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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introdu&#231;&#227;o</span><p id="par0010" class="elsevierStylePara elsevierViewall">O Brasil se tornou o epicentro da infec&#231;&#227;o pelo novo coronav&#237;rus &#40;SARS&#8208;CoV&#8208;2&#41; na Am&#233;rica do Sul e o segundo pa&#237;s com o maior n&#250;mero de casos e mortes no mundo&#46; A COVID&#8208;19&#44; como essa doen&#231;a foi chamada pela Organiza&#231;&#227;o Mundial da Sa&#250;de&#44; ainda representa um desafio na popula&#231;&#227;o pedi&#225;trica&#44; embora o n&#250;mero e a gravidade dos casos sejam menores quando comparados &#224; popula&#231;&#227;o adulta&#46; Dados de v&#225;rios pa&#237;ses mostram que crian&#231;as e adolescentes foram respons&#225;veis por menos de 2&#37; dos casos sintom&#225;ticos&#44; com taxas de hospitaliza&#231;&#227;o &#40;0&#44;6&#8208;20&#37;&#41; e mortalidade &#40;0&#8208;4&#37;&#41; significativamente menores do que nos adultos&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">1&#8211;5</span></a> Beb&#234;s e crian&#231;as com doen&#231;as cr&#244;nicas pr&#233;vias representam a popula&#231;&#227;o pedi&#225;trica mais vulner&#225;vel&#44; com maior gravidade&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">1&#44;2&#44;4&#44;5</span></a> Recentemente&#44; v&#225;rios pa&#237;ses relataram casos de uma s&#237;ndrome inflamat&#243;ria multissist&#234;mica &#40;MIC&#44; do ingl&#234;s <span class="elsevierStyleItalic">multisystemic inflammatory syndrome</span>&#41; em crian&#231;as &#40;MIS&#8208;C&#41; temporariamente associada &#224; COVID&#8208;19&#46; Essa s&#237;ndrome &#233; caracterizada por febre prolongada&#44; sintomas gastrointestinais e marcadores inflamat&#243;rios alterados&#44; associados a sinais de disfun&#231;&#227;o org&#226;nica&#44; insufici&#234;ncia card&#237;aca aguda&#44; doen&#231;a de Kawasaki &#40;completa ou n&#227;o&#41; ou s&#237;ndrome do choque t&#243;xico&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">6&#8211;8</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">O relato da experi&#234;ncia latino&#8208;americana com a COVID&#8208;19 em pediatria ainda &#233; bastante limitado&#44; principalmente em rela&#231;&#227;o a crian&#231;as internadas em unidades de terapia intensiva&#46; Este estudo tem como objetivo descrever as caracter&#237;sticas cl&#237;nicas de uma coorte de crian&#231;as e adolescentes internados em Unidades de Terapia Intensiva Pedi&#225;tricas &#40;UTIPs&#41; no Brasil&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material e m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Desenho do estudo&#44; sele&#231;&#227;o de pacientes e local do estudo</span><p id="par0025" class="elsevierStylePara elsevierViewall">Este &#233; um estudo prospectivo&#44; multic&#234;ntrico&#44; feito em 19 UTIPs associadas &#224; Rede Brasileira de Pesquisa em Terapia Intensiva Pedi&#225;trica &#40;<span class="elsevierStyleItalic">Brazilian Research Network in Pediatric Intensive Car</span>e&#44; BRnet&#8208;PIC&#41;&#46; Pacientes pedi&#225;tricos &#40;um m&#234;s a 19 anos&#41; com COVID&#8208;19 confirmada foram inclu&#237;dos consecutivamente entre 1&#176; de mar&#231;o e 31 de maio de 2020&#44; ap&#243;s a obten&#231;&#227;o do consentimento informado&#46; O estudo foi aprovado pelos Comit&#234;s de &#201;tica em pesquisa de todas as institui&#231;&#245;es&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Diagn&#243;stico e coleta de dados</span><p id="par0030" class="elsevierStylePara elsevierViewall">O diagn&#243;stico de COVID&#8208;19 foi confirmado pelo ensaio de rea&#231;&#227;o em cadeia da polimerase com transcri&#231;&#227;o reversa &#40;RT&#8208;PCR&#41; a partir de <span class="elsevierStyleItalic">swabs</span> oro&#47;nasofar&#237;ngeos ou aspirados traqueais e quando fora do per&#237;odo de positividade para RT&#8208;PCR&#44; foram usados anticorpos IgM e&#47;ou IgG positivos contra SARS&#8208;CoV&#8208;2&#46; Os dados demogr&#225;ficos&#44; epidemiol&#243;gicos&#44; cl&#237;nicos e de desfecho dos pacientes foram coletados prospectivamente&#44; em formul&#225;rios padronizados de relato de caso &#40;REDCap&#44; <span class="elsevierStyleItalic">Vanderbilt University</span>&#44; EUA&#41;&#46; Os pacientes com MIS e n&#227;o MIS foram comparados&#44; de acordo com a presen&#231;a de comorbidades&#44; idade inferior a um ano e necessidade de ventila&#231;&#227;o mec&#226;nica invasiva &#40;VMI&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Processamento de dados e an&#225;lise estat&#237;stica</span><p id="par0035" class="elsevierStylePara elsevierViewall">As vari&#225;veis categ&#243;ricas foram descritas como frequ&#234;ncias e porcentagens e as vari&#225;veis cont&#237;nuas como medianas e intervalos interquartis &#40;IIQs&#41;&#46; As compara&#231;&#245;es entre os grupos foram feitas pelo teste do qui&#8208;quadrado ou exato de Fisher para vari&#225;veis categ&#243;ricas e teste de Mann&#8208;Whitney para vari&#225;veis cont&#237;nuas&#46; Um modelo de regress&#227;o log&#237;stica multivari&#225;vel foi usado para avaliar a associa&#231;&#227;o das covari&#225;veis com idade inferior a um ano&#44; sexo&#44; etnia e presen&#231;a de comorbidades com as formas mais graves da doen&#231;a&#44; caracterizadas pela necessidade de VMI&#46; Foram estabelecidos um n&#237;vel de signific&#226;ncia de 5&#37; &#40;bicaudal&#41; e intervalos de confian&#231;a de 95&#37;&#46; O <span class="elsevierStyleItalic">software</span> R&#44; vers&#227;o 3&#46;6&#46;1 &#40;R Foundation&#44; Viena&#44; &#193;ustria&#41;&#44; foi usado para a an&#225;lise estat&#237;stica&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Resultados</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Caracter&#237;sticas demogr&#225;ficas e epidemiol&#243;gicas</span><p id="par0040" class="elsevierStylePara elsevierViewall">Foram inclu&#237;dos 79 pacientes &#40;10 com MIS&#41;&#46; 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47 pacientes &#40;60&#37;&#41; apresentavam sintomas respirat&#243;rios&#44; a maioria pneumonia ou bronquiolite &#40;70&#37;&#41;&#44; 10 &#40;13&#37;&#41; apresentavam MIS e 60&#37; apresentavam uma condi&#231;&#227;o semelhante &#224; doen&#231;a de Kawasaki&#46; Os outros 22 &#40;28&#37;&#41; apresentavam principalmente sintomas gastrointestinais e neurol&#243;gicos &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46; A mediana do tempo dos sintomas antes da hospitaliza&#231;&#227;o foi de cinco dias no grupo n&#227;o MIS e dois dias no grupo MIS&#46; Os sinais e sintomas mais comuns na apresenta&#231;&#227;o foram febre &#40;76&#37;&#41;&#44; tosse &#40;51&#37;&#41; e taquipneia &#40;50&#37;&#41;&#46; Entretanto&#44; outros achados tamb&#233;m foram prevalentes &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46; No grupo MIS&#44; sintomas graves como taquipneia &#40;60&#37;&#41;&#44; baixa SpO<span class="elsevierStyleInf">2</span> &#40;40&#37;&#41;&#44; prostra&#231;&#227;o &#40;60&#37;&#41;&#44; gem&#234;ncia &#40;30&#37;&#41;&#44; hipotens&#227;o &#40;20&#37;&#41;&#44; batimento de asa nasal &#40;20&#37;&#41; e cianose &#40;10&#37;&#41;&#44; bem como sintomas gastrointestinais &#40;40&#8208;60&#37;&#41;&#44; foram mais frequentes do que no grupo n&#227;o MIS &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Confirma&#231;&#227;o do diagn&#243;stico&#44; achados laboratoriais e radiol&#243;gicos</span><p id="par0050" class="elsevierStylePara elsevierViewall">O diagn&#243;stico foi confirmado por RT&#8208;PCR em 72 pacientes &#40;todos os 79 testados&#44; 91&#37; positivos&#41;&#46; Os demais tiveram o diagn&#243;stico confirmado pela detec&#231;&#227;o de anticorpos IgM e&#47;ou IgG &#40;cinco no grupo MIS&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46; Houve codetec&#231;&#227;o com outros v&#237;rus em 15&#37; dos testados &#40;dois v&#237;rus sincicial respirat&#243;rio&#44; um rinov&#237;rus humano e um uma associa&#231;&#227;o de Parainfluenza 4 com <span class="elsevierStyleItalic">Bordetella pertussis</span>&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Linfopenia foi observada em 36&#37; dos pacientes no grupo n&#227;o MIS &#40;MIS&#44; 50&#37;&#41;&#46; A prote&#237;na C reativa &#40;PCR&#41; foi de 3<span class="elsevierStyleHsp" style=""></span>mg&#47;dL ou superior em 50&#37; dos 63 pacientes do grupo n&#227;o MIS&#44; em compara&#231;&#227;o com 10<span class="elsevierStyleHsp" style=""></span>mg&#47;dL ou superior em 50&#37; dos 10 pacientes do grupo MIS&#46; A velocidade de hemossedimenta&#231;&#227;o &#40;VHS&#41;&#44; a desidrogenase l&#225;ctica &#40;LDH&#41; e o D&#8208;d&#237;mero foram testados em 5&#44; 30 e 22 pacientes&#44; respectivamente&#44; no grupo n&#227;o MIS e quase todos os pacientes no grupo MIS&#46; Eles estavam aumentados em pelo menos 75&#37; de todos os pacientes&#44; mas muito mais altos no grupo MIS&#46; Em contraste&#44; as fun&#231;&#245;es renal e hep&#225;tica foram testadas na maioria dos pacientes e estavam preservadas em pelo menos 75&#37; delas nos dois grupos&#46; A ferritina e a troponina foram testadas em apenas 24 e 17 pacientes&#44; respectivamente&#44; a maioria deles no grupo MIS&#46; A ferritina estava aumentada em pelo menos 50&#37; dos pacientes e foi maior no grupo n&#227;o MIS&#46; A troponina estava elevada em pelo menos 50&#37; dos pacientes do grupo n&#227;o MIS&#44; mas n&#227;o no grupo MIS&#46; Dos outros marcadores de les&#227;o card&#237;aca&#44; a creatinofosfoquinase &#40;CK&#41; apresentou anormalidade em 5 dos 22 pacientes &#40;408&#8208;2&#46;345 U&#47;L&#41; e a creatinofosfoquinase fra&#231;&#227;o MB &#40;CK&#8208;MB&#41; estava elevada em 8 dos 15 pacientes &#40;25 e 89 U&#47;L&#41;&#46; Apenas um desses pacientes estava no grupo MIS &#40;s&#237;ndrome do choque t&#243;xico&#44; CK 1&#46;389 U&#47;L&#44; CK&#8208;MB 28 U&#47;L&#41;&#46; O pept&#237;deo natriur&#233;tico do tipo B &#40;pro&#8208;BNP&#41; estava aumentado em 6 dos 7 &#40;86&#37;&#41; pacientes testados&#44; todos no grupo MIS&#44; com uma mediana de 5&#46;829 &#40;varia&#231;&#227;o de 222&#8208;16&#46;996 pg&#47;mL&#41;&#46; A procalcitonina foi investigada em apenas tr&#234;s pacientes e estava elevada em todos &#40;um no grupo n&#227;o MIS&#44; 0&#44;4 ng&#47;mL&#59; dois no grupo MIS&#58; uma disfun&#231;&#227;o card&#237;aca aguda&#44; 0&#44;37 ng&#47;mL e uma s&#237;ndrome de choque t&#243;xico&#44; 31 ng&#47;mL&#41;&#46; Por fim&#44; a interleucina&#8208;6 foi mensurada em apenas dois pacientes do grupo MIS&#44; ambos com valores muito altos&#44; em um paciente com disfun&#231;&#227;o card&#237;aca aguda &#40;711 pg&#47;mL&#41; e um com s&#237;ndrome de choque t&#243;xico &#40;194 pg&#47;mL&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;</p><p id="par0060" class="elsevierStylePara elsevierViewall">A radiografia de t&#243;rax mostrou anormalidades em 60&#8208;70&#37; dos pacientes nos dois grupos&#44; com predomin&#226;ncia do infiltrado intersticial difuso bilateral &#40;57&#8208;60&#37;&#41;&#46; O derrame pleural estava presente em sete pacientes &#40;43&#37;&#41; no grupo MIS e em apenas tr&#234;s pacientes &#40;9&#37;&#41; no grupo n&#227;o MIS&#46; Trinta e oito pacientes foram submetidos &#224; tomografia computadorizada &#40;TC&#41; de t&#243;rax e opacidades em vidro fosco estavam presentes em 58&#37; no grupo n&#227;o MIS e em apenas 14&#37; no grupo MIS &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Manejo e resultados cl&#237;nicos</span><p id="par0065" class="elsevierStylePara elsevierViewall">Cinquenta e um de todos os pacientes &#40;65&#37;&#41; precisaram de algum tipo de suporte ventilat&#243;rio&#58; 32 &#40;41&#37;&#41; usaram apenas oxigenoterapia&#44; cinco &#40;6&#37;&#41; precisaram apenas de ventila&#231;&#227;o n&#227;o invasiva &#40;VNI&#41; e 14 &#40;18&#37;&#41; necessitaram de VMI&#46; Nos pacientes que necessitaram de VMI&#44; 10 &#40;71&#37;&#41; apresentavam s&#237;ndrome do desconforto respirat&#243;rio agudo &#40;SDRA&#41;&#44; dos quais seis foram classificados como graves&#44; exigiram bloqueio neuromuscular &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41;&#44; manobra de recrutamento alveolar &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#41; e posi&#231;&#227;o prona intermitente &#40;n &#61; 3&#41; Dois desses pacientes desenvolveram hipertens&#227;o arterial pulmonar&#46; A mediana de dura&#231;&#227;o da VMI foi de 7&#44;5 dias &#40;IIQ 5&#8208;10&#41; e a mediana da press&#227;o expirat&#243;ria final positiva &#40;PEEP&#41; mais alta foi de 9&#44;5 cmH<span class="elsevierStyleInf">2</span>O &#40;IIQ 7&#8208;12&#41;&#46; Um desses casos graves de SDRA estava no grupo MIS &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Antibi&#243;ticos foram usados por 76&#37; de todos os pacientes&#44; oseltamivir em 43&#37; e corticosteroides em 23&#37;&#46; Nenhum paciente recebeu hidroxicloroquina &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46; A mediana do tempo de perman&#234;ncia &#40;TP&#41; na UTIP foi de 5 dias &#40;IIQ 2&#44;2&#8208;10&#41; e a maioria dos pacientes recebeu alta &#40;90&#37;&#41;&#46; As &#250;nicas duas mortes &#40;3&#37; de mortalidade&#41; ocorreram no grupo n&#227;o MIS&#44; ambos os pacientes com comorbidades graves e uso cr&#244;nico de corticosteroides &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46; Um caso era uma menina de 14 anos com doen&#231;a hep&#225;tica cr&#244;nica e o outro&#44; uma menina de um ano com doen&#231;a pulmonar cr&#244;nica e s&#237;ndrome do intestino curto&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Subgrupos espec&#237;ficos</span><p id="par0075" class="elsevierStylePara elsevierViewall">O subgrupo de pacientes com comorbidades era significativamente mais velho &#40;m&#233;dia de idade&#58; 7&#44;5 anos <span class="elsevierStyleItalic">vs</span>&#46; 1&#44;8 ano&#44; p 0&#44;01&#41;&#44; tinha maior necessidade de oxigenoterapia &#40;56&#37; <span class="elsevierStyleItalic">vs</span>&#46; 31&#37;&#44; p 0&#44;05&#41; e VMI &#40;31&#37; <span class="elsevierStyleItalic">vs</span>&#46; 9&#37;&#44; p 0&#44;01&#41; e diagn&#243;stico mais frequente de SDRA &#40;25&#37; <span class="elsevierStyleItalic">vs</span>&#46; 4&#37;&#44; p 0&#44;01&#41;&#44; mas n&#227;o houve diferen&#231;as em