Estatísticas

 array:25 [
  "pii" => "S2255553616300787"
  "issn" => "22555536"
  "doi" => "10.1016/j.jpedp.2016.07.002"
  "estado" => "S300"
  "fechaPublicacion" => "2016-09-01"
  "aid" => "402"
  "copyright" => "Sociedade Brasileira de Pediatria"
  "copyrightAnyo" => "2016"
  "documento" => "article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "fla"
  "cita" => "J Pediatr (Rio J). 2016;92:521-7"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 867
    "formatos" => array:3 [
      "EPUB" => 107
      "HTML" => 416
      "PDF" => 344
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:20 [
      "pii" => "S0021755716300614"
      "issn" => "00217557"
      "doi" => "10.1016/j.jped.2015.12.007"
      "estado" => "S300"
      "fechaPublicacion" => "2016-09-01"
      "aid" => "402"
      "copyright" => "Sociedade Brasileira de Pediatria"
      "documento" => "article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "fla"
      "cita" => "J Pediatr (Rio J). 2016;92:521-7"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 926
        "formatos" => array:3 [
          "EPUB" => 98
          "HTML" => 499
          "PDF" => 329
        ]
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
        "titulo" => "Lack of association between genetic polymorphism of <span class="elsevierStyleItalic">FTO</span>&#44; <span class="elsevierStyleItalic">AKT1</span> and <span class="elsevierStyleItalic">AKTIP</span> in childhood overweight and obesity"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "pt"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "521"
            "paginaFinal" => "527"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "pt" => array:1 [
            "titulo" => "Falta de associa&#231;&#227;o entre o polimorfismo gen&#233;tico do <span class="elsevierStyleItalic">FTO</span>&#44; <span class="elsevierStyleItalic">AKT1</span> e <span class="elsevierStyleItalic">AKTIP</span> e o sobrepeso e a obesidade infantis"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "pt" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 675
                "Ancho" => 1657
                "Tamanyo" => 42219
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Dendrogram of gene&#8211;gene interaction of obese patients and controls&#46; The colors of the caption comprise a spectrum representing the transition of synergism &#40;black&#41; for redundancy &#40;gray&#41;&#46; Observe the following interactions&#58; synergism between rs9939609 <span class="elsevierStyleItalic">FTO</span> and rs10149779 <span class="elsevierStyleItalic">AKT1</span> and redundancy between those and rs9302648 <span class="elsevierStyleItalic">AKTIP</span>&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Patr&#237;cia de Ara&#250;jo Pereira, Ant&#243;nio Marcos Alvim-Soares, Val&#233;ria Cristina Sandrim, Carla M&#225;rcia Moreira Lanna, D&#233;bora Cristine Souza-Costa, Vanessa de Almeida Belo, Jonas Jardim de Paula, Jos&#233; Eduardo Tanus-Santos, Marco Aur&#233;lio Romano-Silva, D&#233;bora Marques de Miranda"
            "autores" => array:10 [
              0 => array:2 [
                "nombre" => "Patr&#237;cia de Ara&#250;jo"
                "apellidos" => "Pereira"
              ]
              1 => array:3 [
                "nombre" => "Ant&#243;nio Marcos"
                "apellidos" => "Alvim-Soares"
                "sufijo" => "Jr&#46;"
              ]
              2 => array:2 [
                "nombre" => "Val&#233;ria Cristina"
                "apellidos" => "Sandrim"
              ]
              3 => array:2 [
                "nombre" => "Carla M&#225;rcia Moreira"
                "apellidos" => "Lanna"
              ]
              4 => array:2 [
                "nombre" => "D&#233;bora Cristine"
                "apellidos" => "Souza-Costa"
              ]
              5 => array:2 [
                "nombre" => "Vanessa de Almeida"
                "apellidos" => "Belo"
              ]
              6 => array:2 [
                "nombre" => "Jonas Jardim"
                "apellidos" => "de Paula"
              ]
              7 => array:2 [
                "nombre" => "Jos&#233; Eduardo"
                "apellidos" => "Tanus-Santos"
              ]
              8 => array:2 [
                "nombre" => "Marco Aur&#233;lio"
                "apellidos" => "Romano-Silva"
              ]
              9 => array:2 [
                "nombre" => "D&#233;bora Marques de"
                "apellidos" => "Miranda"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "pt" => array:9 [
          "pii" => "S2255553616300787"
          "doi" => "10.1016/j.jpedp.2016.07.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "pt"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2255553616300787?idApp=UINPBA000049"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0021755716300614?idApp=UINPBA000049"
      "url" => "/00217557/0000009200000005/v1_201609220038/S0021755716300614/v1_201609220038/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2255553616300507"
    "issn" => "22555536"
    "doi" => "10.1016/j.jpedp.2016.05.013"
    "estado" => "S300"
    "fechaPublicacion" => "2016-09-01"
    "aid" => "390"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "J Pediatr &#40;Rio J&#41;. 2016;92:528-31"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 848
      "formatos" => array:3 [
        "EPUB" => 91
        "HTML" => 473
        "PDF" => 284
      ]
    ]
