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        "descripcion" => array:1 [
          "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">N&#237;veis de 17&#8208;OHP de acordo com o gen&#243;tipo &#40;grupo de gravidade de muta&#231;&#227;o&#44; heterozigose e tipo selvagem&#41;&#59; A&#46; N&#237;veis de 17&#8208;OHP na amostra 1&#59; B&#46; N&#237;veis de 17&#8208;OHP na amostra 2&#46; Gen&#243;tipo &#40;1 &#61; Grupo Null&#59; 2 &#61; Grupo A&#59; 3 &#61; Grupo B&#59; 4 &#61; Grupo C&#59; 5 &#61; Heterozigoto&#59; 6 &#61; Tipo Selvagem&#41;&#46; <span class="elsevierStyleSup">a</span> p &#60; 0&#44;05 <span class="elsevierStyleItalic">versus</span> todos os outros grupos&#46; <span class="elsevierStyleSup">b</span> p &#60; 0&#44;05 <span class="elsevierStyleItalic">versus</span> grupo 1 e 2&#46; HAC&#44; hiperplasia adrenal cong&#234;nita&#59; 17&#8208;OHP&#44; 17&#8208;alfa&#8208;hidroxiprogesterona&#59; PS&#44; perdedora de sal&#59; VS&#44; virilizante simples&#59; HAC&#8208;C&#44; hiperplasia adrenal cong&#234;nita cl&#225;ssica&#59; NC&#44; n&#227;o cl&#225;ssica&#44; de in&#237;cio tardio&#59; WT&#44; tipo selvagem&#59; SPSS&#44; <span class="elsevierStyleItalic">Statistical Package for the Social Sciences</span>&#46;</p>"
        ]
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">A hiperplasia adrenal cong&#234;nita &#40;HAC&#41;&#44; doen&#231;a autoss&#244;mica recessiva&#44; &#233; caracterizada pelo comprometimento da s&#237;ntese metab&#243;lica de cortisol e aldosterona&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a> Ela &#233; causada por muta&#231;&#245;es no gene <span class="elsevierStyleItalic">CYP21A2</span> em aproximadamente 90&#37; de todos os casos&#44; leva &#224; defici&#234;ncia de 21&#8208;hidroxilase &#40;21&#8208;OH&#41; e causa ac&#250;mulo de precursores de androg&#234;nio&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">2</span></a> O principal marcador da doen&#231;a &#233; a 17&#8208;alfa&#8208;hidroxiprogesterona &#40;17&#8208;OHP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">2</span></a> Existem tr&#234;s formas cl&#237;nicas reconhecidas de HAC&#58; forma cl&#225;ssica perdedora de sal &#40;PS&#41;&#59; virilizante simples &#40;VS&#41;&#59; e a forma tardia&#44; denominada HAC n&#227;o cl&#225;ssica &#40;NC&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1&#44;3</span></a> O principal objetivo da triagem neonatal &#233; identificar rec&#233;m&#8208;nascidos em risco de serem acometidos pelas duas formas cl&#225;ssicas&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">4&#44;5</span></a> No entanto&#44; casos assintom&#225;ticos com n&#237;veis persistentemente elevados de 17&#8208;OHP na triagem neonatal s&#227;o suspeitos para HAC&#8208;NC e podem ser identificados por diagn&#243;stico molecular&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A incid&#234;ncia global de HAC descrita na literatura &#233; de 1&#58;15&#46;000 em rec&#233;m&#8208;nascidos vivos&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">4</span></a> A preval&#234;ncia de HAC&#8208;NC &#233; estimada em 1&#58;1&#46;000 indiv&#237;duos&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a> Em 2&#47;3 dos casos das formas cl&#225;ssicas&#44; a perda de sal afeta ambos os g&#234;neros e os sintomas come&#231;am na segunda semana de vida&#44; refor&#231;a a import&#226;ncia do diagn&#243;stico precoce&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">5</span></a> Nas meninas&#44; a exposi&#231;&#227;o excessiva ao androg&#234;nio intrauterino causa diferentes graus de viriliza&#231;&#227;o e ambiguidade genital&#44; conforme definido pela Escala de Prader&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">8</span></a> Aumentos na 17&#8208;OHP foram observados em rec&#233;m&#8208;nascidos sem HAC &#40;falso&#8208;positivos&#41; devido a situa&#231;&#245;es estressantes e parto prematuro&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#44;10</span></a> Por sua vez&#44; casos falsos negativos podem ocorrer como resultado do uso materno de corticosteroides no fim da gravidez&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">11&#44;12</span></a> Para minimizar o n&#250;mero de falso&#8208;positivos&#44; foram estabelecidos pontos de corte estratificados por categorias brasileiras e internacionais de peso ao nascer&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#8211;11</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">A an&#225;lise molecular do gene <span class="elsevierStyleItalic">CYP21A2</span> pode melhorar a especificidade da triagem neonatal e auxiliar no manejo cl&#237;nico da doen&#231;a&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">7&#44;13</span></a> As principais muta&#231;&#245;es do gene <span class="elsevierStyleItalic">CYP21A2</span> foram categorizadas em quatro grupos &#40;Null&#44; A&#44; B e C&#41;&#44; de acordo com a atividade enzim&#225;tica residual da 21&#8208;OH&#44; o que permite a determina&#231;&#227;o do fen&#243;tipo esperado&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">2&#44;6&#44;14&#44;15</span></a> Tanto o tipo Null quanto o A est&#227;o associados ao HAC&#8208;PS&#44; o grupo B ao HAC&#8208;VS e o grupo C ao HAC&#8208;NC&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">2&#44;6&#44;13&#8211;15</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">No Brasil&#44; Goi&#225;s&#44; Santa Catarina e S&#227;o Paulo acumularam mais de 10 anos de experi&#234;ncia em triagem de HAC neonatal&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#44;14&#44;16&#44;17</span></a> Assim&#44; os objetivos deste estudo foram&#58; 1&#41; descrever os resultados 24 meses ap&#243;s a triagem neonatal de HAC em um programa de sa&#250;de p&#250;blica no Sul do Brasil&#59; e 2&#41; avaliar os quadros cl&#237;nicos de casos confirmados e suspeitos de HAC&#44; al&#233;m da genotipagem molecular desses casos como uma ferramenta complementar para melhorar o diagn&#243;stico da HAC&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todos</span><p id="par0030" class="elsevierStylePara elsevierViewall">Foi feito um estudo transversal com rec&#233;m&#8208;nascidos inclu&#237;dos nos dois primeiros anos da implanta&#231;&#227;o do programa p&#250;blico de triagem de HAC no Estado do Rio Grande do Sul&#44; Brasil&#46; Foi revisado um banco de dados de beb&#234;s com suspeita de HAC&#44; baseado em valores alterados de 17&#8208;OHP a partir de uma triagem feita de 2014 a 2016&#46; A HAC cl&#225;ssica &#40;HAC&#8208;C&#41;&#44; PS e VS&#44; foi diagnosticada pelo aumento dos n&#237;veis de 17&#8208;OHP detectados na triagem&#44; confirmado por reteste e&#47;ou avalia&#231;&#227;o cl&#237;nica&#44; seguido por estudos genot&#237;picos&#46; As meninas afetadas apresentaram genit&#225;lia externa virilizada&#44; enquanto os meninos n&#227;o necessariamente apresentaram altera&#231;&#245;es genitais&#44; mas o aumento do p&#234;nis p&#244;de ser observado&#46; Os falsos positivos foram caracterizados por n&#237;veis mais baixos de 17&#8208;OHP no reteste e pelo gen&#243;tipo do tipo selvagem &#40;WT&#44; do ingl&#234;s <span class="elsevierStyleItalic">wild type</span>&#41;&#44; de acordo com a <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a>&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">18</span></a> Os dados relacionados &#224; distribui&#231;&#227;o dos gen&#243;tipos foram relatados recentemente&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">19</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">O protocolo do estudo foi aprovado pelo Comit&#234; de &#201;tica em Pesquisa do Hospital Materno&#8208;Infantil Presidente Vargas e pelo Comit&#234; de &#201;tica em Pesquisa da Funda&#231;&#227;o Estadual de Produ&#231;&#227;o e Pesquisa em Sa&#250;de &#40;n&#176; 341&#46;289&#47;8 de junho de 2013&#41;&#59; todos os pais assinaram o termo de consentimento livre e esclarecido&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Amostras de sangue seco foram obtidas com papel de filtro &#40;S&#38;S 903&#41; do 3&#176; ao 40&#176; dia do p&#243;s&#8208;natal&#46; O ensaio de imunofluoresc&#234;ncia <span class="elsevierStyleItalic">GSP de fase s&#243;lida &#40;time&#8208;resolved&#41;</span> &#40;kit Neonatal 17&#8208;OHP&#59; Perkin&#8208;Elmer&#44; Turku&#44; Finl&#226;ndia&#41; foi usado para medir a 17&#8208;OHP&#46; A <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> descreve a estrat&#233;gia do estudo&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#44;11&#44;18</span></a> Os rec&#233;m&#8208;nascidos submetidos ao uso de corticosteroides maternos no fim da gesta&#231;&#227;o&#44; conforme registrado em papel de filtro&#44; foram convocados para uma segunda coleta ap&#243;s 15 dias de vida&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">11&#44;12&#44;18</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A genotipagem foi feita conforme descrito anteriormente por Prado et al&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">19</span></a> em 132 indiv&#237;duos&#46; O ensaio SNaPshot foi usado para todos os indiv&#237;duos&#46; Esse ensaio analisou 12 muta&#231;&#245;es de ponto no gene <span class="elsevierStyleItalic">CYP21A2</span> &#40;p&#46;Gln319Ter&#44; p&#46;Arg357Trp&#44; p&#46;Leu308Phefs&#44; p&#46;Val237Glu&#44; IVS2&#8208;13A&#47;C&#62;G&#44; p&#46;Ile173Asn&#44; p&#46;Pro31Leu&#44; p&#46;Pro454Ser&#44; p&#46;Val282Leu&#44; p&#46;Gly111Valfs&#44; p&#46;Arg409Cys e p&#46;His63Leu&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">19&#8211;21</span></a> Para casos com suspeita cl&#237;nica e&#47;ou bioqu&#237;mica de HAC cl&#225;ssica&#44; mas nenhuma muta&#231;&#227;o identificada pela t&#233;cnica anterior&#44; um kit comercial de amplifica&#231;&#227;o multiplex de sondas dependente de liga&#231;&#227;o &#40;MLPA&#44; do ingl&#234;s <span class="elsevierStyleItalic">Multiplex Ligation&#8208;dependent Probe Amplification</span>&#41; com o kit SALSA MLPA probemix P050&#8208;C1 CAH &#40;MRC Holland&#44; Amsterd&#227;&#44; Holanda&#41; foi usado para detectar eventos de rearranjos&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Os resultados foram expressos como m&#233;dia &#43; desvio padr&#227;o &#40;DP&#41; ou frequ&#234;ncias &#40;&#37;&#41;&#46; As compara&#231;&#245;es entre os grupos foram analisadas por an&#225;lise de vari&#226;ncia &#40;Anova&#41; univariada seguida pelo teste de Tukey&#46; A an&#225;lise de covari&#226;ncia &#40;Ancova&#41; foi usada para ajustes de 17&#8208;OHP por peso ao nascer e os dados foram expressos como m&#233;dia &#43; erro padr&#227;o da m&#233;dia &#40;EPM&#41;&#46; Uma correla&#231;&#227;o parcial foi estimada entre 17&#8208;OHP e eletr&#243;litos&#46; As an&#225;lises foram feitas com o programa SPSS &#40;PASW Estat&#237;stica para Windows&#44; Vers&#227;o 18&#46;0&#46; Chicago&#44; EUA&#41;&#46; Os dados foram considerados significativos quando p &#60; 0&#44;05&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="par0055" class="elsevierStylePara elsevierViewall">De 217&#46;965 amostras obtidas na triagem de dois anos&#44; 15 casos de HAC&#8208;C foram diagnosticados&#44; com uma incid&#234;ncia estimada de 1&#58;14&#46;531&#46; Nove rec&#233;m&#8208;nascidos eram do sexo feminino e seis do masculino e 80&#37; &#40;n &#61; 12&#41; foram clinicamente caracterizados como pacientes com HAC&#8208;PS e o restante como pacientes com a forma VS&#46; De acordo com nossos dados publicados anteriormente&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">18</span></a> 70&#8208;80&#37; da primeira amostra tinham sido coletados entre tr&#234;s e sete dias de vida e esse achado foi semelhante ao HAC&#8208;C &#91;mediana 5 &#40;2&#44;0 a 38&#44;0&#41; dias&#93;&#46; A maioria das amostras de reteste foi coletada em torno da segunda ou terceira semana de vida &#91;mediana 17 &#40;14&#44;0&#8208;21&#44;0&#41; dias&#93;&#44; semelhantemente &#224; HAC&#8208;C &#91;mediana 19 &#40;8&#44;0&#8211;51&#44;0&#41; dias&#93;&#46; A <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> descreve os dados cl&#237;nicos&#44; os valores de 17&#8208;OHP e eletr&#243;litos e a avalia&#231;&#227;o fenot&#237;pica&#8208;genot&#237;pica desses casos&#46; Tr&#234;s meninas &#40;casos 3&#44; 5 e 11&#41; apresentaram viriliza&#231;&#227;o leve &#40;classifica&#231;&#227;o de Prader I&#41; e n&#227;o foram caracterizadas clinicamente como portadoras de clitoromegalia antes da triagem da HAC&#46; Outra menina &#40;caso 2&#41; foi designada como um menino e a outra &#40;caso 10&#41; foi registrada com um nome neutro&#44; adequado para os dois sexos&#44; devido &#224; ambiguidade genital&#46; Nas outras quatro meninas &#40;casos 4&#44; 12&#44; 13 e 14&#41;&#44; a ambiguidade genital foi identificada&#44; mas a HAC n&#227;o foi diagnosticada antes da triagem&#46; Entre os meninos&#44; os casos 6 e 15 apresentaram aumento do p&#234;nis e os outros quatro tinham genit&#225;lia masculina normal&#46; Dez dos 15 casos &#40;66&#44;6&#37;&#41; nasceram com peso &#62; 2&#46;500<span class="elsevierStyleHsp" style=""></span>g e nenhum caso pesava &#60; 2&#46;000<span class="elsevierStyleHsp" style=""></span>g&#46; As m&#227;es de tr&#234;s casos &#40;5&#44; 8 e 10&#41; usavam glicocorticoides no fim de suas gesta&#231;&#245;es&#46; Em dois casos&#44; foi observado um aumento l&#237;quido nos n&#237;veis de 17&#8208;OHP na segunda amostra&#46; Em um terceiro lactente &#40;caso 8&#41;&#44; o in&#237;cio da corticoterapia por perda de sal antecedeu a possibilidade de obten&#231;&#227;o de uma segunda amostra&#46; Quatro beb&#234;s &#40;26&#44;6&#37;&#41; tinham pais consangu&#237;neos&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> tamb&#233;m descreve o perfil cl&#237;nico&#44; os valores de 17&#8208;OHP e a avalia&#231;&#227;o do fen&#243;tipo&#8208;gen&#243;tipo dos casos de HAC&#8208;NC e heterozigotos que foram detectados durante a triagem&#46; Apenas um paciente heterozigoto &#40;caso 31&#41; apresentou baixo peso ao nascer relacionado &#224; prematuridade extrema e valor aumentado de 17&#8208;OHP na segunda amostra&#44; associado &#224; pioria cl&#237;nica na unidade intensiva neonatal&#46; Esse paciente foi acompanhado em um hospital terci&#225;rio distante do centro de triagem&#46; Foram relatados valores eletrol&#237;ticos normais sem qualquer outro sinal cl&#237;nico de HAC por esse hospital&#46; Uma terceira amostra foi coletada ap&#243;s melhoria cl&#237;nica e mostrou uma diminui&#231;&#227;o consider&#225;vel de 17&#8208;OHP &#40;17 ng&#47;mL&#41;&#46; Nesse paciente&#44; o gen&#243;tipo foi crucial para a elucida&#231;&#227;o do diagn&#243;stico&#46; Outros tr&#234;s pacientes com HAC&#8208;NC &#40;16&#44; 17 e 22&#41; apresentaram valores maiores de 17&#8208;OHP na segunda amostra e um hist&#243;rico de uso de corticosteroide pela m&#227;e&#46; N&#227;o foram observadas hiponatremia e hipercalemia nos casos de HAC&#8208;NC e heterozigotos&#46; Entre os casos iniciais suspeitos de HAC&#44; um paciente com hiperpigmenta&#231;&#227;o genital transit&#243;ria &#40;paciente 16&#41; foi diagnosticado como HAC&#8208;NC e tr&#234;s meninas com clitoromegalia transit&#243;ria foram posteriormente identificadas como casos heterozigotos&#46; Nesses casos&#44; a regress&#227;o espont&#226;nea da clitoromegalia foi observada durante o seguimento at&#233; os primeiros seis meses de vida&#46; A consanguinidade dos pais foi encontrada em dois &#40;14&#44;3&#37;&#41; dos pacientes heterozigotos&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> mostra a distribui&#231;&#227;o dos gen&#243;tipos de acordo com os grupos de atividade enzim&#225;tica &#40;Null&#44; A&#44; B e C&#41; e heterozigosidade na popula&#231;&#227;o de rec&#233;m&#8208;nascidos&#46; A concord&#226;ncia gen&#243;tipo&#8208;fen&#243;tipo foi observada em 13 casos de HAC&#8208;C &#40;86&#44;6&#37;&#41;&#46; A muta&#231;&#227;o IVS2&#8208;13A&#47;C&#62;G foi a mais frequente &#40;33&#37; em homozigose e 20&#37; em heterozigosidade composta&#41;&#44; seguida pela p&#46;Ile173Asn&#44; dele&#231;&#227;o e convers&#227;o g&#234;nica&#44; cada uma observada em 20&#37; dos casos de HAC&#8208;C&#46; Sete pacientes apresentaram muta&#231;&#245;es n&#227;o cl&#225;ssicas &#40;grupo C&#41; e os outros 14 pacientes heterozigotos tiveram o alelo WT detectado durante a triagem neonatal&#46; Na amostra total&#44; a muta&#231;&#227;o p&#46;Val282Leu foi a mais frequente nos pacientes com HAC&#8208;NC &#40;57&#37; heterozigotos e 28&#44;5&#37; homozigotos&#41; e tamb&#233;m em seis pacientes heterozigotos &#40;43&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46; Um novo alelo IVS2&#8208;13A&#47;C&#62;T foi descrito por Prado et al&#46; em uma menina heterozigota nascida a termo com peso ao nascer de 2&#46;905<span class="elsevierStyleHsp" style=""></span>g &#40;amostra 1&#58; 17 OHP 18&#44;2 ng&#47;mL e amostra 2&#58; 35&#44;0 ng&#47;mL&#41; e em um menino prematuro tardio com peso de nascimento de 2&#46;540<span class="elsevierStyleHsp" style=""></span>g &#40;amostra 1&#58; 17&#8208;OHP 25&#44;3 ng&#47;mL e amostra 2&#58; 15&#44;9 ng&#47;mL&#41; com triagem positiva&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">19</span></a> Surpreendentemente&#44; a clitoromegalia identificada na menina durante o primeiro exame foi resolvida espontaneamente durante o per&#237;odo de seguimento&#46; Ambos apresentaram perfil eletrol&#237;tico normal e n&#227;o tinham quaisquer outros sintomas associados &#224; HAC durante o seguimento de seis meses&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Os n&#237;veis de 17&#8208;OHP&#44; ajustados para o peso ao nascer&#44; foram analisados de acordo com os grupos &#40;1 &#61; HAC&#8208;C&#59; 2 &#61; HAC&#8208;NC&#59; 3 &#61; heterozigoto&#59; 4 &#61; WT&#41; nas amostras 1 e 2 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>A e B&#44; respectivamente&#41;&#46; Foram observados n&#237;veis significativamente mais altos de 17&#8208;OHP na HAC&#8208;C em compara&#231;&#227;o com outros grupos nas amostras 1 e 2&#46; A <a class="elsevierStyleCrossRef" href="#fig0015">figura 3</a> mostra os n&#237;veis de 17&#8208;OHP&#44; ajustados para o peso ao nascer&#44; nas amostras 1 e 2&#44; classificados de acordo com os grupos de muta&#231;&#227;o&#46; Na amostra 1&#44; indiv&#237;duos com grupos de muta&#231;&#227;o Null e A apresentaram n&#237;veis significativamente mais altos de 17&#8208;OHP e na amostra 2&#44; os grupos de muta&#231;&#227;o Null&#44; A e B mantiveram n&#237;veis mais altos de 17&#8208;OHP&#44; os quais foram estatisticamente diferentes do grupo C &#40;HAC&#8208;NC&#41;&#44; heterozigotos e pacientes WT&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> tamb&#233;m mostra os valores eletrol&#237;ticos nos diferentes grupos&#46; Os casos de HAC&#8208;C apresentaram n&#237;veis mais elevados de Na<span class="elsevierStyleSup">&#43;</span> e K<span class="elsevierStyleSup">&#43;</span>&#46; Foi encontrada uma forte correla&#231;&#227;o inversa entre o 17&#8208;OHP ajustado para o peso ao nascer e o Na<span class="elsevierStyleSup">&#43;</span> &#40;r &#61; &#8722;0&#44;795 para Amostra 1 de 17&#8208;OHP e r &#61; &#8722;0&#44;740&#44; para Amostra 2&#44; p &#60; 0&#44;05&#41; e uma correla&#231;&#227;o positiva com K<span class="elsevierStyleSup">&#43;</span> &#40;r &#61; 0&#44;494 para Amostra 1 de 17&#8208;OHP e r &#61; 0&#44;531 para Amostra 2&#44; p &#60;0&#44;05&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discuss&#227;o</span><p id="par0080" class="elsevierStylePara elsevierViewall">No presente estudo&#44; o programa de triagem neonatal de dois anos da HAC que usou n&#237;veis significativamente mais altos do marcador&#44; a 17&#8208;OHP&#44; permitiu de maneira adequada o diagn&#243;stico de 15 rec&#233;m&#8208;nascidos com HAC cl&#225;ssica&#46; Al&#233;m disso&#44; o reteste foi bem discriminado entre os casos e a gravidade da doen&#231;a apresentou concord&#226;ncia com a investiga&#231;&#227;o do gen&#243;tipo correspondente&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">O programa de triagem foi altamente eficaz na detec&#231;&#227;o de alguns casos que n&#227;o seriam clinicamente reconhecidos antes da triagem&#46; Nesse sentido&#44; atipias genitais leves &#40;casos 3&#44; 4 e 11&#41; e aumento do tamanho do p&#234;nis em meninos &#40;casos 6 e 15&#41; n&#227;o foram detectados antes da avalia&#231;&#227;o especializada&#46; Mesmo naqueles com genit&#225;lia amb&#237;gua&#44; a HAC n&#227;o foi diagnosticada antes da triagem&#44; a designa&#231;&#227;o sexual incorreta foi feita em dois casos &#40;2 e 10&#41;&#46; De fato&#44; observamos que mais de 50&#37; das meninas tiveram uma avalia&#231;&#227;o cl&#237;nica incorreta das caracter&#237;sticas de viriliza&#231;&#227;o&#44; o que foi identificado de maneira similar em estudos anteriores&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#44;15&#44;22</span></a> Isso refor&#231;a a import&#226;ncia da triagem neonatal universal para hiperplasia no Brasil&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Em rela&#231;&#227;o &#224; grande diferen&#231;a observada nos valores de corte de 17&#8208;OHP usados para as categorias de peso ao nascer&#44;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#44;11</span></a> &#233; importante observar que os lactentes das categorias de menor peso s&#227;o comumente internados em unidades de terapia intensiva e continuamente monitorados&#44; inclusive para dist&#250;rbios eletrol&#237;ticos&#46; De fato&#44; como observado anteriormente durante o primeiro ano de triagem&#44; a maioria dos falso&#8208;positivos era de rec&#233;m&#8208;nascidos com peso &#60; 2&#46;000<span class="elsevierStyleHsp" style=""></span>g&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">18</span></a> Uma segunda amostra que mostrou n&#237;veis mais baixos de 17&#8208;OHP em casos assintom&#225;ticos &#233; geralmente suficiente para elucidar os casos falso&#8208;positivos&#44; especialmente em beb&#234;s prematuros e rec&#233;m&#8208;nascidos de baixo peso&#46; Al&#233;m disso&#44; como relatado anteriormente&#44; as taxas de consanguinidade s&#227;o maiores entre os casos de HAC&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">18&#44;23</span></a> Dessa forma&#44; essa informa&#231;&#227;o adicional pode ser &#250;til para distinguir os casos reais dos casos falso&#8208;positivos&#46; Da mesma forma&#44; informa&#231;&#245;es sobre o uso de corticoide pela m&#227;e no fim da gesta&#231;&#227;o s&#227;o relevantes&#46; Nesse caso&#44; a coleta de uma segunda amostra ap&#243;s 15 dias de vida do rec&#233;m&#8208;nascido ajuda a diagnosticar casos como o do paciente 11&#44; que apresentou viriliza&#231;&#227;o leve n&#227;o reconhecida anteriormente e posterior desenvolvimento da HAC&#8208;PS&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">22</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Altos n&#237;veis de 17&#8208;OHP podem estar presentes em rec&#233;m&#8208;nascidos prematuros e criticamente doentes&#44; o que refor&#231;a a triagem estratificada pelo peso ao nascer&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#8211;11</span></a> Al&#233;m disso&#44; o gen&#243;tipo foi recomendado para melhorar o diagn&#243;stico da precis&#227;o da triagem neonatal&#46; Ele ajuda a diferenciar os casos reais de falso&#8208;positivos&#44; esclarece casos lim&#237;trofes e&#44; eventualmente&#44; permite que portadores de HAC&#8208;NC sejam diagnosticados&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">7&#44;13&#44;15</span></a> Nos casos confirmados&#44; valores elevados de 17&#8208;OHP corresponderam &#224; gravidade de cada grupo genot&#237;pico&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">14&#44;15&#44;22</span></a> Curiosamente&#44; quando os n&#237;veis de 17&#8208;OHP foram estratificados de acordo com a gravidade do grupo de muta&#231;&#245;es na segunda amostra&#44; foi observada uma melhor diferencia&#231;&#227;o das formas VS &#40;muta&#231;&#245;es do grupo B&#41; da HAC&#8208;NC &#40;muta&#231;&#245;es do grupo C&#41;&#44; heterozigotos e WT &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">figs&#46; 2 e 3</a>&#41;&#46; Esses tr&#234;s &#250;ltimos grupos apresentam n&#237;veis de 17&#8208;OHP significativamente menores&#44; o que justifica a estrat&#233;gia de retestar esses pacientes e&#44; quando ainda houver d&#250;vidas&#44; fazer a an&#225;lise do gen&#243;tipo&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">22</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">A efic&#225;cia do programa de triagem tamb&#233;m pode ser demonstrada quando formas graves&#44; como portadores de muta&#231;&#245;es do grupo Null&#44; s&#227;o identificadas&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">15</span></a> Dele&#231;&#227;o e grandes convers&#245;es g&#234;nicas que caracterizaram o grupo Null foram observadas em 20&#37; da nossa amostra&#44; o que est&#225; de acordo com um recente e grande estudo de correla&#231;&#227;o gen&#243;tipo&#8208;fen&#243;tipo&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">24</span></a> O grupo de muta&#231;&#245;es Null em homozigose foi observado em 26&#44;67&#37; de nossa amostra &#40;4&#47;15 pacientes&#41; e nos grupos Null e A em heterozigose composta&#44; o que caracterizou a HAC&#8208;PS&#44; em outros tr&#234;s pacientes&#46; No paciente 11&#44; n&#227;o houve correla&#231;&#245;es fen&#243;tipo&#8208;gen&#243;tipo claras como resultado da manifesta&#231;&#227;o de um fen&#243;tipo de HAC&#8208;PS leve&#46; Quando as muta&#231;&#245;es dos grupos Null e B est&#227;o em heterozigose composta&#44; inclusive a p&#46;Ile173Asn em um alelo&#44; a HAC&#8208;VS &#233; esperada na maioria dos casos&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">6&#44;15</span></a> Essa observa&#231;&#227;o foi relatada por outros grupos&#44;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">24&#44;25</span></a> inclusive uma associa&#231;&#227;o muito rara da muta&#231;&#227;o p&#46;Ile173Asn com uma HAC&#8208;NC&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">24</span></a> A HAC&#8208;PS associada &#224; p&#46;Ile173Asn &#233; mais comum quando uma segunda muta&#231;&#227;o mais grave est&#225; associada em heterozigosidade&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">25&#44;26</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">No Brasil&#44; um estudo de Bachega et al&#46; determinou a frequ&#234;ncia de muta&#231;&#245;es de ponto em 130 pacientes com HAC&#8208;C e HAC&#8208;NC e estabeleceu uma correla&#231;&#227;o gen&#243;tipo&#8208;fen&#243;tipo&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">27</span></a> As muta&#231;&#245;es mais frequentes foram a IVS2&#8208;13A&#47;C&#62;G&#44; em 55&#37; dos alelos dos pacientes com a forma PS&#44; a p&#46;Ile173Asn&#44; em 42&#37; das HAC&#8208;VS&#44; e a pVal282Leu&#44; em 70&#37; dos indiv&#237;duos com HAC&#8208;NC&#46; A frequ&#234;ncia da muta&#231;&#227;o IVS2&#8208;13A&#47;C&#62;G em nossa amostra n&#227;o foi&#44; portanto&#44; surpreendente para a popula&#231;&#227;o brasileira &#40;53&#37; em homo e&#47;ou heterozigose na HAC&#8208;C&#41;&#46; Em uma amostra brasileira de S&#227;o Paulo<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">14</span></a> e em um estudo de coorte maior na Argentina&#44; a IVS2&#8208;13A&#47;C&#62; G correspondeu a 21&#37; na frequ&#234;ncia al&#233;lica e a 20&#37; das muta&#231;&#245;es em homozigose&#44;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">28</span></a> respectivamente&#46; O Brasil e a Argentina &#40;AR&#41; apresentam taxas muito semelhantes dessa muta&#231;&#227;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">14&#44;28</span></a> O Estado do Rio Grande do Sul est&#225; pr&#243;ximo da AR e a popula&#231;&#227;o compartilha origens &#233;tnicas comuns&#46; Esse grupo tamb&#233;m descreve a associa&#231;&#227;o dos alelos IVS2&#8208;13A&#47;C&#62;G com as formas VS&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">8</span></a> o que pode explicar o fen&#243;tipo&#8208;gen&#243;tipo n&#227;o concordante no caso 32&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">A nova variante IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;T foi identificada em dois pacientes&#46; O alelo T foi observado nos casos em heterozigose com o alelo C benigno&#44; como descrito anteriormente&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">19</span></a> Como a paciente do sexo feminino apresentou clitoromegalia ao nascimento&#44; mesmo em casos heterozigotos&#44; esse achado n&#227;o pode ser negligenciado e requer estudos gen&#233;ticos adicionais&#46; A descri&#231;&#227;o dos tr&#234;s casos com clitoromegalia transit&#243;ria em nossa amostra &#233; digna de estudo adicional&#46; Tem sido relatado que alguns pacientes heterozigotos apresentaram n&#237;veis mais elevados de andr&#243;genos&#44; especialmente os portadores da muta&#231;&#227;o pVal282Leu com adrenarca precoce&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1&#44;29</span></a> Espera&#8208;se que os pacientes com HAC&#8208;NC e pacientes heterozigotos sejam assintom&#225;ticos ao nascimento&#44; mas nossa hip&#243;tese &#233; que poss&#237;veis eleva&#231;&#245;es androg&#234;nicas transit&#243;rias podem ocorrer&#46; Estudos futuros com vistas a esclarecer esse fen&#244;meno podem usar a genotipagem expandida pelo sequenciamento completo do gene <span class="elsevierStyleItalic">CYP21A2</span> para excluir outras muta&#231;&#245;es n&#227;o detectadas pelos ensaios SNaPshot e MLPA&#46; Em nossa amostra&#44; um melhor entendimento dessa nova variante pode fornecer informa&#231;&#245;es mais espec&#237;ficas&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Um dos pontos fortes deste estudo foi que os diagn&#243;sticos e exames de acompanhamento foram feitos pelo mesmo endocrinologista pedi&#225;trico&#46; Portanto&#44; a avalia&#231;&#227;o cl&#237;nica adequada dos pacientes feita neste estudo &#233; apropriada para a caracteriza&#231;&#227;o cl&#237;nica e molecular dessa amostra na triagem neonatal da HAC&#46; Outro ponto forte foi o fato de os dados terem sido coletados a partir de um programa de triagem populacional&#44; o que favoreceu a avalia&#231;&#227;o de um grande n&#250;mero de indiv&#237;duos&#46; Nesse contexto&#44; nosso estudo foi o primeiro programa de triagem neonatal&#47;genotipagem com o uso da metodologia SNaPshot&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">19</span></a> Essa estrat&#233;gia permite detectar simultaneamente as 12 muta&#231;&#245;es mais comumente associadas &#224; HAC de forma r&#225;pida e &#225;gil e agrega qualidade ao programa de triagem neonatal&#46; Esse grupo de muta&#231;&#245;es de ponto representa 89&#37; das muta&#231;&#245;es detectadas em nossa coorte do sul do Brasil&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">19</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Em conclus&#227;o&#44; os resultados deste estudo ressaltam a efic&#225;cia do programa de triagem na detec&#231;&#227;o de casos de HAC e na exclus&#227;o de casos suspeitos com base em pontos de corte dos n&#237;veis de 17&#8208;OHP ligados &#224; estratifica&#231;&#227;o pelo peso ao nascer&#46; Al&#233;m disso&#44; a coleta da segunda amostra&#44; seguida pela genotipagem das amostras suspeitas&#44; ajudou a diagnosticar adequadamente casos graves de HAC&#8208; PS&#47;VS e casos mais leves de VS&#44; al&#233;m de diferenciar entre casos de HAC&#8208;C e pacientes falsos positivos&#46; Os presentes resultados tamb&#233;m indicaram que a genotipagem &#233; uma ferramenta diagn&#243;stica valiosa e complementar para a triagem neonatal&#44; a qual fornece informa&#231;&#245;es sobre a gravidade da doen&#231;a&#44; permite o aconselhamento gen&#233;tico em casos graves e evita o tratamento excessivo da HAC&#8208;NC de in&#237;cio tardio e dos pacientes falsos positivos&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Financiamento</span><p id="par0125" class="elsevierStylePara elsevierViewall">Este trabalho foi financiado por bolsas de estudo do Instituto Nacional Brasileiro de Horm&#244;nios e Sa&#250;de da Mulher&#44; Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#91;CNPq INCT 573747&#47;2008&#8208;3&#93;&#44; do Sistema Nacional Brasileiro de Sa&#250;de P&#250;blica &#40;PPSUS&#41; e da Funda&#231;&#227;o de Amparo &#224; Pesquisa do Rio Grande do Sul &#40;Fapergs&#41;&#44; Porto Alegre&#44; Brasil&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflitos de interesse</span><p id="par0130" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflitos de interesse&#46;</p></span></span>"
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    "fechaRecibido" => "2017-04-30"
    "fechaAceptado" => "2018-03-12"
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            0 => "Congenital adrenal hyperplasia"
            1 => "Newborn screening"
            2 => "Clinical profile"
            3 => "Molecular diagnosis"
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            0 => "Hiperplasia adrenal cong&#234;nita"
            1 => "Triagem neonatal"
            2 => "Perfil cl&#237;nico"
            3 => "Diagn&#243;stico molecular"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To describe the results obtained in a neonatal screening program after its implementation and to assess the clinical and molecular profiles of confirmed and suspicious congenital adrenal hyperplasia cases&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A cross-sectional study was conducted&#46; Newborns with suspected disease due to high 17-hydroxyprogesterone levels and adjusted for birth weight were selected&#46; Classical congenital adrenal hyperplasia &#40;salt-wasting and simple virilizing forms&#41; was diagnosed by an increase in 17-hydroxyprogesterone levels as confirmed in the retest&#44; clinical evaluation&#44; and genotype determined by SNaPshot and multiplex ligation-dependent probe amplification&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">After 24 months&#44; 15 classic congenital adrenal hyperplasia cases were diagnosed in a total of 217&#44;965 newborns&#44; with an estimated incidence of 1&#58;14&#44;531&#46; From 132 patients&#44; seven non-classical and 14 heterozygous patients were screened for <span class="elsevierStyleItalic">CYP21A2</span> mutations&#44; and 96 patients presented false positives with wild type <span class="elsevierStyleItalic">CYP21A2</span>&#46; On retest&#44; increased 17-hydroxyprogesterone levels were found in classical congenital adrenal hyperplasia patients and showed significant correlation with genotype-related classical genital adrenal hyperplasia&#46; The most frequent mutations were IVS2-13A&#47;C&#62;G followed by gene deletion or rearrangement events in the classical form&#46; In non-classical and heterozygous diseases&#44; p&#46;Val282Leu was the most common mutation&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The results underscore the effectiveness of congenital adrenal hyperplasia neonatal screening in the public health system and indicate that the adopted strategy was appropriate&#46; The second sample collection along with genotyping of suspected cases helped to properly diagnose both severe and milder cases and delineate them from false positive patients&#46;</p></span>"
