Estatísticas

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    "cita" => "J Pediatr (Rio J). 2007;83 Supl 2:155-62"
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      "titulo" => "Função adrenal na sepse e choque séptico"
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          "autoresLista" => "Cristiane Freitas Pizarro, Eduardo Juan Troster"
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              "nombre" => "Cristiane"
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    "cita" => "J Pediatr (Rio J). 2007;83 Supl 2:137-45"
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      "titulo" => "Efeitos hemodinâmicos e metabólicos da infusão de vasopressina em crianças com choque"
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          "autoresLista" => "Elisa Baldasso, Pedro Celiny Ramos Garcia, Jefferson P. Piva, Paulo Roberto Einloft"
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    "titulo" => "Novas opções na terapia insulínica"
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        "autoresLista" => "Helena Schmid"
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            "entidad" => "Doutora&#46; Professora titular&#44; Programa de P&#243;s Gradua&#231;&#227;o em Ci&#234;ncias M&#233;dicas&#44; Funda&#231;&#227;o Faculdade Federal de Ci&#234;ncias M&#233;dicas de Porto Alegre &#40;FFFCMPA&#41;&#44; Porto Alegre&#44; RS&#46;"
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        "titulo" => "Abstract"
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          <html><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To review the new options in insulin therapy for controlling diabetes mellitus in children and adolescents.</p>\n
          \t\t\t\t\t\t   </span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Sources</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Articles indexed in PubMed were located using the search terms insulin analogs in children and adolescents and reviewed. Information was also obtained from American Diabetes Association and Sociedade Brasileira de Diabetes consensus documents.</p>\n
          \t\t\t\t\t\t   </span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Summary of the findings</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Information is presented on new analogs of insulin and, for purposes of comparison, the other insulin modalities currently available are also reviewed, focusing on insulin therapies which attempt to approximate basal-bolus treatment strategies to physiology. With the objective of obtaining improved metabolic control, more and more children are being put on multiple daily injection regimes or using continuous subcutaneous insulin infusion. It is difficult to achieve optimum glycemic control in children due to the increased risk of hypoglycemia resulting from the great variability in dietary intake habits and in physical activity levels. With diabetes type 1, if rapid-acting analogs are given subcutaneously in bolus, they generally reduce hypoglycemia episodes and postprandial glycemia levels, compared with regular human insulin, while basal analogs tend to reduce particularly the number of episodes of nocturnal hypoglycemia.</p>\n
          \t\t\t\t\t\t   </span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conclusions</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><B>:</B> Although the benefits to individual metabolic and clinical outcomes appear modest, the majority of studies demonstrate benefits when insulin analogs are used in the treatment of diabetes type 1 or 2.</p>\n
          \t\t\t\t\t\t   </span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Although the benefits to individual metabolic and clinical outcomes appear modest, the majority of studies demonstrate benefits when insulin analogs are used in the treatment of diabetes type 1 or 2.</p>\n
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        "resumen" => "<html><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Revisar as novas op&ccedil;&otilde;es nas terap&ecirc;uticas insul&iacute;nicas para controlar o diabetes melito de crian&ccedil;as e adolescentes.</p></span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Fontes dos dados</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Foram revisados artigos indexados no PubMed buscados conforme as palavras insulin analogs in children and adolescents e inclu&iacute;das informa&ccedil;&otilde;es contidas nos consensos da American Diabetes Association e Sociedade Brasileira de Diabetes.</p></span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">S&iacute;ntese dos dados</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">S&atilde;o apresentadas informa&ccedil;&otilde;es sobre os novos an&aacute;logos da insulina e, para compara&ccedil;&atilde;o, s&atilde;o tamb&eacute;m revisadas as outras diferentes modalidades de insulina que est&atilde;o atualmente dispon&iacute;veis, focalizando nas terapias insul&iacute;nicas que tentam fornecer uma aproxima&ccedil;&atilde;o mais fisiol&oacute;gica das estrat&eacute;gias basal-bolos no tratamento. Com o objetivo de obter melhor controle metab&oacute;lico, mais e mais crian&ccedil;as est&atilde;o em regimes de m&uacute;ltiplas inje&ccedil;&otilde;es di&aacute;rias ou usando infus&otilde;es subcut&acirc;neas cont&iacute;nuas de insulina. Atingir controle glic&ecirc;mico &oacute;timo nas crian&ccedil;as &eacute; dif&iacute;cil devido ao maior risco de hipoglicemia decorrente da grande variabilidade em h&aacute;bitos de ingerir alimentos e em n&iacute;veis de atividade f&iacute;sica. Se aplicados em bolos, subcut&acirc;neos, no diabetes tipo 1, os an&aacute;logos de a&ccedil;&atilde;o r&aacute;pida, comparados com insulina humana regular, geralmente reduzem os epis&oacute;dios de hipoglicemia e glicemia p&oacute;s-prandial, enquanto os an&aacute;logos basais tendem a reduzir particularmente a hipoglicemia noturna.</p></span><span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conclus&atilde;o</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Embora os benef&iacute;cios nos desfechos individuais metab&oacute;licos e cl&iacute;nicos pare&ccedil;am modestos, a maioria dos estudos demonstra benef&iacute;cios quando s&atilde;o usados an&aacute;logos de insulina no tratamento do diabetes tipo 1 ou 2.</p></span></html>"
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