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&#233; a doen&#231;a viral mais comum das vias a&#233;reas inferiores em lactentes&#44; caracterizada por inflama&#231;&#227;o&#44; edema e necrose de c&#233;lulas epiteliais de pequenas vias a&#233;reas&#44; com aumento de produ&#231;&#227;o de muco e broncoespasmo&#44; cujo diagn&#243;stico &#233; eminentemente cl&#237;nico&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A BVA tem como pat&#243;genos o v&#237;rus sincicial respirat&#243;rio &#40;VSR&#41;&#44; rinov&#237;rus&#44; influenza A e B&#44; parainfluenza&#44; metapneumov&#237;rus&#44; adenov&#237;rus&#44; papilomav&#237;rus e bocav&#237;rus&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a> O VSR &#233; o pat&#243;geno mais comum&#44; respons&#225;vel por 70&#37; dos epis&#243;dios de bronquiolite em crian&#231;as menores de dois anos&#46; Altera&#231;&#245;es na resposta imune das crian&#231;as com hist&#243;ria parental de asma acometidas por BVA causada pelos VSR e rinov&#237;rus est&#227;o implicadas nessa associa&#231;&#227;o v&#237;rus&#47;asma&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">8&#8211;10</span></a> Reinfec&#231;&#245;es s&#227;o comuns durante os dois primeiros anos de vida da crian&#231;a&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> No Brasil&#44; o VSR &#233; respons&#225;vel por 31&#44;9 a 64&#37; das interna&#231;&#245;es por BVA<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">12&#44;13</span></a> e coinfec&#231;&#245;es ocorrem em 40&#37; dos casos&#44; o rinov&#237;rus &#233; o agente mais comum&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">14</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Apesar das evid&#234;ncias da associa&#231;&#227;o entre BVA e manifesta&#231;&#245;es cl&#237;nicas da asma&#44; s&#227;o escassos os estudos que avaliem a a&#231;&#227;o da predisposi&#231;&#227;o gen&#233;tica nessa associa&#231;&#227;o&#46; Assim&#44; o papel da BVA como marcador de asma em crian&#231;as com hist&#243;ria parental de asma para desenvolver asma em m&#233;dio e longo prazo n&#227;o &#233; conhecido com exatid&#227;o&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">O objetivo deste estudo foi verificar a associa&#231;&#227;o entre BVA no primeiro ano de vida e asma na crian&#231;a aos seis anos&#44; conforme a hist&#243;ria parental de asma e outras vari&#225;veis de confundimento&#44; em uma coorte de nascidos vivos no Nordeste do Brasil&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todos</span><p id="par0030" class="elsevierStylePara elsevierViewall">O estudo de corte transversal foi feito em uma cidade de grande porte do Nordeste do Brasil a partir de dados de uma coorte de nascidos vivos&#46; A coorte foi constitu&#237;da entre abril de 2004 e mar&#231;o de 2005 com inclus&#227;o consecutiva de nascidos vivos de todos os 10 hospitais de Feira de Santana&#44; filhos de m&#227;es residentes na cidade&#46; Os dados usados foram relativos aos coletados na maternidade e em quatro visitas domiciliares feitas no primeiro ano de vida &#40;tr&#234;s&#44; seis&#44; nove e 12 meses&#41; e aos seis anos&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Os crit&#233;rios de inclus&#227;o foram m&#227;es e filhos residentes na referida cidade&#59; m&#227;es de rec&#233;m&#8208;nascidos que n&#227;o tiveram complica&#231;&#245;es perinatais&#59; rec&#233;m&#8208;nascidos que n&#227;o foram internados no ber&#231;&#225;rio por per&#237;odo maior do que 24h&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Os crit&#233;rios de n&#227;o inclus&#227;o foram crian&#231;as nascidas de m&#227;es que apresentaram problemas de sa&#250;de que contraindicassem a amamenta&#231;&#227;o ao seio materno e m&#227;es que foram separadas judicialmente de seus filhos&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Instrumento de coleta de dados</span><p id="par0045" class="elsevierStylePara elsevierViewall">As crian&#231;as que deram entrada na coorte ao nascimento foram seguidas mensalmente&#44; por profissionais de sa&#250;de previamente treinados&#44; mediante entrevistas domiciliares mensais nos primeiros seis meses de vida e seguidas a cada tr&#234;s meses at&#233; o fim do primeiro ano e em idades programadas e no sexto ano de vida&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Amostra</span><p id="par0050" class="elsevierStylePara elsevierViewall">O c&#225;lculo do tamanho amostral foi feito em duas etapas&#44; a saber&#44; o c&#225;lculo da amostra para estimar a preval&#234;ncia de asma em escolares e em seguida o c&#225;lculo da amostra para identificar os preditores independentes de asma&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">O c&#225;lculo da amostra da preval&#234;ncia de asma foi feito pelo programa <span class="elsevierStyleItalic">Pepi Sample</span> &#40;<span class="elsevierStyleItalic">Winpepi Computer Programs</span>&#41; com os seguintes par&#226;metros&#58; preval&#234;ncia estimada de asma em escolares de 20&#37;&#44; intervalo de confian&#231;a de 95&#37; e precis&#227;o de 1&#44;25&#37; em torno da