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        "titulo" => "Exposi&#231;&#227;o pr&#233;&#8208;natal a mofo est&#225; associada ao desenvolvimento de dermatite at&#243;pica em neonatos por rea&#231;&#227;o al&#233;rgica"
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          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">A&#44; associa&#231;&#227;o entre os n&#237;veis s&#233;ricos totais de IgE&#44; de acordo com a exposi&#231;&#227;o a mofo durante a gravidez&#44; e a dermatite at&#243;pica&#46; Os dados s&#227;o expressos como a m&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>desvio padr&#227;o&#59; B&#44; correla&#231;&#227;o entre o &#237;ndice de Scorad transformado em logaritmo no primeiro ano de vida e os n&#237;veis s&#233;ricos totais de IgE transformados em logaritmo&#59; C&#44; correla&#231;&#227;o entre a abund&#226;ncia relativa de esp&#233;cies do filo <span class="elsevierStyleItalic">Ascomycota</span> n&#227;o cultivadas encontradas no ambiente com 36 semanas de gesta&#231;&#227;o e os n&#237;veis s&#233;ricos totais de IgE no primeiro ano de vida&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">A preval&#234;ncia de dermatite at&#243;pica &#40;DA&#41; apresentou aumento de acordo com a regi&#227;o e a situa&#231;&#227;o socioecon&#244;mica&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1&#8211;3</span></a> In&#250;meros fatores ambientais podem contribuir para o aumento de DA&#44; ao passo que uma dieta saud&#225;vel e a aplica&#231;&#227;o de emolientes podem desempenhar um papel na preven&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Entre diversos fatores ambientais&#44; a exposi&#231;&#227;o ao mofo durante o in&#237;cio da vida &#233; um fator de risco potencial para o desenvolvimento de doen&#231;as al&#233;rgicas&#44; inclusive a DA&#44; embora os estudos sejam inconclusivos&#46;<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">5&#44;6</span></a> Os resultados inconsistentes podem ser atribu&#237;dos ao menos em parte a diferen&#231;as no momento da exposi&#231;&#227;o ao mofo&#46; Semelhantemente &#224; exposi&#231;&#227;o a bact&#233;rias&#44;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">7</span></a> a exposi&#231;&#227;o ao mofo&#44; especialmente durante per&#237;odos cr&#237;ticos da gesta&#231;&#227;o&#44; pode desempenhar um papel na forma&#231;&#227;o do sistema imunol&#243;gico&#44; afeta&#44; assim&#44; o desenvolvimento da DA&#46; Estudos anteriores da associa&#231;&#227;o entre a exposi&#231;&#227;o ao mofo e o desenvolvimento de DA tiveram como foco o efeito do microbioma da pele&#44; inclusive de esp&#233;cies Malassezia&#44; na DA&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">8</span></a> Entretanto&#44; n&#227;o existem muitos estudos da associa&#231;&#227;o entre a exposi&#231;&#227;o ao mofo ambiental e a DA e os efeitos imunomodulat&#243;rios da exposi&#231;&#227;o ao mofo continuam pouco conhecidos&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Portanto&#44; o objetivo deste estudo foi examinar a associa&#231;&#227;o entre o momento da exposi&#231;&#227;o ao mofo e o desenvolvimento de DA e investigar os mecanismos subjacentes &#224; rela&#231;&#227;o entre a exposi&#231;&#227;o ao mofo no ambiente domiciliar&#44; especialmente nos per&#237;odos cr&#237;ticos da gesta&#231;&#227;o&#44; e o desenvolvimento de DA&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material e m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Popula&#231;&#227;o estudada</span><p id="par0020" class="elsevierStylePara elsevierViewall">O estudo foi feito de novembro de 2008 a dezembro de 2015 como parte do estudo de coorte de nascimento prospectivo da Origem da Asma e de Doen&#231;as Al&#233;rgicas em Crian&#231;as &#40;Cocoa&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">9</span></a> A DA em neonatos com um ano de vida foi diagnosticada por pediatras alergistas com os crit&#233;rios de Hanifin e Rajka&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">10</span></a> O &#205;ndice da Pontua&#231;&#227;o de Dermatite At&#243;pica &#40;Scorad&#41;&#44; que &#233; um &#237;ndice combinado que reflete a extens&#227;o&#44; a gravidade e os sintomas da AD&#44; foi avaliado em rec&#233;m&#8208;nascidos com DA&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">11</span></a> O protocolo do estudo foi aprovado pelo Conselho de Revis&#227;o Institucional &#40;IRB&#41; do Centro M&#233;dico de Asan&#46; O consentimento informado foi fornecido pelos pais de cada neonato e confirmado pelo IRB&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Question&#225;rios</span><p id="par0025" class="elsevierStylePara elsevierViewall">Para investigar a presen&#231;a de manchas &#250;midas vis&#237;veis e mofo nas casas dos participantes&#44; pedimos aos pais que preenchessem um question&#225;rio com 36 semanas de gest&#227;o e aos seis meses&#46; A cada visita de acompanhamento&#44; os pais eram perguntados &#8220;Voc&#234;s encontraram manchas &#250;midas e mofos na casa de voc&#234;s&#63;&#8221;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">12&#44;13</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Amostragem