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      "pt" => array:3 [
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Descrever os resultados obtidos em um programa de triagem neonatal ap&#243;s sua implementa&#231;&#227;o e avaliar os perfis cl&#237;nicos e moleculares de casos confirmados e suspeitos de hiperplasia adrenal cong&#234;nita&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Foi feito um estudo transversal&#46; Rec&#233;m-nascidos com suspeita da doen&#231;a devido aos altos n&#237;veis de 17-alfa-hidroxiprogesterona e ajustados pelo peso ao nascer foram selecionados&#46; A hiperplasia adrenal cong&#234;nita cl&#225;ssica &#40;forma perdedora de sal e forma virilizante simples&#41; foi diagnosticada por um aumento nos n&#237;veis de 17-alfa-hidroxiprogesterona confirmado no reteste&#44; avalia&#231;&#227;o cl&#237;nica e gen&#243;tipo determinado com o uso do ensaio <span class="elsevierStyleItalic">SNaPshot</span> e amplifica&#231;&#227;o multiplex de sondas dependente de liga&#231;&#227;o&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Ap&#243;s 24 meses&#44; 15 casos cl&#225;ssicos de hiperplasia adrenal cong&#234;nita foram diagnosticados em 217&#46;965 rec&#233;m-nascidos&#44; com uma incid&#234;ncia estimada de 1&#58;14&#46;531&#46; De 132 pacientes&#44; sete n&#227;o cl&#225;ssicos e 14 heterozigotos foram submetidos &#224; triagem para muta&#231;&#245;es no gene <span class="elsevierStyleItalic">CYP21A2</span> e 96 pacientes apresentaram resultados falso&#8208;positivos com <span class="elsevierStyleItalic">CYP21A2</span> do tipo selvagem&#46; No reteste&#44; n&#237;veis aumentados de 17-alfa-hidroxiprogesterona foram encontrados em pacientes com hiperplasia adrenal cong&#234;nita cl&#225;ssica e mostraram correla&#231;&#227;o significativa com HAC cl&#225;ssica relacionada ao gen&#243;tipo&#46; As muta&#231;&#245;es mais frequentes foram IVS2-13A&#47;C&#62;G&#44; seguidas de dele&#231;&#227;o g&#234;nica ou eventos de rearranjo na forma cl&#225;ssica&#46; Em casos de doen&#231;as n&#227;o cl&#225;ssicas e heterozigose&#44; a muta&#231;&#227;o p&#46;Val282Leu foi a mais comum&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#245;es</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Os resultados ressaltam a efic&#225;cia da triagem neonatal para a hiperplasia adrenal cong&#234;nita no sistema p&#250;blico de sa&#250;de e indicam que a estrat&#233;gia adotada foi adequada&#46; A segunda coleta de amostras&#44; juntamente com a genotipagem dos casos suspeitos&#44; ajudou a diagnosticar adequadamente os casos graves e mais leves e diferenci&#225;-los de pacientes com resultado falso-positivo&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
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          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
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          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclus&#245;es"
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        ]
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0045">Como citar este artigo&#58; Kopacek C&#44; Prado MJ&#44; da Silva CM&#44; de Castro SM&#44; Beltr&#227;o LA&#44; Vargas PR&#44; et al&#46; Clinical and molecular profile of newborns with confirmed or suspicious congenital adrenal hyperplasia detected after a public screening program implementation&#46; J Pediatr &#40;Rio J&#41;&#46; 2019&#59;95&#58;282&#8211;90&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0050">Estudo feito no Servi&#231;o de Refer&#234;ncia em Triagem Neonatal &#40;centro de refer&#234;ncia para triagem neonatal do Sistema P&#250;blico de Sa&#250;de&#41; do Hospital Materno Infantil Presidente Vargas e no Centro de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#40;CDCT&#41;&#44; Porto Alegre&#44; RS&#44; Brasil&#46;</p>"
      ]
    ]
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      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
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            "Alto" => 1550
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Fluxograma da avalia&#231;&#227;o gen&#243;tipo&#8208;fen&#243;tipo da HAC&#46; 17 OHP&#44; 17&#8208;alfa&#8208;hidroxiprogesterona&#59; HAC&#44; hiperplasia adrenal cong&#234;nita&#46; Adaptado de Kopacek et al&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">18</span></a></p>"
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      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
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            "Alto" => 2284
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">N&#237;veis de 17&#8208;OHP nos quatro grupos &#40;HAC cl&#225;ssica&#44; HAC&#8208;NC&#44; heterozigoto e tipo selvagem&#41;&#46; Quatro grupos &#40;1 &#61; HAC cl&#225;ssica&#59; 2 &#61; HAC NC&#59; 3 &#61; heterozigoto&#59; 4 &#61; Tipo selvagem&#41;&#46; A&#44; N&#237;veis de 17&#8208;OHP na amostra 1&#59; B&#44; N&#237;veis de 17&#8208;OHP na amostra 2&#46; HAC&#44; hiperplasia adrenal cong&#234;nita&#59; NC&#44; n&#227;o cl&#225;ssica&#46; <span class="elsevierStyleSup">a</span> p &#60; 0&#44;05 <span class="elsevierStyleItalic">versus</span> todos os outros grupos&#46;</p>"
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      2 => array:7 [
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        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 2349
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            "Tamanyo" => 86019
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        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">N&#237;veis de 17&#8208;OHP de acordo com o gen&#243;tipo &#40;grupo de gravidade de muta&#231;&#227;o&#44; heterozigose e tipo selvagem&#41;&#59; A&#46; N&#237;veis de 17&#8208;OHP na amostra 1&#59; B&#46; N&#237;veis de 17&#8208;OHP na amostra 2&#46; Gen&#243;tipo &#40;1 &#61; Grupo Null&#59; 2 &#61; Grupo A&#59; 3 &#61; Grupo B&#59; 4 &#61; Grupo C&#59; 5 &#61; Heterozigoto&#59; 6 &#61; Tipo Selvagem&#41;&#46; <span class="elsevierStyleSup">a</span> p &#60; 0&#44;05 <span class="elsevierStyleItalic">versus</span> todos os outros grupos&#46; <span class="elsevierStyleSup">b</span> p &#60; 0&#44;05 <span class="elsevierStyleItalic">versus</span> grupo 1 e 2&#46; HAC&#44; hiperplasia adrenal cong&#234;nita&#59; 17&#8208;OHP&#44; 17&#8208;alfa&#8208;hidroxiprogesterona&#59; PS&#44; perdedora de sal&#59; VS&#44; virilizante simples&#59; HAC&#8208;C&#44; hiperplasia adrenal cong&#234;nita cl&#225;ssica&#59; NC&#44; n&#227;o cl&#225;ssica&#44; de in&#237;cio tardio&#59; WT&#44; tipo selvagem&#59; SPSS&#44; <span class="elsevierStyleItalic">Statistical Package for the Social Sciences</span>&#46;</p>"
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        "identificador" => "tbl0005"
        "etiqueta" => "Tabela 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabela "
            "rol" => "short"
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        "tabla" => array:3 [
          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">F&#44; sexo feminino&#59; HAC&#44; hiperplasia adrenal cong&#234;nita&#59; HT&#44; heterozigoto&#59; LGC&#44; <span class="elsevierStyleItalic">Large Gene Conversion</span>&#59; M&#44; sexo masculino&#59; NC&#44; n&#227;o cl&#225;ssica&#59; nd&#44; n&#227;o definido&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Paciente n&#176;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sexo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Peso &#40;g&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Uso de corticoide materno&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Consanguinidade&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">17 OHP&#40;ng&#47;mL&#41;Amostra 1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">17 OHP&#40;ng&#47;mL&#41;Amostra 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#91;NA<span class="elsevierStyleSup">&#43;</span>&#93;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">e</span></a> &#40;nmol&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#91;K<span class="elsevierStyleSup">&#43;</span>&#93;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">e</span></a> &#40;nmol&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Viriliza&#231;&#227;o&#47;Escala de Prader&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fen&#243;tipo HAC&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Gen&#243;tipo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Grupos de muta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Correla&#231;&#227;o fen&#243;tipo&#47;gen&#243;tipo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="16" align="left" valign="\n
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                  \t\t\t\t">HAC cl&#225;ssica</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;640&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">105&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">283&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5&#44;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C&#62;G &#47; IVS2&#8208;13A&#47;C&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">A&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;325&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">432&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">759&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">108&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Prader IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Del <span class="elsevierStyleItalic">CYP21A2</span> &#47; LGC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">null&#47;null&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;490&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">44&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C&#62;G &#47; IVS2&#8208;13A&#47;C&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">A&#47;A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">512&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Prader III&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Del 30Kb &#47; IVS&#8208;2&#8208;13A&#47;C&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">null&#47;A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Prader I&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">VS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Del <span class="elsevierStyleItalic">CYP21A2</span> &#47; p&#46;Ile173Asn&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">null&#47;B&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Aumento do p&#234;nis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Del <span class="elsevierStyleItalic">CYP21A2</span> &#47; Cluster E6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">109&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Del <span class="elsevierStyleItalic">CYP21A2</span> &#47; p&#46;Arg357Trp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">126&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C&#62;G &#47; IVS2&#8208;13A&#47;C&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">A&#47;A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;395&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">469&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">435&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">8&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C&#62;G &#47; LGC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">null&#47;A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;270&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">37&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">354&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">129&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;G &#47; IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">A&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;890&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">34&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">133&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LGC &#47; p&#46;Ile172Asn&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">null&#47;B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;580&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">459&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;G &#47; IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Prader IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter&#47; p&#46;Gln319Ter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">null&#47;null&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">125&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Leu308Phefs &#47; IVS2&#8208;13A&#47;C&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">null&#47;A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">131&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aumento do p&#234;nis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">20&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">289&#44;57<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a> &#40;&#177; 240&#44;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">331&#44;72<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a> &#40;&#177; 210&#44;37&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">125<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;30<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;10<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;01<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">HAC n&#227;o cl&#225;ssica</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;465&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; p&#46;Val281Leu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;340&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">136&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; p&#46;Val282Leu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;508&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">31&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">5&#44;00&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter &#47; p&#46;Val282Leu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;660&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">47&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Pro454Ser &#47; p&#46;Pro454Ser&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;988&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>p&#46;Arg357Trp<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>p&#46;Leu308Phefs &#47; p&#46;Val282Leu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;830&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;G &#47; p&#46;Val282Leu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;630&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;4<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Arg357Trp &#47; p&#46;Val282Leu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">m&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&#37; positivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;9173&#40;&#177; 0&#44;366&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;92 &#40;&#177; 13&#44;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#44;16 &#40;&#177; 16&#44;28&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">134&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " rowspan="15" align="left" valign="\n
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                  \t\t\t\t">Heterozigoto</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Arg357Trp &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">null&#47;WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">134&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">null&#47;WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;345&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#47;WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;570&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;34<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#47;WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;535&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">134&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">null&#47;WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">137&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Arg357Trp &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">null&#47;WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;550&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#47;WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;215&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127&#44;0<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">h</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clitoromegalia transit&#243;ria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suspeita de HAC<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">f</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clitoromegalia transit&#243;ria<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suspeita de HAC<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">f</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;T &#47; WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;20&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">139&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clitoromegalia transit&#243;ria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suspeita de HAC<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">f</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;T &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                    0 => array:2 [
