomes for children across the country&#46;</p></span></span>"
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Editorial
Advancing pediatric healthcare in Brazil: establishing reliable reference intervals for serum immunoglobulins
Khosrow Adeli
Clinical Biochemistry, Pediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
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    "titulo" => "Advancing pediatric healthcare in Brazil&#58; establishing reliable reference intervals for serum immunoglobulins"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="para0001" class="elsevierStylePara elsevierViewall">The determination of accurate reference intervals &#40;RI&#41; for serum immunoglobulins is indispensable for effective clinical decision-making in pediatric healthcare&#46; These intervals provide vital benchmarks for assessing immune function and diagnosing immune-related disorders in children&#46; However&#44; the process of establishing reliable RI is complex and often constrained by methodological limitations&#44; particularly in pediatric populations&#46; Addressing this gap&#44; a recent population-based study conducted in Cuiab&#225;&#44; MT&#44; Brazil&#44;<a class="elsevierStyleCrossRef" href="#bib0001"><span class="elsevierStyleSup">1</span></a> aimed to define RI for serum immunoglobulins G&#44; M&#44; and E in Brazilian children aged 1 to 10 years&#46; This editorial discusses the significance of this study and its implications for pediatric healthcare in Brazil while incorporating relevant citations from the scientific literature to support key points&#46;</p><span id="sec0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Significance of reference intervals in pediatric healthcare</span><p id="para0002" class="elsevierStylePara elsevierViewall">Reference intervals play a pivotal role in pediatric healthcare by providing clinicians with essential guidance for interpreting laboratory results and making informed clinical decisions&#46; In the context of immunoglobulins&#44; reference intervals enable clinicians to assess immune function&#44; monitor disease progression&#44; and guide therapeutic interventions in pediatric patients with immune-related disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> Accurate reference intervals&#44; tailored to specific age and sex groups&#44; are essential for ensuring the validity and reliability of clinical assessments in children&#46;<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a></p><p id="para0003" class="elsevierStylePara elsevierViewall">Challenges in Establishing Reliable Reference Intervals&#58; Despite their importance&#44; establishing reliable reference intervals for serum immunoglobulins presents numerous challenges in pediatric populations&#46; These challenges include limited sample sizes&#44; demographic variability&#44; methodological discrepancies&#44; and the influence of external factors such as ethnicity and geographic location&#46;<a class="elsevierStyleCrossRef" href="#bib0004"><span class="elsevierStyleSup">4</span></a><span class="elsevierStyleSup">&#44;</span><a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">5</span></a> Inadequate representation of diverse populations and insufficient adherence to standardized methodologies can compromise the accuracy and generalizability of reference intervals&#44; undermining their utility in clinical practice&#46;</p><p id="para0004" class="elsevierStylePara elsevierViewall">The Canadian Laboratory Initiative on Pediatric Reference Intervals &#40;CALIPER&#41; represents a landmark effort in advancing pediatric healthcare globally&#46; By leveraging a vast dataset comprising samples from ethnically diverse pediatric populations&#44; the CALIPER project has contributed significantly to the establishment of comprehensive reference intervals for various analytes&#44; including immunoglobulins&#44; in children&#46;<a class="elsevierStyleCrossRefs" href="#bib0002"><span class="elsevierStyleSup">2&#8211;4</span></a> However&#44; while the CALIPER database offers valuable insights&#44; its applicability to specific populations&#44; such as Brazilian children&#44; may be limited due to variations in demographics and environmental factors&#46;<a class="elsevierStyleCrossRef" href="#bib0003"><span class="elsevierStyleSup">3</span></a></p><p id="para0005" class="elsevierStylePara elsevierViewall">The recent study conducted in Cuiab&#225;&#44; MT&#44; represents a significant milestone in Brazilian pediatric healthcare&#46; Utilizing a rigorous methodology endorsed by the Clinical Laboratory Standards Institute &#40;CLSI&#41;&#44; the study aimed to establish accurate and population-specific reference intervals for serum immunoglobulins G&#44; M&#44; and E in Brazilian children aged 1 to 10 years&#46;<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a> By including a diverse sample population representative of the Brazilian demographic landscape&#44; the study sought to address existing gaps in pediatric reference intervals and enhance the quality of clinical care for Brazilian children&#46;</p><p id="para0006" class="elsevierStylePara elsevierViewall">Implications for Clinical Practice and Future Research&#58; The establishment of robust reference intervals for serum immunoglobulins holds profound implications for clinical practice in Brazil&#46; Clinicians can now rely on accurate and population-specific reference values to interpret laboratory results&#44; diagnose immune-related disorders&#44; and guide therapeutic interventions with confidence&#46;<a class="elsevierStyleCrossRef" href="#bib0006"><span class="elsevierStyleSup">6</span></a> Moreover&#44; the availability of comprehensive reference intervals facilitates the standardization of clinical assessments and promotes consistency in pediatric healthcare delivery across different healthcare settings&#46;</p><p id="para0007" class="elsevierStylePara elsevierViewall">Moving forward&#44; further research is warranted to expand our understanding of immunoglobulin dynamics in Brazilian children and optimize pediatric healthcare outcomes nationwide&#46; Longitudinal studies tracking immunoglobulin levels across different age groups&#44; geographical regions&#44; and ethnicities can provide valuable insights into developmental trends&#44; environmental influences&#44; and disease susceptibility&#46;<a class="elsevierStyleCrossRef" href="#bib0002"><span class="elsevierStyleSup">2</span></a> Collaborative efforts involving multiple research institutions and healthcare stakeholders are essential to ensure the continued advancement of pediatric healthcare in Brazil and address the evolving needs of the pediatric population&#46;</p><p id="para0008" class="elsevierStylePara elsevierViewall">In conclusion&#44; the establishment of reliable reference intervals for serum immunoglobulins in Brazilian children represents a significant advancement in pediatric healthcare&#46; By adhering to a rigorous methodology and incorporating diverse sample populations&#44; the study conducted in Cuiab&#225; has provided clinicians with invaluable tools for assessing immune function and optimizing clinical decision-making in pediatric patients&#46; As Brazil continues to strive for excellence in pediatric healthcare&#44; continued research efforts and collaborative initiatives will be essential to further enhance our understanding of immunoglobulin dynamics and improve healthcare outcomes for children across the country&#46;</p></span></span>"
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Article information
ISSN: 00217557
Original language: English
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