    "pt" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original</span>"
      "titulo" => "Interference of heart and transcutaneous oxygen monitoring in the measurement of bioelectrical impedance analysis in preterm newborns"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "528"
          "paginaFinal" => "531"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Interfer&#234;ncia da monitora&#231;&#227;o card&#237;aca e transcut&#226;nea de oxig&#234;nio na aferi&#231;&#227;o da bioimped&#226;ncia el&#233;trica em rec&#233;m&#8208;nascidos pr&#233;&#8208;termo"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2511
              "Ancho" => 1665
              "Tamanyo" => 137985
            ]
          ]
          "descripcion" => array:1 [
            "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">An&#225;lise da resist&#234;ncia e reat&#226;ncia por meio de bioimped&#226;ncia el&#233;trica monofrequencial&#44; com e sem fios de monitora&#231;&#227;o em RNPT&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Viviane C&#46; Comym, Yuri S&#46; Macedu, Eduardo K&#46;P&#46;B&#46; Neves, Arnaldo C&#46; Bueno, Herminia C&#46; Fernandez, Maria E&#46;L&#46; Moreira, Alan A&#46; Vieira"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Viviane C&#46;"
              "apellidos" => "Comym"
            ]
            1 => array:2 [
              "nombre" => "Yuri S&#46;"
              "apellidos" => "Macedu"
            ]
            2 => array:2 [
              "nombre" => "Eduardo K&#46;P&#46;B&#46;"
              "apellidos" => "Neves"
            ]
            3 => array:2 [
              "nombre" => "Arnaldo C&#46;"
              "apellidos" => "Bueno"
            ]
            4 => array:2 [
              "nombre" => "Herminia C&#46;"
              "apellidos" => "Fernandez"
            ]
            5 => array:2 [
              "nombre" => "Maria E&#46;L&#46;"
              "apellidos" => "Moreira"
            ]
            6 => array:2 [
              "nombre" => "Alan A&#46;"
              "apellidos" => "Vieira"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S0021755716300389"
        "doi" => "10.1016/j.jped.2016.01.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0021755716300389?idApp=UINPBA000049"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2255553616300507?idApp=UINPBA000049"
    "url" => "/22555536/0000009200000005/v1_201609200029/S2255553616300507/v1_201609200029/pt/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2255553616300763"
    "issn" => "22555536"
    "doi" => "10.1016/j.jpedp.2016.06.014"
    "estado" => "S300"
    "fechaPublicacion" => "2016-09-01"
    "aid" => "405"
    "documento" => "article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "fla"
    "cita" => "J Pediatr &#40;Rio J&#41;. 2016;92:512-20"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1153
      "formatos" => array:3 [
        "EPUB" => 84
        "HTML" => 733
        "PDF" => 336
      ]
    ]
    "pt" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original</span>"
      "titulo" => "Association of hypertriglyceridemic&#8208;waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents&#58; the CASPIAN&#8208;III study"
      "tienePdf" => "pt"
      "tieneTextoCompleto" => "pt"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "pt"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "512"
          "paginaFinal" => "520"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "pt" => array:1 [
          "titulo" => "Associa&#231;&#227;o do fen&#243;tipo de cintura hipertriglicerid&#234;mica com enzimas hep&#225;ticas e fatores de risco cardiometab&#243;lico em adolescentes&#58; o estudo CASPIAN&#8208;III"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "pt" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "pt" => true
      ]
      "contienePdf" => array:1 [
        "pt" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Roya Kelishadi, Fahimeh Jamshidi, Mostafa Qorbani, Mohammad Esmaeil Motlagh, Ramin Heshmat, Gelayol Ardalan, Silva Hovsepian"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Roya"
              "apellidos" => "Kelishadi"
            ]
            1 => array:2 [
              "nombre" => "Fahimeh"
              "apellidos" => "Jamshidi"
            ]
            2 => array:2 [
              "nombre" => "Mostafa"
              "apellidos" => "Qorbani"
            ]
            3 => array:2 [
              "nombre" => "Mohammad Esmaeil"
              "apellidos" => "Motlagh"
            ]
            4 => array:2 [
              "nombre" => "Ramin"
              "apellidos" => "Heshmat"
            ]
            5 => array:2 [
              "nombre" => "Gelayol"
              "apellidos" => "Ardalan"
            ]
            6 => array:2 [
              "nombre" => "Silva"
              "apellidos" => "Hovsepian"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "pt"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S002175571630064X"
        "doi" => "10.1016/j.jped.2015.12.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S002175571630064X?idApp=UINPBA000049"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2255553616300763?idApp=UINPBA000049"
    "url" => "/22555536/0000009200000005/v1_201609200029/S2255553616300763/v1_201609200029/pt/main.assets"
  ]
  "pt" => array:21 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Artigo Original</span>"
