was read the article
array:25 [ "pii" => "S0021755721000267" "issn" => "00217557" "doi" => "10.1016/j.jped.2021.01.002" "estado" => "S300" "fechaPublicacion" => "2021-07-01" "aid" => "961" "copyright" => "Sociedade Brasileira de Pediatria" "copyrightAnyo" => "2021" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "J Pediatr (Rio J). 2021;97:366-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S0021755720302096" "issn" => "00217557" "doi" => "10.1016/j.jped.2020.08.008" "estado" => "S300" "fechaPublicacion" => "2021-07-01" "aid" => "921" "copyright" => "Sociedade Brasileira de Pediatria" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "rev" "cita" => "J Pediatr (Rio J). 2021;97:369-77" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review article</span>" "titulo" => "The potential impact of the COVID-19 pandemic on child growth and development: a systematic review" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "369" "paginaFinal" => "377" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3053 "Ancho" => 2508 "Tamanyo" => 320766 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Screening profile.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Liubiana Arantes de Araújo, Cássio Frederico Veloso, Matheus de Campos Souza, João Marcos Coelho de Azevedo, Giulio Tarro" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Liubiana Arantes de" "apellidos" => "Araújo" ] 1 => array:2 [ "nombre" => "Cássio Frederico" "apellidos" => "Veloso" ] 2 => array:2 [ "nombre" => "Matheus de Campos" "apellidos" => "Souza" ] 3 => array:2 [ "nombre" => "João Marcos Coelho de" "apellidos" => "Azevedo" ] 4 => array:2 [ "nombre" => "Giulio" "apellidos" => "Tarro" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0021755720302096?idApp=UINPBA000049" "url" => "/00217557/0000009700000004/v1_202107150608/S0021755720302096/v1_202107150608/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S002175572100036X" "issn" => "00217557" "doi" => "10.1016/j.jped.2021.03.001" "estado" => "S300" "fechaPublicacion" => "2021-07-01" "aid" => "971" "copyright" => "Sociedade Brasileira de Pediatria" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "sco" "cita" => "J Pediatr (Rio J). 2021;97:363-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "What can we learn from measuring IgE to allergens and allergen components in tropical and subtropical settings in Brazil?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "363" "paginaFinal" => "365" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Philip J. Cooper" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Philip J." "apellidos" => "Cooper" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S002175572100036X?idApp=UINPBA000049" "url" => "/00217557/0000009700000004/v1_202107150608/S002175572100036X/v1_202107150608/en/main.assets" ] "asociados" => array:1 [ 0 => array:19 [ "pii" => "S0021755720302023" "issn" => "00217557" "doi" => "10.1016/j.jped.2020.07.007" "estado" => "S300" "fechaPublicacion" => "2021-07-01" "aid" => "914" "copyright" => "Sociedade Brasileira de Pediatria" "documento" => "article" "crossmark" => 1 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "J Pediatr (Rio J). 2021;97:396-401" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Association between asthma and sleep hours in Brazilian adolescents: ERICA" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "396" "paginaFinal" => "401" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Natalia Rocha do Amaral Estanislau, Erica Azevedo de Oliveira Costa Jordão, Gabriela de Azevedo Abreu, Katia Vergetti Bloch, Maria Cristina Caetano Kuschnir, Mara M.R. Felix, Fabio Chigres Kuschnir" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Natalia Rocha do Amaral" "apellidos" => "Estanislau" ] 1 => array:2 [ "nombre" => "Erica Azevedo de Oliveira Costa" "apellidos" => "Jordão" ] 2 => array:2 [ "nombre" => "Gabriela de Azevedo" "apellidos" => "Abreu" ] 3 => array:2 [ "nombre" => "Katia Vergetti" "apellidos" => "Bloch" ] 4 => array:2 [ "nombre" => "Maria Cristina Caetano" "apellidos" => "Kuschnir" ] 5 => array:2 [ "nombre" => "Mara M.R." "apellidos" => "Felix" ] 6 => array:2 [ "nombre" => "Fabio Chigres" "apellidos" => "Kuschnir" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0021755720302023?idApp=UINPBA000049" "url" => "/00217557/0000009700000004/v1_202107150608/S0021755720302023/v1_202107150608/en/main.assets" ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Does asthma cause sleep disorders … or the other way around?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "366" "paginaFinal" => "368" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Luis Garcia-Marcos, Manuel Sanchez-Solis" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Luis" "apellidos" => "Garcia-Marcos" "email" => array:1 [ 0 => "lgmarcos@um.es" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Manuel" "apellidos" => "Sanchez-Solis" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "University of Murcia, Arrixaca University Children’s Hospital, Respiratory and Allergy Units, Murcia, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Carlos III Health Institute, Network of Asthma, and Adverse and Allergy Reactions (ARADyAL) Network, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In the present issue of the Jornal de Pediatria, the paper by Estanislau et al.