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ROC curve for the diagnosis of moderate or severe OSAS (AHI<span class="elsevierStyleHsp" style=""></span>≥<span class="elsevierStyleHsp" style=""></span>5). Area under the curve (AUC): 0.59. Sensitivity of 67% (95% CI: 29.9–92.5) and specificity of 53% (95% CI: 38.5–67.1).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Priscila J.S. Pires, Rita Mattiello, Magali S. Lumertz, Thiago P. Morsch, Simone C. Fagondes, Magda L. Nunes, David Gozal, Renato T. Stein" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Priscila J.S." "apellidos" => "Pires" ] 1 => array:2 [ "nombre" => "Rita" "apellidos" => "Mattiello" ] 2 => array:2 [ "nombre" => "Magali S." "apellidos" => "Lumertz" ] 3 => array:2 [ "nombre" => "Thiago P." "apellidos" => "Morsch" ] 4 => array:2 [ "nombre" => "Simone C." "apellidos" => "Fagondes" ] 5 => array:2 [ "nombre" => "Magda L." "apellidos" => "Nunes" ] 6 => array:2 [ "nombre" => "David" "apellidos" => "Gozal" ] 7 => array:2 [ "nombre" => "Renato T." 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"apellidos" => "Elkoumi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Mustafa I. Abu" "apellidos" => "Hashim" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "Maha A.A." "apellidos" => "Basset" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 6 => array:3 [ "nombre" => "Hossam E." "apellidos" => "Salah" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Zagazig University, Faculty of Medicine, Pediatric Department, Sharkia, Egypt" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Mansoura University, Faculty of Medicine, Pediatric Department, Mansoura, Egypt" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Zagazig University, Faculty of Medicine, Clinical Pathology Department, Sharkia, Egypt" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "pt" => array:1 [ "titulo" => "Estado antioxidante da coenzima Q10 e da vitamina E em crianças com diabetes tipo 1" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Diabetes mellitus (DM) is a metabolic syndrome characterized by disturbed glucose homeostasis. Hyperglycemia that occurs with DM leads to more production of oxygen free radicals, oxidative stress, and diabetic complications.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1,2</span></a> Children with diabetes are liable to increase oxidative stress by different mechanisms, including glucose auto-oxidation and non-enzymatic protein glycation.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> Varieties of natural antioxidants exist to eliminate oxygen free radicals and prevent oxidative damage to biological membranes. These natural antioxidants may be of dietary sources like vitamin A, C, E, and carotenoids or intracellular enzymatic antioxidants, which include superoxide dismutase, glutathione peroxidase, and catalase. In addition to enzymatic antioxidants, numerous small molecules are synthesized or produced within the body that have an antioxidant capacity (<span class="elsevierStyleItalic">e.g.</span> glutathione and uric acid).<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">4–6</span></a> Vitamin E and coenzyme Q10 are considered as indices of antioxidant capacity. Vitamin E is an important chain-breaking antioxidant factor controlling low-density lipoprotein oxidation. Coenzyme Q10 is an electron carrier-proton translocator in the respiratory chain of mitochondria, and is known as a potent antioxidant either by direct removal of free radicals or indirect by regeneration of vitamin E. Changes in the redox status of coenzyme Q10 may be regarded as an indicator of oxidative stress.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a> Few studies have been done on the vitamin E and coenzyme Q10 antioxidant status in type 1 diabetes (T1D).<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a> Therefore, the purpose of this study is to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with T1D.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0010" class="elsevierStylePara elsevierViewall">A case–control study was conducted in the Al-Jedaani Hospital and the Ibn-Sina National College Hospital in Jeddah, Saudi Arabia during the period from November 2014 to July 2016. The study included 72 children with T1D and 48 healthy children, who were age, sex, and ethnicity-matched as a control group. All patients were being treated with insulin and did not receive multivitamins in the previous three months. Written consent was obtained from their parents/guardians before the study, and the study was approved by the local ethical committee from Al-Jedaani Hospital and Ibn-Sina National College Hospital. Patients with T1D were divided according to glycosylated hemoglobin % (A1c %) into two groups;</p><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Group 1</span>: included 34 children with good glycemic control, with A1c % <7.5%.</p><p id="par0020" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Group 2:</span> included 38 children with poor glycemic control, with A1c % ≥7.5%.</p><p id="par0025" class="elsevierStylePara elsevierViewall">All studied groups were subjected to:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1.</span><p id="par0030" class="elsevierStylePara elsevierViewall">Full history-taking regarding the onset of disease, insulin intake, dietary habits, and blood glucose monitoring.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2.