preval&#234;ncia estimada da popula&#231;&#227;o&#46; O resultado final revelou a necessidade de se estudarem 202 crian&#231;as&#44; acresceu&#8208;se a esse total uma perda presum&#237;vel de 10&#37;&#44; total de 223 sujeitos&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Para identificar bronquiolite como preditor de asma&#44; o c&#225;lculo da amostra foi feito com o programa <span class="elsevierStyleItalic">OpenEpi</span> &#40;<span class="elsevierStyleItalic">Open Source Epidemiologic Statistics for Public Health</span>&#44; vers&#227;o 2&#46;3&#46;1&#41;&#46; Adotaram&#8208;se os seguintes par&#226;metros&#58; preval&#234;ncia de BVA de 27&#37;&#44; intervalo de confian&#231;a de 95&#37;&#44; poder estat&#237;stico de 80&#37;&#44; estimativa de risco relativo de 2&#44; considerou&#8208;se a preval&#234;ncia de asma em n&#227;o expostos de 10&#37; e expostos a infec&#231;&#245;es respirat&#243;rias de 20&#37;&#46; Nesse &#250;ltimo c&#225;lculo o n&#250;mero da amostra m&#237;nimo encontrado foi de 438&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Entre os dois c&#225;lculos&#44; optou&#8208;se por aquele que indicou maior n&#250;mero de participantes &#40;438 indiv&#237;duos&#41;&#46; Entretanto&#44; foram inclu&#237;das no estudo todas as 684 crian&#231;as com seis anos em acompanhamento na coorte&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Vari&#225;veis</span><p id="par0070" class="elsevierStylePara elsevierViewall">A defini&#231;&#227;o de asma ativa aos seis anos foi obtida mediante a aplica&#231;&#227;o do question&#225;rio padronizado do estudo ISAAC<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">15</span></a> &#224;s m&#227;es conforme resposta afirmativa &#224; pergunta&#58; &#8220;Seu filho teve &#8216;chiado no peito&#8217; nos &#250;ltimos 12 meses&#63;&#8221;</p><p id="par0075" class="elsevierStylePara elsevierViewall">O crit&#233;rio de diagn&#243;stico cl&#237;nico de BVA seguiu a defini&#231;&#227;o da Academia Americana de Pediatria&#44;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">16</span></a> ou seja&#44; coriza acompanhada por taquipneia&#44; tosse&#44; dispneia e intensifica&#231;&#227;o das manifesta&#231;&#245;es respirat&#243;rias&#44; como batimentos de asa do nariz e tiragem intercostal e ou subcostal&#46; Assim&#44; essa afec&#231;&#227;o foi considerada quando a m&#227;e da crian&#231;a respondeu afirmativamente que seu filho teve uma doen&#231;a respirat&#243;ria e o m&#233;dico informou como diagn&#243;stico BVA ou relatou os sintomas de coriza&#44; acompanhados de tosse&#44; taquipneia&#44; dispneia nos &#250;ltimos 15 dias&#44; nas entrevistas aos tr&#234;s&#44; seis&#44; nove e 12 meses de vida&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Covari&#225;veis</span><p id="par0080" class="elsevierStylePara elsevierViewall">As demais covari&#225;veis foram&#58; idade gestacional &#40;&#60; 37 semanas&#44; &#8805; 37 semanas&#41;&#59; paridade &#40;prim&#237;para&#44; mult&#237;para&#41;&#59; renda familiar &#40;&#60; 2 sal&#225;rios m&#237;nimos&#44; &#8805; 2 sal&#225;rios m&#237;nimos&#41;&#59; escolaridade materna &#40;&#60; 8 anos de escolaridade&#44; &#8805; 8 anos de escolaridade&#41;&#59; sexo &#40;masculino&#44; feminino&#41;&#59; peso ao nascer &#40;&#60; 2&#46;500<span class="elsevierStyleHsp" style=""></span>g&#44; &#8805; 2&#46;500<span class="elsevierStyleHsp" style=""></span>g&#41;&#59; n&#250;mero de c&#244;modos no domic&#237;lio &#40;&#60; 5 c&#244;modos&#44; &#8805; 5 c&#244;modos&#41;&#59; n&#250;mero de pessoas que dormem no quarto com a crian&#231;a &#40;&#60; 4 pessoas&#44; &#8805; 4 pessoas&#41;&#59; tabagismo materno na gesta&#231;&#227;o &#40;sim&#44; n&#227;o&#41;&#59; presen&#231;a de c&#227;o ou gato no domic&#237;lio &#40;sim&#44; n&#227;o&#41;&#59; frequ&#234;ncia em creche at&#233; os dois anos &#40;sim&#44; n&#227;o&#41;&#59; tr&#225;fego de caminh&#245;es na rua de resid&#234;ncia &#40;sim&#44; n&#227;o&#41;&#59; aleitamento materno exclusivo at&#233; o terceiro m&#234;s &#40;sim&#44; n&#227;o&#41;&#59; aleitamento materno exclusivo at&#233; o quarto m&#234;s &#40;sim&#44; n&#227;o&#41;&#46; As informa&#231;&#245;es sobre dados cl&#237;nicos das m&#227;es foram coletadas logo ap&#243;s o nascimento nas maternidades e conferidas por consulta ao respectivo prontu&#225;rio m&#233;dico&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">A hist&#243;ria parental de asma foi considerada por meio da resposta das m&#227;es &#224; pergunta&#58; &#8220;O pai ou a m&#227;e da crian&#231;a tem&#47;teve asma&#63;&#8221; &#40;sim&#59; n&#227;o&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">An&#225;lise estat&#237;stica</span><p id="par0090" class="elsevierStylePara elsevierViewall">A frequ&#234;ncia das caracter&#237;sticas sociodemogr&#225;ficas foi calculada e o teste x<span class="elsevierStyleSup">2</span> usado para comparar propor&#231;&#245;es&#44; considerou&#8208;se significativo p&#8208;valor<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46; Modelos de regress&#227;o log&#237;stica multivariada foram usados para avaliar