e an&#225;lise de mofo dentro das casas</span><p id="par0030" class="elsevierStylePara elsevierViewall">Com 36 semanas de gest&#227;o&#44; foram coletadas&#44; de todos os participantes do estudo de coorte de nascimento Cocoa&#44; amostras de poeira do quarto em que a mulher gr&#225;vida passava a maior parte do tempo&#44; por meio de um aspirador de p&#243; &#40;Electrolux&#174;&#44; Estocolmo&#44; Su&#233;cia&#41;&#46; As amostras foram colhidas no mesmo hor&#225;rio do dia e congeladas imediatamente a &#8208;70<span class="elsevierStyleHsp" style=""></span>&#176;C&#46; Foi analisado o microbioma de 20 neonatos saud&#225;veis escolhidos aleatoriamente e 20 neonatos com DA que participavam do estudo prospectivo Cocoa&#46; O DNA do fungo foi extra&#237;do por meio do kit para solo FastDNA SPIN &#40;Qbiogene&#44; MP Biomedicals&#44; Illkirch&#44; Fran&#231;a&#41;&#46; A an&#225;lise dos microbiomas ambientais na 36&#170; semana de gest&#227;o foi feita por meio da plataforma Illumina MiSeq &#40;Illumina&#174;&#44; CA&#44; EUA&#41;&#46; A diversidade e a composi&#231;&#227;o do microbioma dos dois grupos foram ent&#227;o comparadas&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Medi&#231;&#227;o dos n&#237;veis s&#233;ricos totais de IgE</span><p id="par0035" class="elsevierStylePara elsevierViewall">A IgE s&#233;rica total a um ano de idade foi medida em todos os participantes por meio de amostras de sangue&#44; com o sistema ImmunoCAP &#40;ThermoFisher&#44; Uppsala&#44; Su&#233;cia&#41;&#46; O menor limite de detec&#231;&#227;o foi de 2 kU&#47;L&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">14</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">An&#225;lise de dados</span><p id="par0040" class="elsevierStylePara elsevierViewall">Foram avaliadas rela&#231;&#245;es significativas por meio de um modelo de regress&#227;o log&#237;stica ajustado &#224; idade da m&#227;e&#44; ao &#237;ndice de massa corporal da m&#227;e&#44; ao n&#237;vel de escolaridade materna&#44; ao sexo&#44; ao hist&#243;rico de doen&#231;as al&#233;rgicas dos pais e &#224; esta&#231;&#227;o do nascimento&#46; Para identificar o efeito da exposi&#231;&#227;o ao mofo na gravidez&#44; os dados foram ajustados &#224; exposi&#231;&#227;o ao mofo na inf&#226;ncia e para identificar o efeito da exposi&#231;&#227;o na inf&#226;ncia os dados foram ajustados &#224; exposi&#231;&#227;o ao mofo na gravidez&#46; As rela&#231;&#245;es entre os biomarcadores e a abund&#226;ncia relativa de um mofo espec&#237;fico foram analisadas por meio de testes de correla&#231;&#227;o Pearson&#46; Os dados foram analisados com o <span class="elsevierStyleItalic">software</span> SPSS vers&#227;o 21&#46;0 &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#44; EUA&#41;&#46; Um valor de <span class="elsevierStyleItalic">P</span> de 0&#44;05 ou menos foi considerado significativo&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Resultados</span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Associa&#231;&#227;o entre exposi&#231;&#227;o a mofo e desenvolvimento de DA&#44; de acordo com o momento da exposi&#231;&#227;o</span><p id="par0045" class="elsevierStylePara elsevierViewall">A exposi&#231;&#227;o pr&#233;&#8208;natal a mofo foi associada a um risco mais elevado de DA no primeiro ano de vida &#40;raz&#227;o de chances ajustada &#91;aOR&#93;&#44; 1&#44;36&#59; intervalo de confian&#231;a de &#91;IC de 95&#37;&#93;&#44; 1&#44;01-1&#44;83&#41;&#44; mesmo quando os dados foram ajustados &#224; exposi&#231;&#227;o p&#243;s&#8208;natal a mofo &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46; N&#227;o houve associa&#231;&#227;o entre o risco de DA e a exposi&#231;&#227;o a mofo durante o primeiro ano de vida &#40;aOR&#44; 0&#44;83&#59; IC de 95&#37;&#44; 0&#44;61&#8208;1&#44;13&#41;&#44; mesmo ap&#243;s o ajuste para exposi&#231;&#227;o a mofo durante o per&#237;odo pr&#233;&#8208;natal&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Caracter&#237;sticas dos rec&#233;m&#8208;nascidos e dados do microbioma</span><p id="par0050" class="elsevierStylePara elsevierViewall">As caracter&#237;sticas dos neonatos e os dados do microbioma ambiental durante a gravidez s&#227;o apresentados na <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#46; Com rela&#231;&#227;o aos 20 rec&#233;m&#8208;nascidos com DA&#44; o &#237;ndice Scorad no primeiro ano de vida foi de 14&#44;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;91&#46; O percentual de eosin&#243;filos no sangue do cord&#227;o umbilical foi significativamente maior em rec&#233;m&#8208;nascidos com DA do que em neonatos saud&#225;veis&#46; N&#227;o houve diferen&#231;a significativa entre os grupos em termos de hist&#243;rico familiar de doen&#231;as al&#233;rgicas&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Compara&#231;&#227;o dos n&#237;veis s&#233;ricos totais de IgE no primeiro ano de vida</span><p id="par0055" class="elsevierStylePara elsevierViewall">Os n&#237;veis s&#233;ricos totais de IgE foram significativamente maior em neonatos com DA expostos a mofo