                      "titulo" => "Genetics of congenital adrenal hyperplasia"
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                            0 => "N&#46; Krone"
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                        "tituloSerie" => "Best Pract Res Clin Endocrinol Metab"
                        "fecha" => "2009"
                        "volumen" => "23"
                        "paginaInicial" => "181"
                        "paginaFinal" => "192"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19500762"
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                          ]
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                    0 => array:2 [
                      "titulo" => "The molecular biology&#44; biochemistry&#44; and physiology of human steroidogenesis and its disorders"
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                    0 => array:2 [
                      "doi" => "10.1210/er.2010-0013"
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                        "tituloSerie" => "Endocr Rev"
                        "fecha" => "2011"
                        "volumen" => "32"
                        "paginaInicial" => "81"
                        "paginaFinal" => "151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21051590"
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                          ]
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                            5 => "M&#46;P&#46; Mello"
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                        "tituloSerie" => "Clin Genet"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19930153"
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                    0 => array:2 [
                      "titulo" => "Der Genitalbefund beim Pseudohermaphroditismus Femininus des kongenitalen Adrenogenitalen Syndromes"
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                            4 => "D&#46; Bonneau"
                            5 => "J&#46;M&#46; Limal"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000315959"
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                        "tituloSerie" => "Sex Dev"
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                        "volumen" => "4"
                        "paginaInicial" => "233"
                        "paginaFinal" => "248"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                ]
              ]
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              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular CYP21A2 diagnosis in 480 Brazilian 433 patients with congenital adrenal hyperplasia before newborn screening introduction"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "M&#46;C&#46; Miranda"
                            2 => "L&#46;G&#46; Gomes"
                            3 => "G&#46; Madureira"
                            4 => "J&#46;A&#46; Marcondes"
                            5 => "A&#46;E&#46; Billierbeck"
                          ]
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                      "doi" => "10.1530/EJE-16-0171"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Endocrinol"
                        "fecha" => "2016"
                        "volumen" => "175"
                        "paginaInicial" => "107"
                        "paginaFinal" => "116"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27185867"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
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              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biochemical and genetic diagnosis of 21&#8208;hydroxylase deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Falhammar"
                            1 => "A&#46; Wedell"
                            2 => "A&#46; Nordenstr&#246;m"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s12020-015-0731-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrine"
                        "fecha" => "2015"
                        "volumen" => "50"
                        "paginaInicial" => "306"
                        "paginaFinal" => "314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26336836"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The actual incidence of congenital adrenal hyperplasia in Brazil may not be as high as inferred&#58; an estimate based on a public neonatal screening program in the state of Goi&#225;s"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46;L&#46; Silveira"
                            1 => "E&#46;P&#46; dos Santos"
                            2 => "T&#46;A&#46; Bachega"
                            3 => "I&#46; van der Linden Nader"
                            4 => "J&#46;L&#46; Gross"
                            5 => "R&#46;H&#46; Elnecave"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Endocrinol Metab"
                        "fecha" => "2008"
                        "volumen" => "21"
                        "paginaInicial" => "455"
                        "paginaFinal" => "460"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18655527"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ten&#8208;year evaluation of a neonatal screening program for congenital adrenal hyperplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;L&#46; Nascimento"
                            1 => "A&#46;N&#46; Cristiano"
                            2 => "T&#46; Campos"
                            3 => "M&#46; Ohira"
                            4 => "E&#46; Cechinel"
                            5 => "G&#46; Simoni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arq Bras Endocrinol Metabol"
                        "fecha" => "2014"
                        "volumen" => "58"
                        "paginaInicial" => "765"
                        "paginaFinal" => "771"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25372587"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0235"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neonatal screening for congenital adrenal hyperplasia in Southern Brazil&#58; a population&#8208;based study with 108&#44;409 infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Kopacek"
                            1 => "S&#46;M&#46; Castro"
                            2 => "M&#46;J&#46; Prado"
                            3 => "C&#46;M&#46; Silva"
                            4 => "L&#46;A&#46; Beltr&#227;o"
                            5 => "P&#46;M&#46; Spritzer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/s12887-016-0772-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMC Pediatr"
                        "fecha" => "2017"
                        "volumen" => "17"
                        "paginaInicial" => "22"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28095810"
                            "web" => "Medline"
                          ]
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                          "pii" => "S0140673612616894"
                          "estado" => "S300"
                          "issn" => "01406736"
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                  ]
                ]
              ]
            ]
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              "identificador" => "bib0240"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of CYP21A2 genotyping assay with potential diagnosis of congenital adrenal hyperplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Prado"
                            1 => "S&#46;M&#46; de Castro"
                            2 => "C&#46; Kopacek"
                            3 => "M&#46;P&#46; de Mello"
                            4 => "T&#46; Rispoli"
                            5 => "T&#46; Grandi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Mol Diagn Ther"
                        "fecha" => "2017"
                        "volumen" => "21"
                        "paginaInicial" => "663"
                        "paginaFinal" => "675"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0245"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiplex minisequencing of the 21&#8208;hydroxylase gene as a rapid strategy to confirm 356 congenital adrenal hyperplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Krone"
                            1 => "A&#46; Braun"
                            2 => "S&#46; Weinert"
                            3 => "M&#46; Peter"
                            4 => "A&#46;A&#46; Roscher"
                            5 => "C&#46;J&#46; Partsch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chem"
                        "fecha" => "2002"
                        "volumen" => "48"
                        "paginaInicial" => "818"
                        "paginaFinal" => "825"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12028996"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibition of CYP21A2 enzyme activity caused by novel missense mutations identified in Brazilian and Scandinavian patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;C&#46; Soardi"
                            1 => "M&#46; Barbaro"
                            2 => "I&#46;F&#46; Lau"
                            3 => "S&#46;H&#46; Lemos-Marini"
                            4 => "M&#46;T&#46; Baptista"
                            5 => "G&#46; Guerra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2007-2594"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2008"
                        "volumen" => "93"
                        "paginaInicial" => "2416"
                        "paginaFinal" => "2420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18381579"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genotyping is a valuable diagnostic complement to neonatal screening for congenital adrenal hyperplasia due to steroid 21&#8208;hydroxylase deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Nordenstrom"
                            1 => "L&#46; Thilen"
                            2 => "L&#46; Hagenfeldt"
                            3 => "A&#46; Larsson"
                            4 => "A&#46; Wedell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.84.5.5651"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1999"
                        "volumen" => "84"
                        "paginaInicial" => "1505"
                        "paginaFinal" => "1509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10323369"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular analysis of the CYP21 gene and prenatal diagnosis in families with 21&#8208;hydroxylase deficiency in northeastern Iran"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Vakili"
                            1 => "A&#46; Baradaran-Heravi"
                            2 => "B&#46; Barid-Fatehi"
                            3 => "M&#46; Gholamin"
                            4 => "N&#46; Ghaemi"
                            5 => "M&#46;R&#46; Abbaszadegan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000084570"
                      "Revista" => array:6 [
                        "tituloSerie" => "Horm Res"
                        "fecha" => "2005"
                        "volumen" => "63"
                        "paginaInicial" => "119"
                        "paginaFinal" => "124"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15775714"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genotypephenotype correlation in 1&#44;507 families with congenital adrenal hyperplasia owing to 21&#8208;hydroxylase deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;I&#46; New"
                            1 => "M&#46; Abraham"
                            2 => "B&#46; Gonzalez"
                            3 => "M&#46; Dumic"
                            4 => "M&#46; Razzaghy-Azar"
                            5 => "D&#46; Chitayat"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1073/pnas.1300057110"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Natl Acad Sci U S A"
                        "fecha" => "2013"
                        "volumen" => "110"
                        "paginaInicial" => "2611"
                        "paginaFinal" => "2616"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23359698"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0270"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "S&#237;ndrome suprarrenogenital cong&#233;nito virilizante con mutaci&#243;n de novo I172N&#58; estudio de un nuevo caso"
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                        0 => array:2 [
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                            1 => "A&#46; Rodr&#237;guez Est&#233;vez"
                            2 => "E&#46; Gonz&#225;lez Molina"
                            3 => "M&#46; Mart&#237;nez Ayucar"
                            4 => "B&#46; Rodr&#237;guez P&#233;rez"
                            5 => "B&#46; Ezquieta Zubicaray"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
                        "fecha" => "2010"
                        "volumen" => "72"
                        "paginaInicial" => "72"
                        "paginaFinal" => "78"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Salt wasting in simple virilizing congenital adrenal hyperplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Frish"
                            1 => "T&#46; Battelino"
                            2 => "E&#46; Shober"
                            3 => "S&#46; Baumgartner-Parzer"
                            4 => "P&#46; Nowotny"
                            5 => "H&#46; Vierhapper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2001"
                        "volumen" => "14"
                        "paginaInicial" => "1649"
                        "paginaFinal" => "1655"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular genotyping in Brazilian patients 446 with the classical and nonclassical forms of 21&#8208;hydroxylase deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46;A&#46; Bachega"
                            1 => "A&#46;E&#46; Billerbeck"
                            2 => "G&#46; Madureira"
                            3 => "J&#46;A&#46; Marcondes"
                            4 => "C&#46;A&#46; Longui"
                            5 => "M&#46;V&#46; Leite"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jcem.83.12.5350"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1998"
                        "volumen" => "83"
                        "paginaInicial" => "4416"
                        "paginaFinal" => "4419"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9851787"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Steroid 21&#8208;hydroxylase gene mutational spectrum in 454 Argentinean patients&#58; genotype&#8208;phenotype correlation in a large cohort of patients with congenital adrenal hyperplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Marino"
                            1 => "P&#46; Ramirez"
                            2 => "J&#46; Galeano"
                            3 => "N&#46; Perez Garrido"
                            4 => "C&#46; Rocco"
                            5 => "M&#46; Ciaccio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Clin Endocrinol &#40;Oxf&#41;"
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                        "volumen" => "75"
                        "paginaInicial" => "427"
                        "paginaFinal" => "435"
                      ]
                    ]
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                ]
              ]
            ]
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              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic defects in the CYP21A2 gene in heterozygous girls with premature adrenarche and adolescent females with hyperandrogenemia"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "C&#46; Shammas"
                            2 => "A&#46;P&#46; Phedonos"
                            3 => "E&#46; Karaoli"
                            4 => "A&#46; Kyriakou"
                            5 => "M&#46; Toumba"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Georgian Med News"
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                        "paginaInicial" => "40"
                        "paginaFinal" => "47"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30829587"
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Artigo Original
Clinical and molecular profile of newborns with confirmed or suspicious congenital adrenal hyperplasia detected after a public screening program implementation☆☆
Perfil clínico e molecular de recém‐nascidos com suspeita ou confirmação de hiperplasia adrenal congênita após a implementação de um programa público de triagem neonatal
Cristiane Kopaceka,b,c,
Autor para correspondência
criskopacek@gmail.com

Autor para correspondência.