    "titulo" => "Lack of association between genetic polymorphism of <span class="elsevierStyleItalic">FTO</span>&#44; <span class="elsevierStyleItalic">AKT1</span> and <span class="elsevierStyleItalic">AKTIP</span> in childhood overweight and obesity"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "521"
        "paginaFinal" => "527"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Patr&#237;cia de Ara&#250;jo Pereira, Ant&#243;nio Marcos Alvim&#8208;Soares, Val&#233;ria Cristina Sandrim, Carla M&#225;rcia Moreira Lanna, D&#233;bora Cristine Souza&#8208;Costa, Vanessa de Almeida Belo, Jonas Jardim de Paula, Jos&#233; Eduardo Tanus&#8208;Santos, Marco Aur&#233;lio Romano&#8208;Silva, D&#233;bora Marques de Miranda"
        "autores" => array:10 [
          0 => array:3 [
            "nombre" => "Patr&#237;cia de Ara&#250;jo"
            "apellidos" => "Pereira"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "fn0005"
              ]
            ]
          ]
          1 => array:5 [
            "nombre" => "Ant&#243;nio Marcos"
            "apellidos" => "Alvim&#8208;Soares"
            "sufijo" => "Jr&#46;"
            "email" => array:1 [
              0 => "antonioalvimjr&#64;gmail&#46;com"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">1</span>"
                "identificador" => "fn0005"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Val&#233;ria Cristina"
            "apellidos" => "Sandrim"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Carla M&#225;rcia Moreira"
            "apellidos" => "Lanna"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "D&#233;bora Cristine"
            "apellidos" => "Souza&#8208;Costa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Vanessa de Almeida"
            "apellidos" => "Belo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Jonas Jardim"
            "apellidos" => "de Paula"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Jos&#233; Eduardo"
            "apellidos" => "Tanus&#8208;Santos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "Marco Aur&#233;lio"
            "apellidos" => "Romano&#8208;Silva"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "D&#233;bora Marques"
            "apellidos" => "de Miranda"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:4 [
          0 => array:3 [
            "entidad" => "Universidade Federal de Minas Gerais &#40;UFMG&#41;&#44; INCT de Medicina Molecular&#44; Belo Horizonte&#44; MG&#44; Brasil"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Universidade de S&#227;o Paulo &#40;USP&#41;&#44; Faculdade de Medicina de Ribeir&#227;o Preto &#40;FMRP&#41;&#44; Departamento de Farmacologia&#44; Ribeir&#227;o Preto&#44; SP&#44; Brasil"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Universidade Federal de Juiz de Fora &#40;UFJF&#41;&#44; Instituto de Ci&#234;ncias Biol&#243;gicas&#44; Departamento de Fisiologia&#44; Juiz de Fora&#44; MG&#44; Brasil"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Universidade Estadual Paulista &#40;Unesp&#41;&#44; S&#227;o Paulo&#44; SP&#44; Brasil"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspond&#234;ncia&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "pt" => array:1 [
        "titulo" => "Falta de associa&#231;&#227;o entre o polimorfismo gen&#233;tico do <span class="elsevierStyleItalic">FTO</span>&#44; <span class="elsevierStyleItalic">AKT1</span> e <span class="elsevierStyleItalic">AKTIP</span> e o sobrepeso e a obesidade infantis"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 675
            "Ancho" => 1671
            "Tamanyo" => 38040
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Dendrograma da intera&#231;&#227;o g&#234;nica de pacientes obesos e controles&#46; As cores da legenda incluem um espectro que representa a transi&#231;&#227;o do sinergismo &#40;preto&#41; para redund&#226;ncia &#40;cinza&#41;&#46; Observe as seguintes intera&#231;&#245;es&#58; sinergismo entre o <span class="elsevierStyleItalic">FTO</span> rs9939609 e o <span class="elsevierStyleItalic">AKT1</span> rs10149779 e redund&#226;ncia entre estes e <span class="elsevierStyleItalic">AKTIP</span> rs9302648&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introdu&#231;&#227;o</span><p id="par0005" class="elsevierStylePara elsevierViewall">A obesidade infantil &#233; um problema de sa&#250;de p&#250;blica em todo o mundo&#46; Nas &#250;ltimas d&#233;cadas&#44; as taxas de sobrepeso e obesidade entre crian&#231;as aumentaram em grande parte tanto nos pa&#237;ses desenvolvidos quanto nos mais pobres&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">1</span></a> A obesidade &#233; resultado de fatores ambientais que interagem com um hist&#243;rico polig&#234;nico&#46; A herdabilidade varia de 40&#37; a 70&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">2</span></a> Uma an&#225;lise de metarregress&#227;o atual mostrou que a herdabilidade era maior em crian&#231;as do que em adultos&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">3</span></a> Estudos de longo prazo mostraram que a obesidade infantil leva ao agrupamento de componentes da s&#237;ndrome metab&#243;lica &#40;SM&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">4</span></a> que inclui obesidade abdominal&#44; dislipidemia&#44; resist&#234;ncia &#224; insulina&#44; diabetes tipo II e hipertens&#227;o&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">5</span></a> &#201; bem sabido que crian&#231;as acima do peso e obesas t&#234;m um risco maior de se tornar obesas na vida