durante a gravidez do que em rec&#233;m&#8208;nascidos saud&#225;veis n&#227;o expostos a mofo &#40;m&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>desvio padr&#227;o&#44; 124&#44;96<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>413&#44;82 kU&#47;L em compara&#231;&#227;o com 58&#44;71<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>126&#44;25 kU&#47;L&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;021&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>A&#41;&#46; Mesmo em neonatos com DA&#44; a IgE s&#233;rica total estava menor nos rec&#233;m&#8208;nascidos que n&#227;o foram expostos a mofo durante a gravidez &#40;64&#44;98<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>197&#44;99 kU&#47;L em compara&#231;&#227;o com 124&#44;96<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>413&#44;82 kU&#47;L&#41;&#44; embora a diferen&#231;a n&#227;o seja significativa&#46; Os n&#237;veis s&#233;ricos totais de IgE transformados em logaritmo no primeiro ano de vida de neonatos com DA correlacionam&#8208;se com o &#237;ndice Scorad no primeiro ano de vida &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;186&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;018&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>B&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Compara&#231;&#227;o dos dados do microbioma entre neonatos com DA e os saud&#225;veis</span><p id="par0060" class="elsevierStylePara elsevierViewall">N&#227;o houve diferen&#231;as significativas na diversidade e no n&#237;vel de abund&#226;ncia &#40;Chao1&#44; unidades taxon&#244;micas operacionais&#41; com rela&#231;&#227;o ao microbioma nas 36 semanas de gesta&#231;&#227;o entre os 20 neonatos saud&#225;veis e os com DA &#40;n&#227;o constam os dados&#41;&#46; A abund&#226;ncia relativa das esp&#233;cies de <span class="elsevierStyleItalic">Ascomycota</span> n&#227;o cultivadas foi maior em neonatos com DA &#40;149&#44;75&#37;<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>506&#44;51&#37;&#41; do que em rec&#233;m&#8208;nascidos saud&#225;veis &#40;60&#44;82&#37;<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>81&#44;83&#37;&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">A abund&#226;ncia relativa das esp&#233;cies de <span class="elsevierStyleItalic">Ascomycota</span> n&#227;o cultivadas correlaciona&#8208;se com os n&#237;veis s&#233;ricos totais de IgE no primeiro ano de vida &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;613&#44; <span class="elsevierStyleItalic">P</span> &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#44; <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a>C&#41;&#44; por&#233;m n&#227;o com o &#237;ndice Scorad&#44; em todos os participantes e em neonatos com DA&#46;</p></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Discuss&#227;o</span><p id="par0070" class="elsevierStylePara elsevierViewall">Neste artigo&#44; demonstramos que a exposi&#231;&#227;o a mofo durante o per&#237;odo pr&#233;&#8208;natal est&#225; associada a um risco maior de DA em neonatos que participavamdo de um estudo de coorte de nascimento prospectivo &#40;Cocoa&#41;&#59; a exposi&#231;&#227;o ao mofo durante o per&#237;odo p&#243;s&#8208;natal n&#227;o foi associada ao desenvolvimento de DA&#46; Os n&#237;veis s&#233;ricos totais de IgE em neonatos com DA expostos a mofo durante o per&#237;odo pr&#233;&#8208;natal foram maiores do que nos rec&#233;m&#8208;nascidos saud&#225;veis que n&#227;o foram expostos a mofo durante o per&#237;odo de gesta&#231;&#227;o&#59; esse fato foi verificado mesmo em neonatos com DA que n&#227;o foram expostos a mofo&#46; A abund&#226;ncia relativa no ambiente domiciliar e durante a gravidez de esp&#233;cies de <span class="elsevierStyleItalic">Ascomycota</span> n&#227;o cultivadas foi maior nos casos de neonatos com DA do que nas casas de neonatos saud&#225;veis e correlacionou&#8208;se com os n&#237;veis s&#233;ricos totais de IgE no primeiro ano de vida&#46; Esse fato sugere que a exposi&#231;&#227;o a n&#237;veis mais altos de <span class="elsevierStyleItalic">Ascomycota</span> no ambiente domiciliar durante o per&#237;odo pr&#233;&#8208;natal pode contribuir para o desenvolvimento de DA no in&#237;cio da vida por meio de rea&#231;&#227;o al&#233;rgica mediada por IgE&#46; Assim&#44; evitar ou limitar a exposi&#231;&#227;o ao microbioma ambiental durante per&#237;odos cr&#237;ticos do desenvolvimento pode ajudar a prevenir o desenvolvimento de DA no in&#237;cio da vida&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Embora a fisiopatologia da DA n&#227;o seja completamente entendida&#44; defeitos na barreira cut&#226;nea&#44; respostas imunol&#243;gicas disfuncionais e fatores ambientais s&#227;o considerados as principais causas&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">15</span></a> A disbiose&#44; a coloniza&#231;&#227;o da pele por microbiomas espec&#237;ficos&#44; a inflama&#231;&#227;o por fungos associada &#224; DA<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">16</span></a> e a intera&#231;&#227;o entre o hospedeiro e o microbioma podem agir como um