rela&#231;&#227;o &#224; dura&#231;&#227;o do suporte respirat&#243;rio e do TP na UTIP&#46; Nos pacientes que necessitaram de VMI&#44; o TP na UTIP foi significativamente maior &#40;12&#44;0 <span class="elsevierStyleItalic">vs</span>&#46; 5&#44;0 dias&#44; p 0&#44;01&#41;&#46; A idade inferior a um ano n&#227;o determinou uma apresenta&#231;&#227;o cl&#237;nica diferente&#46; Nos pacientes com MIS&#44; n&#227;o observamos diferen&#231;as significativas entre os pacientes com comorbidades&#44; idade inferior a um ano e necessidade de VMI &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>a&#41;&#46; Tamb&#233;m comparamos esses tr&#234;s grupos espec&#237;ficos&#44; consideramos apenas pacientes que n&#227;o apresentavam MIS&#44; mas os resultados foram bastante semelhantes &#40;<a class="elsevierStyleCrossRef" href="#sec0080">tabelas S1 e S2&#44; material suplementar</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">A an&#225;lise multivariada mostrou que apenas a presen&#231;a de comorbidades estava significativamente associada &#224; gravidade&#44; representada pela necessidade de VMI &#40;<span class="elsevierStyleItalic">OR</span> ajustado 5&#44;5&#59; IC95&#37; 1&#44;43&#8208;21&#44;12&#59; p 0&#44;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>b&#41;&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Discuss&#227;o</span><p id="par0085" class="elsevierStylePara elsevierViewall">Que seja de nosso conhecimento&#44; este &#233; o primeiro estudo prospectivo e multic&#234;ntrico a relatar caracter&#237;sticas e resultados de crian&#231;as com COVID&#8208;19 internadas em UTIPs no Brasil&#44; o atual epicentro da doen&#231;a na Am&#233;rica Latina e o segundo no mundo&#44; depois dos EUA&#46; Embora a maioria das crian&#231;as e adolescentes tenha um curso benigno da doen&#231;a&#44; demonstramos que alguns pacientes podem desenvolver condi&#231;&#245;es cl&#237;nicas agudas graves&#44; especialmente aquelas com comorbidades anteriores&#44; e posteriormente tamb&#233;m apresentam MIS&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Em nossa coorte&#44; embora a mediana de idade fosse de quatro anos e um quarto dos pacientes fosse lactente&#44; 44&#37; eram crian&#231;as em idade escolar&#44; adolescentes e adultos jovens&#44; um percentual superior ao geralmente observado nas UTIPs brasileiras para essa faixa et&#225;ria&#44; geralmente em torno de 25&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">9</span></a> Isso &#233; semelhante ao relatado por um grande estudo europeu<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">10</span></a> e por UTIPs americanas&#44; que relataram uma porcentagem ainda maior de hospitaliza&#231;&#245;es nessa faixa et&#225;ria &#40;70&#37;&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">2&#44;11</span></a> N&#227;o observamos uma grande diferen&#231;a entre as medianas das idades dos grupos MIS e n&#227;o MIS&#44; embora nosso n&#250;mero de pacientes com MIS tenha sido pequeno&#46; Quanto ao sexo&#44; n&#227;o houve diferen&#231;as no grupo n&#227;o MIS&#44; enquanto nos pacientes com MIS houve predom&#237;nio masculino de 4&#58;1&#44; diferentemente do relatado por outros autores&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">12&#44;13</span></a> Houve uma pequena predomin&#226;ncia de pacientes de etnia branca &#40;58&#8208;60&#37;&#41;&#44; o que est&#225; em contraste com a predomin&#226;ncia da popula&#231;&#227;o brasileira&#44; que &#233; de 56&#37; de n&#227;o brancos&#46; Entretanto&#44; cerca de metade dos pacientes era de hospitais particulares&#44; acess&#237;veis apenas &#224; popula&#231;&#227;o de renda m&#233;dia e alta&#44; onde os brancos s&#227;o a maioria&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">As comorbidades t&#234;m sido descritas como um importante fator de risco para casos mais graves de COVID&#8208;19 em crian&#231;as&#44; representam entre 50&#8208;80&#37; das admiss&#245;es em UTIP&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">11&#44;14&#44;15</span></a> Embora tiv&#233;ssemos uma porcentagem um pouco menor desses pacientes &#40;41&#37;&#41;&#44; eles eram significativamente mais velhos e tinham uma apresenta&#231;&#227;o significativamente mais grave &#40;mais SDRA&#44; mais suporte ventilat&#243;rio&#44; mais VMI&#41;&#46; O modelo de regress&#227;o log&#237;stica mostrou que as comorbidades estavam independentemente associadas &#224; necessidade de VMI&#44; com um <span class="elsevierStyleItalic">odds ratio</span> ajustado de 5&#44;5 &#91;IC95&#37;&#44; 1&#44;4&#8208;21&#44;1&#41;&#46; Doen&#231;a neuromuscular&#44; doen&#231;a respirat&#243;ria cr&#244;nica e doen&#231;a onco&#8208;hematol&#243;gica foram as comorbidades mais prevalentes em nossa coorte&#44; o que &#233; um pouco diferente de outros relatos em terapia intensiva pedi&#225;trica&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">5&#44;11&#44;14&#44;15</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Somente cerca de 40&#37; dos pacientes tinham hist&#243;rico pr&#233;vio de contato com um caso suspeito&#44; principalmente em casa&#44; o que &#233; semelhante a outros relatos&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">4</span></a> A febre foi o sintoma predominante&#44; seguido por v&#225;rios sinais e sintomas respirat&#243;rios e gastrointestinais&#44; que n&#227;o diferiram do que foi relatado em outros estudos&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">5&#44;10&#44;14&#44;16</span></a> Houve maior preval&#234;ncia de sintomas gastrointestinais no grupo MIS&#44; como diarreia e v&#244;mito com desidrata&#231;&#227;o&#44; o que tamb&#233;m foi observado por outros autores&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">12&#44;13</span></a> O intervalo entre o in&#237;cio dos sintomas e a hospitaliza&#231;&#227;o foi menor no grupo MIS &#40;mediana&#44; 2 <span class="elsevierStyleItalic">vs</span>&#46; 5 dias&#41;&#46; Isso pode ser explicado pelos casos mais graves nesse grupo&#44; alguns deles apresentaram sinais de choque e insufici&#234;ncia cardiorrespirat&#243;ria&#46; Embora a principal s&#237;ndrome cl&#237;nica na hospitaliza&#231;&#227;o fosse geralmente de origem respirat&#243;ria ou gastrointestinal&#44; tivemos 10 pacientes &#40;13&#37;&#41; internados na UTIP por causa da MIS&#46; Esse &#233; um fen&#244;meno novo relacionado &#224; COVID&#8208;19 em crian&#231;as e espera&#8208;se que muitos desses pacientes precisem de acompanhamento na UTIP e tamb&#233;m por outras especialidades pedi&#225;tricas&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">6</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">A maioria dos nossos pacientes teve seu diagn&#243;stico confirmado por RT&#8208;PCR &#40;91&#37;&#41;&#44; mas observamos uma propor&#231;&#227;o maior de resultados negativos no grupo MIS &#40;50&#37; <span class="elsevierStyleItalic">vs</span>&#46; 15&#37;&#41;&#46; Isso &#233; compat&#237;vel com dados anteriores&#44; mostra que a MIS &#233; uma manifesta&#231;&#227;o tardia associada ao COVID&#8208;19&#44; fora da janela de positividade para a RT&#8208;PCR&#46; Nesse grupo&#44; a associa&#231;&#227;o com uma infec&#231;&#227;o