</span><p id="par0035" class="elsevierStylePara elsevierViewall">Anthropometric measures for each child; height, weight, and waist circumference were measured. The height was measured to the nearest 0.1<span class="elsevierStyleHsp" style=""></span>cm using a Holtain portable anthropometer (manufactured at Holtain's global headquarters in Wales), and the weight was determined to the nearest 0.01<span class="elsevierStyleHsp" style=""></span>kg using a Seca scale balance (Seca – Germany) with the patient dressed in minimal clothes and without shoes. Waist circumference (WC) was measured at the level of the umbilicus with the child standing and breathing normally, and waist circumference to height (WC/HT) was calculated. Each measurement was taken as the mean of three consecutive measurements, using standardized equipment and following the recommendations of the International Biological Program.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a></p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3.</span><p id="par0040" class="elsevierStylePara elsevierViewall">Laboratory investigations: included routine and specific laboratory tests.</p></li></ul></p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Blood collection</span><p id="par0045" class="elsevierStylePara elsevierViewall">The blood was taken from all subjects of study, and each sample was divided into two samples and stored at −84<span class="elsevierStyleHsp" style=""></span>°C. One 2<span class="elsevierStyleHsp" style=""></span>mL sample of blood was collected into EDTA-coated tubes to evaluate the coenzyme Q10 level and its redox status (percentage of oxidized coenzyme Q10 within total coenzyme Q10) in erythrocytes and platelets. Another blood sample of 1<span class="elsevierStyleHsp" style=""></span>mL was collected with heparin for analysis of plasma vitamin E, cholesterol, and coenzyme Q10 levels and its redox status.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Routine laboratory tests</span><p id="par0050" class="elsevierStylePara elsevierViewall">Included assessment of complete blood picture, random plasma glucose (RPG), fasting plasma glucose (FPG), A1c % (Cobas Integra 6000 Roche, Germany), plasma cholesterol level (by an enzymatic photometric test, cholesterol FS, Diagnostic Systems – Holzheim, Germany), plasma triglyceride's level (assayed by the glucokinase peroxidase-peroxidase method on the BS100), high-density lipoprotein (HDL) was assayed by direct method on the BS100 (Shenzhen Mindory bio-medical electronics), and low-density lipoprotein (LDL) was calculated from three primary measurements with the use of Friedewaldl's equation: LDL (mmol/L)<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>TC-HDL-TG/5.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Specific laboratory tests</span><p id="par0055" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">•</span><p id="par0060" class="elsevierStylePara elsevierViewall">Measurement of oxidized and reduced forms of plasma coenzyme Q10 by high-performance liquid chromatography (HPLC) from Sigma (St. Louis, USA).</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">•</span><p id="par0065" class="elsevierStylePara elsevierViewall">Measurement of erythrocytes coenzyme Q10 was done in the EDTA samples after separation by using Ficoll separating solution (Ficoll; Biochrom KG, Berlin, Germany), then centrifugation, then adjustment of the final erythrocyte suspension to make a hematocrit suspension and determination of the number of cells present. The measurement was done within one week by HPLC with electrochemical detection and internal standardization. During the sample preparation, coenzyme Q10 was completely oxidized. Therefore, for erythrocytes, only the total concentration of coenzyme Q10 is measured.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a></p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">•</span><p id="par0070" class="elsevierStylePara elsevierViewall">Measurement of platelets coenzyme Q10 was done in the EDTA samples by the same steps done before in erythrocytes, but it was possible to measure the total coenzyme Q10 and the redox status, as there is no oxidization.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a></p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">•</span><p id="par0075" class="elsevierStylePara elsevierViewall">Plasma vitamin E measurement was done by a modified fluorometric method (Thompson's fluorometric method, modified by ABE and KATsul). The excitation wave-length was 295<span class="elsevierStyleHsp" style=""></span>nm, and the emission wavelength was 340<span class="elsevierStyleHsp" style=""></span>nm.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a></p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Definitions of metabolic syndrome (MS)</span><p id="par0080" class="elsevierStylePara elsevierViewall">Based on the MS criteria proposed by the International Diabetes Federation, patients were diagnosed as having MS when their WC was ≥90th percentile and when at least two of the following factors were present: (1) raised concentration of triglycerides: ≥150<span class="elsevierStyleHsp" style=""></span>mg/dL (1.7<span class="elsevierStyleHsp" style=""></span>mmol/L) or receiving specific treatment for high triglycerides; (2) reduced concentration of HDL cholesterol: <40<span class="elsevierStyleHsp" style=""></span>mg/dL (1.03<span class="elsevierStyleHsp" style=""></span>mmol/L), or receiving specific treatment for this lipid abnormality; (3) raised blood pressure: systolic blood pressure ≥130<span class="elsevierStyleHsp" style=""></span>mmHg or diastolic blood pressure ≥85<span class="elsevierStyleHsp" style=""></span>mmHg, or receiving treatment for previously diagnosed hypertension; and (4) raised FPG concentration: ≥100<span class="elsevierStyleHsp" style=""></span>mg/dL (5.6<span class="elsevierStyleHsp" style=""></span>mmol/L), or known type 2 diabetes.