Estatísticas

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  "doi" => "10.2223/JPED.1781"
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  "cita" => "J Pediatr (Rio J). 2008;84 Supl 1:68-75"
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      "titulo" => "A exposição pré-natal ao álcool como fator de risco para comportamentos disfuncionais: o papel do pediatra"
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          "autoresLista" => "Wakana Momino, Maria Teresa V. Sanseverino, Lavínia Schüler-Faccini"
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    "cita" => "J Pediatr (Rio J). 2008;84 Supl 1:58-67"
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      "titulo" => "Células natural killer e vigilância imunológica"
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          "autoresLista" => "Mariana Jobim, Luiz F. J. Jobim"
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    "titulo" => "O impacto da genética na asma infantil"
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        "autoresLista" => "Leonardo A. Pinto, Renato T. Stein, Michael Kabesch"
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            "entidad" => "Instituto de Pesquisas Biom&#233;dicas&#44; Pontif&#237;cia Universidade Cat&#243;lica do Rio Grande do Sul &#40;PUCRS&#41;&#44; Porto Alegre&#44; RS&#46; Programa de P&#243;s-Gradua&#231;&#227;o em Sa&#250;de da Crian&#231;a e do Adolescente&#44; Universidade Estadual de Campinas &#40;UNICAMP&#41;&#44; Campinas&#44; SP&#46;"
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            "entidad" => "Children&#39;s Hospital&#44; Ludwig Maximilian&#39;s University of Munich&#44; Munich&#44; Germany&#46;"
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        "titulo" => "Abstract"
        "resumen" => """
          <html><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To present the most important and recent results of studies on asthma genetics. These data may help general physicians understand the impact of genetics on this complex disorder and how genes and polymorphisms influence asthma and atopy.</p>\n
          \t\t\t\t\t\t   </span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Sources</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Data were collected from MEDLINE. Genetic association studies were selected from the Genetic Association Database, which is an archive of human genetic association studies of complex diseases and disorders organized by the National Institutes of Health.</p>\n
          \t\t\t\t\t\t   </span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Summary of the findings</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Considering the data from several important twin studies on asthma genetics, heritability, which measures the contribution of genetic factors to the variance of asthma, may be estimated in 0.48-0.79. A huge number of genetic association studies have been trying to identify asthma susceptibility genes. The most replicated results in the genetic association studies involve the following five regions of the human genome: 5q31-32, 6p21, 11q12-13, 16p11-12, and 20p13. Only recently a new asthma susceptibility gene (ORMDL3) has been identified by a whole genome association study, considered to be a major determinant for childhood asthma.</p>\n
          \t\t\t\t\t\t   </span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conclusions</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Genetic contribution to asthma may be estimated ranging from 48 to 79%. Several loci seem to influence asthma susceptibility. Genes located on chromosome 5q (ADRB2, IL13 and IL4) and the recently identified ORMDL3, on chromosome 17, seem to be determinants of childhood asthma. Diagnostics and pharmacogenetics may be the first clinical implication of extensive studies on asthma genetics.</p>\n
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        "resumen" => "<html><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Apresentar os resultados dos estudos mais importantes e recentes sobre a gen&eacute;tica da asma. Estes dados devem auxiliar os cl&iacute;nicos gerais a compreender o impacto da gen&eacute;tica sobre este dist&uacute;rbio complexo e como os genes e polimorfismos influenciam a asma e a atopia.</p></span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fontes dos dados</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Os dados foram coletados do banco de dados MEDLINE. Os estudos de associa&ccedil;&atilde;o gen&eacute;tica foram selecionados do Genetic Association Database, um reposit&oacute;rio de estudos de associa&ccedil;&atilde;o gen&eacute;tica de doen&ccedil;as e dist&uacute;rbios complexos organizado pelo National Institutes of Health.</p></span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">S&iacute;ntese dos dados</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Considerando os dados de diversos importantes estudos de g&ecirc;meos sobre a gen&eacute;tica da asma, a heritabilidade, que mensura a contribui&ccedil;&atilde;o dos fatores gen&eacute;ticos para a vari&acirc;ncia da asma, pode ser estimada entre 0,48 e 0,79. Uma grande quantidade de estudos de associa&ccedil;&atilde;o gen&eacute;tica tentou identificar genes de susceptibilidade &agrave; asma. Os resultados mais replicados nos estudos de associa&ccedil;&atilde;o gen&eacute;tica envolvem as cinco regi&otilde;es do genoma humano a seguir: 5q31-32, 6p21, 11q12-13, 16p11-12, e 20p13. Recentemente, outro gene de susceptibilidade &agrave; asma (ORMDL3), considerado determinante cr&iacute;tico para a asma infantil, foi identificado por um estudo gen&ocirc;mico de associa&ccedil;&atilde;o.</p></span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conclus&otilde;es</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&Eacute; poss&iacute;vel estimar que a contribui&ccedil;&atilde;o gen&eacute;tica &agrave; asma varia entre 48 e 79%. Diversos loci parecem influenciar a susceptibilidade &agrave; asma. Os genes localizados no cromossomo 5q (ADRB2, IL13 e IL4)<i> </i>e o gene<i> </i>ORMDL3, no cromossomo 17, identificado recentemente, parecem ser determinantes para a asma infantil. O diagn&oacute;stico e a farmacogen&eacute;tica podem ser as primeiras implica&ccedil;&otilde;es cl&iacute;nicas de estudos extensivos sobre a gen&eacute;tica da asma.</p></span></html>"
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