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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introdu&#231;&#227;o</span><p id="par0010" class="elsevierStylePara elsevierViewall">A morte neonatal &#233; definida como o &#243;bito de um rec&#233;m&#8208;nascido antes de completar 28 dias&#46;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">1&#44;2</span></a> No Brasil&#44; a mortalidade neonatal&#44; em 2016&#44; foi de oito mortes neonatais para cada 1&#46;000 nascidos vivos &#8211; uma redu&#231;&#227;o significativa quando comparado a 1990&#44; quando esse valor era de 26 mortes neonatais para cada 1&#46;000 nascidos vivos&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;4</span></a> Em 2011&#44; o pa&#237;s alcan&#231;ou a meta 4 dos Objetivos de Desenvolvimento do Mil&#234;nio&#44; um compromisso dos governos integrantes das Na&#231;&#245;es Unidas para a redu&#231;&#227;o da mortalidade infantil&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">3</span></a> A mortalidade neonatal brasileira&#44; apesar dessa redu&#231;&#227;o&#44; ainda continua elevada e desigual regionalmente&#44; a diferen&#231;a entre o Norte&#47;Nordeste e o Sul&#47;Sudeste foi a mais discrepante&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A redu&#231;&#227;o dessa taxa &#233; um objetivo a ser perseguido e uma realidade que pode ser alcan&#231;ada&#44; uma vez que o principal motivo desse valor s&#227;o fatores evit&#225;veis&#44; como o baixo peso ao nascer&#44; a prematuridade&#44; a asfixia neonatal e os cuidados pr&#233;&#8208;natais de baixa qualidade&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">6&#8211;8</span></a> Um fator complementar&#44; por&#233;m&#44; de igual import&#226;ncia&#44; s&#227;o as causas maternas&#44; com uma contribui&#231;&#227;o expressiva na mortalidade neonatal nos pa&#237;ses em desenvolvimento&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">5&#44;8</span></a> No entanto&#44; ainda n&#227;o se tem uma avalia&#231;&#227;o sistem&#225;tica do conjunto desses fatores nos &#250;ltimos tempos no Brasil&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A revis&#227;o sistem&#225;tica com metan&#225;lise mostra&#8208;se&#44; assim&#44; uma possibilidade real para tra&#231;ar o impacto dos fatores de risco na mortalidade neonatal em territ&#243;rio brasileiro&#44; auxiliando na decis&#227;o cl&#237;nica e no entendimento epidemiol&#243;gico dos profissionais&#44; principalmente dos gestores da sa&#250;de p&#250;blica do Brasil&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">9</span></a> O estudo objetiva identificar&#44; atrav&#233;s de uma revis&#227;o sistem&#225;tica e metan&#225;lise de estudos observacionais&#44; quais fatores de risco associam&#8208;se significativamente com a mortalidade neonatal no Brasil e construir uma an&#225;lise nacional abrangente sobre o tema&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todo</span><p id="par0025" class="elsevierStylePara elsevierViewall">Um protocolo Prospero &#40;<a href="https://www.crd.york.ac.uk/prospero/">https&#58;&#47;&#47;www&#46;crd&#46;york&#46;ac&#46;uk&#47;prospero&#47;</a>&#41; foi publicado sob o n&#250;mero CRD42018108716&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A sele&#231;&#227;o dos estudos&#44; a extra&#231;&#227;o de dados e a an&#225;lise do risco de vi&#233;s foram feitas por dois autores&#44; de forma independente&#46; As diverg&#234;ncias foram solucionadas a partir de um acordo entre as partes&#59; caso n&#227;o houvesse consenso&#44; um terceiro autor findaria o impasse&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Crit&#233;rios de elegibilidade</span><p id="par0040" class="elsevierStylePara elsevierViewall">Os crit&#233;rios de inclus&#227;o foram compostos pelos seguintes itens&#58; estudos observacionais sobre mortalidade neonatal&#59; estudos feitos entre 2000 e 2018&#59; estudos feitos em cidades brasileiras&#59; estudos que usaram medidas de risco ajustadas&#44; juntamente com seus intervalos de confian&#231;a&#59; estudos que empregaram um ou mais dos seguintes fatores de exposi&#231;&#227;o&#58; escolaridade materna e&#47;ou situa&#231;&#227;o conjugal da m&#227;e e&#47;ou idade materna &#40;anos&#41; e&#47;ou sexo do rec&#233;m&#8208;nascido e&#47;ou tipo de parto e&#47;ou natimorto pr&#233;vio e&#47;ou tipo de gesta&#231;&#227;o e&#47;ou adequa&#231;&#227;o do pr&#233;&#8208;natal e&#47;ou intercorr&#234;ncias maternas e&#47;ou peso ao nascer &#40;g&#41; e&#47;ou idade gestacional &#40;semanas&#41; e&#47;ou malforma&#231;&#227;o cong&#234;nita e&#47;ou Apgar no 5&#176; minuto de vida&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Base de dados</span><p id="par0045" class="elsevierStylePara elsevierViewall">As bases de dados principais deste estudo foram a Medline&#44; acessada via PubMed &#60;<a href="https://www.ncbi.nlm.nih.gov/pubmed/">https&#58;&#47;&#47;www&#46;ncbi&#46;nlm&#46;nih&#46;gov&#47;pubmed&#47;</a>&#62; e Bireme &#60;<a href="http://bvsalud.org/">http&#58;&#47;&#47;bvsalud&#46;org&#47;</a>&#62;&#46; A base de dados secund&#225;rias foi a Elsevier &#60;<a href="https://www.sciencedirect.com/">https&#58;&#47;&#47;www&#46;sciencedirect&#46;com&#47;</a>&#62;&#46; As bases de dados regionais foram a Lilacs &#60;<a href="http://bvsalud.org/">http&#58;&#47;&#47;bvsalud&#46;org&#47;</a>&#62; e a SciELO &#60;<a href="http://www.scielo.org/php/index.php">http&#58;&#47;&#47;www&#46;scielo&#46;org&#47;php&#47;index&#46;php</a>&#62;&#46; A base de dados de literatura cinzenta foi a Opengrey &#60;<a href="http://www.opengrey.eu/">http&#58;&#47;&#47;www&#46;opengrey&#46;eu&#47;</a>&#62;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Estrat&#233;gia de busca</span><p id="par0050" class="elsevierStylePara elsevierViewall">Foi definida a partir da estrat&#233;gia Pecos &#40;Pacientes &#124; Exposi&#231;&#227;o &#124; Compara&#231;&#227;o &#124; Desfecho &#124; Tipo de estudo&#41;&#46; Diante disso&#44; constru&#237;ram&#8208;se duas estrat&#233;gias&#8208;base&#44; uma no idioma ingl&#234;s&#44; com termos MeSH &#60;<a href="https://www.ncbi.nlm.nih.gov/mesh">https&#58;&#47;&#47;www&#46;ncbi&#46;nlm&#46;nih&#46;gov&#47;mesh</a>&#62;&#44; e outra no idioma portugu&#234;s&#44; com termos DeCS &#60;<a href="http://decs.bvs.br/">http&#58;&#47;&#47;decs&#46;bvs&#46;br&#47;</a>&#62;&#46;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0055" class="elsevierStylePara elsevierViewall">&#40;early neonatal mortality OR neonatal mortality OR perinatal mortality OR infant mortality&#41; AND &#40;risk factors OR socioeconomic factors OR low birth weight OR perinatal care&#41; AND &#40;Brazil OR Brasil&#41; AND &#40;case control studies OR cohort studies&#41;&#59;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0060" class="elsevierStylePara elsevierViewall">&#40;mortalidade neonatal OR mortalidade perinatal OR mortalidade infantil&#41; AND &#40;fatores de risco OR fatores socioecon&#244;micos OR baixo peso ao nascer&#41; AND &#40;caso&#8208;controle OR coorte&#41;&#59;</p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Sele&#231;&#227;o dos estudos</span><p id="par0065" class="elsevierStylePara elsevierViewall">Constituiu&#8208;se de tr&#234;s etapas&#58; fase de t&#237;tulos&#59; fase de resumos e fase de artigos completos&#44; iniciou&#8208;se ap&#243;s as buscas em todas as bases de dados&#46; Al&#233;m dessa sele&#231;&#227;o&#44; a inclus&#227;o dos artigos foi complementada pela procura de aux&#237;lio de especialistas na &#225;rea no encontro de estudos relevantes para este estudo&#46; A remo&#231;&#227;o de duplicatas deu&#8208;se com o aux&#237;lio do <span class="elsevierStyleItalic">software</span> Mendeley 1&#46;17&#46;11 &#40;Elsevier&#44; Nova Iorque&#8208;NY&#44; EUA&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Extra&#231;&#227;o dos dados</span><p id="par0070" class="elsevierStylePara elsevierViewall">Foi constru&#237;da uma planilha com <span class="elsevierStyleItalic">software</span> Microsoft Excel vers&#227;o 2016 &#40;Microsoft&#44; Redmond&#8208;WA&#44; EUA&#41; com os seguintes elementos&#58; nome dos autores do estudo&#59; cidade e estado do estudo&#59; ano do estudo&#59; tipo de estudo&#59; n&#250;mero total de sujeitos do estudo&#59; medidas de risco ajustadas e intervalos de confian&#231;a dos fatores de exposi&#231;&#227;o inclu&#237;dos&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Fatores de exposi&#231;&#227;o e desfecho</span><p id="par0075" class="elsevierStylePara elsevierViewall">Os fatores de exposi&#231;&#227;o analisados foram&#58; &#8220;escolaridade materna&#8221;&#44; &#8220;situa&#231;&#227;o conjugal da m&#227;e&#8221;&#44; &#8220;idade materna &#40;anos&#41;&#8221;&#44; &#8220;sexo do rec&#233;m&#8208;nascido&#8221;&#44; &#8220;natimorto pr&#233;vio&#8221;&#44; &#8220;tipo de gesta&#231;&#227;o&#8221;&#44; &#8220;adequa&#231;&#227;o ao pr&#233;&#8208;natal&#8221;&#44; &#8220;intercorr&#234;ncias durante a gesta&#231;&#227;o&#8221;&#44; &#8220;peso ao nascer&#8221;&#44; &#8220;malforma&#231;&#227;o cong&#234;nita&#8221;&#44; &#8220;Apgar no quinto minuto&#8221;&#44; &#8220;idade gestacional &#40;semanas&#41;&#8221; e &#8220;tipo de parto&#8221;&#46; O desfecho foi a mortalidade neonatal&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Risco de vi&#233;s em estudos individuais</span><p id="par0080" class="elsevierStylePara elsevierViewall">O risco de vi&#233;s foi baseado na Escala de Newcastle&#8208;Ottawa &#40;NOS&#41;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">10</span></a> para avalia&#231;&#227;o da qualidade de estudos n&#227;o randomizados em metan&#225;lise&#46; A NOS avalia o vi&#233;s em tr&#234;s aspectos&#58; a sele&#231;&#227;o dos grupos do estudo&#59; a comparabilidade dos grupos&#59; a apura&#231;&#227;o da exposi&#231;&#227;o para estudos caso&#8208;controle ou desfecho de interesse para estudos coorte&#46; Para o primeiro aspecto&#44; d&#225;&#8208;se o m&#225;ximo de quatro estrelas&#59; para o segundo&#44; duas&#59; e&#44; por fim&#44; para o terceiro&#44; tr&#234;s&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">An&#225;lise de dados</span><p id="par0085" class="elsevierStylePara elsevierViewall">Baseou&#8208;se no estudo quantitativo das vari&#225;veis&#46; Usou&#8208;se&#44; para essa investiga&#231;&#227;o&#44; o <span class="elsevierStyleItalic">software</span> Stata 12 &#40;StataCorp&#44; College Station&#8208;TX&#44; EUA&#41;&#46; Os dados analisados foram as medidas de risco ajustadas em cada fator de exposi&#231;&#227;o analisado&#44; al&#233;m dos seus intervalos de confian&#231;a&#46; Foram usados os logaritmos naturais das medidas de risco e de seus intervalos de confian&#231;a&#44; o m&#233;todo de DerSimonian e Laird como modelo de efeitos aleat&#243;rios e o modelo de Mantel&#8208;Haenszel para estimativa da heterogeneidade&#46; Considerou&#8208;se n&#237;vel de confian&#231;a de 95&#37;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">A heterogeneidade foi considerada importante quando o I<span class="elsevierStyleSup">2</span> foi maior do que 50&#37;&#46; Se necess&#225;rio&#44; a an&#225;lise de sensibilidade foi feita com a remo&#231;&#227;o dos estudos um a um para investigar a origem da diverg&#234;ncia&#46; A avalia&#231;&#227;o do vi&#233;s de publica&#231;&#227;o foi feita com um gr&#225;fico de dispers&#227;o em funil&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Resultados</span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Sele&#231;&#227;o dos estudos</span><p id="par0095" class="elsevierStylePara elsevierViewall">A busca nas bases de dados identificou 10&#46;274 artigos&#46; Desses&#44; 61 eram duplicatas&#44; o que resultou em 10&#46;203 artigos&#46; Ap&#243;s a leitura de todos os t&#237;tulos&#44; restaram 98 artigos a serem analisados na fase de resumos&#46; No fim dessa etapa&#44; foram selecionados 17 artigos&#44; dos quais dez foram inclu&#237;dos no estudo<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;6&#44;11&#8211;18</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; As caracter&#237;sticas gerais dos dez estudos inclu&#237;dos na an&#225;lise est&#227;o na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> e as caracter&#237;sticas pertinentes &#224; an&#225;lise quantitativa est&#227;o na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Avalia&#231;&#227;o do risco de vi&#233;s dos estudos inclu&#237;dos</span><p id="par0100" class="elsevierStylePara elsevierViewall">Os dez estudos inclu&#237;dos na presente an&#225;lise foram avaliados de forma qualitativa por meio da Escala de Newcastle&#8208;Ottawa&#46; Quatro estudos<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;13&#44;16&#44;17</span></a> obtiveram classifica&#231;&#227;o alta&#44; ou seja&#44; s&#227;o estudos de baixo risco de vi&#233;s&#46; Por outro lado&#44; seis estudos<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">6&#44;11&#44;12&#44;14&#44;15&#44;18</span></a> obtiveram classifica&#231;&#227;o intermedi&#225;ria&#8208;alta&#44; compuseram&#44; assim&#44; um risco intermedi&#225;rio&#8208;baixo &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">An&#225;lise dos dados dos estudos inclu&#237;dos</span><p id="par0105" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> ilustra a rela&#231;&#227;o geral entre os fatores analisados e associa&#231;&#227;o com a mortalidade neonatal&#44; representada&#44; na imagem&#44; pelas raz&#245;es de chance ajustadas finais &#40;RCaf&#41; e seus respectivos intervalos de confian&#231;a&#46; Abaixo&#44; segue o resultado de cada fator de exposi&#231;&#227;o separadamente&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Escolaridade materna</span><p id="par0110" class="elsevierStylePara elsevierViewall">Apenas foi poss&#237;vel analisar a escolaridade materna de duas formas&#58; ensino fundamental completo &#40;oito a 11 anos de ensino&#41; e ensino fundamental incompleto &#40;quatro a sete anos de ensino&#41;&#46; O ensino fundamental completo n&#227;o apresentou associa&#231;&#227;o significativa com a mortalidade neonatal &#40;RCaf &#61; 1&#44;853&#59; IC95&#37;&#58; &#91;0&#44;417 &#8211; 8&#44;241&#93;&#59; p &#61; 0&#44;418&#59; I<span class="elsevierStyleSup">2</span> &#61; 87&#44;4&#37;&#59; p &#61; 0&#44;005&#41;&#46; O mesmo foi visto com o ensino fundamental incompleto &#40;RCaf &#61; 1&#44;727&#59; IC95&#37;&#58; &#91;0&#44;466 &#8211; 6&#44;400&#93;&#59; p &#61; 0&#44;414&#59; I<span class="elsevierStyleSup">2</span> &#61; 84&#44;8&#37;&#59; p &#61; 0&#44;010&#41;&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Situa&#231;&#227;o conjugal da m&#227;e</span><p id="par0115" class="elsevierStylePara elsevierViewall">A gesta&#231;&#227;o de m&#227;es que n&#227;o tinham companheiro apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 2&#44;236&#59; IC95&#37;&#58; &#91;1&#44;630 &#8211; 3&#44;068&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;344&#41;&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Idade materna</span><p id="par0120" class="elsevierStylePara elsevierViewall">A gesta&#231;&#227;o de m&#227;es com idade igual ou superior a 35 anos apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 