por SARS&#8208;CoV&#8208;2 foi observada em metade dos pacientes atrav&#233;s de sorologia positiva&#44; principalmente IgG&#46; Por outro lado&#44; no grupo n&#227;o MIS&#44; uma IgM positiva foi detectada em 80&#37; dos poucos casos nos quais foi medida&#46; A codetec&#231;&#227;o com outros v&#237;rus foi observada em 15&#37; dos pacientes nos quais foi investigada &#40;apenas no grupo n&#227;o MIS&#41;&#44; semelhante a outros estudos da COVID&#8208;19<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">5&#44;10</span></a> e em outras infec&#231;&#245;es graves por v&#237;rus respirat&#243;rios em crian&#231;as&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">17</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">A linfopenia foi observada em geral em 38&#37; dos pacientes &#40;50&#37; no grupo MIS&#41;&#44; o que tamb&#233;m j&#225; foi descrito em outros estudos pedi&#225;tricos da COVID&#8208;19&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">5&#44;14&#44;15&#44;18</span></a> Embora alguns estudos em adultos tenham associado linfopenia a um progn&#243;stico ruim&#44;<a class="elsevierStyleCrossRefs" href="#bib0225"><span class="elsevierStyleSup">19&#44;20</span></a> isso ainda n&#227;o est&#225; claro na pediatria&#46; Marcadores inflamat&#243;rios&#44; como VHS&#44; PCR&#44; LDH&#44; D&#8208;D&#237;mero&#44; procalcitonina e ferritina&#44; estavam elevados na maioria dos pacientes testados&#44; mas principalmente no grupo MIS&#44; o que est&#225; de acordo com os crit&#233;rios diagn&#243;sticos para essa s&#237;ndrome&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">21&#8211;23</span></a> Em nossa coorte&#44; medimos a troponina&#44; CK e CK&#8208;MB em menos de 20&#37; dos pacientes e encontramos n&#237;veis elevados em pelo menos 50&#37; deles&#46; Esses biomarcadores de les&#245;es card&#237;acas tamb&#233;m foram relatados com n&#237;veis anormais em outros estudos&#44; principalmente em pacientes com algum tipo de insufici&#234;ncia card&#237;aca&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">12&#8211;14</span></a> Outro marcador sens&#237;vel conhecido para detec&#231;&#227;o de insufici&#234;ncia card&#237;aca&#44; o ProBNP&#44; estava elevado em todos os sete pacientes nos quais foi medido no grupo MIS&#44; como tamb&#233;m relatado em outros estudos&#46;<a class="elsevierStyleCrossRefs" href="#bib0160"><span class="elsevierStyleSup">6&#44;24</span></a> Tamb&#233;m medimos a interleucina&#8208;6 &#40;IL&#8208;6&#41; em dois pacientes do grupo MIS&#44; ambos com disfun&#231;&#227;o card&#237;aca grave e choque e n&#237;veis muito altos foram encontrados&#46; N&#237;veis elevados j&#225; foram descritos em pacientes pedi&#225;tricos cr&#237;ticos com COVID&#8208;19&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">5&#44;8&#44;12</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Outro achado consistente com disfun&#231;&#227;o card&#237;aca em pacientes do grupo MIS foi derrame pleural&#44; detectado por radiografia de t&#243;rax&#44; uma caracter&#237;stica muito menos frequente no grupo n&#227;o MIS&#46; Os outros achados radiol&#243;gicos de infiltrados intersticiais difusos bilaterais e opacidades em vidro fosco&#44; nas radiografias de t&#243;rax e na TC&#44; estavam presentes na maioria dos pacientes&#44; o que &#233; consistente com relatos anteriores&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">10&#44;18&#44;25</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Quanto ao manejo dos pacientes&#44; a maioria necessitou de algum tipo de suporte respirat&#243;rio&#59; a maioria necessitou apenas de oxigenoterapia&#44; mas cerca de 20&#37; necessitaram de VMI &#40;mediana de 7&#44;5 dias&#41;&#44; o que est&#225; dentro da faixa de uso relatada &#40;18&#8208;50&#37;&#41; descrita em outros estudos&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">5&#44;10&#44;11&#44;14</span></a> Desses&#44; 71&#37; desenvolveram SDRA&#44; principalmente grave&#44; exigiram bloqueio neuromuscular&#44; PEEP alta&#44; manobra de recrutamento alveolar e posi&#231;&#227;o prona em alguns casos&#46; Embora n&#227;o pud&#233;ssemos confirmar infec&#231;&#245;es bacterianas&#44; a antibioticoterapia foi usada em tr&#234;s quartos dos pacientes e o oseltamivir em quase metade&#44; o que pode ser explicado pelas diretrizes nacionais para o tratamento da SARS&#44; que indicam o uso inicial do oseltamivir emp&#237;rico&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">26</span></a> A hidroxicloroquina n&#227;o foi prescrita&#44; embora alguns estudos tenham relatado seu uso em 7 a 47&#37; dos pacientes&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">5&#44;10&#44;11&#44;14</span></a> Talvez essa diferen&#231;a possa ser explicada pelo fato de os casos na Europa e nos EUA terem come&#231;ado semanas ou meses antes do Brasil&#44; quando um uso mais compassivo de drogas poderia ser explicado e tamb&#233;m menos estudos estavam dispon&#237;veis&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Comparamos as caracter&#237;sticas demogr&#225;ficas e cl&#237;nicas de acordo com a presen&#231;a de comorbidades&#44; idade abaixo de um ano e necessidade de VMI&#46; Embora nossos n&#250;meros nesses subgrupos fossem pequenos&#44; encontramos diferen&#231;as significativas determinadas pela presen&#231;a de comorbidades&#46; Esses pacientes eram mais velhos e precisavam de mais suporte respirat&#243;rio&#44; com a maioria dos casos de SDRA&#46; As &#250;nicas duas mortes tamb&#233;m ocorreram nesse grupo&#46; A presen&#231;a de comorbidades aumentou de forma independente a chance de VMI&#44; mas os fatores associados a um pior progn&#243;stico precisam de mais investiga&#231;&#227;o&#46; A obesidade&#44; relatada como o pior fator progn&#243;stico em crian&#231;as com COVID&#8208;19&#44;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">5&#44;11</span></a> n&#227;o foi frequente em nossa coorte&#44; na qual as principais comorbidades significativas foram doen&#231;as neuromusculares&#44; doen&#231;as respirat&#243;rias cr&#244;nicas e c&#226;ncer&#46; Idade inferior a um ano&#44; sexo e etnia n&#227;o foram associados a casos mais graves em nosso estudo&#44; embora os lactentes tenham apresentado pior curso cl&#237;nico na China e nos EUA&#46;<a class="elsevierStyleCrossRefs" href="#bib0135"><span class="elsevierStyleSup">1&#44;2</span></a> Como a MIS &#233; uma doen&#231;a pouco compreendida&#44; que parece ocorrer em uma fase subaguda da infec&#231;&#227;o por SARS&#8208;CoV&#8208;2&#44; tamb&#233;m fizemos as mesmas compara&#231;&#245;es de subgrupos e a avalia&#231;&#227;o de preditores de gravidade apenas no grupo n&#227;o MIS&#44; mas os resultados n&#227;o diferiram&#46; Como tamb&#233;m demonstrado em todos os estudos pedi&#225;tricos sobre a COVID&#8208;19&#44; a grande maioria dos nossos pacientes progrediu bem e recebeu alta&#44; com uma taxa de mortalidade de apenas 3&#37;&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Nosso estudo tem algumas limita&#231;&#245;es&#46; Como incluiu apenas pacientes brasileiros&#44; isso pode limitar a generaliza&#231;&#227;o de nossos resultados&#46; Al&#233;m disso&#44; faltam