fatores associados &#224; asma aos seis anos e a BVA aos tr&#234;s&#44; seis&#44; nove e 12 meses e no primeiro ano de vida&#46; Consideraram&#8208;se as principais vari&#225;veis confundidoras e as que tiveram p&#8208;valor<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#44;10 na an&#225;lise bivariada&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">O efeito modificador da hist&#243;ria parental de asma na associa&#231;&#227;o entre BVA e asma foi verificado pela inclus&#227;o do termo de intera&#231;&#227;o entre hist&#243;ria parental de asma e BVA na an&#225;lise de regress&#227;o log&#237;stica multivariada&#46; As an&#225;lises estat&#237;sticas foram feitas por meio do programa estat&#237;stico SPSS &#40;SPSS for Windows&#44; vers&#227;o 14&#46;0&#44; Chicago&#44; EUA&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Aspectos &#233;ticos</span><p id="par0100" class="elsevierStylePara elsevierViewall">O projeto e o termo de consentimento livre e esclarecido foram aprovados pelo Comit&#234; de &#201;tica em Pesquisa da Universidade Estadual de Feira de Santana&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Resultados</span><p id="par0105" class="elsevierStylePara elsevierViewall">Participaram do estudo 672 &#40;98&#44;2&#37;&#41; das 684 crian&#231;as eleg&#237;veis&#44; 12 n&#227;o foram localizadas por mudan&#231;a de endere&#231;o&#46; Foram avaliados 30 participantes a mais do que a amostra previamente estimada&#46; A preval&#234;ncia de asma ativa foi de 13&#44;8&#37;&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">As caracter&#237;sticas cl&#237;nicas e demogr&#225;ficas da amostra est&#227;o representadas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46; A maioria das crian&#231;as dormia em quartos com menos de quatro pessoas e era filha de pais que n&#227;o tinham antecedentes de asma&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">Os fatores de risco para asma na an&#225;lise de regress&#227;o log&#237;stica foram sexo masculino&#44; ter hist&#243;ria parental de asma&#59; BVA aos tr&#234;s e 12 meses e no primeiro&#176; ano de vida&#46; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0120" class="elsevierStylePara elsevierViewall">O n&#250;mero de crian&#231;as expostas a BVA no primeiro ano de vida foi de 50&#44;7&#37; &#40;341&#41; e a frequ&#234;ncia de BVA de 461 epis&#243;dios&#44; 75 &#40;11&#44;5&#37;&#41; no primeiro&#44; 136 &#40;20&#44;3&#37;&#41; no segundo&#44; 114 &#40;16&#44;9&#37;&#41; no terceiro e 136 &#40;20&#44;3&#37;&#41; no quarto trimestre de vida&#46; A frequ&#234;ncia de BVA&#47;crian&#231;a no primeiro ano de vida de um epis&#243;dio foi de 234&#44; dois epis&#243;dios 83 e tr&#234;s ou mais epis&#243;dios 15&#46; A frequ&#234;ncia de BVA n&#227;o esteve associada a maior risco de asma aos seis anos &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">A preval&#234;ncia de aleitamento materno exclusivo at&#233; o terceiro m&#234;s de vida entre as crian&#231;as foi de 36&#44;4&#37; &#40;248&#41; e foi fator de prote&#231;&#227;o para BVA&#44; OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;49 IC95&#37; &#40;0&#44;28&#8208;0&#44;84&#41;&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;009&#46; O aleitamento materno exclusivo at&#233; o quarto m&#234;s n&#227;o conferiu prote&#231;&#227;o para bronquiolite aos seis meses&#44; OR&#58; 0&#44;76 IC95&#37; &#40;0&#44;42&#8208;1&#44;16&#41;&#44; nove meses OR&#58; 1&#44;19 IC95&#37; &#40;0&#44;74&#8208;1&#44;93&#41;&#44; 12 meses&#44; OR&#58; 0&#44;08 IC95&#37; &#40;0&#44;94&#8208;2&#44;29&#41; ou no primeiro&#176; ano de vida das crian&#231;as&#44; OR&#58; 0&#44;60 IC95&#37; &#40;0&#44;29&#8208;1&#44;24&#41;&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Houve efeito modificador da hist&#243;ria parental de asma para a associa&#231;&#227;o entre bronquiolite e asma aos tr&#234;s&#44; seis&#44; nove e 12 meses e no primeiro ano de vida&#59; BVA aos 12 meses e no primeiro ano de vida foi risco para asma nas crian&#231;as com hist&#243;ria parental de asma&#44; OR&#58; 3&#44;90 IC95&#37; &#40;1&#44;36&#8208;11&#44;1&#41; e OR&#58; 2&#44;66 IC95&#37; &#40;1&#44;10&#8208;6&#44;40&#41;&#44; efeito modificador p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001 e p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#44; respectivamente&#46; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabela 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Discuss&#227;o</span><p id="par0135" class="elsevierStylePara elsevierViewall">O presente estudo evidencia que BVA no primeiro ano de vida foi fator de risco de asma em crian&#231;as e aumenta consideravelmente quando associada &#224; hist&#243;ria parental de asma&#46; A exposi&#231;&#227;o a BVA e entre outros m&#250;ltiplos fatores ambientais &#233; importante para o desenvolvimento da doen&#231;a&#44; especialmente em crian&#231;as predispostas&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">17</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">As infec&#231;&#245;es respirat&#243;rias por v&#237;rus e BVA s&#227;o mais