, Mayara J. Pradod,e, Claudia M.D. da Silvad, Simone M. de Castroa,f, Luciana A. Beltrãoa,c, Paula R. Vargasa, Tarciana Grandid, Maria L.R. Rossettid,e, Poli Mara Spritzerb,g
a Hospital Materno Infantil Presidente Vargas, Unidade de Triagem Neonatal, Laboratório de Triagem Neonatal, Porto Alegre, RS, Brasil
b Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós‐graduação em Endocrinologia, Porto Alegre, RS, Brasil
c Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brasil
d Secretaria Estadual da Saúde, Centro de Desenvolvimento Científico e Tecnológico (CDCT), Porto Alegre, RS, Brasil
e Universidade Federal do Rio Grande do Sul (UFRGS), Programa de Pós‐graduação em Biologia Celular e Molecular, Porto Alegre, RS, Brasil
f Universidade Federal do Rio Grande do Sul (UFRGS), Escola de Farmácia, Departamento de Análises, Porto Alegre, RS, Brasil
g Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Clínicas de Porto Alegre, Divisão de Endocrinologia, Unidade de Endocrinologia Ginecológica, Porto Alegre, RS, Brasil
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        "titulo" => "Perfil cl&#237;nico e molecular de rec&#233;m&#8208;nascidos com suspeita ou confirma&#231;&#227;o de hiperplasia adrenal cong&#234;nita ap&#243;s a implementa&#231;&#227;o de um programa p&#250;blico de triagem neonatal"
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          "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">N&#237;veis de 17&#8208;OHP de acordo com o gen&#243;tipo &#40;grupo de gravidade de muta&#231;&#227;o&#44; heterozigose e tipo selvagem&#41;&#59; A&#46; N&#237;veis de 17&#8208;OHP na amostra 1&#59; B&#46; N&#237;veis de 17&#8208;OHP na amostra 2&#46; Gen&#243;tipo &#40;1 &#61; Grupo Null&#59; 2 &#61; Grupo A&#59; 3 &#61; Grupo B&#59; 4 &#61; Grupo C&#59; 5 &#61; Heterozigoto&#59; 6 &#61; Tipo Selvagem&#41;&#46; <span class="elsevierStyleSup">a</span> p &#60; 0&#44;05 <span class="elsevierStyleItalic">versus</span> todos os outros grupos&#46; <span class="elsevierStyleSup">b</span> p &#60; 0&#44;05 <span class="elsevierStyleItalic">versus</span> grupo 1 e 2&#46; HAC&#44; hiperplasia adrenal cong&#234;nita&#59; 17&#8208;OHP&#44; 17&#8208;alfa&#8208;hidroxiprogesterona&#59; PS&#44; perdedora de sal&#59; VS&#44; virilizante simples&#59; HAC&#8208;C&#44; hiperplasia adrenal cong&#234;nita cl&#225;ssica&#59; NC&#44; n&#227;o cl&#225;ssica&#44; de in&#237;cio tardio&#59; WT&#44; tipo selvagem&#59; SPSS&#44; <span class="elsevierStyleItalic">Statistical Package for the Social Sciences</span>&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">A hiperplasia adrenal cong&#234;nita &#40;HAC&#41;&#44; doen&#231;a autoss&#244;mica recessiva&#44; &#233; caracterizada pelo comprometimento da s&#237;ntese metab&#243;lica de cortisol e aldosterona&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a> Ela &#233; causada por muta&#231;&#245;es no gene <span class="elsevierStyleItalic">CYP21A2</span> em aproximadamente 90&#37; de todos os casos&#44; leva &#224; defici&#234;ncia de 21&#8208;hidroxilase &#40;21&#8208;OH&#41; e causa ac&#250;mulo de precursores de androg&#234;nio&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">2</span></a> O principal marcador da doen&#231;a &#233; a 17&#8208;alfa&#8208;hidroxiprogesterona &#40;17&#8208;OHP&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">2</span></a> Existem tr&#234;s formas cl&#237;nicas reconhecidas de HAC&#58; forma cl&#225;ssica perdedora de sal &#40;PS&#41;&#59; virilizante simples &#40;VS&#41;&#59; e a forma tardia&#44; denominada HAC n&#227;o cl&#225;ssica &#40;NC&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1&#44;3</span></a> O principal objetivo da triagem neonatal &#233; identificar rec&#233;m&#8208;nascidos em risco de serem acometidos pelas duas formas cl&#225;ssicas&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">4&#44;5</span></a> No entanto&#44; casos assintom&#225;ticos com n&#237;veis persistentemente elevados de 17&#8208;OHP na triagem neonatal s&#227;o suspeitos para HAC&#8208;NC e podem ser identificados por diagn&#243;stico molecular&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">6&#44;7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">A incid&#234;ncia global de HAC descrita na literatura &#233; de 1&#58;15&#46;000 em rec&#233;m&#8208;nascidos vivos&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">4</span></a> A preval&#234;ncia de HAC&#8208;NC &#233; estimada em 1&#58;1&#46;000 indiv&#237;duos&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a> Em 2&#47;3 dos casos das formas cl&#225;ssicas&#44; a perda de sal afeta ambos os g&#234;neros e os sintomas come&#231;am na segunda semana de vida&#44; refor&#231;a a import&#226;ncia do diagn&#243;stico precoce&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">5</span></a> Nas meninas&#44; a exposi&#231;&#227;o excessiva ao androg&#234;nio intrauterino causa diferentes graus de viriliza&#231;&#227;o e ambiguidade genital&#44; conforme definido pela Escala de Prader&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">8</span></a> Aumentos na 17&#8208;OHP foram observados em rec&#233;m&#8208;nascidos sem HAC &#40;falso&#8208;positivos&#41; devido a situa&#231;&#245;es estressantes e parto prematuro&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#44;10</span></a> Por sua vez&#44; casos falsos negativos podem ocorrer como resultado do uso materno de corticosteroides no fim da gravidez&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">11&#44;12</span></a> Para minimizar o n&#250;mero de falso&#8208;positivos&#44; foram estabelecidos pontos de corte estratificados por categorias brasileiras e internacionais de peso ao nascer&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#8211;11</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">A an&#225;lise molecular do gene <span class="elsevierStyleItalic">CYP21A2</span> pode melhorar a especificidade da triagem neonatal e auxiliar no manejo cl&#237;nico da doen&#231;a&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">7&#44;13</span></a> As principais muta&#231;&#245;es do gene <span class="elsevierStyleItalic">CYP21A2</span> foram categorizadas em quatro grupos &#40;Null&#44; A&#44; B e C&#41;&#44; de acordo com a atividade enzim&#225;tica residual da 21&#8208;OH&#44; o que permite a determina&#231;&#227;o do fen&#243;tipo esperado&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">2&#44;6&#44;14&#44;15</span></a> Tanto o tipo Null quanto o A est&#227;o associados ao HAC&#8208;PS&#44; o grupo B ao HAC&#8208;VS e o grupo C ao HAC&#8208;NC&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">2&#44;6&#44;13&#8211;15</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">No Brasil&#44; Goi&#225;s&#44; Santa Catarina e S&#227;o Paulo acumularam mais de 10 anos de experi&#234;ncia em triagem de HAC neonatal&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#44;14&#44;16&#44;17</span></a> Assim&#44; os objetivos deste estudo foram&#58; 1&#41; descrever os resultados 24 meses ap&#243;s a triagem neonatal de HAC em um programa de sa&#250;de p&#250;blica no Sul do Brasil&#59; e 2&#41; avaliar os quadros cl&#237;nicos de casos confirmados e suspeitos de HAC&#44; al&#233;m da genotipagem molecular desses casos como uma ferramenta complementar para melhorar o diagn&#243;stico da HAC&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todos</span><p id="par0030" class="elsevierStylePara elsevierViewall">Foi feito um estudo transversal com rec&#233;m&#8208;nascidos inclu&#237;dos nos dois primeiros anos da implanta&#231;&#227;o do programa p&#250;blico de triagem de HAC no Estado do Rio Grande do Sul&#44; Brasil&#46; Foi revisado um banco de dados de beb&#234;s com suspeita de HAC&#44; baseado em valores alterados de 17&#8208;OHP a partir de uma triagem feita de 2014 a 2016&#46; A HAC cl&#225;ssica &#40;HAC&#8208;C&#41;&#44; PS e VS&#44; foi diagnosticada pelo aumento dos n&#237;veis de 17&#8208;OHP detectados na triagem&#44; confirmado por reteste e&#47;ou avalia&#231;&#227;o cl&#237;nica&#44; seguido por estudos genot&#237;picos&#46; As meninas afetadas apresentaram genit&#225;lia externa virilizada&#44; enquanto os meninos n&#227;o necessariamente apresentaram altera&#231;&#245;es genitais&#44; mas o aumento do p&#234;nis p&#244;de ser observado&#46; Os falsos positivos foram caracterizados por n&#237;veis mais baixos de 17&#8208;OHP no reteste e pelo gen&#243;tipo do tipo selvagem &#40;WT&#44; do ingl&#234;s <span class="elsevierStyleItalic">wild type</span>&#41;&#44; de acordo com a <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a>&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">18</span></a> Os dados relacionados &#224; distribui&#231;&#227;o dos gen&#243;tipos foram relatados recentemente&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">19</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">O protocolo do estudo foi aprovado pelo Comit&#234; de &#201;tica em Pesquisa do Hospital Materno&#8208;Infantil Presidente Vargas e pelo Comit&#234; de &#201;tica em Pesquisa da Funda&#231;&#227;o Estadual de Produ&#231;&#227;o e Pesquisa em Sa&#250;de &#40;n&#176; 341&#46;289&#47;8 de junho de 2013&#41;&#59; todos os pais assinaram o termo de consentimento livre e esclarecido&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Amostras de sangue seco foram obtidas com papel de filtro &#40;S&#38;S 903&#41; do 3&#176; ao 40&#176; dia do p&#243;s&#8208;natal&#46; O ensaio de imunofluoresc&#234;ncia <span class="elsevierStyleItalic">GSP de fase s&#243;lida &#40;time&#8208;resolved&#41;</span> &#40;kit Neonatal 17&#8208;OHP&#59; Perkin&#8208;Elmer&#44; Turku&#44; Finl&#226;ndia&#41; foi usado para medir a 17&#8208;OHP&#46; A <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a> descreve a estrat&#233;gia do estudo&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#44;11&#44;18</span></a> Os rec&#233;m&#8208;nascidos submetidos ao uso de corticosteroides maternos no fim da gesta&#231;&#227;o&#44; conforme registrado em papel de filtro&#44; foram convocados para uma segunda coleta ap&#243;s 15 dias de vida&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">11&#44;12&#44;18</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">A genotipagem foi feita conforme descrito anteriormente por Prado et al&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">19</span></a> em 132 indiv&#237;duos&#46; O ensaio SNaPshot foi usado para todos os indiv&#237;duos&#46; Esse ensaio analisou 12 muta&#231;&#245;es de ponto no gene <span class="elsevierStyleItalic">CYP21A2</span> &#40;p&#46;Gln319Ter&#44; p&#46;Arg357Trp&#44; p&#46;Leu308Phefs&#44; p&#46;Val237Glu&#44; IVS2&#8208;13A&#47;C&#62;G&#44; p&#46;Ile173Asn&#44; p&#46;Pro31Leu&#44; p&#46;Pro454Ser&#44; p&#46;Val282Leu&#44; p&#46;Gly111Valfs&#44; p&#46;Arg409Cys e p&#46;His63Leu&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">19&#8211;21</span></a> Para casos com suspeita cl&#237;nica e&#47;ou bioqu&#237;mica de HAC cl&#225;ssica&#44; mas nenhuma muta&#231;&#227;o identificada pela t&#233;cnica anterior&#44; um kit comercial de amplifica&#231;&#227;o multiplex de sondas dependente de liga&#231;&#227;o &#40;MLPA&#44; do ingl&#234;s <span class="elsevierStyleItalic">Multiplex Ligation&#8208;dependent Probe Amplification</span>&#41; com o kit SALSA MLPA probemix P050&#8208;C1 CAH &#40;MRC Holland&#44; Amsterd&#227;&#44; Holanda&#41; foi usado para detectar eventos de rearranjos&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Os resultados foram expressos como m&#233;dia &#43; desvio padr&#227;o &#40;DP&#41; ou frequ&#234;ncias &#40;&#37;&#41;&#46; As compara&#231;&#245;es entre os grupos foram analisadas por an&#225;lise de vari&#226;ncia &#40;Anova&#41; univariada seguida pelo teste de Tukey&#46; A an&#225;lise de covari&#226;ncia &#40;Ancova&#41; foi usada para ajustes de 17&#8208;OHP por peso ao nascer e os dados foram expressos como m&#233;dia &#43; erro padr&#227;o da m&#233;dia &#40;EPM&#41;&#46; Uma correla&#231;&#227;o parcial foi estimada entre 17&#8208;OHP e eletr&#243;litos&#46; As an&#225;lises foram feitas com o programa SPSS &#40;PASW Estat&#237;stica para Windows&#44; Vers&#227;o 18&#46;0&#46; Chicago&#44; EUA&#41;&#46; Os dados foram considerados significativos quando p &#60; 0&#44;05&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Resultados</span><p id="par0055" class="elsevierStylePara elsevierViewall">De 217&#46;965 amostras obtidas na triagem de dois anos&#44; 15 casos de HAC&#8208;C foram diagnosticados&#44; com uma incid&#234;ncia estimada de 1&#58;14&#46;531&#46; Nove rec&#233;m&#8208;nascidos eram do sexo feminino e seis do masculino e 80&#37; &#40;n &#61; 12&#41; foram clinicamente caracterizados como pacientes com HAC&#8208;PS e o restante como pacientes com a forma VS&#46; De acordo com nossos dados publicados anteriormente&#44;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">18</span></a> 70&#8208;80&#37; da primeira amostra tinham sido coletados entre tr&#234;s e sete dias de vida e esse achado foi semelhante ao HAC&#8208;C &#91;mediana 5 &#40;2&#44;0 a 38&#44;0&#41; dias&#93;&#46; A maioria das amostras de reteste foi coletada em torno da segunda ou terceira semana de vida &#91;mediana 17 &#40;14&#44;0&#8208;21&#44;0&#41; dias&#93;&#44; semelhantemente &#224; HAC&#8208;C &#91;mediana 19 &#40;8&#44;0&#8211;51&#44;0&#41; dias&#93;&#46; A <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> descreve os dados cl&#237;nicos&#44; os valores de 17&#8208;OHP e eletr&#243;litos e a avalia&#231;&#227;o fenot&#237;pica&#8208;genot&#237;pica desses casos&#46; Tr&#234;s meninas &#40;casos 3&#44; 5 e 11&#41; apresentaram viriliza&#231;&#227;o leve &#40;classifica&#231;&#227;o de Prader I&#41; e n&#227;o foram caracterizadas clinicamente como portadoras de clitoromegalia antes da triagem da HAC&#46; Outra menina &#40;caso 2&#41; foi designada como um menino e a outra &#40;caso 10&#41; foi registrada com um nome neutro&#44; adequado para os dois sexos&#44; devido &#224; ambiguidade genital&#46; Nas outras quatro meninas &#40;casos 4&#44; 12&#44; 13 e 14&#41;&#44; a ambiguidade genital foi identificada&#44; mas a HAC n&#227;o foi diagnosticada antes da triagem&#46; Entre os meninos&#44; os casos 6 e 15 apresentaram aumento do p&#234;nis e os outros quatro tinham genit&#225;lia masculina normal&#46; Dez dos 15 casos &#40;66&#44;6&#37;&#41; nasceram com peso &#62; 2&#46;500<span class="elsevierStyleHsp" style=""></span>g e nenhum caso pesava &#60; 2&#46;000<span class="elsevierStyleHsp" style=""></span>g&#46; As m&#227;es de tr&#234;s casos &#40;5&#44; 8 e 10&#41; usavam glicocorticoides no fim de suas gesta&#231;&#245;es&#46; Em dois casos&#44; foi observado um aumento l&#237;quido nos n&#237;veis de 17&#8208;OHP na segunda amostra&#46; Em um terceiro lactente &#40;caso 8&#41;&#44; o in&#237;cio da corticoterapia por perda de sal antecedeu a possibilidade de obten&#231;&#227;o de uma segunda amostra&#46; Quatro beb&#234;s &#40;26&#44;6&#37;&#41; tinham pais consangu&#237;neos&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> tamb&#233;m descreve o perfil cl&#237;nico&#44; os valores de 17&#8208;OHP e a avalia&#231;&#227;o do fen&#243;tipo&#8208;gen&#243;tipo dos casos de HAC&#8208;NC e heterozigotos que foram detectados durante a triagem&#46; Apenas um paciente heterozigoto &#40;caso 31&#41; apresentou baixo peso ao nascer relacionado &#224; prematuridade extrema e valor aumentado de 17&#8208;OHP na segunda amostra&#44; associado &#224; pioria cl&#237;nica na unidade intensiva neonatal&#46; Esse paciente foi acompanhado em um hospital terci&#225;rio distante do centro de triagem&#46; Foram relatados valores eletrol&#237;ticos normais sem qualquer outro sinal cl&#237;nico de HAC por esse hospital&#46; Uma terceira amostra foi coletada ap&#243;s melhoria cl&#237;nica e mostrou uma diminui&#231;&#227;o consider&#225;vel de 17&#8208;OHP &#40;17 ng&#47;mL&#41;&#46; Nesse paciente&#44; o gen&#243;tipo foi crucial para a elucida&#231;&#227;o do diagn&#243;stico&#46; Outros tr&#234;s pacientes com HAC&#8208;NC &#40;16&#44; 17 e 22&#41; apresentaram valores maiores de 17&#8208;OHP na segunda amostra e um hist&#243;rico de uso de corticosteroide pela m&#227;e&#46; N&#227;o foram observadas hiponatremia e hipercalemia nos casos de HAC&#8208;NC e heterozigotos&#46; Entre os casos iniciais suspeitos de HAC&#44; um paciente com hiperpigmenta&#231;&#227;o genital transit&#243;ria &#40;paciente 16&#41; foi diagnosticado como HAC&#8208;NC e tr&#234;s meninas com clitoromegalia transit&#243;ria foram posteriormente identificadas como casos heterozigotos&#46; Nesses casos&#44; a regress&#227;o espont&#226;nea da clitoromegalia foi observada durante o seguimento at&#233; os primeiros seis meses de vida&#46; A consanguinidade dos pais foi encontrada em dois &#40;14&#44;3&#37;&#41; dos pacientes heterozigotos&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> mostra a distribui&#231;&#227;o dos gen&#243;tipos de acordo com os grupos de atividade enzim&#225;tica &#40;Null&#44; A&#44; B e C&#41; e heterozigosidade na popula&#231;&#227;o de rec&#233;m&#8208;nascidos&#46; A concord&#226;ncia gen&#243;tipo&#8208;fen&#243;tipo foi observada em 13 casos de HAC&#8208;C &#40;86&#44;6&#37;&#41;&#46; A muta&#231;&#227;o IVS2&#8208;13A&#47;C&#62;G foi a mais frequente &#40;33&#37; em homozigose e 20&#37; em heterozigosidade composta&#41;&#44; seguida pela p&#46;Ile173Asn&#44; dele&#231;&#227;o e convers&#227;o g&#234;nica&#44; cada uma observada em 20&#37; dos casos de HAC&#8208;C&#46; Sete pacientes apresentaram muta&#231;&#245;es n&#227;o cl&#225;ssicas &#40;grupo C&#41; e os outros 14 pacientes heterozigotos tiveram o alelo WT detectado durante a triagem neonatal&#46; Na amostra total&#44; a muta&#231;&#227;o p&#46;Val282Leu foi a mais frequente nos pacientes com HAC&#8208;NC &#40;57&#37; heterozigotos e 28&#44;5&#37; homozigotos&#41; e tamb&#233;m em seis pacientes heterozigotos &#40;43&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46; Um novo alelo IVS2&#8208;13A&#47;C&#62;T foi descrito por Prado et al&#46; em uma menina heterozigota nascida a termo com peso ao nascer de 2&#46;905<span class="elsevierStyleHsp" style=""></span>g &#40;amostra 1&#58; 17 OHP 18&#44;2 ng&#47;mL e amostra 