1&#44;568&#59; IC95&#37;&#58; &#91;1&#44;141&#8211;2&#44;154&#93;&#59; p &#61; 0&#44;006&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;882&#41;&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Sexo do rec&#233;m&#8208;nascido</span><p id="par0125" class="elsevierStylePara elsevierViewall">Rec&#233;m&#8208;nascidos do sexo masculino apresentaram chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 1&#44;591&#59; IC95&#37;&#58; &#91;1&#44;193&#8211;2&#44;121&#93;&#59; p &#61; 0&#44;002&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;362&#41;&#46;</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Natimorto pr&#233;vio</span><p id="par0130" class="elsevierStylePara elsevierViewall">A gesta&#231;&#227;o de m&#227;es que tiverem natimorto pr&#233;vio n&#227;o apresentou associa&#231;&#227;o significativa com a mortalidade neonatal &#40;RCaf &#61; 2&#44;090&#59; IC95&#37;&#58; &#91;0&#44;762&#8211;5&#44;733&#93;&#59; p &#61; 0&#44;152&#59; I<span class="elsevierStyleSup">2</span> &#61; 90&#44;6&#37;&#59; p &#61; 0&#44;001&#41;&#46;</p></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Tipo de gesta&#231;&#227;o</span><p id="par0135" class="elsevierStylePara elsevierViewall">A gesta&#231;&#227;o m&#250;ltipla apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 3&#44;361&#59; IC95&#37;&#58; &#91;1&#44;612&#8211;7&#44;009&#93;&#59; p &#61; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 48&#44;7&#37;&#59; p &#61; 0&#44;163&#41;&#46;</p></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Adequa&#231;&#227;o ao pr&#233;&#8208;natal</span><p id="par0140" class="elsevierStylePara elsevierViewall">Apenas foi poss&#237;vel analisar a inadequa&#231;&#227;o e a aus&#234;ncia de pr&#233;&#8208;natal&#46; O pr&#233;&#8208;natal inadequado apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 2&#44;182&#59; IC95&#37;&#58; &#91;1&#44;761&#8211;2&#44;703&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;771&#41;&#46; O mesmo foi visto com a aus&#234;ncia de pr&#233;&#8208;natal &#40;RCaf &#61; 6&#44;799&#59; IC95&#37;&#58; &#91;1&#44;534&#8211;30&#44;147&#93;&#59; p &#61; 0&#44;012&#59; I<span class="elsevierStyleSup">2</span> &#61; 78&#44;8&#37;&#59; p &#61; 0&#44;030&#41;&#46;</p></span><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">Intercorr&#234;ncias durante a gesta&#231;&#227;o</span><p id="par0145" class="elsevierStylePara elsevierViewall">A presen&#231;a de intercorr&#234;ncias durante a gesta&#231;&#227;o apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 6&#44;961&#59; IC95&#37;&#58; &#91;4&#44;979&#8211;9&#44;733&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;381&#41;&#46;</p></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0175">Peso ao nascer</span><p id="par0150" class="elsevierStylePara elsevierViewall">Apenas foi poss&#237;vel analisar o peso ao nascer entre 1&#46;500&#8211;2&#46;499 gramas &#40;RCaf &#61; 4&#44;044&#59; IC95&#37;&#58; &#91;2&#44;260&#8211;7&#44;238&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 77&#44;0&#37;&#59; p &#61; 0&#44;013&#41;&#44; menor do que 1&#46;500 gramas &#40;RCaf &#61; 19&#44;752&#59; IC95&#37;&#58; &#91;5&#44;556&#8211;70&#44;223&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 90&#44;7&#37;&#59; p &#60; 0&#44;001&#41; e menor do que 2&#46;500 gramas &#40;RCaf &#61; 9&#44;876&#59; IC95&#37;&#58; &#91;4&#44;920&#8211;19&#44;826&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 69&#44;4&#37;&#59; p &#61; 0&#44;003&#41;&#46; Ap&#243;s an&#225;lise de sensibilidade&#44; o peso ao nascer entre 1&#46;500&#8211;2&#46;499 gramas &#40;RCaf &#61; 5&#44;424&#59; IC95&#37;&#58; &#91;4&#44;128&#8211;7&#44;126&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;902&#41;&#44; menor do que 1&#46;500 gramas &#40;RCaf &#61; 39&#44;995&#59; IC95&#37;&#58; &#91;29&#44;026&#8211;55&#44;109&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;633&#41; e menor do que 2&#46;500 gramas &#40;RCaf &#61; 15&#44;519&#59; IC95&#37;&#58; &#91;9&#44;997&#8211;24&#44;092&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;684&#41; continuaram a apresentar uma chance significativamente maior de mortalidade neonatal ap&#243;s remo&#231;&#227;o de um estudo na primeira e segunda situa&#231;&#227;o apresentada<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">17</span></a> e de outros dois na terceira&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">6&#44;12</span></a></p></span><span id="sec0120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0180">Malforma&#231;&#227;o cong&#234;nita</span><p id="par0155" class="elsevierStylePara elsevierViewall">Rec&#233;m&#8208;nascidos que tinham malforma&#231;&#227;o cong&#234;nita apresentam chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 14&#44;025&#59; IC95&#37;&#58; &#91;10&#44;849&#8211;18&#44;132&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;402&#41;&#46;</p></span><span id="sec0125" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0185">Apgar no quinto minuto</span><p id="par0160" class="elsevierStylePara elsevierViewall">A presen&#231;a de Apgar menor do que sete no quinto minuto apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 12&#44;397&#59; IC95&#37;&#58; &#91;9&#44;545&#8211;16&#44;102&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;417&#41;&#46;</p></span><span id="sec0130" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0190">Idade gestacional</span><p id="par0165" class="elsevierStylePara elsevierViewall">A idade gestacional menor do que 37 semanas apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 5&#44;738&#59; IC95&#37;&#58; &#91;2&#44;589&#8211;12&#44;716&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 86&#44;9&#37;&#59; p &#60; 0&#44;001&#41;&#46; Ap&#243;s an&#225;lise de sensibilidade&#44; continuou a apresentar uma chance significativamente maior de mortalidade neonatal depois da remo&#231;&#227;o de tr&#234;s estudos<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">11&#44;13&#44;18</span></a> &#40;RCaf &#61; 7&#44;130&#59; IC95&#37;&#58; &#91;4&#44;329&#8211;11&#44;742&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;706&#41;&#46;</p></span><span id="sec0135" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0195">Tipo de parto</span><p id="par0170" class="elsevierStylePara elsevierViewall">O parto cesariano n&#227;o apresentou associa&#231;&#227;o significativa com a mortalidade neonatal &#40;RCaf &#61; 1&#44;233&#59; IC95&#37;&#58; &#91;0&#44;688&#8211;2&#44;210&#93;&#59; p &#61; 0&#44;483&#59; I<span class="elsevierStyleSup">2</span> &#61; 89&#44;7&#37;&#59; p &#60; 0&#44;001&#41;&#46; Ao explorar a heterogeneidade&#44; passou a apresentar uma chance significativamente maior de mortalidade neonatal ap&#243;s remo&#231;&#227;o de um estudo<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">17</span></a> &#40;RCaf &#61; 1&#44;551&#59; IC95&#37;&#58; &#91;1&#44;202&#8211;2&#44;000&#93;&#59; p &#61; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;480&#41;&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">N&#227;o foi poss&#237;vel fazer an&#225;lise de sensibilidade nos fatores ensino fundamental completo&#44; ensino fundamental incompleto&#44; presen&#231;a de natimorto pr&#233;vio e aus&#234;ncia de pr&#233;&#8208;natal&#44; pois foram an&#225;lises compostas por apenas dois estudos&#46; A <a class="elsevierStyleCrossRef" href="#fig0015">figura 3</a> ilustra a rela&#231;&#227;o geral final ap&#243;s an&#225;lise da sensibilidade&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0180" class="elsevierStylePara elsevierViewall">Em rela&#231;&#227;o ao vi&#233;s de publica&#231;&#227;o&#44; n&#227;o foi poss&#237;vel avali&#225;&#8208;lo devido ao n&#250;mero de estudos inclu&#237;dos em cada an&#225;lise&#46; A <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a> demonstra uma tabela&#8208;resumo final dos resultados obtidos na an&#225;lise quantitativa&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span></span></span><span id="sec0140" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0200">Discuss&#227;o</span><p id="par0185" class="elsevierStylePara elsevierViewall">O estudo mostrou que fatores ligados &#224; m&#227;e &#40;aus&#234;ncia de companheiro&#44; idade &#8805; 35 anos&#44; gesta&#231;&#227;o m&#250;ltipla&#44; aus&#234;ncia ou inadequa&#231;&#227;o do pr&#233;&#8208;natal&#44; presen&#231;a de intercorr&#234;ncias durante a gesta&#231;&#227;o e parto cesariano&#41; e ligados ao rec&#233;m&#8208;nascido &#40;sexo masculino&#44; malforma&#231;&#227;o cong&#234;nita&#44; asfixia perinatal&#44; baixo peso ao nascer e prematuridade&#41; s&#227;o riscos &#224; mortalidade neonatal no Brasil&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">O principal fator a ser considerado nesse contexto &#233; o baixo peso ao nascer e&#44; mais precisamente&#44; o muito baixo peso ao nascer&#46; Em um estudo coorte prospectivo&#44; no qual foi analisada a mortalidade neonatal em rec&#233;m&#8208;nascidos prematuros de muito baixo peso na Regi&#227;o Nordeste do Brasil&#44; observou&#8208;se que 76&#37; morreram nas primeiras 24 horas de vida&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">19</span></a> Tal fato se repete em outra coorte prospectiva feita no Brasil a partir da an&#225;lise de nascimentos em 20 centros p&#250;blicos universit&#225;rios&#44; que resultou numa taxa de morte de 30&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">20</span></a> mostrou&#44; dessa forma&#44; que o baixo peso ao nascer &#233; um fator determinante na ocorr&#234;ncia da mortalidade neonatal no Brasil&#44; &#233; seu principal preditor isolado&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;6&#44;11&#8211;19&#44;21&#8211;23</span></a> Esse fator &#233; considerado um dos principais fatores de risco para a mortalidade neonatal em diversos locais e servi&#231;os&#44; a exemplo dos estudos ocorridos na M&#233;xico&#44;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">24</span></a> Jord&#226;nia&#44;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">25</span></a> Trinidad &#38; Tobago&#44;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">26</span></a> Estados Unidos<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">27</span></a> e China&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">28</span></a></p><p id="par0195" class="elsevierStylePara elsevierViewall">Assim como o baixo peso ao nascer&#44; outros fatores s&#227;o modific&#225;veis&#44; a exemplo da asfixia perinatal&#44; prematuridade&#44; intercorr&#234;ncias durante a gesta&#231;&#227;o&#44; feitura de pr&#233;&#8208;natal&#44; parto cesariano&#44; idade materna avan&#231;ada e aus&#234;ncia de companheiro no lar&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;6&#44;11&#44;14&#44;17&#44;19&#44;21&#44;22&#44;29&#8211;33</span></a> Destaca&#8208;se&#44; nesse contexto&#44; o pr&#233;&#8208;natal&#44; o qual&#44; se feito de forma adequada&#44; contribui para a redu&#231;&#227;o dos demais fatores modific&#225;veis&#44; principalmente da prematuridade e do baixo peso ao nascer&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;6&#44;11&#44;14&#44;16&#8211;18</span></a> Essa import&#226;ncia pode ser vista em um estudo transversal feito em um munic&#237;pio da Regi&#227;o Sudeste do Brasil&#44; o qual mostrou que 26&#44;8&#37; das mortes poderiam ter sido evitadas caso fosse feito um pr&#233;&#8208;natal adequado&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">34</span></a> Exemplo semelhante pode ser encontrado em outro estudo transversal feito em v&#225;rios munic&#237;pios de um estado do Sudeste brasileiro&#44; o qual evidenciou que 47&#37; das mortes poderiam ter sido evitadas por a&#231;&#245;es de preven&#231;&#227;o&#44; diagn&#243;stico e tratamento precoces&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">35</span></a> Tais taxas sinalizam problemas na assist&#234;ncia &#224; gestante&#44; em decorr&#234;ncia da falta de capacita&#231;&#227;o do profissional ou de uma estrutura deficiente&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">21&#44;32&#44;33&#44;36&#8211;39</span></a></p><p id="par0200" class="elsevierStylePara elsevierViewall">A exemplo do pr&#233;&#8208;natal&#44; o parto cesariano&#44; se indicado corretamente&#44; reduz a ocorr&#234;ncia da prematuridade&#44; do baixo peso ao nascer e da asfixia perinatal&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;6&#44;7&#44;11&#8211;18</span></a> Um dos grandes problemas s&#227;o as indica&#231;&#245;es incorretas e o n&#250;mero excessivo desse tipo de parto&#46; A taxa no Brasil &#233; de 56&#37;&#44; n&#250;mero bem superior &#224; recomendada&#44; que &#233; de 15&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">40</span></a> Em um estudo observacional multic&#234;ntrico de base hospitalar feito na Regi&#227;o Nordeste do Brasil&#44; observou&#8208;se que 13&#44;7&#37; das mortes neonatais estavam relacionadas ao parto cesariano em Unidades Neonatais de Alto Risco&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">41</span></a></p><p id="par0205" class="elsevierStylePara elsevierViewall">A malforma&#231;&#227;o cong&#234;nita&#44; a gesta&#231;&#227;o m&#250;ltipla e o sexo masculino do rec&#233;m&#8208;nascido mostraram&#8208;se&#44; no nosso estudo&#44; determinantes &#224; mortalidade neonatal no Brasil&#44; entretanto n&#227;o constituem fatores modific&#225;veis&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;6&#44;7&#44;11&#8211;18&#44;32</span></a> Desses&#44; a malforma&#231;&#227;o cong&#234;nita &#233; o fator mais importante&#44; constitui&#8208;se o segundo mais decisivo &#224; mortalidade neonatal no Brasil&#46; Um estudo observacional transversal feito em v&#225;rios munic&#237;pios de um estado do Sudeste brasileiro mostrou que 42&#44;8&#37; das mortes infantis foram causadas por tal fator&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">35</span></a> A mesma tend&#234;ncia pode ser vista em uma coorte prospectiva feita em uma cidade do M&#233;xico&#44; a qual resultou em uma mortalidade neonatal de 32&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">24</span></a></p><p id="par0210" class="elsevierStylePara elsevierViewall">O conhecimento dos fatores de risco &#233; imprescind&#237;vel para a preven&#231;&#227;o da mortalidade neonatal no Brasil&#44; visto que os profissionais de sa&#250;de e gestores&#44; quando a par dessas condi&#231;&#245;es&#44; podem encontrar meios de evitar complica&#231;&#245;es cl&#237;nicas e estruturais&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">21&#44;32&#44;33&#44;36&#8211;39</span></a> Assim&#44; a preven&#231;&#227;o consiste em capacitar profissionais e prover estrutura adequada para o nascimento&#44; oferece&#44; tamb&#233;m&#44; uma aten&#231;&#227;o individualizada &#224;s gesta&#231;&#245;es&#44; atenta&#8208;se para a especificidade de cada condi&#231;&#227;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">32&#44;33&#44;38&#44;39</span></a> Essa individualiza&#231;&#227;o j&#225; &#233; uma tend&#234;ncia mundial desde 2015&#44;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">42</span></a> a qual permitiu uma redu&#231;&#227;o de 