frequentes em lactentes e t&#234;m sido associadas a risco de asma por estar relacionadas &#224; sua patog&#234;nese e ao desencadeamento de exacerba&#231;&#245;es&#46;<a class="elsevierStyleCrossRefs" href="#bib0235"><span class="elsevierStyleSup">17&#44;18</span></a> Embora algumas infec&#231;&#245;es por v&#237;rus influenza e parainfluenza possam inibir o desenvolvimento de asma&#44; a despeito de repetidas infec&#231;&#245;es respirat&#243;rias de vias a&#233;reas superiores nos dois primeiros anos de vida da crian&#231;a&#44; outras infec&#231;&#245;es por VSR e rinov&#237;rus podem favorecer o aparecimento de asma e atopia&#46;<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">7&#44;19&#44;20</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">As hip&#243;teses para explicar os mecanismos imunol&#243;gicos envolvidos na rela&#231;&#227;o entre infec&#231;&#227;o viral&#44; dispneia persistente e asma s&#227;o v&#225;rias&#58; &#40;i&#41; indu&#231;&#227;o da t&#237;pica inflama&#231;&#227;o de asma al&#233;rgica pela diferencia&#231;&#227;o do linf&#243;cito T em Th2&#59; &#40;ii&#41; ativa&#231;&#227;o pelo v&#237;rus sincicial respirat&#243;rio de c&#233;lulas Th17 e produ&#231;&#227;o de IL17&#44; citocina indutora da inflama&#231;&#227;o neutr&#243;fila&#46; As c&#233;lulas Th17 induzem a regula&#231;&#227;o de outras citocinas pr&#243;&#8208;inflamat&#243;rias como a IL6 e TNF&#8208;&#945;&#44; quimiocinas e metaloproteases com poss&#237;vel papel na patog&#234;nese da asma&#59;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">21&#44;22</span></a> &#40;iii&#41; eleva&#231;&#227;o do n&#237;vel de IL&#8208;4 e redu&#231;&#227;o do IFN&#8208;gama&#44; comprovada pela presen&#231;a de teste al&#233;rgico positivo e anticorpos IGE espec&#237;ficos nas crian&#231;as com BVA&#59; &#40;iv&#41; hiperatividade br&#244;nquica mediada por c&#233;lulas inflamat&#243;rias e neuropept&#237;dios de fibras C&#8208; sensitivas decorrentes do aumento da inflama&#231;&#227;o br&#244;nquica&#46; Outros fatores de risco para asma na crian&#231;a podem estar relacionados &#224; associa&#231;&#227;o direta entre bronquiolite e asma&#44; tal como a presen&#231;a de vias a&#233;reas de menor calibre em crian&#231;as do sexo masculino&#44; pode predispor &#224; dispneia durante infec&#231;&#245;es por v&#237;rus e desenvolvimento de asma&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">O tipo de flora bacteriana que comp&#245;e o microbioma da nasofaringe em crian&#231;as nos primeiros anos de vida tem se relacionado a risco futuro de asma&#46; A coloniza&#231;&#227;o da nasofaringe por <span class="elsevierStyleItalic">S&#46; pneumoniae</span>&#44; <span class="elsevierStyleItalic">M&#46; catarrhalis</span> e <span class="elsevierStyleItalic">H&#46; influenzae</span> com um m&#234;s de vida est&#225; associada a risco de asma aos cinco anos&#46; A infec&#231;&#227;o pelo VSR em idade precoce pode alterar o microbioma da nasofaringe e o desequil&#237;brio dessa microbiota pode levar a infec&#231;&#227;o do trato respirat&#243;rio inferior por bact&#233;rias patog&#234;nicas e inflama&#231;&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">H&#225; poucos estudos que consideram o efeito modificador da hist&#243;ria parental de asma na associa&#231;&#227;o entre BVA pelo VSR e rinov&#237;rus e desenvolvimento de asma em crian&#231;as&#46; Carroll et al&#46; demonstraram que o rinov&#237;rus esteve associado a infec&#231;&#227;o de maior gravidade em crian&#231;as de m&#227;es com asma at&#243;pica&#46;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a> Da mesma forma&#44; Jung et al&#46; demonstraram&#44; por meio de genotipagem&#44; que ocorreu efeito modificador de TLR4 &#40;rs1927911&#41;&#44; CD14 &#40;rs2569190&#41; e IL&#8208;13 &#40;rs20541&#41;&#160;na associa&#231;&#227;o entre asma e BVA em crian&#231;as coreanas&#59; o risco de desenvolvimento de asma ap&#243;s BVA foi significativamente mais elevado nas crian&#231;as que tinham um dos tr&#234;s polimorfismos descritos acima&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a> &#201; bem conhecido que a hist&#243;ria parental de asma &#233; o fator de risco mais importante para o desenvolvimento de asma&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">25</span></a> No atual estudo foi um fator de risco independente para asma e exerceu um importante efeito modificador na associa&#231;&#227;o entre BVA e asma&#44; aumentou o risco de asma em crian&#231;as que apresentaram bronquiolite&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Estudo feito em Salvador &#40;BA&#41; para verificar a rela&#231;&#227;o entre infec&#231;&#245;es por v&#237;rus e asma entre crian&#231;as de quatro a 13 anos n&#227;o evidenciou associa&#231;&#227;o entre asma at&#243;pica e n&#227;o at&#243;pica e os v&#237;rus herpes simples&#44; varicela zoster&#44; Epstein&#8208;Barr e hepatite A&#44;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">26</span></a> v&#237;rus n&#227;o relacionados a infec&#231;&#245;es do trato respirat&#243;rio inferior&#46; As infec&#231;&#245;es por