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          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Fluxograma com a popula&#231;&#227;o de pacientes e t&#233;cnicas aplicadas&#46;FISH&#44; fluorescence in situ hybridization&#59; MLPA&#44; multiplexligation probe amplification&#59; CMA&#44; chromosomal microarray&#59; CNVs&#44; copy number variations&#59; ChAS&#44; chromosome analysis suite&#59; DGV&#44;database of genomic variants&#59; DECIPHER&#44; database of chromosomal imbalance and phenotype in humans using ensemble resources&#59;OMIM&#44; Online Mendelian Inheritance In Man&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">A cardiopatia cong&#234;nita &#40;CC&#41; &#233; uma malforma&#231;&#227;o comum que afeta aproximadamente seis de 1&#46;000 nascidos vivos&#46; Ela ocorre isoladamente ou em anomalias cong&#234;nitas m&#250;ltiplas&#44; dentre as quais a s&#237;ndrome de dele&#231;&#227;o 22q11&#46;2 &#233; a mais comum&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">1</span></a> A CC &#233; a manifesta&#231;&#227;o mais cr&#237;tica e principal fator de morbimortalidade na s&#237;ndrome de dele&#231;&#227;o 22q11&#46;2 &#40;22q11&#46;2DS&#41;&#44; afeta entre 74&#37; e 80&#37; dos pacientes&#46; Dentre diversas CCs relatadas&#44; os defeitos conotruncais e&#47;ou do arco a&#243;rtico s&#227;o os mais prevalentes&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">2</span></a> A causa da heterogeneidade fenot&#237;pica card&#237;aca n&#227;o &#233; conhecida&#44; por&#233;m n&#227;o h&#225; provas de correla&#231;&#227;o com sexo&#44; ra&#231;a&#44; tamanho da dele&#231;&#227;o 22q11&#46;2 ou origem parental da dele&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Recomenda&#8208;se que todos os rec&#233;m&#8208;nascidos ou crian&#231;as que apresentem CC e dismorfismo ou outras anomalias cong&#234;nitas sejam examinadas para dele&#231;&#227;o 22q11&#46;2&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">4</span></a> Al&#233;m disso&#44; desequil&#237;brios gen&#244;micos de outras regi&#245;es cromoss&#244;micas&#44; inclusive 10p12&#8208;p15&#44; 4q21&#8208;q35&#44; 8p21&#8208;p23&#44; 17p13 e 18q21&#44; podem ser encontrados em pacientes com suspeita cl&#237;nica de 22q11&#46;2DS e sem dele&#231;&#227;o 22q11&#46;2&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Atualmente&#44; a aplica&#231;&#227;o da an&#225;lise cromoss&#244;mica por <span class="elsevierStyleItalic">microarray</span> &#40;CMA&#41; no diagn&#243;stico cl&#237;nico possibilita a identifica&#231;&#227;o de desequil&#237;brios gen&#244;micos submicrosc&#243;picos indetect&#225;veis&#44; traz novas informa&#231;&#245;es sobre a g&#234;nese dos defeitos cong&#234;nitos&#46; Investigamos um grupo de indiv&#237;duos que apresentam CC com anomalias extracard&#237;acas e exclus&#227;o da 22q11&#46;2DS para identificar desequil&#237;brios gen&#244;micos patog&#234;nicos&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Pacientes e m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Pacientes</span><p id="par0020" class="elsevierStylePara elsevierViewall">O Comit&#234; de &#201;tica em Pesquisa da Universidade de Campinas aprovou este estudo &#40;n&#250;meros 487&#47;2009 e 433&#47;2010&#41;&#46; Todos os participantes ou seus respons&#225;veis assinaram o consentimento informado por escrito&#46; A avalia&#231;&#227;o incluiu um protocolo padronizado como parte de um estudo multic&#234;ntrico do Projeto Cr&#226;nio&#8208;Face Brasil e todos os indiv&#237;duos foram consultados por um geneticista&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Inicialmente&#44; 108 pacientes que apresentam CC com anomalias extracard&#237;acas e suspeita cl&#237;nica de 22q11&#46;2 foram examinado por hibridiza&#231;&#227;o <span class="elsevierStyleItalic">in situ</span> por fluoresc&#234;ncia &#40;FISH&#41; e&#47;ou amplifica&#231;&#227;o de m&#250;ltiplas sondas dependentes de liga&#231;&#227;o &#40;MLPA&#41;&#46; Apenas 78 pacientes &#40;43 homens e 35 mulheres&#41; sem 22q11&#46;2 foram inclu&#237;dos no presente estudo&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Dentre as CCs nessa coorte&#44; foi observada tetralogia de Fallot &#40;ToF&#41; em 40&#37;&#44; defeito do septo ventricular &#40;DSV&#41; em 22&#37; e defeito do septo atrial &#40;DAS&#41; em 8&#37; dos casos&#46; Em 9&#37; dos casos foram observados dois desses tr&#234;s defeitos&#46; O restante dos 21&#37; dos casos apresentou outros defeitos card&#237;acos como <span class="elsevierStyleItalic">truncus arteriosus</span> &#40;TA&#41;&#44; v&#225;lvula a&#243;rtica bic&#250;spide &#40;VAB&#41; e persist&#234;ncia do canal arterial &#40;PCA&#41;&#44; dentre outros&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">As principais caracter&#237;sticas cl&#237;nicas encontradas nesses pacientes&#44; al&#233;m de CC&#44; foram&#58; dismorfismos faciais &#8211; 96&#37; &#40;75&#47;78&#41;&#44; altera&#231;&#245;es neurocognitivas e comportamentais &#8211; 65&#37; &#40;51&#47;78&#41;&#44; altera&#231;&#245;es esquel&#233;ticas &#8211; 58&#37; &#40;45&#47;78&#41;&#44; altera&#231;&#245;es palatinas &#8211; 43&#37; &#40;34&#47;78&#41;&#44; altera&#231;&#245;es imunol&#243;gicas &#8211; 41&#37; &#40;32&#47;78&#41;&#44; atraso no crescimento e&#47;ou altera&#231;&#245;es na alimenta&#231;&#227;o &#8211; 32&#37; &#40;25&#47;78&#41;&#44; anomalias gastrointestinais &#8211; 23&#37; &#40;18&#47;78&#41;&#44; perda de audi&#231;&#227;o &#8211; 10&#37; &#40;8&#47;78&#41;&#44; anomalias no trato urin&#225;rio &#8211; 10&#37; &#40;8&#47;78&#41;&#44; altera&#231;&#245;es visuais &#8211; 9&#37; &#40;7&#47;78&#41; e altera&#231;&#245;es neurol&#243;gicas &#8211; 5&#37; &#40;4&#47;78&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">M&#233;todos</span><p id="par0040" class="elsevierStylePara elsevierViewall">As an&#225;lises cromoss&#244;micas por <span class="elsevierStyleItalic">microarray</span> foram feitas em todos os 78 pacientes&#46; Os pais dos pacientes n&#227;o foram testados&#46; Para cada amostra&#44; 250<span class="elsevierStyleHsp" style=""></span>ng de DNA gen&#244;mico foram marcados e hibridados no chip CytoScan HD &#40;Affymetrix<span class="elsevierStyleSup">&#174;</span>&#44; EUA&#41;&#44; de acordo com as recomenda&#231;&#245;es do fabricante&#46; Os par&#226;metros de controle de qualidade foram avaliados com o pacote de <span class="elsevierStyleItalic">software</span> de sistema de genotipagem Affymetrix<span class="elsevierStyleSup">&#174;</span>&#46; Os dados de <span class="elsevierStyleItalic">array</span> foram analisados com o <span class="elsevierStyleItalic">software</span> de an&#225;lise cromoss&#244;mica &#40;ChAS Affymetrix<span class="elsevierStyleSup">&#174;</span>&#41;&#46; Foram aplicados filtros de 25 marcadores gen&#233;ticos para dele&#231;&#227;o e 50 para duplica&#231;&#245;es&#44; conforme recomendado pelo fabricante&#44; e tamb&#233;m foi aplicado um comprimento m&#237;nimo do segmento de 300<span class="elsevierStyleHsp" style=""></span>kb para duplica&#231;&#245;es e dele&#231;&#245;es &#40;definido como amplas varia&#231;&#245;es no n&#250;mero de c&#243;pias &#40;CNVs&#41;&#46; Essas CNVs foram confirmadas com o <span class="elsevierStyleItalic">software</span> Nexus Copy Number &#40;BioDiscovery<span class="elsevierStyleSup">&#174;</span>&#44; EUA&#41;&#46; As CNVs foram ainda comparadas com um conjunto de dados de CNVs para controle interno&#44; inclusive 105 controles da