5&#44;4&#37; das mortes neonatais mundiais entre 2015&#8208;2017&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">43</span></a></p><p id="par0215" class="elsevierStylePara elsevierViewall">O presente estudo foi composto por seis artigos de baixo risco de vi&#233;s e quatro de intermedi&#225;rio&#8208;baixo&#44; aumentou&#8208;se&#44; assim&#44; o grau de confiabilidade desse trabalho&#46; O motivo da classifica&#231;&#227;o intermedi&#225;ria reside no fato da n&#227;o aleatoriza&#231;&#227;o dos entrevistadores em tr&#234;s estudos&#44; al&#233;m da n&#227;o igualdade entre as perdas dos grupos caso e controle em outro estudo&#46; O primeiro pode ser solucionado se for feita a aleatoriza&#231;&#227;o e garantida a coleta cega dos dados&#44; enquanto a igualdade de perdas entre os grupos solucionaria o segundo impasse&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Os estudos coorte conseguiram representar a popula&#231;&#227;o de forma igualit&#225;ria&#44; al&#233;m de parear de forma equivalente com o grupo controle&#46; Um dos estudos<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">3</span></a> usou uma entrevista estruturada&#44; diferiu dos outros tr&#234;s&#44;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">13&#44;16&#44;17</span></a> que usaram dados de bases oficiais&#46; Em rela&#231;&#227;o &#224; avalia&#231;&#227;o final&#44; todos usaram a an&#225;lise por pareamento &#40;<span class="elsevierStyleItalic">linkage</span>&#41; com bases de dados oficiais&#44; al&#233;m de tra&#231;ar um tempo de seguimento suficiente para a an&#225;lise&#46; Durante o seguimento&#44; um dos estudos<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">17</span></a> obteve uma perda de menos de 10&#37; dos sujeitos&#44; diferiu dos outros&#44; os quais n&#227;o apresentaram perda&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">Os estudos caso&#8208;controle&#44; por sua vez&#44; usaram o recurso de pareamento &#40;<span class="elsevierStyleItalic">linkage</span>&#41; de base de dados oficiais para adequar e representar os casos&#44; bem como selecionar e definir os controles&#46; Na avalia&#231;&#227;o final&#44; tr&#234;s estudos<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">14&#44;15&#44;18</span></a> usaram a an&#225;lise por pareamento &#40;<span class="elsevierStyleItalic">linkage</span>&#41; com dados de bases oficiais&#44; enquanto os outros tr&#234;s<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">6&#44;11&#44;12</span></a> fizeram entrevistas sem cegamento&#46; Um dos estudos<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">14</span></a> obteve uma perda desigual entre os grupos caso e controle&#44; por&#233;m&#44; por ter sido menos do que 10&#37;&#44; o efeito final n&#227;o foi prejudicado&#46; Contudo&#44; apesar desse efeito estat&#237;stico&#44; a Escala de Newcastle&#8208;Ottawa n&#227;o pontua tal fato nos estudos caso&#8208;controle&#46; Em rela&#231;&#227;o aos demais estudos&#44; as taxas foram iguais em ambos os grupos&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">O resultado geral deste estudo mostra a import&#226;ncia desses fatores de risco para a mortalidade neonatal do Brasil&#44; destaca&#8208;se&#44; neste contexto&#44; o poder que as mudan&#231;as estruturais&#44; comportamentais e m&#233;dicas det&#234;m na diminui&#231;&#227;o dessas taxas&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">Os fatores de risco mais significativos apresentados neste estudo s&#227;o modific&#225;veis&#44; o que possibilita almejar uma redu&#231;&#227;o real das mortes neonatais&#44; que ainda permanecem elevadas no pa&#237;s&#46;</p></span><span id="sec0145" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0205">Financiamento</span><p id="par0240" class="elsevierStylePara elsevierViewall">Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#91;n&#176; 129015&#47;2017&#8208;2&#93;&#46;</p></span><span id="sec0150" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0210">Conflitos de interesse</span><p id="par0245" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflitos de interesse&#46;</p></span></span>"
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    "fechaRecibido" => "2018-10-19"
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          "clase" => "keyword"
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            0 => "Neonatal mortality"
            1 => "Risk factors"
            2 => "Brazil"
            3 => "Review systematic"
            4 => "Meta&#8208;analysis"
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            0 => "Mortalidade neonatal"
            1 => "Fatores de risco"
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    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To identify&#44; using a systematic review and meta&#8208;analysis of observational studies&#44; which risk factors are significantly associated with neonatal mortality in Brazil&#44; and to build a comprehensive national analysis on neonatal mortality&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Sources</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This review included observational studies on neonatal mortality&#44; performed between 2000 and 2018 in Brazilian cities&#46; The MEDLINE&#44; Elsevier&#44; Cochrane&#44; LILACS&#44; SciELO&#44; and OpenGrey databases were used&#46; For the qualitative analysis&#44; the Newcastle&#8208;Ottawa Scale was used&#46; For the quantitative analysis&#44; the natural logarithms of the risk measures and their confidence intervals were used&#44; as well as the DerSimonian and Laird method as a random effects model&#44; and the Mantel&#8211;Haenszel model for heterogeneity estimation&#46; A confidence level of 95&#37; was considered&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Summary of findings</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The qualitative analysis resulted in six studies of low and four studies of intermediate&#8208;low bias risk&#46; The following exposure factors were significant&#58; absence of partner&#44; maternal age &#8805;35 years&#44; male gender&#44; multiple gestation&#44; inadequate and absent prenatal care&#44; presence of complications during pregnancy&#44; congenital malformation in the assessed pregnancy&#44; Apgar<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>7 at the fifth minute&#44; low and very low birth weight&#44; gestational age<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>37 weeks&#44; and caesarean delivery&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The most significant risk factors presented in this study are modifiable&#44; allowing aiming at a real reduction in neonatal deaths&#44; which remain high in the country&#46;</p></span>"
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      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Identificar&#44; atrav&#233;s de uma revis&#227;o sistem&#225;tica e da metan&#225;lise de estudos observacionais&#44; quais fatores de risco associam&#8208;se significativamente com a mortalidade neonatal no Brasil e construir uma an&#225;lise nacional abrangente sobre a mortalidade neonatal&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Fontes</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Foram avaliados os estudos observacionais sobre mortalidade neonatal realizados entre 2000 e 2018 em cidades brasileiras&#46; Usaram&#8208;se as bases MEDLINE&#44; Elsevier&#44; Cochrane&#44; LILACS&#44; SciELO e OpenGrey&#46; Para a an&#225;lise qualitativa&#44; foi usada a Escala Newcastle&#8208;Ottawa&#46; Para a an&#225;lise quantitativa&#44; foram utilizados os logaritmos naturais das medidas de risco e de seus intervalos de confian&#231;a&#44; o m&#233;todo de DerSimonian e Laird como modelo de efeitos aleat&#243;rios e o modelo de Mantel&#8208;Haenszel para estimativa da heterogeneidade&#46; Considerou&#8208;se n&#237;vel de confian&#231;a de 95&#37;&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resumo dos achados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A an&#225;lise qualitativa resultou em seis estudos de baixo e quatro estudos de intermedi&#225;rio&#8208;baixo risco de vi&#233;s&#46; Foram significativos os seguintes fatores de exposi&#231;&#227;o&#58; aus&#234;ncia de companheiro&#44; idade materna &#8805; 35 anos&#44; sexo masculino&#44; gesta&#231;&#227;o m&#250;ltipla&#44; pr&#233;&#8208;natal inadequado e ausente&#44; presen&#231;a de intercorr&#234;ncias durante a gesta&#231;&#227;o&#44; de malforma&#231;&#227;o cong&#234;nita na gesta&#231;&#227;o em estudo&#44; Apgar &#60; 7 no quinto minuto&#44; baixo e muito baixo peso ao nascer&#44; idade gestacional &#8804; 37 semanas e parto cesariano&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Os fatores de risco mais significativos apresentados neste estudo s&#227;o modific&#225;veis&#44; o que possibilita almejar uma redu&#231;&#227;o real das mortes neonatais&#44; que ainda permanecem elevadas no pa&#237;s&#46;</p></span>"
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Como citar este artigo&#58; Veloso FC&#44; Kassar LM&#44; Oliveira MJ&#44; Lima TH&#44; Bueno NB&#44; Gurgel RQ&#44; et al&#46; Analysis of neonatal mortality risk factors in Brazil&#58; a systematic review and meta&#8208;analysis of observational studies&#46; J Pediatr &#40;Rio J&#41;&#46; 2019&#59;95&#58;519&#8211;30&#46;</p>"
      ]
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        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Estudo vinculado a Universidade Estadual de Ci&#234;ncias da Sa&#250;de de Alagoas&#44; Macei&#243;&#44; AL&#44; Brasil&#46;</p>"
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          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Fluxograma da sele&#231;&#227;o dos estudos&#46;</p>"
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          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Vis&#227;o geral dos fatores associados &#224; mortalidade neonatal&#46;</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">OR&#44; <span class="elsevierStyleItalic">odds ratio</span>&#59; CI&#44; intervalo de confian&#231;a&#46;</p>"
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          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Rela&#231;&#227;o final dos fatores associados &#224; mortalidade neonatal ap&#243;s a an&#225;lise de heterogeneidade&#46; OR&#44; <span class="elsevierStyleItalic">odds ratio</span>&#59; CI&#44; intervalo de confian&#231;a&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudos analisados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ano&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cidade&#47;Estado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tipo de estudo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#250;mero de sujeitos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vari&#225;veis Analisadas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lansky et al&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">3</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">V&#225;rias cidades das cinco macrorregi&#245;es brasileiras&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coorte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;329&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Escolaridade materna &#124; Situa&#231;&#227;o conjugal da m&#227;e &#124; Idade materna &#124; Sexo do rec&#233;m&#8208;nascido &#124; Natimorto pr&#233;vio &#124; Tipo de gesta&#231;&#227;o &#124; Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124; Intercorr&#234;ncias durante a gesta&#231;&#227;o &#124; Peso ao nascer &#124; Malforma&#231;&#227;o cong&#234;nita &#124; Apgar no quinto minuto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lima et al&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serra&#47;ES&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coorte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#46;275&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Escolaridade materna &#124; Idade materna &#124; Tipo de gesta&#231;&#227;o &#124; Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124;Peso ao nascer &#124; Tipo de parto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Zanini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 microrregi&#245;es&#47;RS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coorte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">138&#46;407&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Natimorto pr&#233;vio &#124; Peso ao nascer &#124; Malforma&#231;&#227;o cong&#234;nita &#124; Apgar no quinto minuto &#124; Idade gestacional &#124; Tipo de parto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Garcia et al&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">16</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Florian&#243;polis&#47;SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coorte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;879&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124; Peso ao nascer &#124; Malforma&#231;&#227;o cong&#234;nita &#124; Apgar no quinto minuto &#124; Tipo de parto &#124; Idade gestacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">V&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Almeida &#38; Barros<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Campinas&#47;SP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso&#8208;Controle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">351&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer &#124; Idade gestacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nascimento et al&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fortaleza&#47;CE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso&#8208;Controle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">396&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo do rec&#233;m&#8208;nascido &#124; Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124; Peso ao nascer &#124; Idade gestacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kassar et al&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Macei&#243;&#47;AL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso&#8208;Controle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">408&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124; Peso ao nascer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VIII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Schoeps et al&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#227;o Paulo&#47;SP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso&#8208;Controle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">459&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Situa&#231;&#227;o conjugal da m&#227;e &#124; Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124; Intercorr&#234;ncias durante a gesta&#231;&#227;o &#124; Peso ao nascer &#124; Idade gestacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IX&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Paulucci &#38; Nascimento<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Taubat&#233;&#47;SP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso&#8208;Controle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">392&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer &#124; Malforma&#231;&#227;o cong&#234;nita&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">X&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mendes et al&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">18</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caxias do Sul&#47;RS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso&#8208;Controle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">354&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124; Peso ao nascer &#124; Tipo de parto &#124; Idade gestacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas gerais dos estudos inclu&#237;dos</p>"