v&#237;rus herpes simples e Epstein&#8208;Barr em crian&#231;as ocasionaram atenua&#231;&#227;o da resposta de hipersensibilidade imediata verificada pelo teste cut&#226;neo de hipersensibilidade imediata por punctura para aeroal&#233;rgenos&#46; O resultado do referido estudo demonstrou que infec&#231;&#245;es virais comuns na crian&#231;a estiveram associadas &#224; atenua&#231;&#227;o da resposta de hipersensibilidade imediata&#44; mas n&#227;o a doen&#231;a cl&#237;nica&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">No atual estudo tivemos frequ&#234;ncia de amamenta&#231;&#227;o exclusiva no quarto m&#234;s de vida de 20&#44;4&#37; compat&#237;vel com a m&#233;dia nacional e esse fato pode ter contribu&#237;do para proteger crian&#231;as de BVA e de asma aos tr&#234;s meses em aleitamento materno exclusivo&#44; pela presen&#231;a de fatores imunol&#243;gicos&#44; anti&#8208;infecciosos e imunomoduladores presente no leite humano&#44; de acordo com o demonstrado no estudo de Kull et al&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">27</span></a></p><p id="par0170" class="elsevierStylePara elsevierViewall">A preval&#234;ncia de asma no atual estudo foi menor quando comparada com estudo pr&#233;vio de preval&#234;ncia feito em Feira de Santana&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">28</span></a> As poss&#237;veis justificativas s&#227;o a elevada taxa de aleitamento materno exclusivo nos primeiros quatro meses de vida das crian&#231;as e as a&#231;&#245;es do programa de controle de asma e rinite al&#233;rgica implantado na cidade em 2004&#44; com a distribui&#231;&#227;o gratuita de medicamentos de controle da asma&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1&#44;2</span></a> Nos estudos planejados para o futuro iremos acrescentar outros crit&#233;rios para a identifica&#231;&#227;o da doen&#231;a&#44; tal como uso regular de medica&#231;&#245;es para a asma&#44; que podem manter os paciente sem sintomas&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">O sexo masculino e a hereditariedade tamb&#233;m representaram fatores de risco para asma no estudo atual&#46; O maior risco de asma no sexo masculino de 2&#44;4 vezes comparado com o sexo feminino em escolares foi tamb&#233;m encontrado no estudo de Casagrande et al&#46; e pode ser justificado pelo menor calibre das vias a&#233;reas de meninos comparados com meninas&#44; nessa faixa et&#225;ria&#44; e que desaparece na adolesc&#234;ncia&#46;<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">29&#44;30</span></a> Estudos t&#234;m demonstrado que ter pais com asma &#233; o principal fator de risco para asma&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">25</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">Algumas limita&#231;&#245;es inerentes a estudo de corte transversal&#44; como o vi&#233;s de mem&#243;ria&#44; foram minimizadas no nosso estudo por ter sido feito em uma coorte prospectiva de crian&#231;as&#46; O diagn&#243;stico de asma&#44; com o question&#225;rio do estudo ISAAC&#44; foi padronizado e validado no Brasil&#44; &#233; usado para medir a preval&#234;ncia mundial de sintomas de asma e doen&#231;as al&#233;rgicas em crian&#231;as em idade escolar&#44; com perguntas limitadas a sintomas no &#250;ltimo ano&#44; o que reduz o vi&#233;s de mem&#243;ria&#46; O diagn&#243;stico de BVA feito por meio de informa&#231;&#245;es das m&#227;es sobre o diagn&#243;stico m&#233;dico e a presen&#231;a de sintomas do trato respirat&#243;rio &#233; pass&#237;vel de erros e pode ter superestimado o diagn&#243;stico de BVA&#46; A taquipneia febril e coriza s&#227;o comuns em infec&#231;&#245;es virais&#46; Em percentual significativo da amostra os sintomas respirat&#243;rios n&#227;o foram acompanhados de febre&#46; A n&#227;o feitura de exames sorol&#243;gicos para identifica&#231;&#227;o de v&#237;rus constituiu tamb&#233;m uma limita&#231;&#227;o do atual estudo&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">A BVA no primeiro ano de vida foi fator de risco para asma em crian&#231;as no Nordeste do Brasil&#46; A hist&#243;ria parental de asma aumenta ainda mais o risco de asma em crian&#231;as expostas a bronquiolite&#46; A ado&#231;&#227;o de medidas de preven&#231;&#227;o e controle de infec&#231;&#245;es respirat&#243;rias pelo VSR e rinov&#237;rus&#44; tais como a vacina&#231;&#227;o para VSR e evitar o cont&#225;gio com lavagem das m&#227;os e locais de aglomera&#231;&#227;o de pessoas&#44; deve ser ampliada e intensificada pelos &#243;rg&#227;os p&#250;blicos de sa&#250;de&#44; sobretudo para crian&#231;as com hist&#243;ria parental de asma&#44; com o objetivo de obter redu&#231;&#227;o na morbimortalidade por bronquiolite e da preval&#234;ncia de asma&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflitos de interesse</span><p id="par0190" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflitos de interesse&#46;</p></span></span>"
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            2 => "Bronchiolitis viral"