<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">12</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Statistical analysis</span><p id="par0085" class="elsevierStylePara elsevierViewall">Testing was performed using SPSS (IBM SPSS Statistics for Windows, version 21.0. NY, USA) Shapiro–Wilk test was used to test data distribution. Mann–Whitney's <span class="elsevierStyleItalic">U</span>-test was used to compare nonparametric samples. One-Way ANOVA with the <span class="elsevierStyleItalic">post hoc</span> Tukey test was used to compare multiple independent samples. The correlation coefficient between variables used was Spearman's rank correlation. <span class="elsevierStyleItalic">p</span>-Values were considered significant if <0.05, non-significant if >0.05.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Results</span><p id="par0090" class="elsevierStylePara elsevierViewall">Demographic data of all children in the study are listed in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">This study included 72 children with T1D, 40 males and 32 females, with a mean age of 10.5 years, and a mean duration of 6.4 years, who were compared with 48 healthy control children with a mean age of 9.8 years, comprising 28 males and 20 females. There was no significant statistical difference regarding age, sex, hemoglobin, hematocrit, WBC, and platelets between diabetic children and the control group (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.05). The blood glucose level and the A1c % level in diabetic children were significantly higher when compared with the control group (median [IQR]: 12.4 [8.8–20.6] and 8.1% [6.5–11.8%] <span class="elsevierStyleItalic">vs.</span> 4.8 [3.7–6.7] and 5.4% [5–6%], respectively, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001). <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> presents the comparison of vitamin E and coenzyme Q10 levels in all groups of the study.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0100" class="elsevierStylePara elsevierViewall">Children with poor glycemic control showed significantly higher plasma vitamin E, coenzyme Q10, FPG, triglyceride, LDL, WC/HT ratio, and cholesterol levels, as well as significantly lower HDL and platelet coenzyme Q10 redox status in comparison to both the good glycemic control patients and control group (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05). No significant differences were present between the studied groups regarding plasma coenzyme Q10/lipid-related, plasma coenzyme Q10 redox status, erythrocyte coenzyme Q10, and platelet coenzyme Q10 (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>0.05).</p><p id="par0105" class="elsevierStylePara elsevierViewall">Correlation between plasma coenzyme Q10 in cases of T1D with other parameters is shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>.</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0110" class="elsevierStylePara elsevierViewall">Plasma coenzyme Q10 showed a positive correlation with the duration of DM, plasma triglyceride, plasma cholesterol, vitamin E and A1c % levels, (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.4, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.03; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.32, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.022; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.35, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.018; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.41; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.008; and <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.36; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.024, respectively), negative correlation with the age of the children (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.30; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.016), and no correlation with the age of onset of DM (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.22, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.6). <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> presents the correlation between the platelet redox status in cases of T1D with other parameters.</p><p id="par0115" class="elsevierStylePara elsevierViewall">The platelet redox status showed a negative correlation with the A1c % levels (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.31; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.022) and the duration of T1D (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.35, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.012). No correlations were observed between the platelet redox status and age of patients, age of onset of T1D, plasma cholesterol, plasma triglyceride, or vitamin E (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.343, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.134; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.134, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.088; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.12, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.34; <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.12, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.07; and <span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.225, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.065, respectively).</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discussion</span><p id="par0120" class="elsevierStylePara elsevierViewall">Oxidative stress is considered an important basic pathogenic mechanism in different diseases, including type 1 and 2 DM, with more production of oxygen-free radicals.