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      ]
      4 => array:8 [
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        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
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          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
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        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vari&#225;veis analisadas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fatores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudos analisados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR ajustada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">IC &#40;95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Escolaridade materna&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensino fundamental completo &#40;8 a 11 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;240&#44;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;61 &#8211; 11&#44;16&#93;&#91;0&#44;59 &#8211; 1&#44;41&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensino fundamental incompleto &#40;4 a 7 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;600&#44;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;43 &#8211; 9&#44;07&#93;&#91;0&#44;60 &#8211; 1&#44;47&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Situa&#231;&#227;o conjugal da m&#227;e&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#227;e sem companheiro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;491&#44;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;69 &#8211; 3&#44;66&#93;&#91;1&#44;00 &#8211; 3&#44;00&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade materna&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade materna maior ou igual a 35 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;621&#44;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;95 &#8208;2&#44;78&#93;&#91;1&#44;04 &#8211; 2&#44;29&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo do rec&#233;m&#8208;nascido&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;492&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;08 &#8211; 2&#44;05&#93;&#91;1&#44;09 &#8211; 4&#44;03&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Natimorto pr&#233;vio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de natimorto pr&#233;vio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;621&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;2&#44;05 &#8211; 6&#44;41&#93;&#91;1&#44;01 &#8211; 1&#44;65&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tipo de gesta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gesta&#231;&#227;o m&#250;ltipla&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;792&#44;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;2&#44;37 &#8211; 9&#44;68&#93;&#91;1&#44;03 &#8211; 4&#44;96&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adequa&#231;&#227;o ao pr&#233;&#8208;natal</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pr&#233;&#8208;natal inadequado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;11&#41;&#40;6&#41;&#40;14&#41;&#40;16&#41;&#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;842&#44;032&#44;492&#44;003&#44;041&#44;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;44 &#8211; 5&#44;62&#93;&#91;1&#44;03 &#8211; 3&#44;99&#93;&#91;1&#44;14 &#8211; 5&#44;40&#93;&#91;2&#44;00 &#8211; 3&#44;50&#93;&#91;1&#44;61 &#8211; 5&#44;97&#93;&#91;0&#44;44 &#8211; 4&#44;77&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aus&#234;ncia de pr&#233;&#8208;natal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;14&#41;&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;103&#44;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;4&#44;70 &#8211; 55&#44;40&#93;&#91;1&#44;86 &#8211; 6&#44;49&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intercorr&#234;ncias durante a gesta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de intercorr&#234;ncias durante a gesta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;078&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;3&#44;85 &#8211; 9&#44;55&#93;&#91;5&#44;00 &#8211; 13&#44;50&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer entre 1&#46;500 a 2&#46;499 gramas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;17&#41;&#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;192&#44;365&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;2&#44;44 &#8211; 11&#44;04&#93;&#91;1&#44;46 &#8211; 3&#44;83&#93;&#91;4&#44;07 &#8211; 7&#44;31&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer menor do que 1&#46;500 gramas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;17&#41;&#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;275&#44;4941&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;12&#44;65 &#8211; 82&#44;35&#93;&#91;2&#44;52 &#8211; 11&#44;96&#93;&#91;29&#44;25 &#8211; 57&#44;87&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer menor do que 2&#46;500 gramas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;12&#41;&#40;11&#41;&#40;6&#41;&#40;14&#41;&#40;15&#41;&#40;16&#41;&#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;8414&#44;752&#44;5717&#44;3022&#44;809&#44;4634&#44;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;18 &#8211; 12&#44;50&#93;&#91;5&#44;26 &#8211; 41&#44;35&#93;&#91;1&#44;16 &#8211; 5&#44;72&#93;&#91;8&#44;40 &#8211; 35&#44;60&#93;&#91;7&#44;52 &#8211; 69&#44;12&#93;&#91;4&#44;06 &#8211; 23&#44;60&#93;&#91;3&#44;84 &#8211; 311&#44;50&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Malforma&#231;&#227;o cong&#234;nita&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de malforma&#231;&#227;o cong&#234;nita&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;13&#41;&#40;15&#41;&#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;5514&#44;7912&#44;916&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;6&#44;47 &#8211; 42&#44;38&#93;&#91;11&#44;18 &#8211; 19&#44;59&#93;&#91;2&#44;13 &#8211; 78&#44;38&#93;&#91;2&#44;14 &#8208; 15&#44;67&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apgar no quinto minuto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de Apgar menor do que 7 no quinto minuto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;13&#41;&#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;7911&#44;3919&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;6&#44;54 &#8211; 38&#44;14&#93;&#91;8&#44;51 &#8208; 15&#44;25&#93;&#91;8&#44;78 &#8211; 42&#44;92&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade gestacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade gestacional menor do que 37 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;12&#41;&#40;11&#41;&#40;14&#41;&#40;13&#41;&#40;16&#41;&#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;373&#44;418&#44;801&#44;846&#44;0943&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;83 &#8208; 17&#44;98&#93;&#91;1&#44;09 &#8211; 4&#44;03&#93;&#91;4&#44;30 &#8208; 17&#44;80&#93;&#91;1&#44;42 &#8211; 2&#44;39&#93;&#91;2&#44;58 &#8208; 15&#44;23&#93;&#91;10&#44;26 &#8211; 83&#44;97&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tipo de parto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parto cesariano&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;17&#41;&#40;13&#41;&#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;520&#44;802&#44;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;17 &#8211; 1&#44;97&#93;&#91;0&#44;68 &#8211; 0&#44;93&#93;&#91;0&#44;70 &#8208; 7&#44;61&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2139623.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas dos estudos inclu&#237;dos na an&#225;lise quantitativa</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:2 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Coorte</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudos analisados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sele&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparabilidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Desfecho&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Classifica&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alta Qualidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alta Qualidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alta Qualidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alta Qualidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2139624.png"
              ]
            ]
            1 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Caso&#8208;Controle</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudos analisados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sele&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparabilidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Exposi&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Classifica&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Qualidade Intermedi&#225;ria &#8211; Alta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Qualidade Intermedi&#225;ria &#8211; Alta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Qualidade Intermedi&#225;ria &#8211; Alta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Qualidade Intermedi&#225;ria &#8211; Alta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alta Qualidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alta Qualidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2139620.png"
              ]
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        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Avalia&#231;&#227;o do risco de vi&#233;s dos estudos inclu&#237;dos</p>"
        ]
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      6 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Tabela 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
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        "tabla" => array:2 [
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fatores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudos inclu&#237;dos na an&#225;lise&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#250;mero total de sujeitos analisados&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR ajustada final&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">IC &#40;95&#37;&#41; final&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">I<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensino fundamental completo &#40;8 a 11 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56604&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;853&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;417 &#8208; 8&#44;241&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;418&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensino fundamental incompleto &#40;4 a 7 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56604&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;727&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;466 &#8211; 6&#44;400&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&#44;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;414&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#227;e sem companheiro<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24788&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;236&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;630 &#8211; 3&#44;068&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;344&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade materna maior ou igual a 35 anos<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56604&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;568&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;141 &#8211; 2&#44;154&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;882&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo masculino<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24725&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">Presen&#231;a de natimorto pr&#233;vio&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gesta&#231;&#227;o m&#250;ltipla<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;3&#41; &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#91;1&#44;612 &#8211; 7&#44;009&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#44;7&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pr&#233;&#8208;natal inadequado<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;11&#41; &#40;6&#41; &#40;14&#41; &#40;16&#41; &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">&#91;1&#44;761 &#8211; 2&#44;703&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aus&#234;ncia de pr&#233;&#8208;natal<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;14&#41; &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de intercorr&#234;ncias durante a gesta&#231;&#227;o<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer entre 1&#46;500 a 2&#46;499 gramas<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;17&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">195011&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;4&#44;128 &#8211; 7&#44;126&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer menor do que 1&#46;500 gramas<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;17&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">195011&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#91;29&#44;026 &#8211; 55&#44;109&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer menor do que 2&#46;500 gramas<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;12&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;3&#41; &#40;6&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;14&#41; &#40;15&#41; &#40;16&#41; &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">18239&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#91;9&#44;997 &#8211; 24&#44;092&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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Artigo de revisão
Analysis of neonatal mortality risk factors in Brazil: a systematic review and meta‐analysis of observational studies
Análise dos fatores de risco na mortalidade neonatal no Brasil: uma revisão sistemática e metanálise de estudos observacionais
Felipe Camilo Santiago Velosoa, Liliana de Meira Lins Kassarb, Michelle Jacintha Cavalcante Oliveirab,c, Telmo Henrique Barbosa de Limaa,c, Nassib Bezerra Buenod, Ricardo Queiroz Gurgele, Samir Buainain Kassarc,
Autor para correspondência
samirbkr@uol.com.br

Autor para correspondência.