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            0 => "Asma"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To verify whether the occurrence of acute viral bronchiolitis &#40;AVB&#41; in the first year of life constitutes a risk factor for asthma at age 6 considering a parental history of asthma&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Cross&#8208;sectional study in a cohort of live births&#46; A standardized questionnaire of the International Study of Asthma and Allergies in Childhood &#40;ISAAC&#41; was applied to the mothers to identify asthma in children at the age of 6 years&#46; AVB diagnosis was performed by maternal report of a medical diagnosis and&#47;or presence of symptoms of coryza accompanied by cough&#44; tachypnea&#44; and dyspnea when participants were 3&#44; 6&#44; 9&#44; and 12 months&#46; Socioeconomic&#44; environmental data&#44; parental history of asthma&#44; and data related to pregnancy were collected in the first 72<span class="elsevierStyleHsp" style=""></span>hours of life of the newborn and in prospective home visits by trained interviewers&#46; The association between AVB and asthma was evaluated by logistic regression analysis and potential modifier effect of parental history was verified by introducing an interaction term into the adjusted logistic regression model&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Prevalence of AVB in the first year of life was 68&#46;6&#37; &#40;461&#41;&#46; The occurrence of AVB was a risk factor for asthma at 6 years of age in children with parental history of asthma OR&#58; 2&#46;66&#44; 95&#37; CI &#40;1&#46;10&#8208;6&#46;40&#41;&#44; modifier effect p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;002&#46; Parental history of asthma OR&#58; 2&#46;07&#44; 95&#37; CI &#40;1&#46;29&#8208;3&#46;30&#41; and male gender OR&#58; 1&#46;69&#44; 95&#37; CI&#44; &#40;1&#46;06&#8208;2&#46;69&#41; were other identified risk factors for asthma&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">AVB in the first year of life is a risk factor for asthma in children with parental history of asthma&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Verificar se a ocorr&#234;ncia de bronquiolite viral aguda &#40;BVA&#41; no primeiro ano de vida constitui fator de risco para asma aos seis anos considerando a hist&#243;ria parental de asma&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudo de corte transversal aninhado a uma coorte de nascidos vivos&#46; O question&#225;rio padronizado do <span class="elsevierStyleItalic">International Study of Asthma and Allergies in Children</span> &#40;ISAAC&#41; foi aplicado &#224;s m&#227;es para identificar asma nas crian&#231;as de seis anos&#46; O diagn&#243;stico de BVA foi feito por relato materno de diagn&#243;stico m&#233;dico e&#47;ou presen&#231;a de sintomas de coriza acompanhados de tosse&#44; taquipneia e dispneia quando os participantes tinham tr&#234;s&#44; seis&#44; nove e 12 meses&#46; Dados socioecon&#244;micos&#44; ambientais&#44; hist&#243;ria parental de asma e referentes &#224; gesta&#231;&#227;o foram coletados nas primeiras 72 horas de vida do rec&#233;m&#8208;nascido e em visitas domiciliares prospectivas por entrevistadores treinados&#46; Associa&#231;&#227;o entre BVA e asma foi avaliada por an&#225;lise de regress&#227;o log&#237;stica e potencial efeito modificador da hist&#243;ria parental verificado pela introdu&#231;&#227;o do termo de intera&#231;&#227;o no modelo de regress&#227;o log&#237;stica ajustada&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A preval&#234;ncia de BVA no primeiro ano de vida foi 68&#44;6&#37; &#40;461&#41;&#46; A ocorr&#234;ncia de BVA foi fator de risco para asma aos seis anos em crian&#231;as com hist&#243;ria parental de asma OR&#58; 2&#44;66 &#40;1&#44;10&#8208;6&#44;40&#41;&#44; efeito modificador p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;002&#46; Hist&#243;ria parental de asma OR&#58; 2&#44;07 IC95&#37; &#40;1&#44;29&#8208;3&#44;30&#41; e sexo masculino OR&#58; 1&#44;69 IC95&#37; &#40;1&#44;06&#8208;2&#44;69&#41; foram outros fatores de risco identificados para asma&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">BVA no primeiro ano de vida &#233; fator de risco para asma em crian&#231;as com hist&#243;ria parental de asma&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0040">Como citar este artigo&#58; Brand&#227;o HV&#44; Vieira GO&#44; Vieira TO&#44; Cruz &#193;A&#44; Guimar&#227;es AC&#44; Teles C&#44; et al&#46; Acute viral bronchiolitis and risk of asthma in schoolchildren&#58; analysis of a Brazilian newborn cohort&#46; J Pediatr &#40;Rio J&#41;&#46; 2017&#59;93&#58;223&#8211;9&#46;</p>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0045">Estudo vinculado &#224; Escola Bahiana de Medicina e Sa&#250;de P&#250;blica&#44; Salvador&#44; BA&#44; Brasil&#46;</p>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;646&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#8805; 2&#46;500&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">642 &#40;95&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Idade gestacional &#40;semanas&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60; 