<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">13</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">This study revealed that plasma vitamin E level in children with poor glycemic control was significantly higher when compared to both children with good glycemic control and the control group. However, Dominguez et al., in a study with children and adolescents with T1D, found a normal vitamin E level.<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">14</span></a> Many studies were conducted and found variable results; either normal, elevated, or decreased plasma vitamin E concentrations have been reported, independent of the type of diabetes.<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">15–17</span></a> Another study on 20 children with T1D showed a low vitamin E level, and upon the administration of vitamin E (600<span class="elsevierStyleHsp" style=""></span>mg/day for 3 months), found improvement of oxidative stress and the antioxidant defense system.<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">18</span></a> The increased vitamin E level in children with diabetes may be secondary to poor metabolic control with over-production of vitamin E secondary to oxidative stress, and as a protective mechanism against the increased oxygen-free radicals. Different studies disagree with these results.<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">19,20</span></a> Nonetheless, other studies agree with the authors’ study.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">8,21</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">The present study demonstrated that the plasma coenzyme Q10 level in children with poor glycemic control was significantly higher when compared to both children with good glycemic control and the control group. After adjustment of coenzyme Q10 to plasma lipids, this difference was equalized. A study conducted by Menke et al. found the same results and explained this elevation in plasma concentration of coenzyme Q10 in children with diabetes as one of the body's protective mechanism against the increased oxidative stress associated with prolonged hyperglycemia.<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">22</span></a> Wittgenstein et al. studied plasma coenzyme Q10 in children with diabetes and found no significant difference regarding total coenzyme Q10 and lipid-related coenzyme Q10, in spite of an increase in the oxidized part of coenzyme Q10, between patients and controls.<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a> A study performed by Lim et al. on children with type 1 diabetes found higher plasma coenzyme Q10 concentration and lower lipid-related coenzyme Q10, in spite of an increase in the oxidized part of coenzyme Q10, between patients and controls. The authors in the same study explained that these changes in coenzyme Q10 occur secondary to increased oxidative stress.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a> A study done by Salaradi et al. found significantly higher plasma vitamin E and coenzyme Q10 levels in children with poor glycemic control than those with good glycemic control.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">In the present study, despite no difference in the intracellular coenzyme Q10 level in both erythrocytes and platelets between all groups of study, the platelet coenzyme Q10 redox status in the poor glycemic control group was significantly lower in comparison to its level in both the group with good glycemic control and the control group. This in agreement with different studies that found the same result and explained that these differences in concentration in the platelet redox status were attributed to the subgroup of patients with poor glycemic control.<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">8,22,25</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">In the current study, a negative correlation was found between plasma coenzyme Q10 and the age of the children; this agrees with a study that found coenzyme Q10 levels in preschool children was higher than coenzyme Q10 levels in school children.<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a> Nevertheless, Miles et al. found that adult patients with metabolic syndrome are associated with elevated plasma total coenzyme Q10.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">26</span></a> Other study found the same results; that plasma coenzyme Q10 is positively correlated with A1c % and vitamin E.<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">In the present study, it was observed that most of the patients are exposed to oxidative stress evidenced by hyperglycemia, higher mean A1c % (8.1%), high plasma vitamin E level, high plasma coenzyme Q10 level, and decreased platelet coenzyme Q10 redox status. All these were supported by the positive correlation between the plasma coenzyme Q10 with both vitamin E and A1c %, and the negative correlation between the platelet coenzyme Q10 redox status and A1c %. The reduced form of coenzyme Q10 inhibits lipid peroxidation by direct removal of free radicals, or indirectly by regeneration of Vitamin E from its oxidized form.<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">27</span></a> This decrease in platelet coenzyme Q10 redox status may be considered as an evidence of protection mechanisms by mitochondria in diabetes, so it is considered as a sign of oxidative stress.