adulta&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">6</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Os estudos de associa&#231;&#227;o gen&#244;mica ampla &#40;GWAS&#41; identificaram que o gene associado &#224; massa de gordura e &#224; obesidade &#40;<span class="elsevierStyleItalic">FTO</span>&#41; est&#225; associado &#224; adiposidade humana&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">7</span></a> O gene <span class="elsevierStyleItalic">FTO</span> est&#225; relacionado ao risco de obesidade&#44; principalmente o SNP rs9939609&#44; que posteriormente foi confirmado por outros estudos independentes em diferentes popula&#231;&#245;es humanas&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">8&#8211;11</span></a> Devido &#224; rela&#231;&#227;o pr&#243;xima entre a diabetes e a obesidade&#44; outro gene interessante &#233; o hom&#243;logo 1 do oncogene viral v&#8208;akt de timoma murino &#40;<span class="elsevierStyleItalic">AKT1</span>&#41;&#44; que&#44; acredita&#8208;se&#44; media muitos efeitos metab&#243;licos&#44; mitog&#234;nicos e antiapopt&#243;ticos da insulina&#44; fator de crescimento semelhante &#224; insulina tipo 1 &#40;IGF&#8208;1&#41;&#44; IL&#8208;3 e outros fatores de crescimento e citocinas&#46;<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">12&#8211;14</span></a> Ademais&#44; o AKT tamb&#233;m estimula a capta&#231;&#227;o de glicose e a s&#237;ntese de glicog&#234;nio&#44;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">14</span></a> bem como a s&#237;ntese proteica&#46;<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">15</span></a> V&#225;rios estudos correlacionam a resist&#234;ncia &#224; insulina a comprometimentos no caminho do AKT e&#44; em algumas doen&#231;as&#44; essas altera&#231;&#245;es podem ser de origem gen&#233;tica&#46; A prote&#237;na de liga&#231;&#227;o <span class="elsevierStyleItalic">AKT1</span> &#40;<span class="elsevierStyleItalic">AKTIP</span> ou Ft1&#41;&#44; localizada pr&#243;ximo ao <span class="elsevierStyleItalic">FTO</span> no mesmo <span class="elsevierStyleItalic">locus</span> de risco de GWAS de obesidade no cromossomo 16 &#40;16q12&#46;2&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">16</span></a> parece ser outro alvo para investiga&#231;&#227;o&#46; A <span class="elsevierStyleItalic">AKTIP</span>&#44; como ligante direta do AKT&#44; modula a integra&#231;&#227;o e sinaliza caminhos&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">17</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">O equil&#237;brio energ&#233;tico &#233; influenciado por uma s&#233;rie de vari&#225;veis&#44; como dieta&#44; estruturas sociais&#44; fatores metab&#243;licos&#44; estilo de vida sedent&#225;rio moderno&#44; abund&#226;ncia de alimentos baratos com alto n&#237;vel cal&#243;rico e gen&#233;tica&#46; Provavelmente&#44; a obesidade comum &#233; o resultado de um ambiente adverso obesog&#234;nico&#44; que trabalha em um gen&#243;tipo suscet&#237;vel&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">4</span></a> At&#233; hoje&#44; a evid&#234;ncia dos poss&#237;veis benef&#237;cios cl&#237;nicos de estudos gen&#233;ticos para doen&#231;as complexas comuns tem sido limitada&#46; Mesmo assim&#44; a busca por fatores gen&#233;ticos envolvidos na obesidade &#233; um desafio e pode fornecer dados extras para responder a essa quest&#227;o complexa&#46; Por meio dessas observa&#231;&#245;es&#44; desenvolvemos este estudo com o objetivo de investigar a associa&#231;&#227;o estat&#237;stica de polimorfismos nos genes <span class="elsevierStyleItalic">FTO</span>&#44; <span class="elsevierStyleItalic">AKT1</span> e <span class="elsevierStyleItalic">AKTIP</span> com obesidade infantil em crian&#231;as brasileiras&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Dados cl&#237;nicos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Os pais e os filhos foram informados sobre a natureza e o objetivo deste estudo e assinaram um consentimento por escrito&#46; Todas as crian&#231;as foram submetidas a um exame f&#237;sico completo&#46; A estatura foi medida com um estadi&#244;metro de parede&#44; ao passo que o peso corporal foi obtido com uma balan&#231;a digital&#46; O &#237;ndice de massa corporal &#40;IMC&#41; foi calculado com as medi&#231;&#245;es de peso e estatura de acordo com a equa&#231;&#227;o IMC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>peso &#40;kg&#41;&#47;estatura<span class="elsevierStyleSup">2</span> &#40;cm&#41;&#46; Os pontos de corte do IMC adotados foram aqueles estabelecidos pela OMS&#46;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">18</span></a> Sobrepeso e obesidade foram definidos como um IMC superior a desvio padr&#227;o de<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>1 e<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>2&#44; respectivamente&#46;<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">19</span></a> A press&#227;o arterial foi medida pelo menos duas vezes e a presen&#231;a de hipertens&#227;o foi definida como PAS e&#47;ou PAD acima do 95&#176; percentil&#46;<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">20</span></a> Nenhuma das crian&#231;as estava sob o uso de medica&#231;&#227;o&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">O perfil lip&#237;dico e a glicemia foram determinados em soro e plasma&#44; respectivamente&#44; com kits comerciais de m&#233;todos enzim&#225;ticos de rotina &#40;Labtest Diagn&#243;stica&#44; S&#46;A&#46;&#44; Brasil&#41;&#46; Os