2&#58; 35&#44;0 ng&#47;mL&#41; e em um menino prematuro tardio com peso de nascimento de 2&#46;540<span class="elsevierStyleHsp" style=""></span>g &#40;amostra 1&#58; 17&#8208;OHP 25&#44;3 ng&#47;mL e amostra 2&#58; 15&#44;9 ng&#47;mL&#41; com triagem positiva&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">19</span></a> Surpreendentemente&#44; a clitoromegalia identificada na menina durante o primeiro exame foi resolvida espontaneamente durante o per&#237;odo de seguimento&#46; Ambos apresentaram perfil eletrol&#237;tico normal e n&#227;o tinham quaisquer outros sintomas associados &#224; HAC durante o seguimento de seis meses&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Os n&#237;veis de 17&#8208;OHP&#44; ajustados para o peso ao nascer&#44; foram analisados de acordo com os grupos &#40;1 &#61; HAC&#8208;C&#59; 2 &#61; HAC&#8208;NC&#59; 3 &#61; heterozigoto&#59; 4 &#61; WT&#41; nas amostras 1 e 2 &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>A e B&#44; respectivamente&#41;&#46; Foram observados n&#237;veis significativamente mais altos de 17&#8208;OHP na HAC&#8208;C em compara&#231;&#227;o com outros grupos nas amostras 1 e 2&#46; A <a class="elsevierStyleCrossRef" href="#fig0015">figura 3</a> mostra os n&#237;veis de 17&#8208;OHP&#44; ajustados para o peso ao nascer&#44; nas amostras 1 e 2&#44; classificados de acordo com os grupos de muta&#231;&#227;o&#46; Na amostra 1&#44; indiv&#237;duos com grupos de muta&#231;&#227;o Null e A apresentaram n&#237;veis significativamente mais altos de 17&#8208;OHP e na amostra 2&#44; os grupos de muta&#231;&#227;o Null&#44; A e B mantiveram n&#237;veis mais altos de 17&#8208;OHP&#44; os quais foram estatisticamente diferentes do grupo C &#40;HAC&#8208;NC&#41;&#44; heterozigotos e pacientes WT&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a> tamb&#233;m mostra os valores eletrol&#237;ticos nos diferentes grupos&#46; Os casos de HAC&#8208;C apresentaram n&#237;veis mais elevados de Na<span class="elsevierStyleSup">&#43;</span> e K<span class="elsevierStyleSup">&#43;</span>&#46; Foi encontrada uma forte correla&#231;&#227;o inversa entre o 17&#8208;OHP ajustado para o peso ao nascer e o Na<span class="elsevierStyleSup">&#43;</span> &#40;r &#61; &#8722;0&#44;795 para Amostra 1 de 17&#8208;OHP e r &#61; &#8722;0&#44;740&#44; para Amostra 2&#44; p &#60; 0&#44;05&#41; e uma correla&#231;&#227;o positiva com K<span class="elsevierStyleSup">&#43;</span> &#40;r &#61; 0&#44;494 para Amostra 1 de 17&#8208;OHP e r &#61; 0&#44;531 para Amostra 2&#44; p &#60;0&#44;05&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discuss&#227;o</span><p id="par0080" class="elsevierStylePara elsevierViewall">No presente estudo&#44; o programa de triagem neonatal de dois anos da HAC que usou n&#237;veis significativamente mais altos do marcador&#44; a 17&#8208;OHP&#44; permitiu de maneira adequada o diagn&#243;stico de 15 rec&#233;m&#8208;nascidos com HAC cl&#225;ssica&#46; Al&#233;m disso&#44; o reteste foi bem discriminado entre os casos e a gravidade da doen&#231;a apresentou concord&#226;ncia com a investiga&#231;&#227;o do gen&#243;tipo correspondente&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">O programa de triagem foi altamente eficaz na detec&#231;&#227;o de alguns casos que n&#227;o seriam clinicamente reconhecidos antes da triagem&#46; Nesse sentido&#44; atipias genitais leves &#40;casos 3&#44; 4 e 11&#41; e aumento do tamanho do p&#234;nis em meninos &#40;casos 6 e 15&#41; n&#227;o foram detectados antes da avalia&#231;&#227;o especializada&#46; Mesmo naqueles com genit&#225;lia amb&#237;gua&#44; a HAC n&#227;o foi diagnosticada antes da triagem&#44; a designa&#231;&#227;o sexual incorreta foi feita em dois casos &#40;2 e 10&#41;&#46; De fato&#44; observamos que mais de 50&#37; das meninas tiveram uma avalia&#231;&#227;o cl&#237;nica incorreta das caracter&#237;sticas de viriliza&#231;&#227;o&#44; o que foi identificado de maneira similar em estudos anteriores&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#44;15&#44;22</span></a> Isso refor&#231;a a import&#226;ncia da triagem neonatal universal para hiperplasia no Brasil&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Em rela&#231;&#227;o &#224; grande diferen&#231;a observada nos valores de corte de 17&#8208;OHP usados para as categorias de peso ao nascer&#44;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#44;11</span></a> &#233; importante observar que os lactentes das categorias de menor peso s&#227;o comumente internados em unidades de terapia intensiva e continuamente monitorados&#44; inclusive para dist&#250;rbios eletrol&#237;ticos&#46; De fato&#44; como observado anteriormente durante o primeiro ano de triagem&#44; a maioria dos falso&#8208;positivos era de rec&#233;m&#8208;nascidos com peso &#60; 2&#46;000<span class="elsevierStyleHsp" style=""></span>g&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">18</span></a> Uma segunda amostra que mostrou n&#237;veis mais baixos de 17&#8208;OHP em casos assintom&#225;ticos &#233; geralmente suficiente para elucidar os casos falso&#8208;positivos&#44; especialmente em beb&#234;s prematuros e rec&#233;m&#8208;nascidos de baixo peso&#46; Al&#233;m disso&#44; como relatado anteriormente&#44; as taxas de consanguinidade s&#227;o maiores entre os casos de HAC&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">18&#44;23</span></a> Dessa forma&#44; essa informa&#231;&#227;o adicional pode ser &#250;til para distinguir os casos reais dos casos falso&#8208;positivos&#46; Da mesma forma&#44; informa&#231;&#245;es sobre o uso de corticoide pela m&#227;e no fim da gesta&#231;&#227;o s&#227;o relevantes&#46; Nesse caso&#44; a coleta de uma segunda amostra ap&#243;s 15 dias de vida do rec&#233;m&#8208;nascido ajuda a diagnosticar casos como o do paciente 11&#44; que apresentou viriliza&#231;&#227;o leve n&#227;o reconhecida anteriormente e posterior desenvolvimento da HAC&#8208;PS&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">22</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Altos n&#237;veis de 17&#8208;OHP podem estar presentes em rec&#233;m&#8208;nascidos prematuros e criticamente doentes&#44; o que refor&#231;a a triagem estratificada pelo peso ao nascer&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">9&#8211;11</span></a> Al&#233;m disso&#44; o gen&#243;tipo foi recomendado para melhorar o diagn&#243;stico da precis&#227;o da triagem neonatal&#46; Ele ajuda a diferenciar os casos reais de falso&#8208;positivos&#44; esclarece casos lim&#237;trofes e&#44; eventualmente&#44; permite que portadores de HAC&#8208;NC sejam diagnosticados&#46;<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">7&#44;13&#44;15</span></a> Nos casos confirmados&#44; valores elevados de 17&#8208;OHP corresponderam &#224; gravidade de cada grupo genot&#237;pico&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">14&#44;15&#44;22</span></a> Curiosamente&#44; quando os n&#237;veis de 17&#8208;OHP foram estratificados de acordo com a gravidade do grupo de muta&#231;&#245;es na segunda amostra&#44; foi observada uma melhor diferencia&#231;&#227;o das formas VS &#40;muta&#231;&#245;es do grupo B&#41; da HAC&#8208;NC &#40;muta&#231;&#245;es do grupo C&#41;&#44; heterozigotos e WT &#40;<a class="elsevierStyleCrossRefs" href="#fig0010">figs&#46; 2 e 3</a>&#41;&#46; Esses tr&#234;s &#250;ltimos grupos apresentam n&#237;veis de 17&#8208;OHP significativamente menores&#44; o que justifica a estrat&#233;gia de retestar esses pacientes e&#44; quando ainda houver d&#250;vidas&#44; fazer a an&#225;lise do gen&#243;tipo&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">22</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">A efic&#225;cia do programa de triagem tamb&#233;m pode ser demonstrada quando formas graves&#44; como portadores de muta&#231;&#245;es do grupo Null&#44; s&#227;o identificadas&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">15</span></a> Dele&#231;&#227;o e grandes convers&#245;es g&#234;nicas que caracterizaram o grupo Null foram observadas em 20&#37; da nossa amostra&#44; o que est&#225; de acordo com um recente e grande estudo de correla&#231;&#227;o gen&#243;tipo&#8208;fen&#243;tipo&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">24</span></a> O grupo de muta&#231;&#245;es Null em homozigose foi observado em 26&#44;67&#37; de nossa amostra &#40;4&#47;15 pacientes&#41; e nos grupos Null e A em heterozigose composta&#44; o que caracterizou a HAC&#8208;PS&#44; em outros tr&#234;s pacientes&#46; No paciente 11&#44; n&#227;o houve correla&#231;&#245;es fen&#243;tipo&#8208;gen&#243;tipo claras como resultado da manifesta&#231;&#227;o de um fen&#243;tipo de HAC&#8208;PS leve&#46; Quando as muta&#231;&#245;es dos grupos Null e B est&#227;o em heterozigose composta&#44; inclusive a p&#46;Ile173Asn em um alelo&#44; a HAC&#8208;VS &#233; esperada na maioria dos casos&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">6&#44;15</span></a> Essa observa&#231;&#227;o foi relatada por outros grupos&#44;<a class="elsevierStyleCrossRefs" href="#bib0265"><span class="elsevierStyleSup">24&#44;25</span></a> inclusive uma associa&#231;&#227;o muito rara da muta&#231;&#227;o p&#46;Ile173Asn com uma HAC&#8208;NC&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">24</span></a> A HAC&#8208;PS associada &#224; p&#46;Ile173Asn &#233; mais comum quando uma segunda muta&#231;&#227;o mais grave est&#225; associada em heterozigosidade&#46;<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">25&#44;26</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">No Brasil&#44; um estudo de Bachega et al&#46; determinou a frequ&#234;ncia de muta&#231;&#245;es de ponto em 130 pacientes com HAC&#8208;C e HAC&#8208;NC e estabeleceu uma correla&#231;&#227;o gen&#243;tipo&#8208;fen&#243;tipo&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">27</span></a> As muta&#231;&#245;es mais frequentes foram a IVS2&#8208;13A&#47;C&#62;G&#44; em 55&#37; dos alelos dos pacientes com a forma PS&#44; a p&#46;Ile173Asn&#44; em 42&#37; das HAC&#8208;VS&#44; e a pVal282Leu&#44; em 70&#37; dos indiv&#237;duos com HAC&#8208;NC&#46; A frequ&#234;ncia da muta&#231;&#227;o IVS2&#8208;13A&#47;C&#62;G em nossa amostra n&#227;o foi&#44; portanto&#44; surpreendente para a popula&#231;&#227;o brasileira &#40;53&#37; em homo e&#47;ou heterozigose na HAC&#8208;C&#41;&#46; Em uma amostra brasileira de S&#227;o Paulo<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">14</span></a> e em um estudo de coorte maior na Argentina&#44; a IVS2&#8208;13A&#47;C&#62; G correspondeu a 21&#37; na frequ&#234;ncia al&#233;lica e a 20&#37; das muta&#231;&#245;es em homozigose&#44;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">28</span></a> respectivamente&#46; O Brasil e a Argentina &#40;AR&#41; apresentam taxas muito semelhantes dessa muta&#231;&#227;o&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">14&#44;28</span></a> O Estado do Rio Grande do Sul est&#225; pr&#243;ximo da AR e a popula&#231;&#227;o compartilha origens &#233;tnicas comuns&#46; Esse grupo tamb&#233;m descreve a associa&#231;&#227;o dos alelos IVS2&#8208;13A&#47;C&#62;G com as formas VS&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">8</span></a> o que pode explicar o fen&#243;tipo&#8208;gen&#243;tipo n&#227;o concordante no caso 32&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">A nova variante IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;T foi identificada em dois pacientes&#46; O alelo T foi observado nos casos em heterozigose com o alelo C benigno&#44; como descrito anteriormente&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">19</span></a> Como a paciente do sexo feminino apresentou clitoromegalia ao nascimento&#44; mesmo em casos heterozigotos&#44; esse achado n&#227;o pode ser negligenciado e requer estudos gen&#233;ticos adicionais&#46; A descri&#231;&#227;o dos tr&#234;s casos com clitoromegalia transit&#243;ria em nossa amostra &#233; digna de estudo adicional&#46; Tem sido relatado que alguns pacientes heterozigotos apresentaram n&#237;veis mais elevados de andr&#243;genos&#44; especialmente os portadores da muta&#231;&#227;o pVal282Leu com adrenarca precoce&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">1&#44;29</span></a> Espera&#8208;se que os pacientes com HAC&#8208;NC e pacientes heterozigotos sejam assintom&#225;ticos ao nascimento&#44; mas nossa hip&#243;tese &#233; que poss&#237;veis eleva&#231;&#245;es androg&#234;nicas transit&#243;rias podem ocorrer&#46; Estudos futuros com vistas a esclarecer esse fen&#244;meno podem usar a genotipagem expandida pelo sequenciamento completo do gene <span class="elsevierStyleItalic">CYP21A2</span> para excluir outras muta&#231;&#245;es n&#227;o detectadas pelos ensaios SNaPshot e MLPA&#46; Em nossa amostra&#44; um melhor entendimento dessa nova variante pode fornecer informa&#231;&#245;es mais espec&#237;ficas&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Um dos pontos fortes deste estudo foi que os diagn&#243;sticos e exames de acompanhamento foram feitos pelo mesmo endocrinologista pedi&#225;trico&#46; Portanto&#44; a avalia&#231;&#227;o cl&#237;nica adequada dos pacientes feita neste estudo &#233; apropriada para a caracteriza&#231;&#227;o cl&#237;nica e molecular dessa amostra na triagem neonatal da HAC&#46; Outro ponto forte foi o fato de os dados terem sido coletados a partir de um programa de triagem populacional&#44; o que favoreceu a avalia&#231;&#227;o de um grande n&#250;mero de indiv&#237;duos&#46; Nesse contexto&#44; nosso estudo foi o primeiro programa de triagem neonatal&#47;genotipagem com o uso da metodologia SNaPshot&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">19</span></a> Essa estrat&#233;gia permite detectar simultaneamente as 12 muta&#231;&#245;es mais comumente associadas &#224; HAC de forma r&#225;pida e &#225;gil e agrega qualidade ao programa de triagem neonatal&#46; Esse grupo de muta&#231;&#245;es de ponto representa 89&#37; das muta&#231;&#245;es detectadas em nossa coorte do sul do Brasil&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">19</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Em conclus&#227;o&#44; os resultados deste estudo ressaltam a efic&#225;cia do programa de triagem na detec&#231;&#227;o de casos de HAC e na exclus&#227;o de casos suspeitos com base em pontos de corte dos n&#237;veis de 17&#8208;OHP ligados &#224; estratifica&#231;&#227;o pelo peso ao nascer&#46; Al&#233;m disso&#44; a coleta da segunda amostra&#44; seguida pela genotipagem das amostras suspeitas&#44; ajudou a diagnosticar adequadamente casos graves de HAC&#8208; PS&#47;VS e casos mais leves de VS&#44; al&#233;m de diferenciar entre casos de HAC&#8208;C e pacientes falsos positivos&#46; Os presentes resultados tamb&#233;m indicaram que a genotipagem &#233; uma ferramenta diagn&#243;stica valiosa e complementar para a triagem neonatal&#44; a qual fornece informa&#231;&#245;es sobre a gravidade da doen&#231;a&#44; permite o aconselhamento gen&#233;tico em casos graves e evita o tratamento excessivo da HAC&#8208;NC de in&#237;cio tardio e dos pacientes falsos positivos&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Financiamento</span><p id="par0125" class="elsevierStylePara elsevierViewall">Este trabalho foi financiado por bolsas de estudo do Instituto Nacional Brasileiro de Horm&#244;nios e Sa&#250;de da Mulher&#44; Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#91;CNPq INCT 573747&#47;2008&#8208;3&#93;&#44; do Sistema Nacional Brasileiro de Sa&#250;de P&#250;blica &#40;PPSUS&#41; e da Funda&#231;&#227;o de Amparo &#224; Pesquisa do Rio Grande do Sul &#40;Fapergs&#41;&#44; Porto Alegre&#44; Brasil&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflitos de interesse</span><p id="par0130" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflitos de interesse&#46;</p></span></span>"
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    "fechaRecibido" => "2017-04-30"
    "fechaAceptado" => "2018-03-12"
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            0 => "Congenital adrenal hyperplasia"
            1 => "Newborn screening"
            2 => "Clinical profile"
            3 => "Molecular diagnosis"
            4 => "Genotype&#8208;phenotype"
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            0 => "Hiperplasia adrenal cong&#234;nita"
            1 => "Triagem neonatal"
            2 => "Perfil cl&#237;nico"
            3 => "Diagn&#243;stico molecular"
            4 => "Gen&#243;tipo&#8208;fen&#243;tipo"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To describe the results obtained in a neonatal screening program after its implementation and to assess the clinical and molecular profiles of confirmed and suspicious congenital adrenal hyperplasia cases&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A cross-sectional study was conducted&#46; Newborns with suspected disease due to high 17-hydroxyprogesterone levels and adjusted for birth weight were selected&#46; Classical congenital adrenal hyperplasia &#40;salt-wasting and simple virilizing forms&#41; was diagnosed by an increase in 17-hydroxyprogesterone levels as confirmed in the retest&#44; clinical evaluation&#44; and genotype determined by SNaPshot and multiplex ligation-dependent probe amplification&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">After 24 months&#44; 15 classic congenital adrenal hyperplasia cases were diagnosed in a total of 217&#44;965 newborns&#44; with an estimated incidence of 1&#58;14&#44;531&#46; From 132 patients&#44; seven non-classical and 14 heterozygous patients were screened for <span class="elsevierStyleItalic">CYP21A2</span> mutations&#44; and 96 patients presented false positives with wild type <span class="elsevierStyleItalic">CYP21A2</span>&#46; On retest&#44; increased 17-hydroxyprogesterone levels were found in classical congenital adrenal hyperplasia patients and showed significant correlation with genotype-related classical genital adrenal hyperplasia&#46; The most frequent mutations were IVS2-13A&#47;C&#62;G followed by gene deletion or rearrangement events in the classical form&#46; In non-classical and heterozygous diseases&#44; p&#46;Val282Leu was the most common mutation&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The results underscore the effectiveness of congenital adrenal hyperplasia neonatal screening in the public health system and indicate that the adopted strategy was appropriate&#46; The second sample collection along with genotyping of suspected cases helped to properly diagnose both severe and milder cases and delineate them from false positive patients&#46;</p></span>"