<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">28</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">Patients with poor glycemic control in this study are more liable to central adiposity and MS than other groups, as they have a higher WC/HT ratio, exceeding 0.50, associated with lower HDL and higher FPG, which increases the possibility of insulin resistance and produces more oxidative stress, which in turn may be a cause of increasing vitamin E and coenzyme Q10. Against these findings, Yen et al., who reported that patients with MS might be under higher oxidative stress, resulting in low levels and consumption of active antioxidant enzymes.<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">29</span></a> Another study conducted by Beydoun et al. found that vitamin E had no consistent association with MS.<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Conclusion</span><p id="par0155" class="elsevierStylePara elsevierViewall">Poorly controlled diabetic children had elevation of plasma vitamin E and coenzyme Q10 levels, and decreased platelet redox status of coenzyme Q10, which may be an indicator of increased oxidative stress. It is important to measure these levels in children with T1D, and further studies about therapeutic potentials of both vitamin E and coenzyme Q10 in protecting against and reversing vascular diseases are needed.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Funding</span><p id="par0160" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public, commercial, or non-profit sectors.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflicts of interest</span><p id="par0165" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres1170077" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1095001" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1170078" "titulo" => "Resumo" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1095000" "titulo" => "Palavras-chave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Blood collection" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Routine laboratory tests" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Specific laboratory tests" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Definitions of metabolic syndrome (MS)" ] 4 => array:2 [ "identificador" => "sec0035" "titulo" => "Statistical analysis" ] ] ] 6 => array:2 [ "identificador" => "sec0040" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0045" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0060" "titulo" => "Conclusion" ] 9 => array:2 [ "identificador" => "sec0050" "titulo" => "Funding" ] 10 => array:2 [ "identificador" => "sec0055" "titulo" => "Conflicts of interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-08-22" "fechaAceptado" => "2017-12-26" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1095001" "palabras" => array:4 [ 0 => "Type 1 diabetes" 1 => "Oxidative stress" 2 => "Vitamin E" 3 => "Coenzyme Q10" ] ] ] "pt" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palavras-chave" "identificador" => "xpalclavsec1095000" "palabras" => array:4 [ 0 => "Diabetes tipo 1" 1 => "Estresse oxidativo" 2 => "Vitamina E" 3 => "Coenzima Q10" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This case–control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity-matched. The diabetic children were divided according to their glycosylated hemoglobin (A1c %) into two groups: poor and good glycemic control groups. All children underwent full history taking, clinical examination, and laboratory measurement of complete blood count, A1c %, plasma cholesterol, triglycerides, and vitamin E levels and coenzyme Q10 levels in plasma, erythrocytes, and platelets.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Children with poor glycemic control showed significantly higher plasma vitamin E, coenzyme Q10, triglycerides, low-density lipoproteins, waist circumference/height ratio, cholesterol levels, and lower high-density lipoproteins and platelet coenzyme Q10 redox status in comparison to those with good glycemic control and the control group (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05). Plasma coenzyme Q10 showed a positive correlation with the duration of type 1 diabetes, triglycerides, cholesterol, vitamin E, and A1c %, and negative correlation with the age of the diabetic group (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05). The platelet redox status showed a negative correlation with the A1c % levels (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.31; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.022) and the duration of type 1 diabetes (<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>−0.35, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.012).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Patients with type 1 diabetes, especially poorly controlled, had elevation of plasma vitamin E and coenzyme Q10 levels and decreased platelet redox status of coenzyme Q10, which may be an indicator of increased oxidative stress.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Method" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] "pt" => array:3 [ "titulo" => "Resumo" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Avaliar o estado antioxidante da vitamina E no plasma e da coenzima Q10 no plasma e intracelular em crianças com diabetes tipo 1.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Método</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Este estudo caso-controle foi realizado em 72 crianças com diabetes tipo 1 comparadas comparado por idade, sexo e etnia de 58 crianças saudáveis. As crianças diabéticas foram divididas em dois grupos de acordo com sua hemoglobina glicosilada (A1c %): grupos de controle glicêmico bom e baixo. Todas as crianças foram submetidas a anamnese total, exame clínico e laboratorial para hemograma completo, A1c %, colesterol no plasma, triglicerídeos e níveis de vitamina E e níveis de coenzima Q10 no plasma, eritrócitos e plaquetas.