imunomodulador&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">17</span></a> Os resultados deste estudo sugerem que a exposi&#231;&#227;o ao microbioma ambiental&#44; especialmente durante os per&#237;odos cr&#237;ticos de desenvolvimento&#44; afeta o desenvolvimento de DA&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Poucos estudos examinaram os mecanismos subjacentes &#224; associa&#231;&#227;o entre o microbioma ambiental e a DA&#44; ou o efeito dos componentes espec&#237;ficos do microbioma na patog&#234;nese da DA&#44; embora o microbioma seja um importante componente do ambiente humano&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">12&#44;18</span></a> Estudos anteriores em pacientes com DA tiveram como foco principal o mofo agindo como um aeroal&#233;rgeno durante o desenvolvimento de doen&#231;as al&#233;rgicas respirat&#243;rias e a inflama&#231;&#227;o da pele relacionada &#224; coloniza&#231;&#227;o por fungos espec&#237;ficos&#44; como as esp&#233;cies Malassezia&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">8&#44;19</span></a> Os mecanismos subjacentes &#224; indu&#231;&#227;o da DA por mofo podem incluir a sensibiliza&#231;&#227;o ao mofo ou o encadeamento de respostas imunol&#243;gicas direcionadas contra componentes espec&#237;ficos do microbioma&#46; Entretanto&#44; poucos estudos&#44; especialmente os estratificados de acordo com o momento da exposi&#231;&#227;o&#44; examinaram a associa&#231;&#227;o entre a exposi&#231;&#227;o ao mofo ambiental e a DA&#59; assim&#44; os mecanismos subjacentes permanecem desconhecidos&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">O resultado deste estudo sugere que a exposi&#231;&#227;o ao mofo encontrado no ambiente domiciliar durante o per&#237;odo pr&#233;&#8208;natal pode afetar o desenvolvimento de DA por imunomodula&#231;&#227;o&#44; possivelmente por meio de uma rea&#231;&#227;o al&#233;rgica relacionada &#224; IgE&#46; Essa hip&#243;tese &#233; embasada na constata&#231;&#227;o de n&#237;veis s&#233;ricos totais de IgE mais elevados em neonatos com DA expostos a mofo durante o per&#237;odo pr&#233;&#8208;natal do que em rec&#233;m&#8208;nascidos com DA que n&#227;o foram expostos&#46; Al&#233;m disso&#44; relatamos anteriormente que a exposi&#231;&#227;o a mofo durante a inf&#226;ncia est&#225; associada a maiores n&#237;veis s&#233;ricos totais de IgE&#44;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">13</span></a> embora os mecanismos subjacentes n&#227;o tenham sido identificados&#46; Os resultados de nosso estudo e de estudos anteriores sugerem que a exposi&#231;&#227;o a mofo no in&#237;cio da vida pode induzir a rea&#231;&#227;o al&#233;rgica mediada por IgE&#59; contudo&#44; n&#227;o encontramos correla&#231;&#227;o significativa entre a gravidade da DA e a abund&#226;ncia relativa de <span class="elsevierStyleItalic">Ascomycota</span> n&#227;o cultivado &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;347&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;399&#44; n&#227;o constam os dados&#41;&#46; Esse fato sugere uma fun&#231;&#227;o dos componentes espec&#237;ficos do microbioma como indutores de rea&#231;&#227;o al&#233;rgica por IgE no desenvolvimento de DA&#46; S&#227;o necess&#225;rios estudos adicionais a fim de identificar os mecanismos subjacentes &#224; associa&#231;&#227;o entre a exposi&#231;&#227;o ao mofo durante o per&#237;odo da gesta&#231;&#227;o e o desenvolvimento de DA no in&#237;cio da vida&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">A exposi&#231;&#227;o a fatores ambientais durante o per&#237;odo pr&#233;&#8208;natal pode afetar o desenvolvimento do sistema imunol&#243;gico&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">20</span></a> O estresse pr&#233;&#8208;natal da m&#227;e e v&#225;rios fatores ambientais podem causar mudan&#231;as na express&#227;o gen&#233;tica por meio de mecanismos epigen&#233;ticos&#44; especialmente durante per&#237;odos cr&#237;ticos do desenvolvimento&#44; e afetar&#44; assim&#44; o desenvolvimento e a diferencia&#231;&#227;o do sistema imunol&#243;gico&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">20&#8211;22</span></a> A pr&#243;pria exposi&#231;&#227;o ao mofo pode causar respostas imunol&#243;gicas al&#233;rgicas e os componentes do mofo&#44; como as proteases&#44; podem irritar a pele ou agir como indutores de rea&#231;&#227;o al&#233;rgica por via a&#233;rea&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">23&#44;24</span></a> Com base nas constata&#231;&#245;es acima&#44; a altera&#231;&#227;o da resposta imunol&#243;gica materna devido &#224; exposi&#231;&#227;o a mofo durante a gravidez pode afetar o desenvolvimento do sistema imunol&#243;gico dos filhos e&#44; assim&#44; pode estar relacionada ao desenvolvimento de DA em neonatos&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">25</span></a> Neste estudo&#44; n&#227;o encontramos diferen&#231;as significativas na diversidade do microbioma entre neonatos saud&#225;veis e com DA durante o per&#237;odo pr&#233;&#8208;natal&#59; contudo&#44; essa abund&#226;ncia relativa de fungos espec&#237;ficos&#44; como