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> assesses the association between the hours of sleep and the suffering from asthma in adolescents. The study was designed considering that the independent variable in the regression analyses is sleep, while the dependent one is asthma. The authors conclude that asthma prevalence is significantly higher in individuals who sleep less hours. It is a study which has the great strength of including 59,442 adolescents in the analyses. Still, there is an important issue when considering the results: it is a crossover study, which does not allow the knowledge of whether asthma precedes sleep disturbance or the other way around. Casual relationship in epidemiology need three conditions: association, direction and temporal relationship.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> The authors find an interesting association, but does the lack of sleep have a causal relationship to asthma?</p><p id="par0010" class="elsevierStylePara elsevierViewall">It is perfectly known that asthma presents frequently nocturnal symptoms which are associated with a bad quality of sleep, usually including arousing, parasomnias and breathing difficulties, apart for a lower quality of life of parents when the patients are children.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">There is an interesting question that one might ask to oneself, and this is whether asthmatic condition associates an altered sleep architecture or a consequence of a higher prevalence of obstructive sleep apnea syndrome (OSA), which is the most frequent sleep disorder in childhood. On the other hand, could asthma be the cause of the sleep disorder or vice-versa? It is even possible to consider a bi-directional association and thus asthma would be a risk factor for OSA in some children while OSA might be a risk factor for asthma in other. OSA is considered a disorder in which by –ideally– polysomnography an abnormal number of apnea episodes of obstructive origin are detected during normal sleep. However, respiratory sleep disorder (RSD) is a wider term and includes any respiratory disorder during sleep and not only OSA. In children, the assessment of RSD is frequently performed by means of questionnaires.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Is there an altered sleep architecture in asthmatic children and adolescents?</span><p id="par0020" class="elsevierStylePara elsevierViewall">As it has been already said previously, asthma has nocturnal symptoms which may alter the normal sleep architecture as compared with the healthy population. In fact, the study by Khassawneh et al.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> found significant differences in the aforementioned architecture as assessed by polysomnography in a selected group of 85 asthmatic adolescents with low risk of OSA, as evaluated by the Pediatric Sleep Questionnaire. Those patients had less sleep time, less sleep time in REM phase, less sleep latency and less SatO2 nadir. They had also more time awake after they initially slept (wake after sleep onset — WASO), higher arousal index both spontaneous and due to respiratory causes and, finally, higher apnea/hypopnea index (AHI). In fact, 29% of participants had patterns compatible with OSA in spite of having low risk scores. But even in asthmatic patients with normal AHI, that is, without OSA, those sleep values are significantly altered as compared to normal values; except, of course, for the arousal index from respiratory causes and the AHI. It is also of interest that sleep disturbances were not related to asthma control.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Is asthma a risk factor of OSA or RSD?</span><p id="par0025" class="elsevierStylePara elsevierViewall">The association between asthma and OSA in children has been studied widely. There is even a systematic Review and meta-analysis<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> which includes 17 studies with a total of 45,155 children (53% male) of a mean age of 8.6 ± 2.5 years. The authors found a higher risk of OSA among asthmatic patients (OR 1.91; 95%CI: 1.04–2.13) independently of the diagnostic method (polygraph or polysomnography). Some years later, the same authors performed a new systematic review with the aim of unravelling the relationship between asthma and SRD, with special focus on the impact of treatment.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> This study selected 32 previous ones and include 143,343 children (51% male) with a mean age of 8.4 ± 2.5 years: the man conclusion is that asthmatic children have higher likelihood of suffering from OSA.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Finally, the same group made a systematic search in the attempt to demonstrate asthma causes RSD considering the whole nine criteria for associations: strength of the association, consistency, specificity, temporality, biological gradient, plausibility, coherence, experimentality and analogy. This concludes that temporality criteria cannot be demonstrated, as there are no cohort studies showing that asthma precedes OSA. Therefore, directionality (asthma causing OSA) cannot be established.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Thus, the current knowledge seems to indicate that asthmatic children have a higher prevalence of OSA, being asthma a potential risk factor for RSD.