popula&#231;&#227;o geral brasileira designada com o Cytoscan HD &#40;Affymetrix<span class="elsevierStyleSup">&#174;</span>&#41;&#46; Apenas os desequil&#237;brios gen&#244;micos encontrados em todas as abordagens foram selecionados para investiga&#231;&#227;o mais detalhada&#44; com as seguintes bases de dados&#58; <span class="elsevierStyleItalic">Database of Genomic Variants</span> &#40;DGV&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">6</span></a><span class="elsevierStyleItalic">Database of Chromosomal Imbalance and Phenotype in Humans</span> &#40;DECIPHER&#41;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">7</span></a> e <span class="elsevierStyleItalic">Online Mendelian Inheritance in Man</span> &#40;OMIM&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">8</span></a> As CNVs consideradas relevantes foram transferidas para confirma&#231;&#227;o por outra plataforma de <span class="elsevierStyleItalic">microarray</span>&#46; Essa confirma&#231;&#227;o foi feita para 18 pacientes&#44; com o microarray de genoma humano G3 SurePrint 8<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>K<span class="elsevierStyleHsp" style=""></span>da Agilent &#40;Agilent Technologies&#174;&#44; EUA&#41;&#46; O DNA extra&#237;do dos pacientes e os controles de refer&#234;ncia &#40;Promega&#174;&#44; EUA&#41; foram medidos para concentra&#231;&#227;o e pureza com o espectrofot&#244;metro Qubit<span class="elsevierStyleSup">&#174;</span> &#40;Life Technologies&#174;&#44; EUA&#41;&#46; A quantidade de 500<span class="elsevierStyleHsp" style=""></span>ng de DNA do paciente e um DNA de refer&#234;ncia com correspond&#234;ncia sexual foi processada para rotulagem e hibridiza&#231;&#227;o de acordo com o protocolo do fabricante &#40;hibridiza&#231;&#227;o gen&#244;mica comparativa &#40;CGH&#41; &#8211; <span class="elsevierStyleItalic">array</span> de oligonucleot&#237;deos da Agilent para an&#225;lise do DNA gen&#244;mico &#8211; protocolo de rotulagem enzim&#225;tica v7&#46;3&#41;&#46; Os slides foram digitalizados em um scanner dual&#8208;laser G4900DA &#40;Agilent Technologies&#174;&#44; EUA&#41; e as imagens foram extra&#237;das e analisadas com o <span class="elsevierStyleItalic">software</span> de extra&#231;&#227;o de recursos Agilent &#40;v&#46;11&#46;5&#46;1&#46;1&#41;&#46; Os dados de <span class="elsevierStyleItalic">array</span> foram analisados com o <span class="elsevierStyleItalic">software</span> de citogen&#233;tica &#40;v&#46;3&#46;0&#46;1&#46;1&#41;&#46; Um fluxograma com a popula&#231;&#227;o de pacientes estudada encontra&#8208;se resumido na <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Resultados</span><p id="par0045" class="elsevierStylePara elsevierViewall">Foram detectadas 67 CNVs &#8805; 300<span class="elsevierStyleHsp" style=""></span>kb&#44; 33 dele&#231;&#245;es e 34 duplica&#231;&#245;es&#46; As CNVs com menos de 100&#37; de sobreposi&#231;&#227;o de casos na DECIPHER e as CNVs com mais de quatro ocorr&#234;ncias na DGV &#40;sobreposi&#231;&#227;o de mais de 50&#37;&#41; n&#227;o foram consideradas potencialmente relevantes&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Dentre as 67 CNVs &#8805; 300<span class="elsevierStyleHsp" style=""></span>kb&#44; 25 abrangem genes&#44; 11 dele&#231;&#245;es e 14 duplica&#231;&#245;es&#59; 18 CNVs foram confirmadas por outra plataforma de <span class="elsevierStyleItalic">microarray</span> e duas foram anteriormente detectadas pelas t&#233;cnicas de FISH e&#47;ou MLPA &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46; As s&#237;ndromes de anomalias cong&#234;nitas m&#250;ltiplas j&#225; foram relatadas na literatura e envolvem oito dessas CNVs&#58; s&#237;ndrome de dele&#231;&#227;o 16p11&#46;2 OMIM 611913 &#40;caso 8&#41;&#44; s&#237;ndrome de dele&#231;&#227;o 17q12 OMIM 614527 &#40;caso 26&#41;&#44; s&#237;ndrome de dele&#231;&#227;o 5p OMIM 123450 &#40;caso 29&#41;&#44; s&#237;ndrome de duplica&#231;&#227;o 3q &#40;caso 40&#41;&#44; s&#237;ndrome de dele&#231;&#227;o 10q22&#8208;q23 OMIM 612242 &#40;caso 71&#41;&#44; s&#237;ndrome de dele&#231;&#227;o 4q &#40;caso 72&#41;&#44; s&#237;ndrome de dele&#231;&#227;o 8p23&#46;1 &#40;caso 77&#41; e s&#237;ndrome de dele&#231;&#227;o 22q13&#46;33 OMIM 606232 &#40;caso 78&#41;&#46; Esses pacientes apresentaram caracter&#237;sticas cl&#237;nicas que sobrepuseram 22q11&#46;2DS &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Portanto&#44; as CNVs patog&#234;nicas foram detectadas em oito dos 78 pacientes &#40;10&#37;&#41;&#44; com tamanhos de 611 Kb a 17&#44;4 Mb&#46; Os genes que reconhecidamente participam do desenvolvimento card&#237;aco e que s&#227;o candidatos a CC s&#227;o relatados na <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#46; Al&#233;m disso&#44; foram identificadas duas CNVs potencialmente relevantes que abrangem genes card&#237;acos &#40;duplica&#231;&#227;o de 993<span class="elsevierStyleHsp" style=""></span>kb em 15q21&#46;1 e duplica&#231;&#227;o de 706<span class="elsevierStyleHsp" style=""></span>kb em 2p22&#46;3&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discuss&#227;o</span><p id="par0060" class="elsevierStylePara elsevierViewall">Elucidar a contribui&#231;&#227;o gen&#233;tica de doen&#231;as complexas &#233; dif&#237;cil devido ao grande n&#250;mero&#44; &#224; baixa frequ&#234;ncia e ao efeito vari&#225;vel do local de predisposi&#231;&#227;o&#46; As CNVs gen&#244;micas foram estabelecidas como uma importante fonte de varia&#231;&#227;o gen&#233;tica humana inerente a v&#225;rias s&#237;ndromes de anomalias cong&#234;nitas m&#250;ltiplas&#44; inclusive a 22q11&#46;2DS&#46; Para determinar se a CNV contribui ou n&#227;o para um fen&#243;tipo depende de diversos fatores&#44; inclusive do modo de heran&#231;a&#44; do conte&#250;do gen&#233;tico&#44; do n&#250;mero de c&#243;pias &#40;perda ou ganho&#41;&#44; da plataforma de <span class="elsevierStyleItalic">array</span> usada e se ela foi encontrada em grupos de controle da popula&#231;&#227;o geral&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">9</span></a> Em geral&#44; CNVs mais amplas t&#234;m um maior potencial de patogenia&#44; pois &#233; mais poss&#237;vel o envolvimento de um gene sens&#237;vel &#224; dosagem e&#47;ou que um maior n&#250;mero de genes esteja inclu&#237;do no desequil&#237;brio&#44; o que resulta em um fen&#243;tipo anormal&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">10</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">A classifica&#231;&#227;o de uma varia&#231;&#227;o no n&#250;mero de c&#243;pias CNV n&#227;o relatada anteriormente&#44; e que n&#227;o inclui um gene de doen&#231;a anteriormente conhecida&#44; pode variar entre diferentes popula&#231;&#245;es&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">10</span></a> Portanto&#44; nossa an&#225;lise das CNVs foi feita com foco no diagn&#243;stico e de acordo com tr&#234;s abordagens anal&#237;ticas&#44; pois ainda n&#227;o h&#225; uma base de dados de controle populacional brasileira dispon&#237;vel&#46; Consideramos um tamanho m&#237;nimo de 300<span class="elsevierStyleHsp" style=""></span>kb &#40;definido como CNVs amplas&#41;&#44; o n&#250;mero recomendado de marcadores gen&#233;ticos e apenas CNVs identificadas por todas as tr&#234;s abordagens selecionadas para pesquisa e confirma&#231;&#227;o&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">CNVs patog&#234;nicas foram detectadas em oito dos 78 pacientes &#40;10&#37;&#41; e os genes envolvidos&#44; como <span class="elsevierStyleItalic">IRX4&#44; BMPR1A&#44; SORBS2&#44; ID2&#44; ROCK2&#44; E2F6&#44; GATA4</span> e <span class="elsevierStyleItalic">SOX7</span>&#44; s&#227;o conhecidos por atuar no desenvolvimento card&#237;aco e seriam candidatos a CC&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">11&#8211;18</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">O caso 8 mostrou uma dele&#231;&#227;o de 611<span class="elsevierStyleHsp" style=""></span>kb com sobreposi&#231;&#227;o &#224; regi&#227;o cr&#237;tica da s&#237;ndrome de dele&#231;&#227;o 16p11&#46;2&#46; Os pacientes com essa s&#237;ndrome normalmente apresentam atraso no desenvolvimento&#44; defici&#234;ncia intelectual&#44; caracter&#237;sticas de transtornos do espectro autista&#44; convuls&#245;es &#40;epilepsia&#41; e obesidade&#44;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">19</span></a> n&#227;o apresentados por nossos pacientes&#46; Menos frequentemente&#44; foram observados CC&#44; dismorfismos faciais menores e atraso na fala&#44;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">19</span></a> em concord&#226;ncia com nosso paciente&#46; Nosso paciente apresentou ToF e arco a&#243;rtico interrompido&#46; Essa regi&#227;o exclu&#237;da n&#227;o aloca genes candidatos a CC&#44; at&#233; o momento&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">O caso 26 mostrou uma dele&#231;&#227;o de 1&#44;8<span class="elsevierStyleHsp" style=""></span>kb com sobreposi&#231;&#227;o &#224; regi&#227;o cr&#237;tica da s&#237;ndrome de dele&#231;&#227;o 17q12&#46; As dele&#231;&#245;es dessa regi&#227;o&#44; inclusive o gene <span class="elsevierStyleItalic">HNF1&#946;</span>&#44; foram encontradas em pacientes com diabete tipo MODY 5 &#40;MODY5&#41; e em pacientes com doen&#231;a renal c&#237;stica&#44; dilata&#231;&#245;es renais&#44; atrofia pancre&#225;tica e anormalidades hep&#225;ticas&#44;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">20</span></a> n&#227;o apresentadas por nosso paciente&#46; Recentemente&#44; defici&#234;ncia intelectual&#44; atraso na fala e dismorfismos faciais foram associados a dele&#231;&#227;o&#44;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">21</span></a> compat&#237;vel com nosso paciente&#44; por&#233;m CC n&#227;o foi mencionada&#46; Nosso paciente apresentou VAB&#46; N&#227;o houve relato de genes candidatos a CC at&#233; o momento&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">O caso 29 apresentou dele&#231;&#227;o de 17&#44;4 Mb em 5p15&#46;1&#8208;p15&#46;33&#44; abrangeu a s&#237;ndrome de dele&#231;&#227;o 5p &#40;s&#237;ndrome de Cri Du Chat&#41;&#46; Os neonatos com essa condi&#231;&#227;o normalmente apresentam grudo agudo que soa como o de um gato&#44; microcefalia&#44; baixo peso ao nascer e hipotonia&#44;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">22</span></a> n&#227;o relatados pelos pais dos pacientes &#40;avaliado por um ano&#41;&#46; Os indiv&#237;duos afetados tamb&#233;m apresentam defici&#234;ncia intelectual e atraso no desenvolvimento&#44; caracter&#237;sticas faciais distintivas&#44; inclusive hipertelorismo&#44; orelhas baixas&#44; mand&#237;bula pequena e CC&#44;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">22</span></a> observados em nosso paciente&#46; A baixa resolu&#231;&#227;o do cari&#243;tipo anterior &#91;46&#44;XY&#93; prejudicou o diagn&#243;stico desse paciente&#44; que foi aprimorado com hibrida&#231;&#227;o gen&#244;mica em <span class="elsevierStyleItalic">arrays</span> &#40;aGH&#41;&#46; Nosso paciente apresenta PCA&#46; A regi&#227;o exclu&#237;da aloca um gene com fator de transcri&#231;&#227;o card&#237;aco&#44; o <span class="elsevierStyleItalic">IRX4</span>&#44; nas quais as muta&#231;&#245;es estavam relacionadas a CC&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">11</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">O caso 40 apresentou duplica&#231;&#227;o de 2 Mb em 3q26&#46;2&#44; n&#227;o abrangeu a regi&#227;o cr&#237;tica da s&#237;ndrome de duplica&#231;&#227;o 3q &#40;definida como 3q26&#46;31&#8208;q27&#46;3&#41;&#46; Recentemente&#44; casos com duplica&#231;&#245;es parciais 3q que envolvem a regi&#227;o de nossa CNV foram relatados e associados a essa s&#237;ndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">23</span></a> O fen&#243;tipo normalmente envolve CC&#44; anomalias cerebrais&#44; microcefalia e dismorfismos faciais at&#237;picos compat&#237;veis com nosso paciente&#46; Nosso paciente apresentou ToF&#44; DAS&#44; atresia pulmonar e persist&#234;ncia da veia cava superior esquerda&#46; N&#227;o houve relato de genes candidatos a CC nessa regi&#227;o duplicada at&#233; o momento&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">O caso 71 mostrou uma dele&#231;&#227;o de 7&#44;8 Mb em 10q22&#46;3&#8208;q23&#46;2 e essa regi&#227;o foi recentemente associada a uma nova s&#237;ndrome caracterizada por comprometimento comportamental e do desenvolvimento neurol&#243;gico&#44; inclusive atraso cognitivo&#44; autismo&#44; hiperatividade e doen&#231;a psiqui&#225;trica&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">24</span></a> Nosso paciente apresentou apenas atraso no desenvolvimento&#46; Al&#233;m disso&#44; dismorfismos faciais leves e CC foram observados de forma menos frequente na s&#237;ndrome de dele&#231;&#227;o 10q22&#8208;q23&#44;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">25</span></a> ambos apresentados por nosso paciente&#46; Nosso paciente apresentou ToF&#46; Essa regi&#227;o exclu&#237;da abrange o gene <span class="elsevierStyleItalic">BMPR1A</span>&#44; sugere um gene candidato a CC devido a seu papel no desenvolvimento embrion&#225;rio e na forma&#231;&#227;o do cora&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">12</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">O caso 72 apresentou dele&#231;&#227;o de 4&#44;5 Mb em 4q35&#46;1&#8208;q35&#46;2&#46; As dele&#231;&#245;es em 4q s&#227;o raras e associadas a defici&#234;ncia intelectual&#44; dismorfismos craniofaciais&#44; orelhas baixas&#44; fissura palatina&#44; CC e anomalias do quinto dedo&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">26</span></a> Nosso paciente apresentou a maior parte dessas caracter&#237;sticas&#44; exceto orelhas baixas e fissura palatina&#46; Al&#233;m disso&#44; esse paciente mostrou uma duplica&#231;&#227;o de 14&#44;8 Mb em 2p24&#46;3&#8208;p25&#46;3 e duplica&#231;&#227;o de 375 bK em 16p12&#46;2&#44; ambas CNVs sem um fen&#243;tipo espec&#237;fico descrito at&#233; o momento&#46; Nosso paciente apresentou DSV&#44; DAS&#44; atresia pulmonar e transposi&#231;&#227;o das grandes art&#233;rias&#46; A regi&#227;o exclu&#237;da 4q35&#46;1&#8208;q35&#46;2 aloca o gene <span class="elsevierStyleItalic">SORBS2</span>&#44; que &#233; altamente expresso em discos intercalares de tecidos normais do cora&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">13</span></a> A regi&#227;o duplicada de<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>2p24&#46;3&#8208;p25s abrange os genes <span class="elsevierStyleItalic">ID2</span>&#44; <span class="elsevierStyleItalic">ROCK2</span> e <span class="elsevierStyleItalic">E2F6</span>&#44; que atuam no desenvolvimento do cora&#231;&#227;o e s&#227;o genes candidatos a CC&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">14&#8211;16</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">O caso 77 mostrou uma dele&#231;&#227;o de 3&#44;8<span