n&#237;veis de insulina foram medidos com um kit &#40;Genese Produtos Diagn&#243;sticos&#44; S&#227;o Paulo&#44; Brasil&#41;&#46; A resist&#234;ncia &#224; insulina foi calculada pelo &#237;ndice do modelo de avalia&#231;&#227;o de homeostase &#40;HOMA&#8208;IR&#41;&#44; conforme descrito por Wallace et al&#46;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">21</span></a> At&#233; hoje&#44; poucos estudos definiram os n&#237;veis de corte para HOMA&#8208;IR em indiv&#237;duos pr&#233;&#8208;p&#250;beres e p&#250;beres&#46; Com base nisso&#44; o HOMA&#8208;IR foi testado como uma vari&#225;vel cont&#237;nua e foi controlado pela situa&#231;&#227;o do IMC dos indiv&#237;duos&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">O comit&#234; de &#233;tica local aprovou este estudo sob o protocolo CAAE 06400000180&#8208;7&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Pacientes acima do peso e obesos</span><p id="par0035" class="elsevierStylePara elsevierViewall">Nossa amostra incluiu 195 obesos&#47;acima do peso com m&#233;dia de 11 anos &#40;&#177; 3&#44;9&#41; &#40;104 meninas&#41;&#44; IMC de 26&#44;7 &#40;&#177; 4&#44;5&#41;&#46; Todos foram recrutados do Ambulat&#243;rio de Endocrinologia do Instituto da Crian&#231;a e do Adolescente em Juiz de Fora e do Ambulat&#243;rio de Endocrinologia Pedi&#225;trico da Funda&#231;&#227;o Instituto Mineiro de Estudo e Pesquisa em Nefrologia &#40;Imepen&#41; em Juiz de Fora e residiam em &#225;reas urbanas&#46;<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">22&#44;23</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Grupo de controle</span><p id="par0040" class="elsevierStylePara elsevierViewall">As pessoas no grupo de controle foram cuidadosamente escolhidas da comunidade local e consistiam em 153 pessoas magras e normotensas com m&#233;dia de 11&#44;9 anos &#40;&#177; 3&#44;2&#41; &#40;91 meninas&#41;&#44; IMC de 17&#44;9 &#40;&#177; 2&#44;3&#41;&#46; Todos forneceram um consentimento informado por escrito e o Comit&#234; de &#201;tica da Universidade aprovou os protocolos&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Genotipagem</span><p id="par0045" class="elsevierStylePara elsevierViewall">O DNA gen&#244;mico foi isolado com o m&#233;todo de teor elevado de sal ap&#243;s a coleta de sangue perif&#233;rico em tubos a v&#225;cuo&#46;<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">24</span></a> As sondas selecionadas corresponderam aos seguintes SNPs&#58; <span class="elsevierStyleItalic">FTO</span>&#58; rs9939609&#59; <span class="elsevierStyleItalic">AKTIP</span>&#58; rs9302648&#44; rs7189819&#59; <span class="elsevierStyleItalic">AKT1</span>&#58; rs2494738&#44; rs3730358&#44; rs10149779&#46; Para melhorar o poder estat&#237;stico&#44; escolhemos apenas SNPs com menor frequ&#234;ncia do alelo &#62;<span class="elsevierStyleHsp" style=""></span>0&#44;2 em pessoas brancas e iorub&#225;s na base de dados HapMap&#46; A genotipagem foi feita com prote&#237;na C reativa &#40;PCR&#41; em tempo real com um 7&#46;500 Real&#8208;Time PCR System &#40;Applied Biosystems Inc&#46;&#44; CA&#44; EUA&#41;&#44; na modalidade de discrimina&#231;&#227;o al&#233;lica&#46; Os protocolos de PCR foram feitos de acordo com as instru&#231;&#245;es do fabricante do TaqMan&#174; Genotyping Master Mix &#40;Applied Biosystems&#44; CA&#44; EUA&#41;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">An&#225;lise estat&#237;stica</span><p id="par0050" class="elsevierStylePara elsevierViewall">As frequ&#234;ncias al&#233;licas&#44; haplot&#237;picas e genot&#237;picas foram comparadas entre grupos com o teste <span class="elsevierStyleItalic">X</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span> e o <span class="elsevierStyleItalic">software</span> Unphased &#40;Unphased&#44; v&#46;3&#46;0&#46;13&#44; Cambridge&#44; Reino Unido&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">25</span></a> O teste de 1&#46;000 permuta&#231;&#245;es &#40;teste posterior&#41; foi feito em cada teste para estimar a relev&#226;ncia global de todas as an&#225;lises e validar os valores de expectativa&#8208;maximiza&#231;&#227;o&#46; O <span class="elsevierStyleItalic">software</span> Haploview &#40;Haploview&#44; v 4&#46;1&#44; Broad Institute&#44; MA&#44; EUA&#41; foi usado para avaliar as matrizes de desequil&#237;brio de liga&#231;&#227;o &#40;DL&#41; entre cada SNP para examinar a estrutura em blocos do DL e o equil&#237;brio de Hardy&#8208;Weinberg &#40;corte de 0&#44;05&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">26</span></a> Ap&#243;s a corre&#231;&#227;o de Bonferroni&#44; o n&#237;vel de signific&#226;ncia foi estabelecido em 0&#44;0083 para as compara&#231;&#245;es do grupo do gen&#243;tipo x&#46; As caracter&#237;sticas cl&#237;nicas do grupo de obesos&#47;acima do peso foram comparadas com aquelas das crian&#231;as e adolescentes controle por an&#225;lise de vari&#226;ncia &#40;Anova&#41; unidirecional&#44; seguida do teste de Tukey <span class="elsevierStyleItalic">post hoc</span>&#46; Para verificar a detec&#231;&#227;o de intera&#231;&#245;es entre genes associadas a doen&#231;as humanas complexas&#44; usamos a redu&#231;&#227;o multifatorial da dimensionalidade &#40;MDR&#41; e a redu&#231;&#227;o multifatorial da dimensionalidade &#8211; teste de desequil&#237;brio &#40;MDR&#8208;PDT&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">27</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Pelo menos 10&#37; das