Estatísticas

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  "doi" => "10.2223/JPED.1802"
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  "cita" => "J Pediatr (Rio J). 2008;84 Supl 1:40-51"
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    "doi" => "10.2223/JPED.1785"
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    "cita" => "J Pediatr (Rio J). 2008;84 Supl 1:52-7"
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      "titulo" => "Leucemia: fatores prognósticos e genética"
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          "autoresLista" => "Nelson Hamerschlak"
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              "nombre" => "Nelson"
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    "doi" => "10.2223/JPED.1800"
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    "cita" => "J Pediatr (Rio J). 2008;84 Supl 1:33-9"
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      "titulo" => "A genética das epilepsias"
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          "autoresLista" => "Iscia Lopes-Cendes"
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              "nombre" => "Iscia"
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    "titulo" => "Genética das doenças hematológicas: as hemoglobinopatias hereditárias"
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        "autoresLista" => "Maria de Fátima Sonati, Fernando Ferreira Costa"
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            "nombre" => "Maria"
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            "entidad" => "Livre-docente&#46; Professora associada&#44; Departamento de Patologia Cl&#237;nica&#44; Faculdade de Ci&#234;ncias M&#233;dicas&#44; Universidade Estadual de Campinas &#40;Unicamp&#41;&#44; Campinas&#44; SP&#46;"
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        "titulo" => "Abstract"
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          <html><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To summarize recently published data on the pathophysiology, diagnosis and treatment of sickle cell diseases and &acirc;-Thalassemias, the most relevant hereditary hemoglobinopathies in the global population.</p>\n
          \t\t\t\t\t\t   </span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Sources</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Searches were run on the MEDLINE and SCIELO databases, limited to the period from 2003 to May 2008, using the terms hereditary hemoglobinopathies, sickle cell diseases and &acirc;-thalassemia. Two books and two chapters were also included.</p>\n
          \t\t\t\t\t\t   </span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Summary of the findings</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">More than 2,000 articles were identified; those providing the most important information and broadest views were selected.</p>\n
          \t\t\t\t\t\t   </span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conclusions</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Morbidity and mortality rates from sickle cell diseases and &acirc;-thalassemia are still very high and represent an important challenge. Increased understanding of pathophysiological aspects has lead to significant improvements in treatment and prevention of these diseases.</p>\n
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        "resumen" => "<html><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Sumarizar os dados dispon&iacute;veis na literatura recente sobre os aspectos fisiopatol&oacute;gicos, de diagn&oacute;stico e tratamento das doen&ccedil;as falciformes e da talassemia &acirc;, hemoglobinopatias heredit&aacute;rias de maior relev&acirc;ncia nas popula&ccedil;&otilde;es.</p></span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fontes dos dados</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">MEDLINE e SciELO, utilizando os termos hemoglobinopatias heredit&aacute;rias, doen&ccedil;as falciformes e talassemia beta, no per&iacute;odo de 2003 a maio de 2008. Dois livros e dois cap&iacute;tulos de livro foram tamb&eacute;m inclu&iacute;dos.</p></span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">S&iacute;ntese dos dados</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Foram encontrados mais de 2.000 artigos, sendo selecionados aqueles de maior pertin&ecirc;ncia e amplitude.</p></span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conclus&otilde;es</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">As taxas de morbidade e a mortalidade das doen&ccedil;as falciformes e da talassemia &acirc; s&atilde;o ainda bastante expressivas e constituem importante desafio. Um maior conhecimento dos mecanismos fisiopatol&oacute;gicos tem permitido avan&ccedil;os significativos nas formas de tratamento e preven&ccedil;&atilde;o dessas doen&ccedil;as.</p></span></html>"
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