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">As crianças com baixo controle glicêmico mostraram nível de vitamina E no plasma significativamente maior, coenzima Q10, triglicerídeos, lipoproteína de baixa densidade, proporção da circunferência da cintura/estatura e níveis de colesterol e menor nível de lipoproteína de alta densidade e estado redox da coenzima Q10 em comparação aos com bom controle glicêmico com o grupo de controle (p < 0,05). A coenzima Q10 no plasma mostrou correlação positiva com a duração da diabetes tipo 1, triglicerídeos, colesterol, vitamina E e A1c % e correlação negativa com a idade do grupo diabético (p < 0,05). O estado redox das plaquetas mostrou correlação negativa com os níveis de A1c % (r = -0,31; p = 0,022) e a duração da diabetes tipo 1 (r = -0,35, p = 0,012).</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusão</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Os pacientes com diabetes tipo 1, principalmente mal controlados, apresentaram aumento nos níveis de vitamina E no plasma e coenzima Q10 e redução no estado redox das plaquetas da coenzima Q10 que podem indicar aumento do estresse oxidativo.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivo" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Método" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusão" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Alkholy UM, Abdalmonem N, Zaki A, Elkoumi MA, Hashim MI, Basset MA, et al. The antioxidant status of coenzyme Q10 and vitamin E in children with type 1 diabetes. J Pediatr (Rio J). 2019;95:224–30.</p>" ] ] "multimedia" => array:3 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Data presented as median (IQR).</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">A1c %, glycosylated hemoglobin; RPG, random plasma glucose.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Patient group<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>72 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Control group<br><span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>48 \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age, years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10.5 (4–16) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">9.8 (4–15) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.65 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sex (males/females) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">40/32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">28/20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mean duration of DM (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6.4 (4–8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hemoglobin level gm.% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13.2 (11.4–14.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">13.5 (11.8–14.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.55 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hematocrit value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">44% (39–48%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">45% (39–49%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.52 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">White blood cell count \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8600 (6000–12,800) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7900 (5800–10,800) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.15 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Platelet count \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">290,000 (160,000–450,000) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">286,000 (150.000–422,000) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.45 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">A1c % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8.1% (6.5–11.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5.4% (5–6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">RPG (mmol/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12.4 (8.8–20.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.8 (3.7–6.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1997350.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Demographic data of all patients in the study.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">A1c%, glycosylated hemoglobin; FPG, fasting plasma glucose; WC/HT, waist-to-height ratio.</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Data presented as median (IQR).</p><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Values presented as median (range).</p><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Similar letters indicate significant difference between groups.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Good glycemic control (Group 1) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Poor glycemic control (Group 2) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Control group \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>-Value \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">n</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">A1c% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><7.5% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">≥7.5% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5.4% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age/years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10.1 (4–15) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10.7 (4.5–16) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">9.8 (4–15) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.55 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sex (male/female) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">19/15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">21/17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">28/20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age of onset of T1D/years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7.6 (3.3–9.