a Universidade Estadual de Ciências da Saúde de Alagoas (UNCISAL), Curso de Medicina, Maceió, AL, Brasil
b Universidade Federal de Alagoas (UFAL), Faculdade de Medicina, Maceió, AL, Brasil
c Centro Universitário Tiradentes, Curso de Medicina, Maceió, AL, Brasil
d Universidade Federal de Alagoas (UFAL), Faculdade de Nutrição, Maceió, AL, Brasil
e Universidade Federal de Sergipe (UFS), Faculdade de Medicina, Aracaju, SE, Brasil
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apesar dessa redu&#231;&#227;o&#44; ainda continua elevada e desigual regionalmente&#44; a diferen&#231;a entre o Norte&#47;Nordeste e o Sul&#47;Sudeste foi a mais discrepante&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A redu&#231;&#227;o dessa taxa &#233; um objetivo a ser perseguido e uma realidade que pode ser alcan&#231;ada&#44; uma vez que o principal motivo desse valor s&#227;o fatores evit&#225;veis&#44; como o baixo peso ao nascer&#44; a prematuridade&#44; a asfixia neonatal e os cuidados pr&#233;&#8208;natais de baixa qualidade&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">6&#8211;8</span></a> Um fator complementar&#44; por&#233;m&#44; de igual import&#226;ncia&#44; s&#227;o as causas maternas&#44; com uma contribui&#231;&#227;o expressiva na mortalidade neonatal nos pa&#237;ses em desenvolvimento&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">5&#44;8</span></a> No entanto&#44; ainda n&#227;o se tem uma avalia&#231;&#227;o sistem&#225;tica do conjunto desses fatores nos &#250;ltimos tempos no Brasil&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A revis&#227;o sistem&#225;tica com metan&#225;lise mostra&#8208;se&#44; assim&#44; uma possibilidade real para tra&#231;ar o impacto dos fatores de risco na mortalidade neonatal em territ&#243;rio brasileiro&#44; auxiliando na decis&#227;o cl&#237;nica e no entendimento epidemiol&#243;gico dos profissionais&#44; principalmente dos gestores da sa&#250;de p&#250;blica do Brasil&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">9</span></a> O estudo objetiva identificar&#44; atrav&#233;s de uma revis&#227;o sistem&#225;tica e metan&#225;lise de estudos observacionais&#44; quais fatores de risco associam&#8208;se significativamente com a mortalidade neonatal no Brasil e construir uma an&#225;lise nacional abrangente sobre o tema&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todo</span><p id="par0025" class="elsevierStylePara elsevierViewall">Um protocolo Prospero &#40;<a href="https://www.crd.york.ac.uk/prospero/">https&#58;&#47;&#47;www&#46;crd&#46;york&#46;ac&#46;uk&#47;prospero&#47;</a>&#41; foi publicado sob o n&#250;mero CRD42018108716&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">A sele&#231;&#227;o dos estudos&#44; a extra&#231;&#227;o de dados e a an&#225;lise do risco de vi&#233;s foram feitas por dois autores&#44; de forma independente&#46; As diverg&#234;ncias foram solucionadas a partir de um acordo entre as partes&#59; caso n&#227;o houvesse consenso&#44; um terceiro autor findaria o impasse&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Crit&#233;rios de elegibilidade</span><p id="par0040" class="elsevierStylePara elsevierViewall">Os crit&#233;rios de inclus&#227;o foram compostos pelos seguintes itens&#58; estudos observacionais sobre mortalidade neonatal&#59; estudos feitos entre 2000 e 2018&#59; estudos feitos em cidades brasileiras&#59; estudos que usaram medidas de risco ajustadas&#44; juntamente com seus intervalos de confian&#231;a&#59; estudos que empregaram um ou mais dos seguintes fatores de exposi&#231;&#227;o&#58; escolaridade materna e&#47;ou situa&#231;&#227;o conjugal da m&#227;e e&#47;ou idade materna &#40;anos&#41; e&#47;ou sexo do rec&#233;m&#8208;nascido e&#47;ou tipo de parto e&#47;ou natimorto pr&#233;vio e&#47;ou tipo de gesta&#231;&#227;o e&#47;ou adequa&#231;&#227;o do pr&#233;&#8208;natal e&#47;ou intercorr&#234;ncias maternas e&#47;ou peso ao nascer &#40;g&#41; e&#47;ou idade gestacional &#40;semanas&#41; e&#47;ou malforma&#231;&#227;o cong&#234;nita e&#47;ou Apgar no 5&#176; minuto de vida&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Base de dados</span><p id="par0045" class="elsevierStylePara elsevierViewall">As bases de dados principais deste estudo foram a Medline&#44; acessada via PubMed &#60;<a href="https://www.ncbi.nlm.nih.gov/pubmed/">https&#58;&#47;&#47;www&#46;ncbi&#46;nlm&#46;nih&#46;gov&#47;pubmed&#47;</a>&#62; e Bireme &#60;<a href="http://bvsalud.org/">http&#58;&#47;&#47;bvsalud&#46;org&#47;</a>&#62;&#46; A base de dados secund&#225;rias foi a Elsevier &#60;<a href="https://www.sciencedirect.com/">https&#58;&#47;&#47;www&#46;sciencedirect&#46;com&#47;</a>&#62;&#46; As bases de dados regionais foram a Lilacs &#60;<a href="http://bvsalud.org/">http&#58;&#47;&#47;bvsalud&#46;org&#47;</a>&#62; e a SciELO &#60;<a href="http://www.scielo.org/php/index.php">http&#58;&#47;&#47;www&#46;scielo&#46;org&#47;php&#47;index&#46;php</a>&#62;&#46; A base de dados de literatura cinzenta foi a Opengrey &#60;<a href="http://www.opengrey.eu/">http&#58;&#47;&#47;www&#46;opengrey&#46;eu&#47;</a>&#62;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Estrat&#233;gia de busca</span><p id="par0050" class="elsevierStylePara elsevierViewall">Foi definida a partir da estrat&#233;gia Pecos &#40;Pacientes &#124; Exposi&#231;&#227;o &#124; Compara&#231;&#227;o &#124; Desfecho &#124; Tipo de estudo&#41;&#46; Diante disso&#44; constru&#237;ram&#8208;se duas estrat&#233;gias&#8208;base&#44; uma no idioma ingl&#234;s&#44; com termos MeSH &#60;<a href="https://www.ncbi.nlm.nih.gov/mesh">https&#58;&#47;&#47;www&#46;ncbi&#46;nlm&#46;nih&#46;gov&#47;mesh</a>&#62;&#44; e outra no idioma portugu&#234;s&#44; com termos DeCS &#60;<a href="http://decs.bvs.br/">http&#58;&#47;&#47;decs&#46;bvs&#46;br&#47;</a>&#62;&#46;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0055" class="elsevierStylePara elsevierViewall">&#40;early neonatal mortality OR neonatal mortality OR perinatal mortality OR infant mortality&#41; AND &#40;risk factors OR socioeconomic factors OR low birth weight OR perinatal care&#41; AND &#40;Brazil OR Brasil&#41; AND &#40;case control studies OR cohort studies&#41;&#59;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0060" class="elsevierStylePara elsevierViewall">&#40;mortalidade neonatal OR mortalidade perinatal OR mortalidade infantil&#41; AND &#40;fatores de risco OR fatores socioecon&#244;micos OR baixo peso ao nascer&#41; AND &#40;caso&#8208;controle OR coorte&#41;&#59;</p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Sele&#231;&#227;o dos estudos</span><p id="par0065" class="elsevierStylePara elsevierViewall">Constituiu&#8208;se de tr&#234;s etapas&#58; fase de t&#237;tulos&#59; fase de resumos e fase de artigos completos&#44; iniciou&#8208;se ap&#243;s as buscas em todas as bases de dados&#46; Al&#233;m dessa sele&#231;&#227;o&#44; a inclus&#227;o dos artigos foi complementada pela procura de aux&#237;lio de especialistas na &#225;rea no encontro de estudos relevantes para este estudo&#46; A remo&#231;&#227;o de duplicatas deu&#8208;se com o aux&#237;lio do <span class="elsevierStyleItalic">software</span> Mendeley 1&#46;17&#46;11 &#40;Elsevier&#44; Nova Iorque&#8208;NY&#44; EUA&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Extra&#231;&#227;o dos dados</span><p id="par0070" class="elsevierStylePara elsevierViewall">Foi constru&#237;da uma planilha com <span class="elsevierStyleItalic">software</span> Microsoft Excel vers&#227;o 2016 &#40;Microsoft&#44; Redmond&#8208;WA&#44; EUA&#41; com os seguintes elementos&#58; nome dos autores do estudo&#59; cidade e estado do estudo&#59; ano do estudo&#59; tipo de estudo&#59; n&#250;mero total de sujeitos do estudo&#59; medidas de risco ajustadas e intervalos de confian&#231;a dos fatores de exposi&#231;&#227;o inclu&#237;dos&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Fatores de exposi&#231;&#227;o e desfecho</span><p id="par0075" class="elsevierStylePara elsevierViewall">Os fatores de exposi&#231;&#227;o analisados foram&#58; &#8220;escolaridade materna&#8221;&#44; &#8220;situa&#231;&#227;o conjugal da m&#227;e&#8221;&#44; &#8220;idade materna &#40;anos&#41;&#8221;&#44; &#8220;sexo do rec&#233;m&#8208;nascido&#8221;&#44; &#8220;natimorto pr&#233;vio&#8221;&#44; &#8220;tipo de gesta&#231;&#227;o&#8221;&#44; &#8220;adequa&#231;&#227;o ao pr&#233;&#8208;natal&#8221;&#44; &#8220;intercorr&#234;ncias durante a gesta&#231;&#227;o&#8221;&#44; &#8220;peso ao nascer&#8221;&#44; &#8220;malforma&#231;&#227;o cong&#234;nita&#8221;&#44; &#8220;Apgar no quinto minuto&#8221;&#44; &#8220;idade gestacional &#40;semanas&#41;&#8221; e &#8220;tipo de parto&#8221;&#46; O desfecho foi a mortalidade neonatal&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Risco de vi&#233;s em estudos individuais</span><p id="par0080" class="elsevierStylePara elsevierViewall">O risco de vi&#233;s foi baseado na Escala de Newcastle&#8208;Ottawa &#40;NOS&#41;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">10</span></a> para avalia&#231;&#227;o da qualidade de estudos n&#227;o randomizados em metan&#225;lise&#46; A NOS avalia o vi&#233;s em tr&#234;s aspectos&#58; a sele&#231;&#227;o dos grupos do estudo&#59; a comparabilidade dos grupos&#59; a apura&#231;&#227;o da exposi&#231;&#227;o para estudos caso&#8208;controle ou desfecho de interesse para estudos coorte&#46; Para o primeiro aspecto&#44; d&#225;&#8208;se o m&#225;ximo de quatro estrelas&#59; para o segundo&#44; duas&#59; e&#44; por fim&#44; para o terceiro&#44; tr&#234;s&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">An&#225;lise de dados</span><p id="par0085" class="elsevierStylePara elsevierViewall">Baseou&#8208;se no estudo quantitativo das vari&#225;veis&#46; Usou&#8208;se&#44; para essa investiga&#231;&#227;o&#44; o <span class="elsevierStyleItalic">software</span> Stata 12 &#40;StataCorp&#44; College Station&#8208;TX&#44; EUA&#41;&#46; Os dados analisados foram as medidas de risco ajustadas em cada fator de exposi&#231;&#227;o analisado&#44; al&#233;m dos seus intervalos de confian&#231;a&#46; Foram usados os logaritmos naturais das medidas de risco e de seus intervalos de confian&#231;a&#44; o m&#233;todo de DerSimonian e Laird como modelo de efeitos aleat&#243;rios e o modelo de Mantel&#8208;Haenszel para estimativa da heterogeneidade&#46; Considerou&#8208;se n&#237;vel de confian&#231;a de 95&#37;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">A heterogeneidade foi considerada importante quando o I<span class="elsevierStyleSup">2</span> foi maior do que 50&#37;&#46; Se necess&#225;rio&#44; a an&#225;lise de sensibilidade foi feita com a remo&#231;&#227;o dos estudos um a um para investigar a origem da diverg&#234;ncia&#46; A avalia&#231;&#227;o do vi&#233;s de publica&#231;&#227;o foi feita com um gr&#225;fico de dispers&#227;o em funil&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Resultados</span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Sele&#231;&#227;o dos estudos</span><p id="par0095" class="elsevierStylePara elsevierViewall">A busca nas bases de dados identificou 10&#46;274 artigos&#46; Desses&#44; 61 eram duplicatas&#44; o que resultou em 10&#46;203 artigos&#46; Ap&#243;s a leitura de todos os t&#237;tulos&#44; restaram 98 artigos a serem analisados na fase de resumos&#46; No fim dessa etapa&#44; foram selecionados 17 artigos&#44; dos quais dez foram inclu&#237;dos no estudo<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;6&#44;11&#8211;18</span></a> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; As caracter&#237;sticas gerais dos dez estudos inclu&#237;dos na an&#225;lise est&#227;o na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> e as caracter&#237;sticas pertinentes &#224; an&#225;lise quantitativa est&#227;o na <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Avalia&#231;&#227;o do risco de vi&#233;s dos estudos inclu&#237;dos</span><p id="par0100" class="elsevierStylePara elsevierViewall">Os dez estudos inclu&#237;dos na presente an&#225;lise foram avaliados de forma qualitativa por meio da Escala de Newcastle&#8208;Ottawa&#46; Quatro estudos<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;13&#44;16&#44;17</span></a> obtiveram classifica&#231;&#227;o alta&#44; ou seja&#44; s&#227;o estudos de baixo risco de vi&#233;s&#46; Por outro lado&#44; seis estudos<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">6&#44;11&#44;12&#44;14&#44;15&#44;18</span></a> obtiveram classifica&#231;&#227;o intermedi&#225;ria&#8208;alta&#44; compuseram&#44; assim&#44; um risco intermedi&#225;rio&#8208;baixo &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">An&#225;lise dos dados dos estudos inclu&#237;dos</span><p id="par0105" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a> ilustra a rela&#231;&#227;o geral entre os fatores analisados e associa&#231;&#227;o com a mortalidade neonatal&#44; representada&#44; na imagem&#44; pelas raz&#245;es de chance ajustadas finais &#40;RCaf&#41; e seus respectivos intervalos de confian&#231;a&#46; Abaixo&#44; segue o resultado de cada fator de exposi&#231;&#227;o separadamente&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Escolaridade materna</span><p id="par0110" class="elsevierStylePara elsevierViewall">Apenas foi poss&#237;vel analisar a escolaridade materna de duas formas&#58; ensino fundamental completo &#40;oito a 11 anos de ensino&#41; e ensino fundamental incompleto &#40;quatro a sete anos de ensino&#41;&#46; O ensino fundamental completo n&#227;o apresentou associa&#231;&#227;o significativa com a mortalidade neonatal &#40;RCaf &#61; 1&#44;853&#59; IC95&#37;&#58; &#91;0&#44;417 &#8211; 8&#44;241&#93;&#59; p &#61; 0&#44;418&#59; I<span class="elsevierStyleSup">2</span> &#61; 87&#44;4&#37;&#59; p &#61; 0&#44;005&#41;&#46; O mesmo foi visto com o ensino fundamental incompleto &#40;RCaf &#61; 1&#44;727&#59; IC95&#37;&#58; &#91;0&#44;466 &#8211; 6&#44;400&#93;&#59; p &#61; 0&#44;414&#59; I<span class="elsevierStyleSup">2</span> &#61; 84&#44;8&#37;&#59; p &#61; 0&#44;010&#41;&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Situa&#231;&#227;o conjugal da m&#227;e</span><p id="par0115" class="elsevierStylePara elsevierViewall">A gesta&#231;&#227;o de m&#227;es que n&#227;o tinham companheiro apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 2&#44;236&#59; IC95&#37;&#58; &#91;1&#44;630 &#8211; 3&#44;068&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;344&#41;&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Idade materna</span><p id="par0120" class="elsevierStylePara elsevierViewall">A gesta&#231;&#227;o de m&#227;es com idade igual ou superior a 35 anos apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 1&#44;568&#59; IC95&#37;&#58; &#91;1&#44;141&#8211;2&#44;154&#93;&#59; p &#61; 0&#44;006&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;882&#41;&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Sexo do rec&#233;m&#8208;nascido</span><p id="par0125" class="elsevierStylePara elsevierViewall">Rec&#233;m&#8208;nascidos do sexo masculino apresentaram chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 1&#44;591&#59; IC95&#37;&#58; &#91;1&#44;193&#8211;2&#44;121&#93;&#59; p &#61; 0&#44;002&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;362&#41;&#46;</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Natimorto