37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28 &#40;4&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;46 &#40;0&#44;10&#8208;2&#44;00&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;295&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#8805; 37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">644 &#40;95&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Renda familiar &#40;sal&#225;rio m&#237;nimo&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>At&#233; 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">477 &#40;71&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;28 &#40;0&#44;77&#8208;2&#44;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;326&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#8805; 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">195 &#40;29&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Escolaridade da m&#227;e &#40;anos de estudo&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>At&#233; 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">202 &#40;30&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;88 &#40;0&#44;54&#8208;1&#44;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;634&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#62; 8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">470 &#40;69&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Paridade</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Prim&#237;para&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">336 &#40;50&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;88 &#40;0&#44;56&#8208;1&#44;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;576&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Mult&#237;para&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">336 &#40;50&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Aleitamento materno exclusivo 3&#176; m&#234;s</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">248 &#40;36&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;93 &#40;0&#44;59&#8208;1&#44;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;760&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">424 &#40;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Aleitamento materno exclusivo 4&#176; m&#234;s</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">137 &#40;20&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;08 &#40;0&#44;63&#8208;1&#44;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;773&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">535 &#40;79&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Tabagismo materno na gesta&#231;&#227;o</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20 &#40;3&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;13 &#40;0&#44;75&#8208;6&#44;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;142&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">652 &#40;97&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Pessoas que dormem no quarto da crian&#231;a &#40;pessoas&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60; 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">641 &#40;95&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;71 &#40;1&#44;20&#8208;6&#44;09&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#8805; 4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31 &#40;4&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">C&#244;modos no domic&#237;lio &#40;c&#244;modos&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#60; 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">541 &#40;80&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;74 &#40;0&#44;44&#8208;1&#44;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;275&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#8805; 5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">131 &#40;19&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Frequentou creche 24</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">m</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">104 &#40;15&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;69 &#40;0&#44;35&#8208;1&#44;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;277&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">568 &#40;84&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">C&#227;o ou gato em casa</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">297 &#40;44&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;99 &#40;0&#44;77&#8208;1&#44;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;982&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">375 &#40;55&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Tr&#225;fego de caminh&#227;o na rua domic&#237;lio</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">341 &#40;50&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;02 &#40;0&#44;85&#8208;1&#44;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;814&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">331 &#40;49&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Hist&#243;ria parental de