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7.8 (3.7–10) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of T1D/years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6.2 (4–7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6.6 (5–8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">– \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.55 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">WC/HT ratio \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.46 (0.43–0.51)<span class="elsevierStyleSup">a</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.51 (0.44–0.55)<span class="elsevierStyleSup">a,b</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.45 (0.43–0.47)<span class="elsevierStyleSup">b</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.03 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">FPG (mmol/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">5.6 (4.6–6.4)<span class="elsevierStyleSup">c</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 (5.4–12.2)<span class="elsevierStyleSup">c,d</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.8 (4.1–6.1)<span class="elsevierStyleSup">d</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Plasma vitamin E (μg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">15.2 (8.6–20.6)<span class="elsevierStyleSup">e</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">18.8 (10.8–26.4)<span class="elsevierStyleSup">e,f</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">14.8(8.4–20)<span class="elsevierStyleSup">f</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.016 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Plasma cholesterol (mmol/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.96 (3.82–4.08)<span class="elsevierStyleSup">g</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4.28 (3.89–4.38)<span class="elsevierStyleSup">g,h</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3.68 (3.08–4.06)<span class="elsevierStyleSup">h</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.028 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Plasma triglycerides (mmol/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.50 (1.09–1.89)<span class="elsevierStyleSup">i</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.66 (1.14–2.10)<span class="elsevierStyleSup">i,j</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.27 (1.22–1.66)<span class="elsevierStyleSup">j</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.022 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">LDL (mmol/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.5 (0.98–2.1)<span class="elsevierStyleSup">k</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2.17 (1.6–3.0)<span class="elsevierStyleSup">k,l</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.98 (0.82–1.3)<span class="elsevierStyleSup">l</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HDL (mmol/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.93 (0.69–1.1)<span class="elsevierStyleSup">m</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.72 (0.54–0.98)<span class="elsevierStyleSup">m,n</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.2 (0.88–1.7)<span class="elsevierStyleSup">n</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Plasma coenzyme Q10 (μmol/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.898 (0.820–0.998)<span class="elsevierStyleSup">o</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1.028 (0.866–1.120)<span class="elsevierStyleSup">o,p</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.824 (0.686–1.062)<span class="elsevierStyleSup">p</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.025 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Plasma coenzyme Q10/lipid related (μmol Q10/mol cholesterol) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">228 (214–240) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">240 (222–255) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">223 (186–302) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.35 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Plasma coenzyme Q10/lipid related (μmol Q10/mol triglyceride) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">598 (528–725) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">619 (533–759) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">601 (562 –672) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.31 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Plasma coenzyme Q10 redox status \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7.8 (7.1–9.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7.4 (6.4–8.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8.0 (7.5–9.