pr&#233;vio</span><p id="par0130" class="elsevierStylePara elsevierViewall">A gesta&#231;&#227;o de m&#227;es que tiverem natimorto pr&#233;vio n&#227;o apresentou associa&#231;&#227;o significativa com a mortalidade neonatal &#40;RCaf &#61; 2&#44;090&#59; IC95&#37;&#58; &#91;0&#44;762&#8211;5&#44;733&#93;&#59; p &#61; 0&#44;152&#59; I<span class="elsevierStyleSup">2</span> &#61; 90&#44;6&#37;&#59; p &#61; 0&#44;001&#41;&#46;</p></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Tipo de gesta&#231;&#227;o</span><p id="par0135" class="elsevierStylePara elsevierViewall">A gesta&#231;&#227;o m&#250;ltipla apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 3&#44;361&#59; IC95&#37;&#58; &#91;1&#44;612&#8211;7&#44;009&#93;&#59; p &#61; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 48&#44;7&#37;&#59; p &#61; 0&#44;163&#41;&#46;</p></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Adequa&#231;&#227;o ao pr&#233;&#8208;natal</span><p id="par0140" class="elsevierStylePara elsevierViewall">Apenas foi poss&#237;vel analisar a inadequa&#231;&#227;o e a aus&#234;ncia de pr&#233;&#8208;natal&#46; O pr&#233;&#8208;natal inadequado apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 2&#44;182&#59; IC95&#37;&#58; &#91;1&#44;761&#8211;2&#44;703&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;771&#41;&#46; O mesmo foi visto com a aus&#234;ncia de pr&#233;&#8208;natal &#40;RCaf &#61; 6&#44;799&#59; IC95&#37;&#58; &#91;1&#44;534&#8211;30&#44;147&#93;&#59; p &#61; 0&#44;012&#59; I<span class="elsevierStyleSup">2</span> &#61; 78&#44;8&#37;&#59; p &#61; 0&#44;030&#41;&#46;</p></span><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">Intercorr&#234;ncias durante a gesta&#231;&#227;o</span><p id="par0145" class="elsevierStylePara elsevierViewall">A presen&#231;a de intercorr&#234;ncias durante a gesta&#231;&#227;o apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 6&#44;961&#59; IC95&#37;&#58; &#91;4&#44;979&#8211;9&#44;733&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;381&#41;&#46;</p></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0175">Peso ao nascer</span><p id="par0150" class="elsevierStylePara elsevierViewall">Apenas foi poss&#237;vel analisar o peso ao nascer entre 1&#46;500&#8211;2&#46;499 gramas &#40;RCaf &#61; 4&#44;044&#59; IC95&#37;&#58; &#91;2&#44;260&#8211;7&#44;238&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 77&#44;0&#37;&#59; p &#61; 0&#44;013&#41;&#44; menor do que 1&#46;500 gramas &#40;RCaf &#61; 19&#44;752&#59; IC95&#37;&#58; &#91;5&#44;556&#8211;70&#44;223&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 90&#44;7&#37;&#59; p &#60; 0&#44;001&#41; e menor do que 2&#46;500 gramas &#40;RCaf &#61; 9&#44;876&#59; IC95&#37;&#58; &#91;4&#44;920&#8211;19&#44;826&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 69&#44;4&#37;&#59; p &#61; 0&#44;003&#41;&#46; Ap&#243;s an&#225;lise de sensibilidade&#44; o peso ao nascer entre 1&#46;500&#8211;2&#46;499 gramas &#40;RCaf &#61; 5&#44;424&#59; IC95&#37;&#58; &#91;4&#44;128&#8211;7&#44;126&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;902&#41;&#44; menor do que 1&#46;500 gramas &#40;RCaf &#61; 39&#44;995&#59; IC95&#37;&#58; &#91;29&#44;026&#8211;55&#44;109&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;633&#41; e menor do que 2&#46;500 gramas &#40;RCaf &#61; 15&#44;519&#59; IC95&#37;&#58; &#91;9&#44;997&#8211;24&#44;092&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;684&#41; continuaram a apresentar uma chance significativamente maior de mortalidade neonatal ap&#243;s remo&#231;&#227;o de um estudo na primeira e segunda situa&#231;&#227;o apresentada<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">17</span></a> e de outros dois na terceira&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">6&#44;12</span></a></p></span><span id="sec0120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0180">Malforma&#231;&#227;o cong&#234;nita</span><p id="par0155" class="elsevierStylePara elsevierViewall">Rec&#233;m&#8208;nascidos que tinham malforma&#231;&#227;o cong&#234;nita apresentam chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 14&#44;025&#59; IC95&#37;&#58; &#91;10&#44;849&#8211;18&#44;132&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;402&#41;&#46;</p></span><span id="sec0125" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0185">Apgar no quinto minuto</span><p id="par0160" class="elsevierStylePara elsevierViewall">A presen&#231;a de Apgar menor do que sete no quinto minuto apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 12&#44;397&#59; IC95&#37;&#58; &#91;9&#44;545&#8211;16&#44;102&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;417&#41;&#46;</p></span><span id="sec0130" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0190">Idade gestacional</span><p id="par0165" class="elsevierStylePara elsevierViewall">A idade gestacional menor do que 37 semanas apresentou chance significativamente maior de mortalidade neonatal &#40;RCaf &#61; 5&#44;738&#59; IC95&#37;&#58; &#91;2&#44;589&#8211;12&#44;716&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 86&#44;9&#37;&#59; p &#60; 0&#44;001&#41;&#46; Ap&#243;s an&#225;lise de sensibilidade&#44; continuou a apresentar uma chance significativamente maior de mortalidade neonatal depois da remo&#231;&#227;o de tr&#234;s estudos<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">11&#44;13&#44;18</span></a> &#40;RCaf &#61; 7&#44;130&#59; IC95&#37;&#58; &#91;4&#44;329&#8211;11&#44;742&#93;&#59; p &#60; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;706&#41;&#46;</p></span><span id="sec0135" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0195">Tipo de parto</span><p id="par0170" class="elsevierStylePara elsevierViewall">O parto cesariano n&#227;o apresentou associa&#231;&#227;o significativa com a mortalidade neonatal &#40;RCaf &#61; 1&#44;233&#59; IC95&#37;&#58; &#91;0&#44;688&#8211;2&#44;210&#93;&#59; p &#61; 0&#44;483&#59; I<span class="elsevierStyleSup">2</span> &#61; 89&#44;7&#37;&#59; p &#60; 0&#44;001&#41;&#46; Ao explorar a heterogeneidade&#44; passou a apresentar uma chance significativamente maior de mortalidade neonatal ap&#243;s remo&#231;&#227;o de um estudo<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">17</span></a> &#40;RCaf &#61; 1&#44;551&#59; IC95&#37;&#58; &#91;1&#44;202&#8211;2&#44;000&#93;&#59; p &#61; 0&#44;001&#59; I<span class="elsevierStyleSup">2</span> &#61; 0&#44;0&#37;&#59; p &#61; 0&#44;480&#41;&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">N&#227;o foi poss&#237;vel fazer an&#225;lise de sensibilidade nos fatores ensino fundamental completo&#44; ensino fundamental incompleto&#44; presen&#231;a de natimorto pr&#233;vio e aus&#234;ncia de pr&#233;&#8208;natal&#44; pois foram an&#225;lises compostas por apenas dois estudos&#46; A <a class="elsevierStyleCrossRef" href="#fig0015">figura 3</a> ilustra a rela&#231;&#227;o geral final ap&#243;s an&#225;lise da sensibilidade&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0180" class="elsevierStylePara elsevierViewall">Em rela&#231;&#227;o ao vi&#233;s de publica&#231;&#227;o&#44; n&#227;o foi poss&#237;vel avali&#225;&#8208;lo devido ao n&#250;mero de estudos inclu&#237;dos em cada an&#225;lise&#46; A <a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a> demonstra uma tabela&#8208;resumo final dos resultados obtidos na an&#225;lise quantitativa&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span></span></span><span id="sec0140" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0200">Discuss&#227;o</span><p id="par0185" class="elsevierStylePara elsevierViewall">O estudo mostrou que fatores ligados &#224; m&#227;e &#40;aus&#234;ncia de companheiro&#44; idade &#8805; 35 anos&#44; gesta&#231;&#227;o m&#250;ltipla&#44; aus&#234;ncia ou inadequa&#231;&#227;o do pr&#233;&#8208;natal&#44; presen&#231;a de intercorr&#234;ncias durante a gesta&#231;&#227;o e parto cesariano&#41; e ligados ao rec&#233;m&#8208;nascido &#40;sexo masculino&#44; malforma&#231;&#227;o cong&#234;nita&#44; asfixia perinatal&#44; baixo peso ao nascer e prematuridade&#41; s&#227;o riscos &#224; mortalidade neonatal no Brasil&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">O principal fator a ser considerado nesse contexto &#233; o baixo peso ao nascer e&#44; mais precisamente&#44; o muito baixo peso ao nascer&#46; Em um estudo coorte prospectivo&#44; no qual foi analisada a mortalidade neonatal em rec&#233;m&#8208;nascidos prematuros de muito baixo peso na Regi&#227;o Nordeste do Brasil&#44; observou&#8208;se que 76&#37; morreram nas primeiras 24 horas de vida&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">19</span></a> Tal fato se repete em outra coorte prospectiva feita no Brasil a partir da an&#225;lise de nascimentos em 20 centros p&#250;blicos universit&#225;rios&#44; que resultou numa taxa de morte de 30&#37;&#44;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">20</span></a> mostrou&#44; dessa forma&#44; que o baixo peso ao nascer &#233; um fator determinante na ocorr&#234;ncia da mortalidade neonatal no Brasil&#44; &#233; seu principal preditor isolado&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;6&#44;11&#8211;19&#44;21&#8211;23</span></a> Esse fator &#233; considerado um dos principais fatores de risco para a mortalidade neonatal em diversos locais e servi&#231;os&#44; a exemplo dos estudos ocorridos na M&#233;xico&#44;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">24</span></a> Jord&#226;nia&#44;<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">25</span></a> Trinidad &#38; Tobago&#44;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">26</span></a> Estados Unidos<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">27</span></a> e China&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">28</span></a></p><p id="par0195" class="elsevierStylePara elsevierViewall">Assim como o baixo peso ao nascer&#44; outros fatores s&#227;o modific&#225;veis&#44; a exemplo da asfixia perinatal&#44; prematuridade&#44; intercorr&#234;ncias durante a gesta&#231;&#227;o&#44; feitura de pr&#233;&#8208;natal&#44; parto cesariano&#44; idade materna avan&#231;ada e aus&#234;ncia de companheiro no lar&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;6&#44;11&#44;14&#44;17&#44;19&#44;21&#44;22&#44;29&#8211;33</span></a> Destaca&#8208;se&#44; nesse contexto&#44; o pr&#233;&#8208;natal&#44; o qual&#44; se feito de forma adequada&#44; contribui para a redu&#231;&#227;o dos demais fatores modific&#225;veis&#44; principalmente da prematuridade e do baixo peso ao nascer&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;6&#44;11&#44;14&#44;16&#8211;18</span></a> Essa import&#226;ncia pode ser vista em um estudo transversal feito em um munic&#237;pio da Regi&#227;o Sudeste do Brasil&#44; o qual mostrou que 26&#44;8&#37; das mortes poderiam ter sido evitadas caso fosse feito um pr&#233;&#8208;natal adequado&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">34</span></a> Exemplo semelhante pode ser encontrado em outro estudo transversal feito em v&#225;rios munic&#237;pios de um estado do Sudeste brasileiro&#44; o qual evidenciou que 47&#37; das mortes poderiam ter sido evitadas por a&#231;&#245;es de preven&#231;&#227;o&#44; diagn&#243;stico e tratamento precoces&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">35</span></a> Tais taxas sinalizam problemas na assist&#234;ncia &#224; gestante&#44; em decorr&#234;ncia da falta de capacita&#231;&#227;o do profissional ou de uma estrutura deficiente&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">21&#44;32&#44;33&#44;36&#8211;39</span></a></p><p id="par0200" class="elsevierStylePara elsevierViewall">A exemplo do pr&#233;&#8208;natal&#44; o parto cesariano&#44; se indicado corretamente&#44; reduz a ocorr&#234;ncia da prematuridade&#44; do baixo peso ao nascer e da asfixia perinatal&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;6&#44;7&#44;11&#8211;18</span></a> Um dos grandes problemas s&#227;o as indica&#231;&#245;es incorretas e o n&#250;mero excessivo desse tipo de parto&#46; A taxa no Brasil &#233; de 56&#37;&#44; n&#250;mero bem superior &#224; recomendada&#44; que &#233; de 15&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">40</span></a> Em um estudo observacional multic&#234;ntrico de base hospitalar feito na Regi&#227;o Nordeste do Brasil&#44; observou&#8208;se que 13&#44;7&#37; das mortes neonatais estavam relacionadas ao parto cesariano em Unidades Neonatais de Alto Risco&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">41</span></a></p><p id="par0205" class="elsevierStylePara elsevierViewall">A malforma&#231;&#227;o cong&#234;nita&#44; a gesta&#231;&#227;o m&#250;ltipla e o sexo masculino do rec&#233;m&#8208;nascido mostraram&#8208;se&#44; no nosso estudo&#44; determinantes &#224; mortalidade neonatal no Brasil&#44; entretanto n&#227;o constituem fatores modific&#225;veis&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">3&#44;6&#44;7&#44;11&#8211;18&#44;32</span></a> Desses&#44; a malforma&#231;&#227;o cong&#234;nita &#233; o fator mais importante&#44; constitui&#8208;se o segundo mais decisivo &#224; mortalidade neonatal no Brasil&#46; Um estudo observacional transversal feito em v&#225;rios munic&#237;pios de um estado do Sudeste brasileiro mostrou que 42&#44;8&#37; das mortes infantis foram causadas por tal fator&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">35</span></a> A mesma tend&#234;ncia pode ser vista em uma coorte prospectiva feita em uma cidade do M&#233;xico&#44; a qual resultou em uma mortalidade neonatal de 32&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">24</span></a></p><p id="par0210" class="elsevierStylePara elsevierViewall">O conhecimento dos fatores de risco &#233; imprescind&#237;vel para a preven&#231;&#227;o da mortalidade neonatal no Brasil&#44; visto que os profissionais de sa&#250;de e gestores&#44; quando a par dessas condi&#231;&#245;es&#44; podem encontrar meios de evitar complica&#231;&#245;es cl&#237;nicas e estruturais&#46;<a class="elsevierStyleCrossRefs" href="#bib0320"><span class="elsevierStyleSup">21&#44;32&#44;33&#44;36&#8211;39</span></a> Assim&#44; a preven&#231;&#227;o consiste em capacitar profissionais e prover estrutura adequada para o nascimento&#44; oferece&#44; tamb&#233;m&#44; uma aten&#231;&#227;o individualizada &#224;s gesta&#231;&#245;es&#44; atenta&#8208;se para a especificidade de cada condi&#231;&#227;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">32&#44;33&#44;38&#44;39</span></a> Essa individualiza&#231;&#227;o j&#225; &#233; uma tend&#234;ncia mundial desde 2015&#44;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">42</span></a> a qual permitiu uma redu&#231;&#227;o de 5&#44;4&#37; das mortes neonatais mundiais entre 2015&#8208;2017&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">43</span></a></p><p id="par0215" class="elsevierStylePara elsevierViewall">O presente estudo foi composto por seis artigos de baixo risco de vi&#233;s e quatro de intermedi&#225;rio&#8208;baixo&#44; aumentou&#8208;se&#44; assim&#44; o grau de confiabilidade desse trabalho&#46; O motivo da classifica&#231;&#227;o intermedi&#225;ria reside no fato da n&#227;o aleatoriza&#231;&#227;o dos entrevistadores em tr&#234;s estudos&#44; al&#233;m da n&#227;o igualdade entre as perdas