do <span class="elsevierStyleItalic">Ascomycota</span> n&#227;o cultivado&#44; no ambiente domiciliar durante os per&#237;odos pr&#233;&#8208;natais foi maior em rec&#233;m&#8208;nascidos com DA do que em neonatos saud&#225;veis&#46; Os resultados deste estudo sugerem que a exposi&#231;&#227;o a componentes espec&#237;ficos do microbioma&#44; em vez do pr&#243;prio mofo&#44; especialmente durante per&#237;odos cr&#237;ticos do desenvolvimento&#44; pode estar associada ao desenvolvimento de DA durante a inf&#226;ncia&#46; S&#227;o necess&#225;rios estudos adicionais em grande escala a fim de confirmar esses resultados&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Um componente proteico do <span class="elsevierStyleItalic">Ascomycota</span> pode se ligar aos ARNm e modul&#225;&#8208;los&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">26</span></a> Al&#233;m disso&#44; polissacar&#237;deos f&#250;ngicos&#44; inclusive os provenientes do filo <span class="elsevierStyleItalic">Ascomycota</span>&#44; podem induzir a produ&#231;&#227;o de radicais livres e a produ&#231;&#227;o de citocinas associadas &#224; inflama&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">27</span></a> Em um estudo anterior&#44; demonstramos que a exposi&#231;&#227;o a mofo estava associada ao desenvolvimento de DA pela produ&#231;&#227;o&#44; por meio da citocina Th2&#44; de esp&#233;cies reativas de oxig&#234;nio &#40;ERO&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">12</span></a> Desequil&#237;brios na produ&#231;&#227;o de ERO tamb&#233;m podem afetar a express&#227;o gen&#233;tica&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">28</span></a> Em conjunto&#44; esses resultados sugerem que a exposi&#231;&#227;o a mofo em ambiente domiciliar&#44; inclusive o <span class="elsevierStyleItalic">Ascomycota</span>&#44; durante o per&#237;odo pr&#233;&#8208;natal pode afetar o desenvolvimento de DA por meio de efeitos imunomodeladores&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">13</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">Este estudo tem algumas limita&#231;&#245;es&#46; Primeiramente&#44; a exposi&#231;&#227;o a mofo foi determinada por meio de um question&#225;rio do estudo de coorte de nascimento prospectivo &#40;Cocoa&#41;&#46; Entretanto&#44; um estudo anterior demonstrou que determinar a exposi&#231;&#227;o ao mofo por meio de um question&#225;rio ou pela medi&#231;&#227;o do total de esporos encontrados no ar gera resultados semelhantes&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">29</span></a> Em segundo&#44; as an&#225;lises de microbiomas encontrados em ambiente domiciliar foram limitadas pelo pequeno tamanho da amostra&#59; contudo&#44; foi poss&#237;vel identificar uma associa&#231;&#227;o entre componentes espec&#237;ficos do microbioma e rea&#231;&#227;o al&#233;rgica&#46; O ponto forte do estudo &#233; sua qualifica&#231;&#227;o como estudo de coorte de nascimento prospectivo geral de base populacional&#46; Os dados ajudar&#227;o a determinar o papel da exposi&#231;&#227;o ao mofo no ambiente domiciliar durante per&#237;odos cr&#237;ticos no desenvolvimento de doen&#231;as al&#233;rgicas&#44; inclusive a DA&#46; Por fim&#44; a exposi&#231;&#227;o a mofo em ambiente domiciliar durante o per&#237;odo da gesta&#231;&#227;o est&#225; associada ao desenvolvimento de DA no in&#237;cio da vida&#44; possivelmente por meio da rea&#231;&#227;o al&#233;rgica mediada por IgE&#46; Portanto&#44; evitar ou limitar a exposi&#231;&#227;o ao mofo durante o per&#237;odo pr&#233;&#8208;natal pode ajudar a prevenir a DA na inf&#226;ncia&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Financiamento</span><p id="par0105" class="elsevierStylePara elsevierViewall">Este estudo foi financiado pelo projeto coreano de P&#38;D de tecnologia na &#225;rea da sa&#250;de do Minist&#233;rio da Sa&#250;de e Bem&#8208;Estar&#44; Coreia do Sul &#40;bolsa n&#176; HI13C16740000&#41;&#44; e pela Pesquisa do Centro de Controle e Preven&#231;&#227;o de Doen&#231;as da Coreia do Sul &#40;2008&#8208;E33030&#8208;00&#44; 2009&#8208;E33033&#8208;00&#44; 2011&#8208;E33021&#8208;00&#44; 2012&#8208;E33012&#8208;00&#44; 2013&#8208;E51003&#8208;00&#44; e 2014&#8208;E51004&#8208;00&#41;&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conflitos de interesse</span><p id="par0110" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflitos de interesse&#46;</p></span></span>"
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              "titulo" => "Amostragem e an&#225;lise de mofo dentro das casas"
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              "titulo" => "Medi&#231;&#227;o dos n&#237;veis s&#233;ricos totais de IgE"
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              "titulo" => "An&#225;lise de dados"
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              "titulo" => "Associa&#231;&#227;o entre exposi&#231;&#227;o a mofo e desenvolvimento de DA&#44; de acordo com o momento da exposi&#231;&#227;o"
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              "identificador" => "sec0050"