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            "identificador" => "abst0005"
            "titulo" => "Objective"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
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          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
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        ]
      ]
      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Descrever os resultados obtidos em um programa de triagem neonatal ap&#243;s sua implementa&#231;&#227;o e avaliar os perfis cl&#237;nicos e moleculares de casos confirmados e suspeitos de hiperplasia adrenal cong&#234;nita&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Foi feito um estudo transversal&#46; Rec&#233;m-nascidos com suspeita da doen&#231;a devido aos altos n&#237;veis de 17-alfa-hidroxiprogesterona e ajustados pelo peso ao nascer foram selecionados&#46; A hiperplasia adrenal cong&#234;nita cl&#225;ssica &#40;forma perdedora de sal e forma virilizante simples&#41; foi diagnosticada por um aumento nos n&#237;veis de 17-alfa-hidroxiprogesterona confirmado no reteste&#44; avalia&#231;&#227;o cl&#237;nica e gen&#243;tipo determinado com o uso do ensaio <span class="elsevierStyleItalic">SNaPshot</span> e amplifica&#231;&#227;o multiplex de sondas dependente de liga&#231;&#227;o&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Ap&#243;s 24 meses&#44; 15 casos cl&#225;ssicos de hiperplasia adrenal cong&#234;nita foram diagnosticados em 217&#46;965 rec&#233;m-nascidos&#44; com uma incid&#234;ncia estimada de 1&#58;14&#46;531&#46; De 132 pacientes&#44; sete n&#227;o cl&#225;ssicos e 14 heterozigotos foram submetidos &#224; triagem para muta&#231;&#245;es no gene <span class="elsevierStyleItalic">CYP21A2</span> e 96 pacientes apresentaram resultados falso&#8208;positivos com <span class="elsevierStyleItalic">CYP21A2</span> do tipo selvagem&#46; No reteste&#44; n&#237;veis aumentados de 17-alfa-hidroxiprogesterona foram encontrados em pacientes com hiperplasia adrenal cong&#234;nita cl&#225;ssica e mostraram correla&#231;&#227;o significativa com HAC cl&#225;ssica relacionada ao gen&#243;tipo&#46; As muta&#231;&#245;es mais frequentes foram IVS2-13A&#47;C&#62;G&#44; seguidas de dele&#231;&#227;o g&#234;nica ou eventos de rearranjo na forma cl&#225;ssica&#46; Em casos de doen&#231;as n&#227;o cl&#225;ssicas e heterozigose&#44; a muta&#231;&#227;o p&#46;Val282Leu foi a mais comum&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#245;es</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Os resultados ressaltam a efic&#225;cia da triagem neonatal para a hiperplasia adrenal cong&#234;nita no sistema p&#250;blico de sa&#250;de e indicam que a estrat&#233;gia adotada foi adequada&#46; A segunda coleta de amostras&#44; juntamente com a genotipagem dos casos suspeitos&#44; ajudou a diagnosticar adequadamente os casos graves e mais leves e diferenci&#225;-los de pacientes com resultado falso-positivo&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
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          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclus&#245;es"
          ]
        ]
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    ]
    "NotaPie" => array:2 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0045">Como citar este artigo&#58; Kopacek C&#44; Prado MJ&#44; da Silva CM&#44; de Castro SM&#44; Beltr&#227;o LA&#44; Vargas PR&#44; et al&#46; Clinical and molecular profile of newborns with confirmed or suspicious congenital adrenal hyperplasia detected after a public screening program implementation&#46; J Pediatr &#40;Rio J&#41;&#46; 2019&#59;95&#58;282&#8211;90&#46;</p>"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0050">Estudo feito no Servi&#231;o de Refer&#234;ncia em Triagem Neonatal &#40;centro de refer&#234;ncia para triagem neonatal do Sistema P&#250;blico de Sa&#250;de&#41; do Hospital Materno Infantil Presidente Vargas e no Centro de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#40;CDCT&#41;&#44; Porto Alegre&#44; RS&#44; Brasil&#46;</p>"
      ]
    ]
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      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
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            "Alto" => 1550
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Fluxograma da avalia&#231;&#227;o gen&#243;tipo&#8208;fen&#243;tipo da HAC&#46; 17 OHP&#44; 17&#8208;alfa&#8208;hidroxiprogesterona&#59; HAC&#44; hiperplasia adrenal cong&#234;nita&#46; Adaptado de Kopacek et al&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">18</span></a></p>"
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      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2284
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        "descripcion" => array:1 [
          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">N&#237;veis de 17&#8208;OHP nos quatro grupos &#40;HAC cl&#225;ssica&#44; HAC&#8208;NC&#44; heterozigoto e tipo selvagem&#41;&#46; Quatro grupos &#40;1 &#61; HAC cl&#225;ssica&#59; 2 &#61; HAC NC&#59; 3 &#61; heterozigoto&#59; 4 &#61; Tipo selvagem&#41;&#46; A&#44; N&#237;veis de 17&#8208;OHP na amostra 1&#59; B&#44; N&#237;veis de 17&#8208;OHP na amostra 2&#46; HAC&#44; hiperplasia adrenal cong&#234;nita&#59; NC&#44; n&#227;o cl&#225;ssica&#46; <span class="elsevierStyleSup">a</span> p &#60; 0&#44;05 <span class="elsevierStyleItalic">versus</span> todos os outros grupos&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
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            "Alto" => 2349
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        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">N&#237;veis de 17&#8208;OHP de acordo com o gen&#243;tipo &#40;grupo de gravidade de muta&#231;&#227;o&#44; heterozigose e tipo selvagem&#41;&#59; A&#46; N&#237;veis de 17&#8208;OHP na amostra 1&#59; B&#46; N&#237;veis de 17&#8208;OHP na amostra 2&#46; Gen&#243;tipo &#40;1 &#61; Grupo Null&#59; 2 &#61; Grupo A&#59; 3 &#61; Grupo B&#59; 4 &#61; Grupo C&#59; 5 &#61; Heterozigoto&#59; 6 &#61; Tipo Selvagem&#41;&#46; <span class="elsevierStyleSup">a</span> p &#60; 0&#44;05 <span class="elsevierStyleItalic">versus</span> todos os outros grupos&#46; <span class="elsevierStyleSup">b</span> p &#60; 0&#44;05 <span class="elsevierStyleItalic">versus</span> grupo 1 e 2&#46; HAC&#44; hiperplasia adrenal cong&#234;nita&#59; 17&#8208;OHP&#44; 17&#8208;alfa&#8208;hidroxiprogesterona&#59; PS&#44; perdedora de sal&#59; VS&#44; virilizante simples&#59; HAC&#8208;C&#44; hiperplasia adrenal cong&#234;nita cl&#225;ssica&#59; NC&#44; n&#227;o cl&#225;ssica&#44; de in&#237;cio tardio&#59; WT&#44; tipo selvagem&#59; SPSS&#44; <span class="elsevierStyleItalic">Statistical Package for the Social Sciences</span>&#46;</p>"
        ]
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        "identificador" => "tbl0005"
        "etiqueta" => "Tabela 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabela "
            "rol" => "short"
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        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0090" class="elsevierStyleSimplePara elsevierViewall">F&#44; sexo feminino&#59; HAC&#44; hiperplasia adrenal cong&#234;nita&#59; HT&#44; heterozigoto&#59; LGC&#44; <span class="elsevierStyleItalic">Large Gene Conversion</span>&#59; M&#44; sexo masculino&#59; NC&#44; n&#227;o cl&#225;ssica&#59; nd&#44; n&#227;o definido&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Paciente n&#176;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sexo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Uso de corticoide materno&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Consanguinidade&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">17 OHP&#40;ng&#47;mL&#41;Amostra 1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">17 OHP&#40;ng&#47;mL&#41;Amostra 2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#91;NA<span class="elsevierStyleSup">&#43;</span>&#93;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">e</span></a> &#40;nmol&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#91;K<span class="elsevierStyleSup">&#43;</span>&#93;<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">e</span></a> &#40;nmol&#47;L&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Viriliza&#231;&#227;o&#47;Escala de Prader&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fen&#243;tipo HAC&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Gen&#243;tipo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Grupos de muta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Correla&#231;&#227;o fen&#243;tipo&#47;gen&#243;tipo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="16" align="left" valign="\n
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                  \t\t\t\t">HAC cl&#225;ssica</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;640&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">105&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">283&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5&#44;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C&#62;G &#47; IVS2&#8208;13A&#47;C&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">A&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;325&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">432&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">759&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">108&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5&#44;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Del <span class="elsevierStyleItalic">CYP21A2</span> &#47; LGC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">null&#47;null&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;490&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">44&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">94&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">132&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C&#62;G &#47; IVS2&#8208;13A&#47;C&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">A&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;040&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">512&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">521&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">126&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5&#44;34&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Del 30Kb &#47; IVS&#8208;2&#8208;13A&#47;C&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">null&#47;A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">61&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">209&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">132&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">5&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Del <span class="elsevierStyleItalic">CYP21A2</span> &#47; p&#46;Ile173Asn&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">null&#47;B&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;450&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">733&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">120&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Aumento do p&#234;nis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Del <span class="elsevierStyleItalic">CYP21A2</span> &#47; Cluster E6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;980&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">461&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">489&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">109&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6&#44;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Del <span class="elsevierStyleItalic">CYP21A2</span> &#47; p&#46;Arg357Trp&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">null&#47;null&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">126&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C&#62;G &#47; IVS2&#8208;13A&#47;C&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">A&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;395&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">469&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">435&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C&#62;G &#47; LGC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">null&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;270&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">354&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;G &#47; IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;890&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">133&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader I&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">LGC &#47; p&#46;Ile172Asn&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">null&#47;B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;580&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">459&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;G &#47; IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter&#47; p&#46;Gln319Ter&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">null&#47;null&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;500&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">125&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Prader III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Leu308Phefs &#47; IVS2&#8208;13A&#47;C&#62;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">null&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">32&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">131&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aumento do p&#234;nis&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">VS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">m&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&#47;&#37; positivo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">289&#44;57<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a> &#40;&#177; 240&#44;13&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">331&#44;72<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a> &#40;&#177; 210&#44;37&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">125<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#44;30<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;10<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;01<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " rowspan="8" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">HAC n&#227;o cl&#225;ssica</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;465&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; p&#46;Val281Leu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;340&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">136&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; p&#46;Val282Leu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;508&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">31&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5&#44;00&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter &#47; p&#46;Val282Leu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;660&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">38&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">47&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Pro454Ser &#47; p&#46;Pro454Ser&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;988&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>p&#46;Arg357Trp<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>p&#46;Leu308Phefs &#47; p&#46;Val282Leu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;830&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;G &#47; p&#46;Val282Leu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;630&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;4<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Arg357Trp &#47; p&#46;Val282Leu&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">m&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&#37; positivo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;9173&#40;&#177; 0&#44;366&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">43&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;92 &#40;&#177; 13&#44;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#44;16 &#40;&#177; 16&#44;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">134&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#44;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " rowspan="15" align="left" valign="\n