alguns detalhes sobre o tratamento&#44; como o motivo do alto percentual de uso de antibi&#243;ticos ou corticosteroides&#46; Nem todos os pacientes tiveram os marcadores inflamat&#243;rios medidos&#59; portanto&#44; eles n&#227;o puderam ser comparados dependendo da gravidade da doen&#231;a&#46; Apesar dessas limita&#231;&#245;es&#44; acreditamos que nosso estudo pode contribuir para uma melhor compreens&#227;o da COVID&#8208;19&#44; pois descreve a primeira grande s&#233;rie de pacientes internados em UTIPs no hemisf&#233;rio sul&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Mostramos que as caracter&#237;sticas dessa doen&#231;a em locais tropicais e subtropicais s&#227;o semelhantes &#224;s de outros pa&#237;ses&#46; Em nossa coorte&#44; a letalidade foi baixa e as doen&#231;as cr&#244;nicas e outras comorbidades desempenharam um papel importante no desenvolvimento de formas graves da doen&#231;a&#46; Diferentemente de outros estudos&#44; a idade inferior a um ano n&#227;o foi associada a um pior progn&#243;stico&#46; Pacientes com MIS apresentaram sintomas mais graves&#44; n&#237;veis mais altos de biomarcadores inflamat&#243;rios e maior predom&#237;nio do sexo masculino&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Financiamento</span><p id="par0140" class="elsevierStylePara elsevierViewall">Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#40;CNPq&#41;&#44; processo n&#176; 401597&#47;2020&#8208;2&#46; Funda&#231;&#227;o Carlos Chagas Filho de Amparo &#224; Pesquisa do Estado do Rio de Janeiro &#40;Faperj&#41;&#44; processo n&#176; E&#8208;26&#47;010&#46;000160&#47;2020&#44; concess&#227;o n&#176; 2020&#47;0996&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflitos de interesse</span><p id="par0145" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflitos de interesse&#46;</p></span></span>"
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              "titulo" => "Caracter&#237;sticas demogr&#225;ficas e epidemiol&#243;gicas"
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              "titulo" => "Apresenta&#231;&#227;o cl&#237;nica"
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              "titulo" => "Confirma&#231;&#227;o do diagn&#243;stico&#44; achados laboratoriais e radiol&#243;gicos"
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              "titulo" => "Manejo e resultados cl&#237;nicos"
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    "fechaRecibido" => "2020-07-16"
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            0 => "COVID&#8208;19"
            1 => "SARS&#8208;CoV&#8208;2"
            2 => "Pediatric intensive care"
            3 => "Pediatrics"
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            0 => "COVID&#8208;19"
            1 => "SARS&#8208;CoV&#8208;2"
            2 => "Terapia intensiva pedi&#225;trica"
            3 => "Pediatria"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To describe the clinical characteristics of children and adolescents admitted to intensive care with confirmed COVID&#8208;19&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Prospective&#44; multicenter&#44; observational study&#44; in 19 pediatric intensive care units&#46; Patients aged 1 month to 19 years admitted consecutively &#40;March&#8211;May 2020&#41; were included&#46; Demographic&#44; clinical&#8208;epidemiological features&#44; treatment&#44; and outcomes were collected&#46; Subgroups were compared according to comorbidities&#44; age &#60; 1 year&#44; and need for invasive mechanical ventilation&#46; A multivariable logistic regression model was used for predictors of severity&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Seventy&#8208;nine patients were included &#40;ten with multisystemic inflammatory syndrome&#41;&#46; Median age 4 years&#59; 54&#37; male &#40;multisystemic inflammatory syndrome&#44; 80&#37;&#41;&#59; 41&#37; had comorbidities &#40;multisystemic inflammatory syndrome&#44; 20&#37;&#41;&#46; Fever &#40;76&#37;&#41;&#44; cough &#40;51&#37;&#41;&#44; and tachypnea &#40;50&#37;&#41; were common in both groups&#46; Severe symptoms&#44; gastrointestinal symptoms&#44; and higher inflammatory markers were more frequent in multisystemic inflammatory syndrome&#46; Interstitial lung infiltrates were common in both groups&#44; but pleural effusion was more prevalent in the multisystemic inflammatory syndrome group &#40;43&#37; <span class="elsevierStyleItalic">vs&#46;</span> 14&#37;&#41;&#46; Invasive mechanical ventilation was used in 18&#37; &#40;median 7&#46;5 days&#41;&#59; antibiotics&#44; oseltamivir&#44; and corticosteroids were used in 76&#37;&#44; 43&#37;&#44; and 23&#37;&#44; respectively&#44; but not hydroxychloroquine&#46; The median pediatric intensive care unit length&#8208;of&#8208;stay was five days&#59; there were two deaths &#40;3&#37;&#41; in the non&#8208; multisystemic inflammatory syndrome group&#46; Patients with comorbidities were older and comorbidities were independently associated with the need for invasive mechanical ventilation &#40;OR 5&#46;5&#59; 95&#37; CI&#44; 1&#46;43&#8211;21&#46;12&#59; p<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In Brazilian pediatric intensive care units&#44; COVID&#8208;19 had low mortality&#44; age less than 1 year was not associated with a worse prognosis&#44; and patients with multisystemic inflammatory syndrome had more severe symptoms&#44; higher inflammatory biomarkers&#44; and a greater predominance of males&#44; but only comorbidities and chronic diseases were independent predictors of severity&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Descrever as caracter&#237;sticas cl&#237;nicas de crian&#231;as e adolescentes internados em unidade de terapia intensiva com COVID&#8208;19 confirmada&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudo prospectivo&#44; multic&#234;ntrico&#44; observacional&#44; em 19 unidades de terapia intensiva pedi&#225;trica&#46; Foram inclu&#237;dos pacientes entre um m&#234;s e 19 anos&#44; admitidos consecutivamente &#40;mar&#231;o a maio de 2020&#41;&#46; As caracter&#237;sticas demogr&#225;ficas&#44; cl&#237;nico&#8208;epidemiol&#243;gicas&#44; o tratamento e os resultados foram coletados&#46; Os subgrupos foram comparados de acordo com as comorbidades&#44; idade &#60; 1 ano e necessidade de ventila&#231;&#227;o mec&#226;nica invasiva&#46; Um modelo de regress&#227;o log&#237;stica multivari&#225;vel foi utilizado para preditores de gravidade&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Setenta e nove pacientes foram inclu&#237;dos &#40;10 com s&#237;ndrome inflamat&#243;ria multi-ssist&#234;mica&#41;&#46; Mediana de idade&#44; quatro anos&#59; 54&#37; eram do sexo masculino &#40;s&#237;ndrome inflamat&#243;ria multissist&#234;mica&#44; 80&#37;&#41;&#59; 41&#37; tinham comorbidades &#40;s&#237;ndrome inflamat&#243;ria multissist&#234;mica&#44; 20&#37;&#41;&#46; Febre &#40;76&#37;&#41;&#44; tosse &#40;51&#37;&#41; e taquipneia &#40;50&#37;&#41; foram comuns nos dois grupos&#46; Sintomas graves egastrointestinais e marcadores inflamat&#243;rios mais elevados foram mais frequentes na presen&#231;a de s&#237;ndrome inflamat&#243;ria