              "titulo" => "Caracter&#237;sticas dos rec&#233;m&#8208;nascidos e dados do microbioma"
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              "titulo" => "Compara&#231;&#227;o dos n&#237;veis s&#233;ricos totais de IgE no primeiro ano de vida"
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              "titulo" => "Compara&#231;&#227;o dos dados do microbioma entre neonatos com DA e os saud&#225;veis"
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    "fechaRecibido" => "2018-03-25"
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          "palabras" => array:6 [
            0 => "Allergic inflammation"
            1 => "Atopic dermatitis"
            2 => "Environment"
            3 => "Mold"
            4 => "Mycobiome"
            5 => "Prenatal"
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        ]
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          "palabras" => array:6 [
            0 => "Rea&#231;&#227;o al&#233;rgica"
            1 => "Dermatite at&#243;pica"
            2 => "Ambiente"
            3 => "Mofo"
            4 => "Microbioma"
            5 => "Pr&#233;&#8208;natal"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Mold exposure in early life may be associated with development of atopic dermatitis&#59; however&#44; studies of this link are inconclusive and evidence for the underlying mechanism&#40;s&#41; is lacking&#46; This study identified the association between the time of mold exposure and development of atopic dermatitis and investigated the underlying mechanisms&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The association between atopic dermatitis and mold exposure was examined in the Cohort for Childhood Origin of Asthma and Allergic Diseases birth cohort study &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1446&#41;&#46; Atopic dermatitis was diagnosed at 1 year of age by pediatric allergists&#46; Exposure to mold was assessed by questionnaire&#46; The Illumina MiSeq platform was used to examine the environmental mycobiome in 20 randomly selected healthy infants and 20 infants with atopic dermatitis at 36 weeks of gestation&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Prenatal&#44; but not postnatal&#44; mold exposure was significantly associated with atopic dermatitis &#40;adjusted odds ratio&#44; 1&#46;36&#59; 95&#37; confidence interval&#44; 1&#46;01-1&#46;83&#41;&#46; Levels of total serum IgE at 1 year of age were higher in infants with atopic dermatitis exposed to mold during pregnancy than in healthy infants not exposed to mold during pregnancy &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;021&#41;&#46; The relative abundance of uncultured Ascomycota was higher in infants with atopic dermatitis than in healthy infants&#46; The relative abundance of uncultured Ascomycota correlated with total serum IgE levels at 1 year of age &#40;<span class="elsevierStyleItalic">r</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;613&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Indoor mold exposure during the fetal period is associated with development of atopic dermatitis <span class="elsevierStyleItalic">via</span> IgE&#8208;mediated allergic inflammation&#46; Avoidance of mold exposure during this critical period might prevent the development of atopic dermatitis&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A exposi&#231;&#227;o ao mofo no in&#237;cio da vida pode estar associada ao desenvolvimento de dermatite at&#243;pica&#59; contudo&#44; os estudos sobre esse v&#237;nculo s&#227;o inconclusivos e faltam evid&#234;ncias dos mecanismos subjacentes&#46; Identificamos a associa&#231;&#227;o entre o momento da exposi&#231;&#227;o ao mofo e o desenvolvimento de dermatite at&#243;pica e investigamos os mecanismos subjacentes&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todo</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A associa&#231;&#227;o entre dermatite at&#243;pica e exposi&#231;&#227;o a mofo foi examinada em um estudo de coorte de nascimento da Origem da Asma e de Doen&#231;as Al&#233;rgicas em Crian&#231;as &#40;COCOA&#41; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1446&#41;&#46; A dermatite at&#243;pica foi diagnosticada em pacientes com um ano de vida por pediatras alergistas&#46; A exposi&#231;&#227;o ao mofo foi avaliada por um question&#225;rio&#46; A plataforma Illumina MiSeq foi utilizada para examinar o microbioma ambiental em 20 neonatos saud&#225;veis escolhidos aleatoriamente e 20 com dermatite at&#243;pica a 36 semanas de gesta&#231;&#227;o&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A exposi&#231;&#227;o pr&#233;&#8208;natal&#44; por&#233;m n&#227;o p&#243;s&#8208;natal&#44; ao mofo foi significativamente associada &#224; dermatite at&#243;pica &#40;raz&#227;o de chances ajustada&#44; 1&#44;36&#59; intervalo de confian&#231;a de 95&#37;&#44; 1&#44;01-1&#44;83&#41;&#46; Os n&#237;veis s&#233;ricos totais de Imunoglobulina E &#40;IgE&#41; no primeiro ano de vida foram maiores em neonatos com dermatite at&#243;pica expostos a mofo durante a gravidez do que em neonatos n&#227;o expostos a