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Is RSD risk factors for asthma?</span><p id="par0040" class="elsevierStylePara elsevierViewall">This is the direction of the study by Estanislau et al.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and other studies, from which it is worth mentioning one published in 2015 by Li et al.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> for in one hand they assess this association by a cross-sectional study by means of questionnaires in a big population of 20,672 children (response rate 91.9% and age range 5–12 years); and on the other, they include a meta-analysis of 12 previous studies including 38,766 children. In the cross-sectional study the find that both snoring (OR = 1.28, 95%CI: 1.01–1.62) and OSA (OR = 1.92; 95%CI: 1.34–2.76) are statistically significant asthma predictors. The meta-analysis also showed that RSD is a risk factor for asthma (OR = 1.55; 95%CI: 1.44–1.66) both considering cross-sectional studies (OR = 1.56, 95%CI: 1.45–1.68) and cohort studies (OR = 1.46; 95%CI: 1.16–1.75).</p><p id="par0045" class="elsevierStylePara elsevierViewall">The review by Sánchez et al.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> also shows that RSD is associated to more severe cases of asthma and that OSA treatment (tonsillectomy) was associated to a significant improvement of asthma. On the other hand, Ross et al.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> studied 108 asthmatic children that were followed prospectively over one year that had been managed according to international guidelines and observed that asthma grave was found in 55% of children with RSD but only in 20% of children without SRD (OR = 3.63; 95%CI: 1.26–10.4) after adjusting for obesity, gender and ethnicity.</p><p id="par0050" class="elsevierStylePara elsevierViewall">More recently, the study by Oka et al.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> showed in a numerous population of 27,935 children between 6 and 17 years of age admitted to hospital due to an asthma attack, that in 1.4% of them in which OSA coexisted, non-invasive ventilation was more frequently needed (OR = 1.2; 95%CI: 1.16–1–24) to manage the attack; and that hospital stays were longer (OR = 1.2; 95%CI 1.16–1–24).</p><p id="par0055" class="elsevierStylePara elsevierViewall">In a systematic review on the effect of tonsillectomy on asthma control Kohli et al.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> found that the procedure might be of help, although it is cautioned that there are few studies and that their design is not the most adequate.</p><p id="par0060" class="elsevierStylePara elsevierViewall">According to the previous evidence, it could be concluded that SRD and OSA are risk factors for asthma, end even of an increased severity of the condition.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Is it plausible a bidirectionality in the relationship between asthma and SRD?</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors can certainly find arguments to try and understand this relationship: certain comorbidities are frequent in both conditions and could contribute in both directions. Obesity is a factor related to asthma<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> and with SRD.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Gastroesophageal reflux is also related to asthma<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> and it has also been demonstrated that more than 40% of children with OSA due to tonsillar hypertrophy have abnormal esophageal pHmetry.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Finally, the prevalence of allergic rhinitis among asthmatics is very high<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> and it is also associated with SRD.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">On the other hand, asthma and OSA are conditions which share inflammatory characteristics with interrelationships between them<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">18,19</span></a> and it has been described that OSA may contribute to airway remodeling in severe cases of asthma.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The clinical implications of the associations between SRD and asthma are obvious because asthma is aggravated and further disturbs the quality of life of patients. Pediatricians must be aware of this comorbidity that is so frequent.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:6 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Is there an altered sleep architecture in asthmatic children and adolescents?" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Is asthma a risk factor of OSA or RSD?" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Is RSD risk factors for asthma?" ] 3 => array:2 [ "identificador" => "sec0020" "titulo" => "Is it plausible a bidirectionality in the relationship between asthma and SRD?" ] 4 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflicts of interest" ] 5 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar1005">See paper by Estanislau et al. in pages 396-401.