multissist&#234;mica&#46; Infiltrados intersticiais pulmonares foram comuns em ambos os grupos&#44; mas o derrame pleural foi mais prevalente no grupo com s&#237;ndrome inflamat&#243;ria multissist&#234;mica &#40;43&#37; vs&#46; 14&#37;&#41;&#46; A ventilac&#184;&#227;o mec&#226;nica invasiva foi utilizada em 18&#37; &#40;mediana 7&#44;5 dias&#41;&#59; antibi&#243;ticos&#44; oseltamivir e corticosteroides foram utilizados em 76&#37;&#44; 43&#37; e 23&#37;&#44; respectivamente&#44; mas n&#227;o a hidroxicloroquina&#46; A mediana do tempo de perman&#234;ncia na unidade de terapia intensiva pedi&#225;trica foi de 5 dias&#59; duas mortes ocorreram &#40;3&#37;&#41; no grupo n&#227;o- s&#237;ndrome inflamat&#243;ria multissist&#234;mica&#46; Os pacientes com comorbidades eram mais velhos&#44; e as comorbidades foram independentemente associadas &#224; necessidade de ventilac&#184;&#227;o mec&#226;nica invasiva&#40;<span class="elsevierStyleItalic">OR</span> 5&#44;5&#59; IC95&#37;&#44; 1&#44;43-21&#44;12&#59; P 0&#44;01&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#245;es</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Nas unidades de terapia intensiva pedi&#225;trica brasileiras&#44; a COVID&#8208;19 apresentou baixa mortalidade&#44; a idade inferior a um ano n&#227;o foi associada a um pior progn&#243;stico&#44; os pacientes com s&#237;ndrome inflamat&#243;ria multissist&#234;mica apresentaram sintomas mais graves&#44; biomarcadores inflamat&#243;rios mais elevados e uma grande predomin&#226;ncia no sexo masculino&#44; mas apenas a presen&#231;a de comorbidades e doen&#231;as cr&#244;nicas foi um preditor independente de gravidade&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0050">Como citar este artigo&#58; Prata&#8208;Barbosa A&#44; Lima&#8208;Setta F&#44; Santos GR&#44; Lanziotti VS&#44; Castro RE&#44; Souza DC&#44; et al&#46; Pediatric patients with COVID&#8208;19 admitted to intensive care units in Brazil&#58; a prospective multicenter study&#46; J Pediatr &#40;Rio J&#41;&#46; 2020&#59;96&#58;570&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0055">Estudo vinculado &#224; Rede Brasileira de Pesquisa em Medicina Intensiva Pedi&#225;trica &#40;BRnet&#8208;PIC&#41;&#44; Brasil&#46;</p>"
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          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">COVID&#8208;19&#44; doen&#231;a do coronav&#237;rus 2019&#59; IIQ&#44; intervalo interquartil&#59; MIS&#44; S&#237;ndrome Inflamat&#243;ria Multissist&#234;mica&#59; UTIP&#44; Unidade de Terapia Intensiva Pedi&#225;trica&#44; SpO<span class="elsevierStyleInf">2</span>&#44; satura&#231;&#227;o de oxig&#234;nio no ox&#237;metro de pulso&#46;</p>"
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5&#44;2 &#40;1&#44;5&#8208;8&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;1&#8208;10&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lactentes &#40;&#60; 12 m&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">19 &#40;24&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Crian&#231;a pequena &#40;&#8805; 12 m&#44; &#60; 3 a&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18 &#40;23&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pr&#233;&#8208;escolar &#40;&#8805; 3 a&#44; &#60; 5 a&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Crian&#231;a no Ensino Fundamental I &#40;&#8805; 5 a&#44; &#60; 12 a&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">15 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">19 &#40;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Adolescente &#40;&#8805; 12 a&#44; &#60; 18 a&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">13 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Jovem Adulto &#40;&#8805; 18 a&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">35 &#40;51&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;80&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">43 &#40;54&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">34 &#40;49&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">36 &#40;46&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="4" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Cor da pele&#47;etnia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Branca&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">40 &#40;58&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">46 &#40;58&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Parda&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">19 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">20 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Negra&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">10 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">12 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Asi&#225;tico&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbidades</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">30 &#40;43&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">32 &#40;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;a neuromuscular<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10 &#40;31&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;a respirat&#243;ria cr&#244;nica<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6 &#40;19&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;a onco&#8208;hematol&#243;gica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6 &#40;19&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;a card&#237;aca cong&#234;nita&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5 &#40;16&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Subnutri&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;13&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;6&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Prematuridade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;6&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doen&#231;a hep&#225;tica cr&#244;nica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Obesidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Contato comum caso suspeito &#40;N</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">o</span></span><span class="elsevierStyleItalic">&#46; 31&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">24 &#40;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">31 &#40;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Em casa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">20 &#40;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">27 &#40;87&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Outro lugar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Principal s&#237;ndrome cl&#237;nica na apresenta&#231;&#227;o</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Respirat&#243;ria<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MIS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Condi&#231;&#227;o similar &#224; doen&#231;a de Kawasaki&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Disfun&#231;&#227;o card&#237;aca aguda&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>S&#237;ndrome do choque t&#243;xico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>S&#237;ndrome