dos grupos caso e controle em outro estudo&#46; O primeiro pode ser solucionado se for feita a aleatoriza&#231;&#227;o e garantida a coleta cega dos dados&#44; enquanto a igualdade de perdas entre os grupos solucionaria o segundo impasse&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Os estudos coorte conseguiram representar a popula&#231;&#227;o de forma igualit&#225;ria&#44; al&#233;m de parear de forma equivalente com o grupo controle&#46; Um dos estudos<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">3</span></a> usou uma entrevista estruturada&#44; diferiu dos outros tr&#234;s&#44;<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">13&#44;16&#44;17</span></a> que usaram dados de bases oficiais&#46; Em rela&#231;&#227;o &#224; avalia&#231;&#227;o final&#44; todos usaram a an&#225;lise por pareamento &#40;<span class="elsevierStyleItalic">linkage</span>&#41; com bases de dados oficiais&#44; al&#233;m de tra&#231;ar um tempo de seguimento suficiente para a an&#225;lise&#46; Durante o seguimento&#44; um dos estudos<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">17</span></a> obteve uma perda de menos de 10&#37; dos sujeitos&#44; diferiu dos outros&#44; os quais n&#227;o apresentaram perda&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">Os estudos caso&#8208;controle&#44; por sua vez&#44; usaram o recurso de pareamento &#40;<span class="elsevierStyleItalic">linkage</span>&#41; de base de dados oficiais para adequar e representar os casos&#44; bem como selecionar e definir os controles&#46; Na avalia&#231;&#227;o final&#44; tr&#234;s estudos<a class="elsevierStyleCrossRefs" href="#bib0285"><span class="elsevierStyleSup">14&#44;15&#44;18</span></a> usaram a an&#225;lise por pareamento &#40;<span class="elsevierStyleItalic">linkage</span>&#41; com dados de bases oficiais&#44; enquanto os outros tr&#234;s<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">6&#44;11&#44;12</span></a> fizeram entrevistas sem cegamento&#46; Um dos estudos<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">14</span></a> obteve uma perda desigual entre os grupos caso e controle&#44; por&#233;m&#44; por ter sido menos do que 10&#37;&#44; o efeito final n&#227;o foi prejudicado&#46; Contudo&#44; apesar desse efeito estat&#237;stico&#44; a Escala de Newcastle&#8208;Ottawa n&#227;o pontua tal fato nos estudos caso&#8208;controle&#46; Em rela&#231;&#227;o aos demais estudos&#44; as taxas foram iguais em ambos os grupos&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">O resultado geral deste estudo mostra a import&#226;ncia desses fatores de risco para a mortalidade neonatal do Brasil&#44; destaca&#8208;se&#44; neste contexto&#44; o poder que as mudan&#231;as estruturais&#44; comportamentais e m&#233;dicas det&#234;m na diminui&#231;&#227;o dessas taxas&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">Os fatores de risco mais significativos apresentados neste estudo s&#227;o modific&#225;veis&#44; o que possibilita almejar uma redu&#231;&#227;o real das mortes neonatais&#44; que ainda permanecem elevadas no pa&#237;s&#46;</p></span><span id="sec0145" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0205">Financiamento</span><p id="par0240" class="elsevierStylePara elsevierViewall">Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#91;n&#176; 129015&#47;2017&#8208;2&#93;&#46;</p></span><span id="sec0150" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0210">Conflitos de interesse</span><p id="par0245" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflitos de interesse&#46;</p></span></span>"
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    "fechaRecibido" => "2018-10-19"
    "fechaAceptado" => "2018-12-18"
    "PalabrasClave" => array:2 [
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        0 => array:4 [
          "clase" => "keyword"
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          "identificador" => "xpalclavsec1159708"
          "palabras" => array:5 [
            0 => "Neonatal mortality"
            1 => "Risk factors"
            2 => "Brazil"
            3 => "Review systematic"
            4 => "Meta&#8208;analysis"
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          "palabras" => array:5 [
            0 => "Mortalidade neonatal"
            1 => "Fatores de risco"
            2 => "Brasil"
            3 => "Revis&#227;o sistem&#225;tica"
            4 => "Metan&#225;lise"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To identify&#44; using a systematic review and meta&#8208;analysis of observational studies&#44; which risk factors are significantly associated with neonatal mortality in Brazil&#44; and to build a comprehensive national analysis on neonatal mortality&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Sources</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This review included observational studies on neonatal mortality&#44; performed between 2000 and 2018 in Brazilian cities&#46; The MEDLINE&#44; Elsevier&#44; Cochrane&#44; LILACS&#44; SciELO&#44; and OpenGrey databases were used&#46; For the qualitative analysis&#44; the Newcastle&#8208;Ottawa Scale was used&#46; For the quantitative analysis&#44; the natural logarithms of the risk measures and their confidence intervals were used&#44; as well as the DerSimonian and Laird method as a random effects model&#44; and the Mantel&#8211;Haenszel model for heterogeneity estimation&#46; A confidence level of 95&#37; was considered&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Summary of findings</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The qualitative analysis resulted in six studies of low and four studies of intermediate&#8208;low bias risk&#46; The following exposure factors were significant&#58; absence of partner&#44; maternal age &#8805;35 years&#44; male gender&#44; multiple gestation&#44; inadequate and absent prenatal care&#44; presence of complications during pregnancy&#44; congenital malformation in the assessed pregnancy&#44; Apgar<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>7 at the fifth minute&#44; low and very low birth weight&#44; gestational age<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>37 weeks&#44; and caesarean delivery&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The most significant risk factors presented in this study are modifiable&#44; allowing aiming at a real reduction in neonatal deaths&#44; which remain high in the country&#46;</p></span>"
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      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Identificar&#44; atrav&#233;s de uma revis&#227;o sistem&#225;tica e da metan&#225;lise de estudos observacionais&#44; quais fatores de risco associam&#8208;se significativamente com a mortalidade neonatal no Brasil e construir uma an&#225;lise nacional abrangente sobre a mortalidade neonatal&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Fontes</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Foram avaliados os estudos observacionais sobre mortalidade neonatal realizados entre 2000 e 2018 em cidades brasileiras&#46; Usaram&#8208;se as bases MEDLINE&#44; Elsevier&#44; Cochrane&#44; LILACS&#44; SciELO e OpenGrey&#46; Para a an&#225;lise qualitativa&#44; foi usada a Escala Newcastle&#8208;Ottawa&#46; Para a an&#225;lise quantitativa&#44; foram utilizados os logaritmos naturais das medidas de risco e de seus intervalos de confian&#231;a&#44; o m&#233;todo de DerSimonian e Laird como modelo de efeitos aleat&#243;rios e o modelo de Mantel&#8208;Haenszel para estimativa da heterogeneidade&#46; Considerou&#8208;se n&#237;vel de confian&#231;a de 95&#37;&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resumo dos achados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A an&#225;lise qualitativa resultou em seis estudos de baixo e quatro estudos de intermedi&#225;rio&#8208;baixo risco de vi&#233;s&#46; Foram significativos os seguintes fatores de exposi&#231;&#227;o&#58; aus&#234;ncia de companheiro&#44; idade materna &#8805; 35 anos&#44; sexo masculino&#44; gesta&#231;&#227;o m&#250;ltipla&#44; pr&#233;&#8208;natal inadequado e ausente&#44; presen&#231;a de intercorr&#234;ncias durante a gesta&#231;&#227;o&#44; de malforma&#231;&#227;o cong&#234;nita na gesta&#231;&#227;o em estudo&#44; Apgar &#60; 7 no quinto minuto&#44; baixo e muito baixo peso ao nascer&#44; idade gestacional &#8804; 37 semanas e parto cesariano&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Os fatores de risco mais significativos apresentados neste estudo s&#227;o modific&#225;veis&#44; o que possibilita almejar uma redu&#231;&#227;o real das mortes neonatais&#44; que ainda permanecem elevadas no pa&#237;s&#46;</p></span>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Como citar este artigo&#58; Veloso FC&#44; Kassar LM&#44; Oliveira MJ&#44; Lima TH&#44; Bueno NB&#44; Gurgel RQ&#44; et al&#46; Analysis of neonatal mortality risk factors in Brazil&#58; a systematic review and meta&#8208;analysis of observational studies&#46; J Pediatr &#40;Rio J&#41;&#46; 2019&#59;95&#58;519&#8211;30&#46;</p>"
      ]
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        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Estudo vinculado a Universidade Estadual de Ci&#234;ncias da Sa&#250;de de Alagoas&#44; Macei&#243;&#44; AL&#44; Brasil&#46;</p>"
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          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Fluxograma da sele&#231;&#227;o dos estudos&#46;</p>"
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          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Vis&#227;o geral dos fatores associados &#224; mortalidade neonatal&#46;</p> <p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">OR&#44; <span class="elsevierStyleItalic">odds ratio</span>&#59; CI&#44; intervalo de confian&#231;a&#46;</p>"
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          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Rela&#231;&#227;o final dos fatores associados &#224; mortalidade neonatal ap&#243;s a an&#225;lise de heterogeneidade&#46; OR&#44; <span class="elsevierStyleItalic">odds ratio</span>&#59; CI&#44; intervalo de confian&#231;a&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudos analisados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ano&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cidade&#47;Estado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tipo de estudo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#250;mero de sujeitos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vari&#225;veis Analisadas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lansky et al&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">3</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">V&#225;rias cidades das cinco macrorregi&#245;es brasileiras&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coorte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#46;329&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Escolaridade materna &#124; Situa&#231;&#227;o conjugal da m&#227;e &#124; Idade materna &#124; Sexo do rec&#233;m&#8208;nascido &#124; Natimorto pr&#233;vio &#124; Tipo de gesta&#231;&#227;o &#124; Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124; Intercorr&#234;ncias durante a gesta&#231;&#227;o &#124; Peso ao nascer &#124; Malforma&#231;&#227;o cong&#234;nita &#124; Apgar no quinto minuto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">II&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lima et al&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">17</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Serra&#47;ES&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coorte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#46;275&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Escolaridade materna &#124; Idade materna &#124; Tipo de gesta&#231;&#227;o &#124; Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124;Peso ao nascer &#124; Tipo de parto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Zanini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">13</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 microrregi&#245;es&#47;RS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coorte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">138&#46;407&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Natimorto pr&#233;vio &#124; Peso ao nascer &#124; Malforma&#231;&#227;o cong&#234;nita &#124; Apgar no quinto minuto &#124; Idade gestacional &#124; Tipo de parto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Garcia et al&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">16</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2019&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Florian&#243;polis&#47;SC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coorte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;879&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124; Peso ao nascer &#124; Malforma&#231;&#227;o cong&#234;nita &#124; Apgar no quinto minuto &#124; Tipo de parto &#124; Idade gestacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">V&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Almeida &#38; Barros<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">12</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Campinas&#47;SP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso&#8208;Controle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">351&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer &#124; Idade gestacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nascimento et al&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fortaleza&#47;CE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso&#8208;Controle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">396&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo do rec&#233;m&#8208;nascido &#124; Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124; Peso ao nascer &#124; Idade gestacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Kassar et al&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">6</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Macei&#243;&#47;AL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso&#8208;Controle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">408&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124; Peso ao nascer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VIII&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Schoeps et al&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">14</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S&#227;o Paulo&#47;SP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso&#8208;Controle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">459&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Situa&#231;&#227;o conjugal da m&#227;e &#124; Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124; Intercorr&#234;ncias durante a gesta&#231;&#227;o &#124; Peso ao nascer &#124; Idade gestacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IX&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Paulucci &#38; Nascimento<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">15</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Taubat&#233;&#47;SP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso&#8208;Controle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">392&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer &#124; Malforma&#231;&#227;o cong&#234;nita&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">X&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mendes et al&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">18</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caxias do Sul&#47;RS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caso&#8208;Controle&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">354&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adequa&#231;&#227;o ao pr&#233;&#8208;natal &#124; Peso ao nascer &#124; Tipo de parto &#124; Idade gestacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => "xTab2139622.png"