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                  \t\t\t\t">Heterozigoto</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;680&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">null&#47;WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;750&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Arg357Trp &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">null&#47;WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">134&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">null&#47;WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;345&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#47;WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;570&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">133&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;34<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#47;WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;535&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">36&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">134&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">null&#47;WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;600&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">137&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Arg357Trp &#47; WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">null&#47;WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;550&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">131&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&#47;WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;215&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">30&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">127&#44;0<a class="elsevierStyleCrossRef" href="#tblfn0040"><span class="elsevierStyleSup">h</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Normal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">p&#46;Val282Leu &#47; WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clitoromegalia transit&#243;ria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suspeita de HAC<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">f</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; WT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Gln319Ter &#47; WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clitoromegalia transit&#243;ria<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suspeita de HAC<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">f</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">p&#46;Val282Leu &#47; WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Nenhuma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IVS2&#8208;13A&#47;C<span class="elsevierStyleHsp" style=""></span>&#62;T &#47; WT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;20&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">139&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Clitoromegalia transit&#243;ria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Suspeita de HAC<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">f</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                    0 => array:2 [
                      "titulo" => "Genetics of congenital adrenal hyperplasia"
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                            0 => "N&#46; Krone"
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                        "tituloSerie" => "Best Pract Res Clin Endocrinol Metab"
                        "fecha" => "2009"
                        "volumen" => "23"
                        "paginaInicial" => "181"
                        "paginaFinal" => "192"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19500762"
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                          ]
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                    0 => array:2 [
                      "titulo" => "The molecular biology&#44; biochemistry&#44; and physiology of human steroidogenesis and its disorders"
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                    0 => array:2 [
                      "doi" => "10.1210/er.2010-0013"
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                        "tituloSerie" => "Endocr Rev"
                        "fecha" => "2011"
                        "volumen" => "32"
                        "paginaInicial" => "81"
                        "paginaFinal" => "151"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21051590"
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                          ]
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                        "tituloSerie" => "Screening"
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                            5 => "M&#46;P&#46; Mello"
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                        "tituloSerie" => "Clin Genet"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19930153"
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                      "titulo" => "Der Genitalbefund beim Pseudohermaphroditismus Femininus des kongenitalen Adrenogenitalen Syndromes"
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                            4 => "D&#46; Bonneau"
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                    0 => array:2 [
                      "titulo" => "Impact of molecular genetics on congenital adrenal hyperplasia management"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Balsamo"
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                            2 => "S&#46; Menab&#242;"
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                        "tituloSerie" => "Sex Dev"
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                        "volumen" => "4"
                        "paginaInicial" => "233"
                        "paginaFinal" => "248"
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                          0 => array:2 [
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                      "titulo" => "Molecular CYP21A2 diagnosis in 480 Brazilian 433 patients with congenital adrenal hyperplasia before newborn screening introduction"
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                          "etal" => true
                          "autores" => array:6 [
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                        "tituloSerie" => "Eur J Endocrinol"
                        "fecha" => "2016"
                        "volumen" => "175"
                        "paginaInicial" => "107"
                        "paginaFinal" => "116"
                        "link" => array:1 [
                          0 => array:2 [
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                      "titulo" => "Biochemical and genetic diagnosis of 21&#8208;hydroxylase deficiency"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Falhammar"
                            1 => "A&#46; Wedell"
                            2 => "A&#46; Nordenstr&#246;m"
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                    ]
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                        "tituloSerie" => "Endocrine"
                        "fecha" => "2015"
                        "volumen" => "50"
                        "paginaInicial" => "306"
                        "paginaFinal" => "314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26336836"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "The actual incidence of congenital adrenal hyperplasia in Brazil may not be as high as inferred&#58; an estimate based on a public neonatal screening program in the state of Goi&#225;s"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "E&#46;P&#46; dos Santos"
                            2 => "T&#46;A&#46; Bachega"
                            3 => "I&#46; van der Linden Nader"
                            4 => "J&#46;L&#46; Gross"
                            5 => "R&#46;H&#46; Elnecave"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Endocrinol Metab"
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                        "volumen" => "21"
                        "paginaInicial" => "455"
                        "paginaFinal" => "460"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18655527"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Ten&#8208;year evaluation of a neonatal screening program for congenital adrenal hyperplasia"
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                          "autores" => array:6 [
                            0 => "M&#46;L&#46; Nascimento"
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                            2 => "T&#46; Campos"
                            3 => "M&#46; Ohira"
                            4 => "E&#46; Cechinel"
                            5 => "G&#46; Simoni"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arq Bras Endocrinol Metabol"
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                        "volumen" => "58"
                        "paginaInicial" => "765"
                        "paginaFinal" => "771"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25372587"
                            "web" => "Medline"
                          ]
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                    ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Neonatal screening for congenital adrenal hyperplasia in Southern Brazil&#58; a population&#8208;based study with 108&#44;409 infants"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
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                            1 => "S&#46;M&#46; Castro"
                            2 => "M&#46;J&#46; Prado"
                            3 => "C&#46;M&#46; Silva"
                            4 => "L&#46;A&#46; Beltr&#227;o"
                            5 => "P&#46;M&#46; Spritzer"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1186/s12887-016-0772-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMC Pediatr"
                        "fecha" => "2017"
                        "volumen" => "17"
                        "paginaInicial" => "22"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28095810"
                            "web" => "Medline"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Development of CYP21A2 genotyping assay with potential diagnosis of congenital adrenal hyperplasia"
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                          "etal" => true
                          "autores" => array:6 [
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                            1 => "S&#46;M&#46; de Castro"
                            2 => "C&#46; Kopacek"
                            3 => "M&#46;P&#46; de Mello"
                            4 => "T&#46; Rispoli"
                            5 => "T&#46; Grandi"
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Mol Diagn Ther"
                        "fecha" => "2017"
                        "volumen" => "21"
                        "paginaInicial" => "663"
                        "paginaFinal" => "675"
                      ]
                    ]
                  ]
                ]
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                    0 => array:2 [
                      "titulo" => "Multiplex minisequencing of the 21&#8208;hydroxylase gene as a rapid strategy to confirm 356 congenital adrenal hyperplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "A&#46; Braun"
                            2 => "S&#46; Weinert"
                            3 => "M&#46; Peter"
                            4 => "A&#46;A&#46; Roscher"
                            5 => "C&#46;J&#46; Partsch"
                          ]
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chem"
                        "fecha" => "2002"
                        "volumen" => "48"
                        "paginaInicial" => "818"
                        "paginaFinal" => "825"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12028996"
                            "web" => "Medline"
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              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibition of CYP21A2 enzyme activity caused by novel missense mutations identified in Brazilian and Scandinavian patients"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46;C&#46; Soardi"
                            1 => "M&#46; Barbaro"
                            2 => "I&#46;F&#46; Lau"
                            3 => "S&#46;H&#46; Lemos-Marini"
                            4 => "M&#46;T&#46; Baptista"
                            5 => "G&#46; Guerra"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/jc.2007-2594"
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                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "2008"
                        "volumen" => "93"
                        "paginaInicial" => "2416"
                        "paginaFinal" => "2420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18381579"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
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              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Genotyping is a valuable diagnostic complement to neonatal screening for congenital adrenal hyperplasia due to steroid 21&#8208;hydroxylase deficiency"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Nordenstrom"
                            1 => "L&#46; Thilen"
                            2 => "L&#46; Hagenfeldt"
                            3 => "A&#46; Larsson"
                            4 => "A&#46; Wedell"
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                      "doi" => "10.1210/jcem.84.5.5651"
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                        "tituloSerie" => "J Clin Endocrinol Metab"
                        "fecha" => "1999"
                        "volumen" => "84"
                        "paginaInicial" => "1505"
                        "paginaFinal" => "1509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10323369"
                            "web" => "Medline"
                          ]
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                    ]
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              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Molecular analysis of the CYP21 gene and prenatal diagnosis in families with 21&#8208;hydroxylase deficiency in northeastern Iran"
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                          "etal" => false
                          "autores" => array:6 [
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                            2 => "B&#46; Barid-Fatehi"
                            3 => "M&#46; Gholamin"
                            4 => "N&#46; Ghaemi"
                            5 => "M&#46;R&#46; Abbaszadegan"
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                        ]
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Horm Res"
                        "fecha" => "2005"
                        "volumen" => "63"
                        "paginaInicial" => "119"
                        "paginaFinal" => "124"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15775714"
                            "web" => "Medline"
                          ]
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              "etiqueta" => "24"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Genotypephenotype correlation in 1&#44;507 families with congenital adrenal hyperplasia owing to 21&#8208;hydroxylase deficiency"
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                            2 => "B&#46; Gonzalez"
                            3 => "M&#46; Dumic"
                            4 => "M&#46; Razzaghy-Azar"
                            5 => "D&#46; Chitayat"
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                    ]
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                        "tituloSerie" => "Proc Natl Acad Sci U S A"
                        "fecha" => "2013"
                        "volumen" => "110"
                        "paginaInicial" => "2611"
                        "paginaFinal" => "2616"
                        "link" => array:1 [
                          0 => array:2 [
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                            4 => "B&#46; Rodr&#237;guez P&#233;rez"
                            5 => "B&#46; Ezquieta Zubicaray"
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                        "tituloSerie" => "An Pediatr &#40;Barc&#41;"
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                        "paginaInicial" => "72"
                        "paginaFinal" => "78"
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                    ]
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              "etiqueta" => "26"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Salt wasting in simple virilizing congenital adrenal hyperplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46; Frish"
                            1 => "T&#46; Battelino"
                            2 => "E&#46; Shober"
                            3 => "S&#46; Baumgartner-Parzer"
                            4 => "P&#46; Nowotny"
                            5 => "H&#46; Vierhapper"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Clin Endocrinol Metab"
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                        "volumen" => "14"
                        "paginaInicial" => "1649"
                        "paginaFinal" => "1655"
                      ]
                    ]
                  ]
                ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Molecular genotyping in Brazilian patients 446 with the classical and nonclassical forms of 21&#8208;hydroxylase deficiency"
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                          "etal" => true
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                        "tituloSerie" => "J Clin Endocrinol Metab"
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                        "paginaInicial" => "4416"
                        "paginaFinal" => "4419"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                          "etal" => true
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                            4 => "C&#46; Rocco"
                            5 => "M&#46; Ciaccio"
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                        "paginaInicial" => "427"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Genetic defects in the CYP21A2 gene in heterozygous girls with premature adrenarche and adolescent females with hyperandrogenemia"
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                        "tituloSerie" => "Georgian Med News"
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                        "paginaFinal" => "47"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30829587"
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Informação do artigo
ISSN: 22555536
Idioma original: Português
DOI:10.1016/j.jpedp.2018.05.003
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Edição nº 1
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1934
Jornal do Pediatria nº1
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