de ativa&#231;&#227;o de macr&#243;fagos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Sintomas antes da hospitaliza&#231;&#227;o&#44; mediana &#40;IIQ&#41;&#44; dias</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Caracter&#237;sticas cl&#237;nicas na apresenta&#231;&#227;o</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Febre&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tosse&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Taquipneia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Baixa SpO<span class="elsevierStyleInf">2</span> &#40;&#60;92&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Prostra&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Retra&#231;&#227;o tor&#225;cica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Coriza&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diarreia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Recusa em alimentar&#8208;se&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>V&#244;mitos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Desidrata&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Batimento de asa nasal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Gem&#234;ncia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cianose&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipotens&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Teste r&#225;pido para v&#237;rus sincicial respirat&#243;rio&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Outro v&#237;rus&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Rinov&#237;rus humano&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">ValoresMediana &#40;IIQ&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">ValoresMediana &#40;IIQ&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">N<span class="elsevierStyleSup">o</span>&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">ValoresMediana &#40;IIQ&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Contagem total de leuc&#243;citos &#40;x1&#46;000&#47;&#956;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18&#46;275 &#40;14&#46;293&#8208; 23&#46;868&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">12&#46;520 &#40;8&#46;382&#8208;19&#46;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Contagem deplaquetas&#40;x1&#44;000&#47;&#956;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">260&#46;500 &#40;159&#46;250&#8208;374&#46;500&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">226&#46;500 &#40;136&#46;750&#8208;367&#46;000&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Linfopenia N</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">o</span></span><span class="elsevierStyleItalic">&#46; &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">26 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Prote&#237;na C&#8208;reativa &#40;mg&#47;dL&#41;&#44;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;0&#46;6&#8208;18&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10 &#40;9&#8208;30&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5&#46;1 &#40;0&#46;7&#8208;20&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Velocidade de hemossedimenta&#231;&#227;o &#40;mm&#47;1</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">a</span></span><span class="elsevierStyleItalic">h&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Achados radiol&#243;gicos na admiss&#227;o na UTIP</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Imagens alteradas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Imagens alteradas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Radiografias tor&#225;cicas anormais</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrado intersticial difuso&#44; bilateral&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrado intersticial&#44; localizado&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Consolida&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Atelectasia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>PEEP mais alta&#44; mediana &#40;IIQ&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;0 &#40;7&#44;0&#44; 11&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#44;0 &#40;12&#44;0&#44; 12&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;5 &#40;7&#44;0&#44; 12&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Posi&#231;&#227;o prona intermitente&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Recrutamento alveolar&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;60&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Hipertens&#227;o arterial pulmonar</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">71 &#40;90&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Morte&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Caracter&#237;stica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comorbidades</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Idade inferior a um ano</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ventila&#231;&#227;o mec&#226;nica invasiva</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Idade&#44; mediana &#40;IIQ&#41;&#44; a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;5 &#40;2&#44;1&#44; 12&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;8 &#40;0&#44;8&#44; 7&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;01<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5 &#40;0&#44;2&#44; 0&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;0 &#40;1&#44;9&#44; 12&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;6 &#40;1&#44;2&#44; 10&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;2 &#40;1&#44;2&#44; 10&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;94<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo&#44; N</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">o</span></span><span class="elsevierStyleItalic">&#46; &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34 &#40;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;51<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28 &#40;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Etnia&#44; No&#46; &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Branca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;62&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;57<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;17<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>N&#227;o branca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;58&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22 &#40;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Comorbidades&#44; N</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">o</span></span><span class="elsevierStyleItalic">&#46; &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27 &#40;45&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;19<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10 &#40;71&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">22 &#40;34&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " rowspan="2" align="left" valign="\n