amostras foram regenotipadas aleatoriamente para fins de controle de qualidade&#44; o que minimizou erros de genotipagem&#46; Foi obtida uma concord&#226;ncia de 100&#37; entre os resultados de ambos os testes&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Uma an&#225;lise secund&#225;ria testou se os SNPs estudados em nossa pesquisa estavam linearmente associados ao HOMA&#8208;IR e ao IMC&#46; Usamos um modelo de regress&#227;o linear para testar a rela&#231;&#227;o de cada vari&#225;vel preditora independente &#40;SNP&#41; com cada resultado metab&#243;lico &#40;HOMA&#8208;IR ou IMC&#41;&#46; V&#225;rias regress&#245;es lineares eram usadas se mais de uma vari&#225;vel preditora mostrasse rela&#231;&#227;o com cada resultado&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Resultados</span><p id="par0065" class="elsevierStylePara elsevierViewall">Seis SNPs foram genotipados em 348 indiv&#237;duos&#46; Todos os SNPs estavam em equil&#237;brio de Hardy&#8208;Weinberg e apresentaram menor frequ&#234;ncia do alelo &#40;MAF&#41; acima de 10&#37;&#44; o que indica uma boa penetra&#231;&#227;o dos alelos na popula&#231;&#227;o&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">As caracter&#237;sticas cl&#237;nicas e laboratoriais dos grupos estudados s&#227;o apresentadas na <a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#46; Como esperado&#44; os indiv&#237;duos do grupo obeso&#47;acima do peso apresentavam maiores &#237;ndices de massa corporal&#46; Em compara&#231;&#227;o com o grupo de controle&#44; o grupo obeso&#47;acima do peso mostrou maior glicemia de jejum&#44; &#237;ndice de HOMA&#8208;IR&#44; colesterol total&#44; lipoprote&#237;na de baixa densidade e triglicer&#237;deos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabela 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a> apresenta a distribui&#231;&#227;o de gen&#243;tipos e alelos nos grupos&#46; Na an&#225;lise de alelos&#44; o <span class="elsevierStyleItalic">AKT1</span> rs10149779 apresentou uma associa&#231;&#227;o sem risco com o alelo ancestral G &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;2&#59; RC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;70&#59; <span class="elsevierStyleItalic">X</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>4&#44;40&#59; gl<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41; entre o grupo obeso&#47;acima do peso e o de controle ap&#243;s o teste de 1&#46;000 permuta&#231;&#245;es &#40;teste posterior&#41;&#46; O mesmo polimorfismo tamb&#233;m n&#227;o apresentou associa&#231;&#227;o genot&#237;pica G&#47;G &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;09&#59; RC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;61&#59; <span class="elsevierStyleItalic">X</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#44;29&#59; gl<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41; em compara&#231;&#227;o a indiv&#237;duos eutr&#243;ficos&#46; O gen&#243;tipo T&#47;T para o marcador <span class="elsevierStyleItalic">AKTIP</span> rs9302648 tamb&#233;m n&#227;o apresentou associa&#231;&#227;o &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;09&#59; RC<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;03&#59; <span class="elsevierStyleItalic">X</span><span class="elsevierStyleSup"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#44;15&#59; gl<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41; ap&#243;s o teste de 1&#46;000 permuta&#231;&#245;es &#40;teste posterior&#41;&#46; Nenhuma associa&#231;&#227;o foi encontrada nos outros marcadores &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabela 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Na an&#225;lise da intera&#231;&#227;o entre genes por meio da redu&#231;&#227;o multifatorial de dimensionalidade&#44; o dendrograma apresenta uma rela&#231;&#227;o entre os pares de genes&#46; O termo sinergia denota uma situa&#231;&#227;o em que a intera&#231;&#227;o baseada em entropia entre dois SNPs gera mais informa&#231;&#245;es que a correla&#231;&#227;o entre o par&#46; Ao passo que a redund&#226;ncia &#233; usada nos casos em que a intera&#231;&#227;o entre dois SNPs gera menos informa&#231;&#245;es do que a correla&#231;&#227;o entre os pares &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Quando a an&#225;lise da resist&#234;ncia &#224; insulina e desses polimorfismos foi conclu&#237;da&#44; n&#227;o foi encontrada associa&#231;&#227;o &#40;dados n&#227;o apresentados&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Embora n&#227;o tenhamos obtido um valor de p significativo na an&#225;lise gen&#233;tica do <span class="elsevierStyleItalic">FTO</span> rs9939609&#44; quando a an&#225;lise g&#234;nica foi conclu&#237;da&#44; foi encontrada uma intera&#231;&#227;o entre o <span class="elsevierStyleItalic">FTO</span> e o <span class="elsevierStyleItalic">AKT1</span> rs10149779&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">A <a class="elsevierStyleCrossRef" href="#tbl0015">tabela 3</a> apresenta o resultado dos modelos de regress&#227;o linear&#46; N&#227;o encontramos associa&#231;&#227;o significativa entre cada SNP e o HOMA&#8208;RI ou o IMC&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Discuss&#227;o</span><p id="par0100" class="elsevierStylePara elsevierViewall">A obesidade &#233; uma doen&#231;a cl&#237;nica complexa modulada por muitos fatores gen&#233;ticos e n&#227;o gen&#233;ticos&#44; com diversas intera&#231;&#245;es