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between asthma and sleep hours in Brazilian adolescents: ERICA" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N.R. Estanislau" 1 => "E.A. Jordão" 2 => "G.A. Abreu" 3 => "K.V. Bloch" 4 => "M.C. Kuschnir" 5 => "M.M. Felix" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Pediatr (Rio J)" "fecha" => "2021" "volumen" => "97" "paginaInicial" => "396" "paginaFinal" => "401" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What is a cause and how do we know one? A grammar for pragmatic epidemiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Susser" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/oxfordjournals.aje.a115939" "Revista" => array:6 [ "tituloSerie" => "Am J Epidemiol" "fecha" => "1991" "volumen" => "133" "paginaInicial" => "635" "paginaFinal" => "648" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2018019" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nocturnal asthma symptoms and poor sleep quality among urban school children with asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Fagnano" 1 => "A.L. Bayer" 2 => "C.A. Isensee" 3 => "T. Hernandez" 4 => "J.S. Halterman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.acap.2011.05.006" "Revista" => array:6 [ "tituloSerie" => "Acad Pediatr" "fecha" => "2011" "volumen" => "11" "paginaInicial" => "493" "paginaFinal" => "499" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21816697" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polysomnographic characteristics of adolescents with asthma and low risk for sleep-disordered breathing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Khassawneh" 1 => "S.C. Tsai" 2 => "L.J. Meltzer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11325-018-01774-3" "Revista" => array:6 [ "tituloSerie" => "Sleep Breath" "fecha" => "2019" "volumen" => "23" "paginaInicial" => "943" "paginaFinal" => "951" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30689097" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of asthma on sleep disordered breathing in children: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.E. Brockmann" 1 => "P. Bertrand" 2 => "J.A. Castro-Rodriguez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.smrv.2014.01.005" "Revista" => array:6 [ "tituloSerie" => "Sleep Med Rev" "fecha" => "2014" "volumen" => "18" "paginaInicial" => "393" "paginaFinal" => "397" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24629825" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sleep-disordered breathing in children with asthma: a systematic review on the impact of treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T. Sánchez" 1 => "J.A. Castro-Rodríguez" 2 => "P.E. Brockmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/JAA.S85624" "Revista" => array:6 [ "tituloSerie" => "J Asthma Allergy" "fecha" => "2016" "volumen" => "9" "paginaInicial" => "83" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27143940" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relation between asthma and sleep disordered breathing in children: is the association causal?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.A. Castro-Rodriguez" 1 => "P.E. Brockmann" 2 => "C.L. Marcus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.prrv.2016.08.010" "Revista" => array:6 [ "tituloSerie" => "Paediatr Respir Rev" "fecha" => "2017" "volumen" => "22" "paginaInicial" => "72" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27818068" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sleep-disordered breathing and asthma: evidence from a large multicentric epidemiological study in China" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Li" 1 => "Z. Xu" 2 => "X. Jin" 3 => "C. Yan" 4 => "F. Jiang" 5 => "S. Tong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s12931-015-0215-5" "Revista" => array:5 [ "tituloSerie" => "Respir Res" "fecha" => "2015" "volumen" => "16" "paginaInicial" => "56" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25958333" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sleep-disordered breathing is associated with asthma severity in children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K.R. Ross" 1 => "A. Storfer-Isser" 2 => "M.A. Hart" 3 => "A.M. Kibler" 4 => "M. Rueschman" 5 => "C.L. Rosen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Pediatr" "fecha" => "2012" "volumen" => "160" "paginaInicial" => "736" "paginaFinal" => "742" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of obstructive sleep apnea with severity of patients hospitalized for acute asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Oka" 1 => "T. Goto" 2 => "A. Hirayama" 3 => "M. Kamal Faridi" 4 => "C.A. Camargo Jr." 5 => "K. Hasegawa" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Ann Allergy Asthma Immunol" "fecha" => "2020" "volumen" => "124" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma outcomes after adenotonsillectomy: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Kohli" 1 => "D. DeCarlo" 2 => "N.A. Goldstein" 3 => "J. Silverman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Pediatr Otorhinolaryngol" "fecha" => "2016" "volumen" => "90" "paginaInicial" => "107" "paginaFinal" => "112" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A review of obesity and asthma across the life span" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F. Khalid" 1 => "F. Holguin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Asthma" "fecha" => "2018" "volumen" => "55" "paginaInicial" => "1286" "paginaFinal" => "1300" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S. Redline" 