mofo durante a gravidez &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;021&#41;&#46; A abund&#226;ncia relativa de <span class="elsevierStyleItalic">Ascomycota</span> n&#227;o cultivado foi maior em neonatos com dermatite at&#243;pica do que em neonatos saud&#225;veis&#46; A abund&#226;ncia relativa de <span class="elsevierStyleItalic">Ascomycota</span> n&#227;o cultivado correlacionou&#8208;se com os n&#237;veis s&#233;ricos totais de IgE no primeiro ano de vida &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;613&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A exposi&#231;&#227;o ao mofo no ambiente domiciliar durante a gravidez est&#225; associada ao desenvolvimento de dermatite at&#243;pica por meio de rea&#231;&#227;o al&#233;rgica mediada por IgE&#46; A preven&#231;&#227;o &#224; exposi&#231;&#227;o ao mofo durante o per&#237;odo cr&#237;tico da gravidez pode prevenir o desenvolvimento de dermatite at&#243;pica&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0020">Como citar este artigo&#58; Lee E&#44; Choi KY&#44; Kang M&#8208;J&#44; Lee S&#8208;Y&#44; Yoon J&#44; Cho H&#8208;J&#44; et al&#46; Prenatal mold exposure is associated with development of atopic dermatitis in infants through allergic inflammation&#46; J Pediatr &#40;Rio J&#41;&#46; 2020&#59;96&#58;125&#8211;31&#46;</p>"
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vari&#225;vel&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">33&#44;04<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&#44;54&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1160 &#40;70&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">492 &#40;29&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">327 &#40;22&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Outono&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Inverno&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">445 &#40;30&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8804; Ensino M&#233;dio&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;5&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8804; Universidade&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1053 &#40;72&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#8805; P&#243;s&#8208;Gradua&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">316 &#40;21&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">G&#234;nero da crian&#231;a</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Menino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">685 &#40;47&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Menina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">761 &#40;52&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Idade gestacional &#40;semanas&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&#44;18<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;20&nbsp;\t\t\t\t\t\t\n
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          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Os dados s&#227;o apresentados em &#8220;n&#8221; ou &#8220;&#37;&#8221;&#46;DA&#44; dermatite at&#243;pica&#46;</p><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">A signific&#226;ncia em negrito significa que o risco de DA estava aumentado em lactentes com exposi&#231;&#227;o ao mofo durante o per&#237;odo pr&#233;&#8208;natal&#44; em compara&#231;&#227;o com aqueles sem exposi&#231;&#227;o ao mofo durante o mesmo per&#237;odo&#44; utilizando&#8208;se um modelo de regress&#227;o log&#237;stica&#46;</p>"
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">DA&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">DA&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Raz&#227;o de chances ajustada &#40;aOR&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&#40;Intervalo de confian&#231;a de 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">DA&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">aOR<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " rowspan="2" align="left" valign="\n
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                  \t\t\t\t">Durante a gravidez</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#40;&#8208;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">186&#47;1065 &#40;17&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">179&#47;1016 &#40;17&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">179&#47;1016 &#40;17&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;ref&#46;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#43;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">85&#47;381 &#40;22&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">1&#44;36 &#40;1&#44;02&#8211;1&#44;81&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#47;369 &#40;22&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">1&#44;36 &#40;1&#44;01&#8211;1&#44;83&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83&#47;369 &#40;22&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">1&#44;36 &#40;1&#44;01&#8211;1&#44;83&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Durante os primeiros 6 meses de