class="elsevierStyleHsp" style=""></span>kb que abrangeu a regi&#227;o cr&#237;tica da s&#237;ndrome de dele&#231;&#227;o 8p23&#46;1&#59; a CC &#233; a marca registrada dessa s&#237;ndrome&#44; principalmente defeitos do septo atrioventricular&#44; defeito do septo atrial e estenose pulmonar&#44;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">5</span></a> compat&#237;vel com os achados de nosso paciente&#46; Al&#233;m disso&#44; foi observado que microcefalia&#44; dismorfismos faciais&#44; atraso no desenvolvimento e problemas comportamentais est&#227;o associados a essa s&#237;ndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">5</span></a> Nosso paciente apresentou DSV&#44; DAS&#44; atresia pulmonar e persist&#234;ncia da veia cava superior esquerda&#46; Essa regi&#227;o exclu&#237;da abrange os genes <span class="elsevierStyleItalic">GATA4 e SOX7</span>&#44; ambos fatores de transcri&#231;&#227;o que atuam na embriog&#234;nese card&#237;aca&#46; Eles foram sugeridos como os genes candidatos a CC&#44; com base em modelos animais&#44; muta&#231;&#245;es relatadas por pacientes e estudos sobre CNVs&#46;<a class="elsevierStyleCrossRefs" href="#bib0245"><span class="elsevierStyleSup">17&#44;18</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">O caso 78 apresentou uma dele&#231;&#227;o de 1&#44;1 Mb que abrangeu a regi&#227;o cr&#237;tica da s&#237;ndrome de dele&#231;&#227;o 22q13&#46;33 &#40;s&#237;ndrome de Phelan&#8208;McDermid&#41;&#44; caracterizada por atraso no desenvolvimento&#44; retardo ou aus&#234;ncia de fala e caracter&#237;sticas autistas&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">27</span></a> Nosso paciente apresenta atraso no desenvolvimento e na fala&#46; Al&#233;m disso&#44; e de forma menos frequente&#44; foram observados dismorfismos faciais&#44; infec&#231;&#245;es recorrentes&#44; CC e dificuldade na alimenta&#231;&#227;o&#44;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">28</span></a> compat&#237;vel com nosso paciente&#46; Nosso paciente apresentou VAB&#44; ectasia da aorta e seio de valsalva&#46; Essa regi&#227;o exclu&#237;da n&#227;o aloca genes candidatos a CC at&#233; o momento&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Os estudos sobre CNVs em pacientes com fen&#243;tipos semelhantes de doen&#231;as bem conhecidas podem contribuir para um melhor conhecimento dos fen&#243;tipos e para a identifica&#231;&#227;o dos genes e das vias envolvidas em CCs espec&#237;ficas e outras altera&#231;&#245;es&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">29</span></a> As CNVs detectadas neste estudo anteriormente descritas em s&#237;ndromes clinicamente reconhec&#237;veis podem ajuda no manejo cl&#237;nico e proporcionar aconselhamento gen&#233;tico adequado para esses pacientes e suas fam&#237;lias&#46; Esses achados tamb&#233;m refor&#231;am a import&#226;ncia da CMA para o diagn&#243;stico&#46; Al&#233;m disso&#44; duas CNVs detectadas aqui possivelmente est&#227;o relacionadas a CC&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">O caso 35 apresentou duplica&#231;&#227;o em 15q21&#46;1 &#40;993<span class="elsevierStyleHsp" style=""></span>kb&#41;&#44; inclusive sete genes&#44; dois dos quais podem ser real&#231;ados&#46; O gene <span class="elsevierStyleItalic">SEMA6D</span> atua na morfog&#234;nese do cora&#231;&#227;o&#59;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">30</span></a> e o gene <span class="elsevierStyleItalic">FBN1</span> atua no desenvolvimento do cora&#231;&#227;o e as muta&#231;&#245;es nesse gene s&#227;o associadas a CC&#46;<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">31</span></a> Essa CNV &#233; descrita em quatro indiv&#237;duos na DECIPHER &#40;286150&#44; 250179&#44; 260222&#44; 278520&#41;&#44; que apresentam somente essa varia&#231;&#227;o&#59; contudo&#44; nenhum deles apresentou CC&#46; Essa CNV n&#227;o foi detectada na DGV&#46; Nosso paciente apresentou ToF&#44; atresia pulmonar e persist&#234;ncia da veia cava superior esquerda&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">O caso 52 apresentou duplica&#231;&#227;o em 2p22&#46;3 &#40;706<span class="elsevierStyleHsp" style=""></span>kb&#41;&#44; inclusive sete genes como <span class="elsevierStyleItalic">LTPB1</span>&#44; que &#233; o maior regulador do gene <span class="elsevierStyleItalic">TGFB1</span> e atua no desenvolvimento da v&#225;lvula do cora&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">32</span></a> Essa CNV foi encontrada em dois indiv&#237;duos na DECIPHER &#40;249550&#44; 249780&#41;&#44; que apresentaram apenas essa varia&#231;&#227;o&#59; contudo&#44; sem CC&#46; Essa CNV foi descrita em quatro estudos na DGV &#40;Varia&#231;&#227;o&#95;8367&#44; Varia&#231;&#227;o&#95;53694&#44; Varia&#231;&#227;o&#95;5203&#44; Varia&#231;&#227;o&#95;5202&#41;&#46; Nosso paciente apresentou ToF&#44; atresia pulmonar e DAS&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">CNVs clinicamente significativas foram identificadas em 10&#37; dos casos&#46; Isso refor&#231;a que a CMA &#233; uma tecnologia confi&#225;vel para pacientes que apresentam CC com anomalias extracard&#237;acas e exclus&#227;o de 22q11&#46;2DS&#46; H&#225; uma sobreposi&#231;&#227;o entre as manifesta&#231;&#245;es cl&#237;nicas de v&#225;rias s&#237;ndromes listadas aqui&#44; apesar de abranger caracter&#237;sticas distintas&#46; O mesmo aplica&#8208;se ao fen&#243;tipo de nossos indiv&#237;duos&#46; Isso refor&#231;a os mecanismos complexos envolvidos na embriog&#234;nese humana&#44; que implica a correta intera&#231;&#227;o entre os genes&#46; Como v&#225;rios mecanismos de intera&#231;&#227;o entre os genes n&#227;o foram completamente elucidados&#44; nosso estudo enfatiza a poss&#237;vel atua&#231;&#227;o das CNVs na CC&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Financiamento</span><p id="par0135" class="elsevierStylePara elsevierViewall">Funda&#231;&#227;o de Amparo &#224; Pesquisa do Estado de S&#227;o Paulo &#40;Fapesp&#41; &#40;2008&#47;10596&#8208;0&#44; 2008&#47;50421&#8208;4&#44; 2009&#47;08756&#8208;1 e 2011&#47;23794&#8208;7&#41; e Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#40;CNPq&#41; &#40;149600&#47;2010&#8208;0 e 471422&#47;2011&#8208;8&#41;&#46; VLGSL conta com o apoio de CNPq 304455&#47;2012&#8208;1&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflitos de interesse</span><p id="par0140" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflitos de interesse&#46;</p></span></span>"
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          "titulo" => "Pacientes e m&#233;todos"
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    "fechaRecibido" => "2016-07-27"
    "fechaAceptado" => "2016-11-21"
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          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec884890"
          "palabras" => array:5 [
            0 => "DNA copy number variations"
            1 => "Congenital heart defects"
            2 => "22q11 deletion syndrome"
            3 => "Comparative genomic hybridization"
            4 => "Chromosome aberrations"
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          "palabras" => array:5 [
            0 => "Varia&#231;&#245;es do n&#250;mero de c&#243;pias de DNA"
            1 => "Cardiopatias cong&#234;nitas"
            2 => "S&#237;ndrome de dele&#231;&#227;o 22q11"
            3 => "Hibridiza&#231;&#227;o gen&#244;mica comparativa"