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas gerais dos estudos inclu&#237;dos</p>"
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      ]
      4 => array:8 [
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        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
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          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabela "
            "rol" => "short"
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        "tabla" => array:1 [
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            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vari&#225;veis analisadas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fatores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudos analisados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR ajustada&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">IC &#40;95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Escolaridade materna&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensino fundamental completo &#40;8 a 11 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;240&#44;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;61 &#8211; 11&#44;16&#93;&#91;0&#44;59 &#8211; 1&#44;41&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensino fundamental incompleto &#40;4 a 7 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;600&#44;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;43 &#8211; 9&#44;07&#93;&#91;0&#44;60 &#8211; 1&#44;47&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Situa&#231;&#227;o conjugal da m&#227;e&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#227;e sem companheiro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;491&#44;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;69 &#8211; 3&#44;66&#93;&#91;1&#44;00 &#8211; 3&#44;00&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade materna&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade materna maior ou igual a 35 anos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;621&#44;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;95 &#8208;2&#44;78&#93;&#91;1&#44;04 &#8211; 2&#44;29&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo do rec&#233;m&#8208;nascido&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;492&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;08 &#8211; 2&#44;05&#93;&#91;1&#44;09 &#8211; 4&#44;03&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Natimorto pr&#233;vio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de natimorto pr&#233;vio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;621&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;2&#44;05 &#8211; 6&#44;41&#93;&#91;1&#44;01 &#8211; 1&#44;65&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tipo de gesta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gesta&#231;&#227;o m&#250;ltipla&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;792&#44;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;2&#44;37 &#8211; 9&#44;68&#93;&#91;1&#44;03 &#8211; 4&#44;96&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Adequa&#231;&#227;o ao pr&#233;&#8208;natal</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pr&#233;&#8208;natal inadequado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;11&#41;&#40;6&#41;&#40;14&#41;&#40;16&#41;&#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;842&#44;032&#44;492&#44;003&#44;041&#44;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;44 &#8211; 5&#44;62&#93;&#91;1&#44;03 &#8211; 3&#44;99&#93;&#91;1&#44;14 &#8211; 5&#44;40&#93;&#91;2&#44;00 &#8211; 3&#44;50&#93;&#91;1&#44;61 &#8211; 5&#44;97&#93;&#91;0&#44;44 &#8211; 4&#44;77&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aus&#234;ncia de pr&#233;&#8208;natal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;14&#41;&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;103&#44;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;4&#44;70 &#8211; 55&#44;40&#93;&#91;1&#44;86 &#8211; 6&#44;49&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intercorr&#234;ncias durante a gesta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de intercorr&#234;ncias durante a gesta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;078&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;3&#44;85 &#8211; 9&#44;55&#93;&#91;5&#44;00 &#8211; 13&#44;50&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer entre 1&#46;500 a 2&#46;499 gramas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;17&#41;&#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;192&#44;365&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;2&#44;44 &#8211; 11&#44;04&#93;&#91;1&#44;46 &#8211; 3&#44;83&#93;&#91;4&#44;07 &#8211; 7&#44;31&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer menor do que 1&#46;500 gramas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;17&#41;&#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;275&#44;4941&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;12&#44;65 &#8211; 82&#44;35&#93;&#91;2&#44;52 &#8211; 11&#44;96&#93;&#91;29&#44;25 &#8211; 57&#44;87&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer menor do que 2&#46;500 gramas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;12&#41;&#40;11&#41;&#40;6&#41;&#40;14&#41;&#40;15&#41;&#40;16&#41;&#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;8414&#44;752&#44;5717&#44;3022&#44;809&#44;4634&#44;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;18 &#8211; 12&#44;50&#93;&#91;5&#44;26 &#8211; 41&#44;35&#93;&#91;1&#44;16 &#8211; 5&#44;72&#93;&#91;8&#44;40 &#8211; 35&#44;60&#93;&#91;7&#44;52 &#8211; 69&#44;12&#93;&#91;4&#44;06 &#8211; 23&#44;60&#93;&#91;3&#44;84 &#8211; 311&#44;50&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Malforma&#231;&#227;o cong&#234;nita&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de malforma&#231;&#227;o cong&#234;nita&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;13&#41;&#40;15&#41;&#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;5514&#44;7912&#44;916&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;6&#44;47 &#8211; 42&#44;38&#93;&#91;11&#44;18 &#8211; 19&#44;59&#93;&#91;2&#44;13 &#8211; 78&#44;38&#93;&#91;2&#44;14 &#8208; 15&#44;67&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Apgar no quinto minuto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de Apgar menor do que 7 no quinto minuto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&#40;13&#41;&#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;7911&#44;3919&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;6&#44;54 &#8211; 38&#44;14&#93;&#91;8&#44;51 &#8208; 15&#44;25&#93;&#91;8&#44;78 &#8211; 42&#44;92&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade gestacional&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade gestacional menor do que 37 semanas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;12&#41;&#40;11&#41;&#40;14&#41;&#40;13&#41;&#40;16&#41;&#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;373&#44;418&#44;801&#44;846&#44;0943&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;83 &#8208; 17&#44;98&#93;&#91;1&#44;09 &#8211; 4&#44;03&#93;&#91;4&#44;30 &#8208; 17&#44;80&#93;&#91;1&#44;42 &#8211; 2&#44;39&#93;&#91;2&#44;58 &#8208; 15&#44;23&#93;&#91;10&#44;26 &#8211; 83&#44;97&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tipo de parto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Parto cesariano&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;17&#41;&#40;13&#41;&#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;520&#44;802&#44;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;17 &#8211; 1&#44;97&#93;&#91;0&#44;68 &#8211; 0&#44;93&#93;&#91;0&#44;70 &#8208; 7&#44;61&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2139623.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas dos estudos inclu&#237;dos na an&#225;lise quantitativa</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:2 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Coorte</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudos analisados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sele&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparabilidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Desfecho&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Classifica&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alta Qualidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alta Qualidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alta Qualidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alta Qualidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2139624.png"
              ]
            ]
            1 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Caso&#8208;Controle</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudos analisados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sele&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Comparabilidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Exposi&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Classifica&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Qualidade Intermedi&#225;ria &#8211; Alta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Qualidade Intermedi&#225;ria &#8211; Alta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Qualidade Intermedi&#225;ria &#8211; Alta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Qualidade Intermedi&#225;ria &#8211; Alta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alta Qualidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#42;&#42;&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#42;&#47;9&#42;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alta Qualidade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2139620.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Avalia&#231;&#227;o do risco de vi&#233;s dos estudos inclu&#237;dos</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Tabela 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fatores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudos inclu&#237;dos na an&#225;lise&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&#250;mero total de sujeitos analisados&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR ajustada final&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">IC &#40;95&#37;&#41; final&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">I<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensino fundamental completo &#40;8 a 11 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56604&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;853&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;417 &#8208; 8&#44;241&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87&#44;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;418&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ensino fundamental incompleto &#40;4 a 7 anos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56604&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;727&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;0&#44;466 &#8211; 6&#44;400&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84&#44;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;414&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&#227;e sem companheiro<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24788&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;236&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;630 &#8211; 3&#44;068&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;344&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Idade materna maior ou igual a 35 anos<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56604&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;568&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;141 &#8211; 2&#44;154&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;882&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo masculino<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24725&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;591&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#91;1&#44;193 &#8211; 2&#44;121&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;362&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de natimorto pr&#233;vio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">&#91;0&#44;762 &#8211; 5&#44;733&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gesta&#231;&#227;o m&#250;ltipla<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;3&#41; &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pr&#233;&#8208;natal inadequado<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;11&#41; &#40;6&#41; &#40;14&#41; &#40;16&#41; &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aus&#234;ncia de pr&#233;&#8208;natal<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;14&#41; &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de intercorr&#234;ncias durante a gesta&#231;&#227;o<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer entre 1&#46;500 a 2&#46;499 gramas<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#40;3&#41; &#40;17&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">195011&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#91;4&#44;128 &#8211; 7&#44;126&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer menor do que 1&#46;500 gramas<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#40;3&#41; &#40;17&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">195011&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer menor do que 2&#46;500 gramas<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;12&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;3&#41; &#40;6&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a> &#40;14&#41; &#40;15&#41; &#40;16&#41; &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">18239&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#91;9&#44;997 &#8211; 24&#44;092&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Presen&#231;a de malforma&#231;&#227;o cong&#234;nita<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;3&#41; &#40;13&#41; &#40;15&#41; &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">179007&nbsp;\t\t\t\t\t\t\n
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Informação do artigo
ISSN: 22555536
Idioma original: Português
DOI:10.1016/j.jpedp.2019.05.020
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