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                  \t\t\t\t">0&#44;01<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;74&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">33 &#40;55&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;29&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">43 &#40;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Principal apresenta&#231;&#227;o&#44; N</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">o</span></span><span class="elsevierStyleItalic">&#46; &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Respirat&#243;ria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">22 &#40;69&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">25 &#40;53&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;11<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">13 &#40;68&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">34 &#40;57&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;72<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">11 &#40;79&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">26 &#40;48&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;08<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>MIS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;18<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;67<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Condi&#231;&#227;o similar &#224; doen&#231;a de Kawasaki&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;56<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;50&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;56<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;30<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Disfun&#231;&#227;o card&#237;aca aguda&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">2 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>S&#237;ndrome do choque t&#243;xico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>S&#237;ndrome da ativa&#231;&#227;o de macr&#243;fagos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Outras&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;85<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18 &#40;30&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;73<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">20 &#40;37&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;12<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="10" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="10" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Manejo&#44; N</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">o</span></span><span class="elsevierStyleItalic">&#46; &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Apenas oxigenoterapia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18 &#40;56&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;05<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27 &#40;45&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;24<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">32 &#40;49&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Ventila&#231;&#227;o n&#227;o invasiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;39<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Ventila&#231;&#227;o mec&#226;nica invasiva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">10 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;01<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">11 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Dias de uso&#44; mediana &#40;IIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;5 &#40;5&#44;5&#8208; 9&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">12&#44;5 &#40;8&#44;8&#44; 16&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;67<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;0 &#40;9&#44;0&#8208; 9&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;0 &#40;5&#44;0&#44; 11&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;66<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;5 &#40;5&#44;0&#8208; 10&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diagn&#243;stico de SDRA&#44; N</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">o</span></span><span class="elsevierStyleItalic">&#46; &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;01<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;44<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TP UTIP&#44; dias&#44; mediana &#40;IIQ&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;5 &#40;2&#44;8&#44; 10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;2&#8208;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;88<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;4&#8208;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;2&#8208;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;18<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;6&#8208;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;0 &#40;2&#8208;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;01<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="10" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Desfecho&#44; N</span><span class="elsevierStyleSup">o</span><span class="elsevierStyleItalic">&#46; &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Alta hospitalar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;10<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54 &#40;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;79<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61 &#40;94&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;01<a class="elsevierStyleCrossRef" href="#tblfn0035"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Morte&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Transfer&#234;ncia para outro hospital&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
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            1 => array:2 [
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                0 => """
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                  \t\t\t\t\tvoid\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tabela 4 b &#8208; <span class="elsevierStyleItalic">Odds ratio</span> n&#227;o ajustados e ajustados<a class="elsevierStyleCrossRef" href="#tblfn0045"><span class="elsevierStyleSup">d</span></a> e intervalos de confian&#231;a de 95&#37; para pacientes pedi&#225;tricos com COVID&#8208;19&#44; de acordo com a necessidade de ventila&#231;&#227;o mec&#226;nica invasiva &#40;n &#61; 79&#41;</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ventila&#231;&#227;o mec&#226;nica invasiva</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#227;o ajustadoOR &#40;CI 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">AjustadoOR &#40;CI 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#8208;valor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade &#60; 1 ano&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;00 &#40;0&#44;99&#8208;1&#44;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;99 &#40;0&#44;99&#8208;1&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo&#44; masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;57 &#40;0&#44;18&#8208;1&#44;82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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