            4 => "Aberra&#231;&#245;es cromoss&#244;micas"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To identify pathogenic genomic imbalances in patients presenting congenital heart disease &#40;CHD&#41; with extra cardiac anomalies and exclusion of 22q11&#46;2 deletion syndrome &#40;22q11&#46;2 DS&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">78 patients negative for the 22q11&#46;2 deletion&#44; previously screened by fluorescence in situ hybridization &#40;FISH&#41; and&#47;or multiplex ligation probe amplification &#40;MLPA&#41; were tested by chromosomal microarray analysis &#40;CMA&#41;&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Clinically significant copy number variations &#40;CNVs &#8805;300<span class="elsevierStyleHsp" style=""></span>kb&#41; were identified in 10&#37; &#40;8&#47;78&#41; of cases&#46; In addition&#44; potentially relevant CNVs were detected in two cases &#40;993<span class="elsevierStyleHsp" style=""></span>kb duplication in 15q21&#46;1 and 706<span class="elsevierStyleHsp" style=""></span>kb duplication in 2p22&#46;3&#41;&#46; Genes inside the CNV regions found in this study&#44; such as IRX4&#44; BMPR1A&#44; SORBS2&#44; ID2&#44; ROCK2&#44; E2F6&#44; GATA4&#44; SOX7&#44; SEMAD6D&#44; FBN1&#44; and LTPB1 are known to participate in cardiac development and could be candidate genes for CHD&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">These data showed that patients presenting CHD with extra cardiac anomalies and exclusion of 22q11&#46;2 DS should be investigated by CMA&#46; The present study emphasizes the possible role of CNVs in CHD&#46;</p></span>"
        "secciones" => array:4 [
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          1 => array:2 [
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Identificar desequil&#237;brios gen&#244;micos patog&#234;nicos em pacientes que apresentam cardiopatias cong&#234;nitas &#40;CC&#41; e anomalias extracard&#237;acas e exclus&#227;o da s&#237;ndrome de dele&#231;&#227;o 22q11&#46;2 &#40;SD22q11&#46;2&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Foram avaliados por <span class="elsevierStyleItalic">microarray</span> cromoss&#244;mico &#40;CMA&#41; 78 pacientes negativos para a dele&#231;&#227;o 22q11&#46;2&#44; previamente testados por hibrida&#231;&#227;o <span class="elsevierStyleItalic">in situ</span> com fluoresc&#234;ncia &#40;FISH&#41; e&#47;ou amplifica&#231;&#227;o de m&#250;ltiplas sondas dependentes de liga&#231;&#227;o &#40;MLPA&#41;&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Foram identificadas varia&#231;&#245;es do n&#250;mero de c&#243;pias de DNA &#40;CNVs&#41; clinicamente significativas &#40;&#8805; 300<span class="elsevierStyleHsp" style=""></span>kb&#41; em 10&#37; &#40;8&#47;78&#41; dos casos&#44; al&#233;m de CNVs potencialmente relevantes em dois casos &#40;duplica&#231;&#227;o de 993<span class="elsevierStyleHsp" style=""></span>kb em 15q21&#46;1 e duplica&#231;&#227;o de 706<span class="elsevierStyleHsp" style=""></span>kb em 2p22&#46;3&#41;&#46; Genes envolvidos como IRX4&#44; BMPR1A&#44; SORBS2&#44; ID2&#44; ROCK2&#44; E2F6&#44; GATA4&#44; SOX7&#44; SEMAD6D&#44; FBN1 e LTPB1 s&#227;o conhecidos por atuar no desenvolvimento card&#237;aco e podem ser genes candidatos a CC&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Esses dados mostram que pacientes que apresentam CC&#44; com anomalias extracard&#237;acas e exclus&#227;o da SD22q11&#46;2&#44; devem ser investigados por CMA&#46; Ainda&#44; este estudo enfatiza a poss&#237;vel fun&#231;&#227;o das CNVs nas CC&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Como citar este artigo&#58; Molck MC&#44; Simioni M&#44; Vieira TP&#44; Sgardioli IC&#44; Monteiro FP&#44; Souza J&#44; et al&#46; Genomic imbalances in syndromic congenital heart disease&#46; J Pediatr &#40;Rio J&#41;&#46; 2017&#59;93&#58;497&#8211;507&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Estudo realizado na Universidade Estadual de Campinas &#40;UNICAMP&#41;&#44; Departamento de Gen&#233;tica M&#233;dica&#44; Campinas&#44; SP&#44; Brasil&#46;</p>"
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          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Fluxograma com a popula&#231;&#227;o de pacientes e t&#233;cnicas aplicadas&#46;FISH&#44; fluorescence in situ hybridization&#59; MLPA&#44; multiplexligation probe amplification&#59; CMA&#44; chromosomal microarray&#59; CNVs&#44; copy number variations&#59; ChAS&#44; chromosome analysis suite&#59; DGV&#44;database of genomic variants&#59; DECIPHER&#44; database of chromosomal imbalance and phenotype in humans using ensemble resources&#59;OMIM&#44; Online Mendelian Inheritance In Man&#46;</p>"
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        "etiqueta" => "Tabela 1"
        "tipo" => "MULTIMEDIATABLA"
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        "detalles" => array:1 [
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            "identificador" => "at1"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">&#8208;&#44; aus&#234;ncia&#59; &#43;&#44; presen&#231;a&#59; AAI&#44; arco a&#243;rtico interrompido&#59; aCGH&#44; hibridiza&#231;&#227;o gen&#244;mica comparativa em <span class="elsevierStyleItalic">array</span> &#40;com o microarray de Genoma Humano G3 SurePrint 8<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>60<span class="elsevierStyleHsp" style=""></span>K<span class="elsevierStyleHsp" style=""></span>da Agilent&#41;&#59; AP&#44; atresia pulmonar&#59; bp&#44; pares de base&#59; CC&#44; cardiopatia cong&#234;nita&#59; CNV&#44; varia&#231;&#227;o no n&#250;mero de c&#243;pias&#59; DAS&#44; defeito do septo atrial&#59; DECIPHER&#44; <span class="elsevierStyleItalic">Database of Chromosomal Imbalance and Phenotype in Humans using Ensembl Resources</span><a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup"><span class="elsevierStyleItalic">7</span></span></a>&#59; del&#44; exclus&#227;o&#59; DGV&#44; Database of Genomic Variants&#59;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">6</span></a> DSV&#44; defeito do septo ventricular&#59; dup&#44; duplica&#231;&#227;o&#59; EA&#44; ectasia da aorta&#59; ID&#44; identifica&#231;&#227;o do paciente&#59; kb&#44; kilobase&#59; NR&#44; n&#227;o realizado&#59; PCA&#44; persist&#234;ncia do canal arterial&#59; PVCSE&#44; persist&#234;ncia da veia cava superior esquerda&#59; PVM&#44; prolapso da v&#225;lvula mitral&#59; SV&#44; seio de valsalva&#59; TA&#44; <span class="elsevierStyleItalic">truncus arteriosus</span>&#59; TGA&#44; transposi&#231;&#227;o das grandes art&#233;rias&#59; ToF&#44; tetralogia de Fallot&#59; VA&#44; validado anteriormente &#40;detectado pelas t&#233;cnicas de FISH e&#47;ou MLPA&#41;&#59; VAB&#44; v&#225;lvula a&#243;rtica bic&#250;spide&#46;</p>"