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.25 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Erythrocyte coenzyme Q10 (pmol/cells<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">29 (23–36) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">27 (22–32) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">25 (19–32) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.35 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Platelet coenzyme Q10 (pmol/cells<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">9</span>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">210 (165–244) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">190 (155–238) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">200 (158–256) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.07 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Platelet coenzyme Q10 redox status \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">22.6 (16.9–26.3)<span class="elsevierStyleSup">q</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">18.6 (16.4–20.4)<span class="elsevierStyleSup">q,r</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">27.8 (19.8–35.9)<span class="elsevierStyleSup">r</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.015 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1997348.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Comparison of lipid profile, vitamin E, and coenzyme Q10 levels among all groups of study.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">T1D, type 1 diabetes; A1c %, glycosylated hemoglobin.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Plasma Co Q10 (μmol/L)</th><th class="td" title="table-head " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Platelet Co Q10 redox status</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">r</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">r</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.016 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.343 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.132 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age of onset of T1D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.34 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Duration of T1D \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.012 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Triglyceride \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.022 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.07 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cholesterol \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.018 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.134 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.088 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vitamin E \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.008 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.225 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.065 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">A1c % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.024 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">−0.31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.022 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1997349.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Correlation between plasma coenzyme Q10 (Co Q10) and platelet Co Q10 redox status with other parameters in diabetic patients.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0155" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pathobiology of diabetic complications: a unifying mechanism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. 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Year/Month | Html | Total | |
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2024 November | 4 | 12 | 16 |
2024 October | 27 | 92 | 119 |
2024 September | 24 | 116 | 140 |
2024 August | 42 | 120 | 162 |
2024 July | 94 | 119 | 213 |
2024 June | 24 | 104 | 128 |
2024 May | 29 | 97 | 126 |
2024 April | 26 | 99 | 125 |
2024 March | 22 | 102 | 124 |
2024 February | 23 | 93 | 116 |
2024 January | 15 | 67 | 82 |
2023 December | 16 | 65 | 81 |
2023 November | 27 | 79 | 106 |
2023 October | 22 | 64 | 86 |
2023 September | 19 | 76 | 95 |
2023 August | 20 | 57 | 77 |
2023 July | 26 | 53 | 79 |
2023 June | 29 | 53 | 82 |
2023 May | 45 | 61 | 106 |
2023 April | 38 | 47 | 85 |
2023 March | 47 | 64 | 111 |
2023 February | 42 | 59 | 101 |
2023 January | 24 | 54 | 78 |
2022 December | 50 | 77 | 127 |
2022 November | 20 | 51 | 71 |
2022 October | 45 | 37 | 82 |
2022 September | 31 | 37 | 68 |
2022 August | 25 | 27 | 52 |
2022 July | 28 | 34 | 62 |
2022 June | 20 | 27 | 47 |
2022 May | 25 | 31 | 56 |
2022 April | 36 | 50 | 86 |
2022 March | 28 | 40 | 68 |
2022 February | 18 | 18 | 36 |
2022 January | 14 | 29 | 43 |
2021 December | 19 | 24 | 43 |
2021 November | 7 | 28 | 35 |
2021 October | 9 | 19 | 28 |
2021 September | 7 | 11 | 18 |
2021 August | 7 | 11 | 18 |
2021 July | 12 | 12 | 24 |
2021 June | 7 | 9 | 16 |
2021 May | 11 | 20 | 31 |
2021 April | 21 | 25 | 46 |
2021 March | 23 | 25 | 48 |
2021 February | 11 | 17 | 28 |
2021 January | 13 | 15 | 28 |
2020 December | 17 | 17 | 34 |
2020 November | 13 | 21 | 34 |
2020 October | 13 | 8 | 21 |
2020 September | 20 | 18 | 38 |
2020 August | 11 | 11 | 22 |
2020 July | 7 | 10 | 17 |
2020 June | 11 | 11 | 22 |
2020 May | 18 | 16 | 34 |
2020 April | 8 | 16 | 24 |
2020 March | 10 | 8 | 18 |
2020 February | 26 | 20 | 46 |
2020 January | 23 | 21 | 44 |
2019 December | 22 | 15 | 37 |
2019 November | 12 | 21 | 33 |
2019 October | 23 | 17 | 40 |
2019 September | 17 | 16 | 33 |
2019 August | 25 | 16 | 41 |
2019 July | 22 | 16 | 38 |
2019 June | 28 | 13 | 41 |
2019 May | 22 | 24 | 46 |
2019 April | 46 | 11 | 57 |
2019 March | 13 | 7 | 20 |
2019 February | 8 | 6 | 14 |
2019 January | 8 | 11 | 19 |
2018 December | 8 | 3 | 11 |
2018 November | 16 | 4 | 20 |
2018 October | 45 | 15 | 60 |
2018 September | 12 | 6 | 18 |
2018 August | 7 | 8 | 15 |
2018 July | 6 | 6 | 12 |
2018 June | 5 | 3 | 8 |
2018 May | 1 | 12 | 13 |
2018 April | 1 | 5 | 6 |
2018 March | 0 | 15 | 15 |
2018 February | 0 | 10 | 10 |