vida</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#8208;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">187&#47;921 &#40;20&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">178&#47;871 &#40;20&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">178&#47;871 &#40;20&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;ref&#46;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;&#43;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#47;421 &#40;17&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;82 &#40;0&#44;61&#8211;1&#44;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#47;407 &#40;17&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;83 &#40;0&#44;61&#8211;1&#44;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&#47;407 &#40;17&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;83 &#40;0&#44;61&#8211;1&#44;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            0 => array:3 [
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            1 => array:3 [
              "identificador" => "tblfn0010"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Ajustada &#224; idade da m&#227;e&#44; ao &#237;ndice de massa corporal da m&#227;e&#44; ao n&#237;vel de escolaridade materna&#44; ao g&#234;nero da crian&#231;a&#44; ao hist&#243;rico de doen&#231;as al&#233;rgicas dos pais&#44; &#224; esta&#231;&#227;o do nascimento&#44; e &#224; exposi&#231;&#227;o pr&#233;&#8208;natal e p&#243;s&#8208;natal a mofo&#46;</p>"
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          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Associa&#231;&#227;o entre a exposi&#231;&#227;o a mofo e a DA relatada pelos pais e diagnosticada por um m&#233;dico no primeiro ano de vida&#44; de acordo com o momento da exposi&#231;&#227;o</p>"
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">DA&#44; dermatite at&#243;pica&#59; DP&#44; desvio padr&#227;o&#59; n&#44; n&#250;mero&#59; NA&#44; n&#227;o aplic&#225;vel&#59; Scorad&#44; Pontua&#231;&#227;o da Dermatite At&#243;pica&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Os n&#237;veis de eosin&#243;filos no sangue do cord&#227;o umbilical &#40;&#37;&#41; e os n&#237;veis s&#233;ricos log&#8208;transformados de IgE total no sangue do cord&#227;o umbilical estavam aumentados significativamente em lactentes com DA em compara&#231;&#227;o com lactentes saud&#225;veis e s&#227;o indicados em negrito&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vari&#225;vel&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Neonatos saud&#225;veis&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Neonatos com DA&#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> valor<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Idade gestacional &#40;semanas&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&#44;18<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">39&#44;53<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;339&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo masculino&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#47;20 &#40;50&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#47;20 &#40;60&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;525&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Peso ao nascer&#44; media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP &#40;g&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3088&#44;33<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>264&#44;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3043&#44;58<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>849&#44;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;832&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#205;ndice Scorad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>18&#44;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hist&#243;rico de doen&#231;as al&#233;rgicas dos pais &#91;sim&#44; n &#40;&#37;&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#47;20 &#40;60&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#47;19 &#40;63&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;839&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Eosin&#243;filos no sangue do cord&#227;o umbilical &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;53<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;20<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;011</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#237;vel s&#233;rico total de IgE no sangue do cord&#227;o umbilical transformado em logaritmo&#44; m&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP &#40;kUA&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;2&#44;02<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;1&#44;24<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#44;012</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#237;vel s&#233;rico total de IgE no primeiro ano de vida transformado em logaritmo&#44; m&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP &#40;kUA&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;11<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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