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">ID&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tipo de CC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">CNV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Local&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">N&#250;mero de c&#243;pias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">In&#237;cio &#40;bp&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Final &#40;bp&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tamanho &#40;kb&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Genes RefSeq&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">DGV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">DECIPHER&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Validado por aCGH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DAS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12p12&#46;1&#8208;p12&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20&#46;994&#46;908&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#46;415&#46;634&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">421&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">SLCO1B3&#44; SLCO1B7&#44; SLCO1B1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DAS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15q22&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&#46;209&#46;640&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&#46;543&#46;660&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">334&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">VPS13</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">C&#44; C2CD4A&#44; C2CD4B</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ToF&#44; AAI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16p11&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;567&#46;295&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#46;177&#46;916&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">611&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">SLC7A5P1&#44; SPN&#44; QPRT&#44; ZG16&#44; KIF22&#44; MAZ&#44; PRRT2&#44; MVP&#44; CDIPT&#44; SEZ6L2&#44; ASPHD1&#44; KCTD13&#44; TMEM219&#44; TAOK2&#44; HIRIP3&#44; INO80E&#44; DOC2A&#44; FAM57B&#44; ALDOA&#44; PPP4</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">C&#44; TBX6&#44; YPEL3&#44; GDPD3&#44; MAPK3</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">TA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8p11&#46;1&#8208;p11&#46;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">42&#46;935&#46;729&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43&#46;776&#46;564&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">841&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">FNTA&#44; SGK196&#44; HGSNAT&#44; POTEA</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DSV&#44; DAS&#44; AP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10q25&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">110&#46;420&#46;129&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">111&#46;116&#46;531&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">696&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">RNU6&#8208;53&#44; MAPKAPK5P1&#8208;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DSV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Yp11&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#46;664&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#46;997&#46;425&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">333&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">TTTY23&#44; TTTY23B</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DAS&#44; PDA&#44; AP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2q13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">110&#46;504&#46;318&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">111&#46;365&#46;996&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">862&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">RGPD5&#44; RGPD6&#44; LIMS3&#44; LIMS3L&#44; LIMS3&#8208;LOC440895&#44; LOC440895&#44; LOC100288570&#44; LOC440894&#44; MIR4267&#44; MALL&#44; MIR4436B2&#44; MIR4436B1&#44; NPHP1&#44; LINC00116&#44; LOC100507334&#44; LOC151009</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DAS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7q21&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">88&#46;819&#46;024&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">89&#46;678&#46;695&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">860&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">ZNF804B</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DAS&#44; TA&#44; AP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16p11&#46;1&#8208;p11&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#46;197&#46;616&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35&#46;158&#46;405&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">961&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">UBE2MP1&#44; LOC283914&#44; LOC146481&#44; LOC100130700&#44; RN5S411&#44; FLJ26245</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">VAB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17q12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34&#46;477&#46;385&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">36&#46;283&#46;612&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;806&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">TBC1D3B&#44; CCL3L3&#44; CCL3L1&#44; CCL4L2&#44; CCL4L1&#44; TBC1D3</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">C&#44; TBC1D3H&#44; TBC1D3G&#44; ZNHIT3&#44; MYO19&#44; PIGW&#44; GGNBP2&#44; DHRS11&#44; MRM1&#44; LHX1&#44; AATF&#44; MIR2909&#44; ACACA&#44; C17orf78&#44; TADA2A&#44; DUSP14&#44; SYNRG&#44; DDX52&#44; HNF1B&#44; LOC284100</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">PCA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5p15&#46;1&#8208;p15&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">113&#46;576&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#46;511&#46;896&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#46;398&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">PLEKHG4B&#44; LRRC14B&#44; CCDC127&#44; SDHA&#44; PDCD6&#44; AHRR&#44; C5orf55&#44; EXOC3&#44; PP7080&#44; SLC9A3&#44; MIR4456&#44; CEP72&#44; TPPP&#44; ZDHHC11&#44; BRD9&#44; TRIP13&#44; LOC100506688&#44; NKD2&#44; SLC12A7&#44; MIR4635&#44; SLC6A19&#44; SLC6A18&#44; TERT&#44; MIR4457&#44; CLPTM1L&#44; SLC6A3&#44; LPCAT1&#44; SDHAP3&#44; LOC728613&#44; MIR4277&#44; MRPL36&#44; NDUFS6&#44; IRX4&#44; IRX2&#44; C5orf38&#44; LOC285577&#44; IRX1&#44; LOC340094&#44; ADAMTS16&#44; KIAA0947&#44; FLJ33360&#44; MED10&#44; UBE2QL1&#44; LOC255167&#44; NSUN2&#44; SRD5A1&#44; PAPD7&#44; MIR4278&#44; MIR4454&#44; LOC442132&#44; ADCY2&#44; C5orf49&#44; FASTKD3&#44; MTRR&#44; LOC729506&#44; LOC100505738&#44; MIR4458&#44; SEMA5A&#44; MIR4636&#44; LOC100505806&#44; SNORD123&#44; TAS2R1&#44; LOC285692&#44; FAM173B&#44; CCT5&#44; CMBL&#44; MARCH6&#44; ROPN1L&#44; ANKRD33B&#44; DAP&#44; CTNND2&#44; TAG&#44; DNAH5&#44; TRIO&#44; FAM105A&#44; FAM105B&#44; ANKH&#44; LOC100130744&#44; MIR4637&#44; FBXL7&#44; MARCH11&#44; ZNF622&#44; FAM134B&#44; MYO10&#44; LOC285696&#44; BASP1&#44; LOC401177</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DAS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5q33&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">154&#46;330&#46;014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">154&#46;664&#46;212&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">334&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">MRPL22&#44; KIF4B</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ToF&#44; AP&#44; PLSVC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15q21&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48&#46;023&#46;616&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&#46;017&#46;024&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">993&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">SEMA6D&#44; SLC24A5&#44; MYEF2&#44; CTXN2&#44; SLC12A1&#44; DUT&#44; FBN1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ToF&#44; AP&#44; DAS&#44; PVCSE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3q26&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