entre muitos deles&#46; Foram investigados seis SNPs n&#227;o codificados dos genes <span class="elsevierStyleItalic">AKT1</span>&#44; <span class="elsevierStyleItalic">AKTIP</span> e <span class="elsevierStyleItalic">FTO</span> como poss&#237;veis genes da obesidade em crian&#231;as brasileiras&#46; Nossos resultados sugerem que os polimorfismos <span class="elsevierStyleItalic">AKT1</span>&#44; <span class="elsevierStyleItalic">FTO</span> e <span class="elsevierStyleItalic">AKTIP</span> n&#227;o foram associados &#224; obesidade&#47;sobrepeso em crian&#231;as brasileiras&#46; Vale observar o fato de que as crian&#231;as obesas&#47;acima do peso com o alelo A do <span class="elsevierStyleItalic">FTO</span> rs9939609 n&#227;o apresentaram risco maior de se tornar obesas nessa popula&#231;&#227;o&#46; Esse polimorfismo foi associado ao IMC e &#224; diabetes tipo II em diversas popula&#231;&#245;es&#44; como finlandeses e asi&#225;ticos&#46;<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">28&#8211;30</span></a> Recentemente&#44; os estudos de associa&#231;&#227;o de todo o genoma em crian&#231;as brancas<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">31</span></a> e chinesas<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">32</span></a> reconheceram v&#225;rios polimorfismos de nucleot&#237;deo simples &#40;SNPs&#41;&#44; incluindo o gene <span class="elsevierStyleItalic">FTO</span>&#44; associados ao IMC e &#224; obesidade&#46; Embora diversas varia&#231;&#245;es do gene <span class="elsevierStyleItalic">FTO</span> tenham sido associadas &#224; obesidade em popula&#231;&#245;es com hist&#243;rico europeu&#44; seus efeitos em outras etnias ainda devem ser estabelecidos&#46; Em um estudo que envolveu 478 crian&#231;as negras&#44; n&#227;o foi encontrada associa&#231;&#227;o entre as varia&#231;&#245;es do gene <span class="elsevierStyleItalic">FTO</span> e o IMC&#44; resultado semelhante a outros estudos com popula&#231;&#245;es negras e gambianas&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">33</span></a> A mistura &#233;tnica brasileira pode ser um motivo para a inexist&#234;ncia de associa&#231;&#227;o com um polimorfismo associado &#224; obesidade cl&#225;ssico&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Poucos estudos com rela&#231;&#227;o a variantes do <span class="elsevierStyleItalic">FTO</span> e IMC em crian&#231;as e adolescentes latino&#8208;americanos foram publicados at&#233; agora&#46; Da Silva et al&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">34</span></a> relataram uma associa&#231;&#227;o significativa entre o gen&#243;tipo A&#47;A do <span class="elsevierStyleItalic">FTO</span> rs9939609 e aumento de IMC e gordura subcut&#226;nea em 348 crian&#231;as brasileiras&#46;<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">35</span></a> Curiosamente&#44; em outro estudo a respeito de crian&#231;as brasileiras&#44; o alelo <span class="elsevierStyleItalic">FTO</span> rs9939609 A foi associado a um aumento de IMC entre crian&#231;as com insufici&#234;ncia de vitamina D&#44; ao passo que nenhum efeito significativo foi encontrado entre aquelas com situa&#231;&#227;o adequada de vitamina D&#46; Esse pode ser um erro do tipo I&#44; mas tamb&#233;m pode significar que esse problema &#233; mais complexo do que o esperado e envolveu outros fatores metab&#243;licos&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">At&#233; o momento&#44; poucos estudos associaram as variantes no gene <span class="elsevierStyleItalic">AKT1</span> e a resist&#234;ncia &#224; insulina&#46; Em um estudo recente&#44; um hapl&#243;tipo que incluiu o primeiro &#233;xon do <span class="elsevierStyleItalic">AKT1</span> foi associado a maior frequ&#234;ncia de s&#237;ndrome metab&#243;lica em indiv&#237;duos americanos descendentes de negros e de europeus&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">36</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">Quando fizemos a an&#225;lise g&#234;nica &#40;MDR&#41;&#44; foi encontrada uma intera&#231;&#227;o entre o <span class="elsevierStyleItalic">FTO</span> rs9939609 e o <span class="elsevierStyleItalic">AKT1</span> rs10149779&#46; Uma poss&#237;vel raz&#227;o para essa diferen&#231;a entre polimorfismo &#250;nico e os resultados da an&#225;lise MDR pode ser devido &#224; epistasia&#44; definida como a intera&#231;&#227;o entre dois ou mais genes ou seus produtos proteicos de mRNA&#44; que modulam um fen&#243;tipo&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">37</span></a> As an&#225;lises estat&#237;sticas e os modelos animais mostraram que a epistasia &#233; um fen&#244;meno comum na obesidade&#46; Desse modo&#44; os genes da obesidade conferem&#44; isoladamente&#44; pequenos aumentos nas taxas de risco de obesidade&#46; Contudo&#44; podem influenciar o desenvolvimento da obesidade por mecanismos mais complexos&#44; principalmente intera&#231;&#245;es entre genes e entre gene e o ambiente&#46;<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">38</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Como o <span class="elsevierStyleItalic">FTO</span> apresentou efeitos maiores sobre o IMC na inf&#226;ncia em percentis maiores em alguns estudos&#44; fizemos uma regress&#227;o linear&#46;<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">39</span></a> Contudo&#44; n&#227;o foi encontrada associa&#231;&#227;o&#46; Alguns dos achados de associa&#231;&#227;o negativa podem resultar de