1 => "P.V. Tishler" 2 => "M. Schluchter" 3 => "J. Aylor" 4 => "K. Clark" 5 => "G. Graham" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.159.5.9809079" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1999" "volumen" => "159" "paginaInicial" => "1527" "paginaFinal" => "1532" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10228121" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gastroesophageal reflux and asthma in children: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Thakkar" 1 => "R.O. Boatright" 2 => "M.A. Gilger" 3 => "H.B. El-Serag" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1542/peds.2009-2382" "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "2010" "volumen" => "125" "paginaInicial" => "e925" "paginaFinal" => "e930" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20351005" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gastroesophageal reflux and obstructive sleep apnea in childhood" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.C. Noronha" 1 => "V.M. de Bruin" 2 => "M.A. Nobre e Souza" 3 => "M.R. de Freitas" 4 => "R. de Paula Araújo" 5 => "R.M. Salani Mota" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijporl.2008.11.002" "Revista" => array:6 [ "tituloSerie" => "Int J Pediatr Otorhinolaryngol" "fecha" => "2009" "volumen" => "73" "paginaInicial" => "383" "paginaFinal" => "389" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19108903" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meta-analysis of the comorbidity rate of allergic rhinitis and asthma in Chinese children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W. Kou" 1 => "X. Li" 2 => "H. Yao" 3 => "P. Wei" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijporl.2018.02.001" "Revista" => array:6 [ "tituloSerie" => "Int J Pediatr Otorhinolaryngol" "fecha" => "2018" "volumen" => "107" "paginaInicial" => "131" "paginaFinal" => "134" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29501293" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors for obstructive sleep apnea syndrome in children: state of the art" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Gulotta" 1 => "G. Iannella" 2 => "C. Vicini" 3 => "A. Polimeni" 4 => "A. Greco" 5 => "M. de Vincentiis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Int J Environ Res Public Health" "fecha" => "2019" "volumen" => "16" "paginaInicial" => "3235" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The bidirectional relationship between asthma and obstructive sleep apnea: which came first?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Y. Zhi Min" 1 => "P. Subbarao" 2 => "I. Narang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jpeds.2016.05.058" "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "2016" "volumen" => "176" "paginaInicial" => "10" "paginaFinal" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27318377" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obstructive sleep apnoea modulates airway inflammation and remodelling in severe asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Taillé" 1 => "A. Rouvel-Tallec" 2 => "M. Stoica" 3 => "C. Danel" 4 => "M. Dehoux" 5 => "V. Marin-Esteban" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0166947" "Revista" => array:4 [ "tituloSerie" => "PLoS One" "fecha" => "2016" "volumen" => "11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28002457" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00217557/0000009700000004/v1_202107150608/S0021755721000267/v1_202107150608/en/main.assets" "Apartado" => array:4 [ "identificador" => "10177" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Editorials" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/00217557/0000009700000004/v1_202107150608/S0021755721000267/v1_202107150608/en/main.pdf?idApp=UINPBA000049&text.app=https://jped.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0021755721000267?idApp=UINPBA000049" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 3 | 2 | 5 |
2024 October | 27 | 26 | 53 |
2024 September | 28 | 25 | 53 |
2024 August | 36 | 36 | 72 |
2024 July | 43 | 35 | 78 |
2024 June | 29 | 14 | 43 |
2024 May | 24 | 15 | 39 |
2024 April | 33 | 30 | 63 |
2024 March | 21 | 21 | 42 |
2024 February | 28 | 21 | 49 |
2024 January | 20 | 28 | 48 |
2023 December | 37 | 31 | 68 |
2023 November | 29 | 41 | 70 |
2023 October | 25 | 34 | 59 |
2023 September | 27 | 42 | 69 |
2023 August | 24 | 22 | 46 |
2023 July | 21 | 13 | 34 |
2023 June | 17 | 9 | 26 |
2023 May | 22 | 15 | 37 |
2023 April | 25 | 12 | 37 |
2023 March | 50 | 29 | 79 |
2023 February | 21 | 23 | 44 |
2023 January | 28 | 23 | 51 |
2022 December | 49 | 33 | 82 |
2022 November | 43 | 29 | 72 |
2022 October | 52 | 36 | 88 |
2022 September | 36 | 25 | 61 |
2022 August | 36 | 31 | 67 |
2022 July | 37 | 36 | 73 |
2022 June | 26 | 35 | 61 |
2022 May | 23 | 29 | 52 |
2022 April | 34 | 37 | 71 |
2022 March | 34 | 34 | 68 |
2022 February | 22 | 25 | 47 |
2022 January | 25 | 22 | 47 |
2021 December | 28 | 27 | 55 |
2021 November | 32 | 17 | 49 |
2021 October | 21 | 23 | 44 |
2021 September | 48 | 23 | 71 |
2021 August | 97 | 18 | 115 |
2021 July | 133 | 35 | 168 |
2021 June | 7 | 2 | 9 |
2021 May | 5 | 9 | 14 |
2021 April | 28 | 6 | 34 |
2021 March | 14 | 9 | 23 |
2021 February | 18 | 16 | 34 |