">168&#46;485&#46;398&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">170&#46;468&#46;489&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;983&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">EGFEM1P&#44; MECOM&#44; TERC&#44; ACTRT3&#44; MYNN&#44; LRRC34&#44; LRRIQ4&#44; LRRC31&#44; SAMD7&#44; LOC100128164&#44; SEC62&#44; GPR160&#44; PHC3&#44; PRKCI&#44; SKIL&#44; CLDN11&#44; SLC7A14</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ToF&#44; AP&#44; DAS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2p22&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&#46;628&#46;617&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33&#46;334&#46;307&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">706&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">BIRC6&#44; MIR558&#44; TTC27&#44; MIR4765&#44; LINC00486&#44; LOC100271832&#44; LTBP1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ToF&#44; AP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6q14&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">87&#46;387&#46;316&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">87&#46;921&#46;049&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">534&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">HTR1E&#44; CGA&#44; ZNF292</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ToF&#44; AP&#44; MVP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16q23&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77&#46;923&#46;068&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">78&#46;596&#46;237&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">673&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">VAT1L&#44; CLEC3A&#44; WWOX</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ToF&#44; AP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3p26&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;750&#46;535&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;205&#46;306&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">455&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">CNTN4&#44; CNTN4&#8208;AS2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ToF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3p26&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;775&#46;844&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;158&#46;248&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">382&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">CNTN4&#44; CNTN4&#8208;AS2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">ToF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10q22&#46;3&#8208;q23&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">81&#46;446&#46;577&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">89&#46;253&#46;430&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;807&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">LOC650623&#44; LOC642361&#44; LOC100288974&#44; MBL1P&#44; SFTPD&#44; LOC219347&#44; C10orf57&#44; PLAC9&#44; ANXA11&#44; LOC439990&#44; MAT1A&#44; DYDC1&#44; DYDC2&#44; FAM213A&#44; TSPAN14&#44; SH2D4B&#44; NRG3&#44; GHITM&#44; C10orf99&#44; CDHR1&#44; LRIT2&#44; LRIT1&#44; RGR&#44; LOC170425&#44; FAM190B&#44; GRID1&#8208;AS1&#44; GRID1&#44; MIR346&#44; WAPAL&#44; OPN4&#44; LDB3&#44; BMPR1A&#44; MMRN2&#44; SNCG&#44; C10orf116&#44; AGAP11&#44; FAM25A&#44; GLUD1&#44; FAM35A&#44; FAM22A&#44; LOC728190&#44; LOC439994&#44; FAM22D&#44; LOC728218</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8208;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DAS&#44; AP&#44; ASD&#44; TGA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2p24&#46;3&#8208;p25&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#46;770&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#46;851&#46;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">14&#46;838&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">FAM110</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">C&#44; SH3YL1&#44; ACP1&#44; FAM150B&#44; TMEM18&#44; LOC339822&#44; SNTG2&#44; TPO&#44; PXDN&#44; MYT1L&#44; LOC730811&#44; TSSC1&#44; TRAPPC12&#44; ADI1&#44; RNASEH1&#44; LOC100506054&#44; RPS7&#44; COLEC11&#44; ALLC&#44; LOC100505964&#44; LOC727982&#44; SOX11&#44; LOC150622&#44; LOC400940&#44; LINC00487&#44; CMPK2&#44; RSAD2&#44; LOC386597&#44; RNF144A&#44; LOC100506274&#44; LOC339788&#44; LINC00299&#44; ID2&#44; KIDINS220&#44; MBOAT2&#44; ASAP2&#44; ITGB1BP1&#44; CPSF3&#44; IAH1&#44; ADAM17&#44; YWHAQ&#44; TAF1B&#44; GRHL1&#44; KLF11&#44; CYS1&#44; RRM2&#44; C2orf48&#44; MIR4261&#44; HPCAL1&#44; ODC1&#44; SNORA80B&#44; NOL10&#44; ATP6V1C2&#44; PDIA6&#44; KCNF1&#44; FLJ33534&#44; C2orf50&#44; PQLC3&#44; ROCK2&#44; LINC00570&#44; E2F6&#44; GREB1&#44; MIR4429&#44; NTSR2&#44; LPIN1&#44; MIR4262&#44; TRIB2&#44; MIR3125&#44; LOC100506474&#44; FAM84A</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4q35&#46;1&#8208;q35&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">186&#46;464&#46;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">190&#46;957&#46;473&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;493&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">SORBS2&#44; TLR3&#44; FAM149A&#44; FLJ38576&#44; CYP4V2&#44; KLKB1&#44; F11&#44; LOC285441&#44; MTNR1A&#44; FAT1&#44; LOC339975&#44; ZFP42&#44; TRIML2&#44; TRIML1&#44; LOC401164&#44; HSP90AA4P&#44; FRG1&#44; LOC100288255&#44; FRG2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16p12&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#46;576&#46;802&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21&#46;951&#46;415&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">375&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">METTL9&#44; IGSF6&#44; OTOA&#44; RRN3P1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">DSV&#44; AP&#44; DAS&#44; PVCSE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8p23&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#46;093&#46;065&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#46;935&#46;465&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;842&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">FLJ10661&#44; SGK223&#44; CLDN23&#44; MFHAS1&#44; ERI1&#44; MIR4660&#44; PPP1R3B&#44; LOC157273&#44; TNKS&#44; MIR597&#44; LINC00599&#44; MIR124&#8208;1&#44; MSRA&#44; PRSS55&#44; RP1L1&#44; C8orf74&#44; SOX7&#44; PINX1&#44; MIR1322&#44; XKR6&#44; MIR598&#44; MTMR9&#44; SLC35G5&#44; TDH&#44; C8orf12&#44; FAM167A&#44; BLK&#44; LINC00208&#44; GATA4&#44; NEIL2&#44; FDFT1&#44; CTSB&#44; DEFB136&#44; DEFB135&#44; DEFB134&#44; LOC100133267&#44; DEFB130</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">VA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">VAB&#44; EA&#44; SV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22q13&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50&#46;100&#46;435&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">51&#46;197&#46;838&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;097&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">BRD1&#44; LOC90834&#44; ZBED4&#44; ALG12&#44; CRELD2&#44; PIM3&#44; IL17REL&#44; MLC1&#44; MOV10L1&#44; PANX2&#44; TRABD&#44; SELO&#44; TUBGCP6&#44; HDAC10&#44; MAPK12&#44; MAPK11&#44; PLXNB2&#44; FAM116B&#44; PPP6R2&#44; SBF1&#44; ADM2&#44; MIOX&#44; LMF2&#44; NCAPH2&#44; SCO2&#44; TYMP&#44; ODF3B&#44; KLHDC7B&#44; SYCE3&#44; CPT1B&#44; CHKB&#8208;CPT1B&#44; CHKB&#44; LOC100144603&#44; MAPK8IP2&#44; ARSA&#44; SHANK3&#44; ACR&#44; RPL23AP82</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">VA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Tipo de CC e CNVs &#8805; 300<span class="elsevierStyleHsp" style=""></span>kb observado na coorte</p>"