asma</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sim&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">180 &#40;26&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;01 &#40;1&#44;27&#8208;3&#44;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>N&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">492 &#40;73&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas da amostra e associa&#231;&#227;o das vari&#225;veis com asma &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>672&#41;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Vari&#225;veis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR &#40;IC95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;79 &#40;1&#44;14&#8208;2&#44;81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;69 &#40;1&#44;06&#8208;2&#44;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;025&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bronquiolite aos 3 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;82 &#40;1&#44;00&#8208;3&#44;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;047&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;76 &#40;0&#44;95&#8208;3&#44;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bronquiolite aos 6 meses&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;749&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;08 &#40;0&#44;62&#8208;1&#44;86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;772&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bronquiolite aos 9 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;20 &#40;0&#44;68&#8208;2&#44;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;513&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;02 &#40;0&#44;57&#8208;1&#44;82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;930&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bronquiolite aos 12 meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;71 &#40;1&#44;49&#8208;4&#44;91&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;42 &#40;1&#44;31&#8208;4&#44;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bronquiolite no 1&#176; ano de vida&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;31 &#40;1&#44;00&#8208;1&#44;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;028&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;59 &#40;1&#44;01&#8208;2&#44;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;040&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hist&#243;ria parental de asma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;01 &#40;1&#44;27&#8208;3&#44;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;07 &#40;1&#44;29&#8208;3&#44;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;002&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;31 &#40;0&#44;99&#8208;5&#44;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;051&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              "identificador" => "tblfn0015"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Teste de regress&#227;o log&#237;stica multivariada ajustada para sexo&#44; BVA&#44; hist&#243;ria parental de asma&#44; n&#250;mero de pessoas que dormem no quarto com a crian&#231;a&#44; tabagismo materno na gesta&#231;&#227;o&#46;</p>"
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;540&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;454&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;73 &#40;0&#44;96&#8208;3&#44;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;610&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;58 &#40;0&#44;87&#8208;2&#44;88&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;132&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;485&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;717&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">OR &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">OR &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">OR &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col">OR &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Crua&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ajustada&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ajustada<a class="elsevierStyleCrossRef" href="#tblfn0030"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;35 &#40;0&#44;57&#8208;3&#44;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;37 &#40;0&#44;58&#8208;3&#44;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;30 &#40;0&#44;93&#8208;5&#44;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;48 &#40;0&#44;94&#8208;6&#44;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;003&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;05 &#40;0&#44;53&#8208;2&#44;09&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;14 &#40;0&#44;47&#8208;2&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;30 &#40;0&#44;51&#8208;3&#44;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;96 &#40;0&#44;38&#8208;2&#44;43&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;004&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60; 0&#44;001&nbsp;\t\t\t\t\t\t\n
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