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          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">&#8208;&#44; aus&#234;ncia&#59;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleMonospace">&#44;</span>presen&#231;a&#59; 22q11&#46;2DS&#44; s&#237;ndrome de dele&#231;&#227;o 22q11&#46;2&#59; a&#44; anos&#59; del&#44; dele&#231;&#227;o&#59; dip&#44; duplica&#231;&#227;o&#59; Kb&#44; kilobase&#59; Mb&#44; megabase&#59;</p><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">NR&#44; n&#227;o relatado&#44;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Caso 08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Caso 26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Caso 29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Caso 40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Caso 71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Caso 72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Caso 77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Caso 78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">22q11&#46;2DS<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Desequil&#237;brio gen&#244;mico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del 16p11&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del 17q12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del 5p15&#46;1&#8208;p15&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">dup 3q26&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del 10q22&#46;3&#8208;q23&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del 4q35&#46;1&#8208;q35&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del 8p23&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del 22q13&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">del 22q11&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tamanho da aberra&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">611 Kb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;8 Mb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#44;4 Mb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;0 Mb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;8 Mb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;5 Mb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;8 Mb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;1 Mb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;5&#8208;3&#44;0 Mb&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sexo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">masculino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Distribu&#237;da igualmente&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Idade na avalia&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&#37; &#8804;5 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Atraso no crescimento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cardiopatia cong&#234;nita&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anomalias palatais&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dismorfismos faciais&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Comum&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anomalias imunol&#243;gicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Comum&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Atraso no desenvolvimento&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&#8208;90&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Problemas na alimenta&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">30&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Perda auditiva&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anomalias oculares&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8805;69&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anomalias neurol&#243;gicas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anomalias no trato urin&#225;rio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anomalias gastrointestinais&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anomalias esquel&#233;ticas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#8211;&nbsp;\t\t\t\t\t\t\n
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          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas cl&#237;nicas dos pacientes que apresentam CNVs relacionadas a s&#237;ndromes com anomalias cong&#234;nitas m&#250;ltiplas que com sobreposi&#231;&#227;o da 22q11&#46;2DS</p>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="center" valign="middle">Receptor de BMP&#44; fator de transcri&#231;&#227;o RNA&#8208;polimerase II&#44; homodimeriza&#231;&#227;o de prote&#237;nas e atividade de prote&#237;na serina&#47;treonina quinase&#59; ATP&#44; SMAD&#44; glicoprote&#237;na&#44; liga&#231;&#227;o de &#237;ons met&#225;licos e prote&#237;nas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="center" valign="middle">Atividade do adaptador citoesquel&#233;tico&#44; &#237;on met&#225;lico&#44; RNA poli &#40;A&#41; e<br>liga&#231;&#227;o da prote&#237;na&#59; componente estrutural do citoesqueleto&#59; componente estrutural do m&#250;sculo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="center" valign="middle">ATP&#44; prote&#237;na Rho GTPase&#44; &#237;on met&#225;lico&#44; RNA poli&#40;A&#41; e liga&#231;&#227;o da prote&#237;na&#59; atividade de dimeriza&#231;&#227;o proteica&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="center" valign="middle"><span class="elsevierStyleItalic">morfog&#234;nese do septo membranoso</span>&#59; desenvolvimento metan&#233;frico&#59; desenvolvimento do organismos multicelulares&#59; diferencia&#231;&#227;o celular das c&#233;lulas <span class="elsevierStyleItalic">natural killer</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="center" valign="middle">Prote&#237;na serina dependente de Rho&#44; prote&#237;na serina&#47;treonina quinase e atividade molecular estrutural&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="middle">duplica&#231;&#227;o dos centrossomas&#59; organiza&#231;&#227;o do citoesqueleto de actina cortical&#59; via de sinaliza&#231;&#227;o do receptor de efrina&#59; <span class="elsevierStyleItalic">regula&#231;&#227;o negativa da angiog&#234;nese</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="center" valign="middle"><span class="elsevierStyleItalic">E2F6</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="center" valign="middle"><span class="elsevierStyleItalic">SOX7</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="center" valign="middle">612202&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="center" valign="middle">Prote&#237;na&#44; atividade do fator de transcri&#231;&#227;o&#44; liga&#231;&#227;o espec&#237;fica ao DNA e liga&#231;&#227;o ao DNA &#224; regi&#227;o reguladora da transcri&#231;&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="center" valign="middle">forma&#231;&#227;o da endoderme&#59; regula&#231;&#227;o negative de prolifera&#231;&#227;o celular&#59; regula&#231;&#227;o negativa da transcri&#231;&#227;o&#44; modelo do DNA&#59; regula&#231;&#227;o positiva da atividade da ciste&#237;na endopeptidase envolvida no processo apopt&#243;tico&#59; regula&#231;&#227;o da via de sinaliza&#231;&#227;o can&#244;nica Wnt&#59; transcri&#231;&#227;o&#44; modelo do DNA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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