alguma limita&#231;&#227;o de nosso estudo&#44; principalmente o tamanho pequeno da amostra total&#46; Ademais&#44; n&#227;o consideramos fatores ambientais&#44; como os padr&#245;es de atividade f&#237;sica&#44; presen&#231;a de pais acima do peso&#47;obesos&#44; bem como dados relativos &#224; ingest&#227;o de alimentos&#44; o que impede uma an&#225;lise mais detalhada&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">A obesidade &#233; uma doen&#231;a complexa e os mecanismos envolvidos na intera&#231;&#227;o entre gen&#243;tipo e ambiente ainda precisam ser esclarecidos&#46; Nossos dados podem lan&#231;ar alguma luz para entender melhor esse problema de sa&#250;de complexo e relevante&#46; Deve&#8208;se considerar o vi&#233;s da publica&#231;&#227;o existente em estudos com abordagem de genes candidatos&#46; Al&#233;m disso&#44; muitos estudos sobre a gen&#233;tica da obesidade podem apresentar um poder estat&#237;stico inadequado&#44; o que aumenta o risco de associa&#231;&#245;es falso positivas&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">40</span></a></p><p id="par0130" class="elsevierStylePara elsevierViewall">Em resumo&#44; n&#227;o encontramos evid&#234;ncia de associa&#231;&#227;o entre polimorfismos <span class="elsevierStyleItalic">AKT1</span>&#44; <span class="elsevierStyleItalic">AKTIP</span> e <span class="elsevierStyleItalic">FTO</span> com a obesidade e a resist&#234;ncia &#224; insulina nesta amostra de crian&#231;as brasileiras&#46; S&#227;o muitos os motivos para os resultados contrastantes observados nos estudos&#44; incluindo diferen&#231;as no hist&#243;rico gen&#233;tico das diferentes amostras&#46; Considerando as associa&#231;&#245;es encontradas em outros estudos&#44; acreditamos que os estudos que envolvem um n&#250;mero maior de pessoas de diferentes grupos &#233;tnicos ter&#227;o elucidar a fun&#231;&#227;o desses genes com a obesidade&#46; Dessa forma&#44; nosso trabalho enfatiza a import&#226;ncia do cuidado ao analisar estudos de genes candidatos e refor&#231;a a necessidade de estudos bem conduzidos para ampliar nosso entendimento dos fatores gen&#233;ticos e ambientais envolvidos na obesidade e na resist&#234;ncia &#224; insulina&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Financiamento</span><p id="par0135" class="elsevierStylePara elsevierViewall">Coordena&#231;&#227;o de Aperfei&#231;oamento de Pessoa de N&#237;vel Superior &#40;Capes&#41;&#44; Funda&#231;&#227;o de Amparo &#224; Pesquisa do Estado de S&#227;o Paulo &#40;Fapesp&#41;&#44; Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#40;CNPq&#44; 573646&#47;2008&#8208;2&#41; e Funda&#231;&#227;o de Amparo &#224; Pesquisa do Estado de Minas Gerais &#40;Fapemig&#44; CBB&#8208;APQ&#8208;00075&#8208;09 e CDS&#8208;BPD&#8208;00296&#8208;14&#41;&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Conflitos de interesse</span><p id="par0140" class="elsevierStylePara elsevierViewall">Os autores declaram n&#227;o haver conflitos de interesses&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres732282"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objective"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec736203"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres732283"
          "titulo" => "Resumo"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objetivo"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclus&#227;o"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec736202"
          "titulo" => "Palavras&#8208;chave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introdu&#231;&#227;o"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "M&#233;todos"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Dados cl&#237;nicos"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Pacientes acima do peso e obesos"
            ]
            2 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Grupo de controle"
            ]
            3 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Genotipagem"
            ]
            4 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "An&#225;lise estat&#237;stica"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Resultados"
        ]
        7 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Discuss&#227;o"
        ]
        8 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Financiamento"
        ]
        9 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Conflitos de interesse"
        ]
        10 => array:1 [
          "titulo" => "Refer&#234;ncias"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-07-15"
    "fechaAceptado" => "2015-12-15"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec736203"
          "palabras" => array:6 [
            0 => "Single&#8208;nucleotide polymorphisms"
            1 => "Childhood obesity"
            2 => "Fat mass and obesity associated"
            3 => "Gene"
            4 => "<span class="elsevierStyleItalic">AKT1</span>"
            5 => "<span class="elsevierStyleItalic">AKTIP</span>"
          ]
        ]
      ]
      "pt" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palavras&#8208;chave"
          "identificador" => "xpalclavsec736202"
          "palabras" => array:6 [
            0 => "Polimorfismos de nucleot&#237;deo &#250;nico"
            1 => "Obesidade infantil"
            2 => "Massa de gordura e obesidade associadas"
            3 => "Gene"
            4 => "<span class="elsevierStyleItalic">AKT1</span>"
            5 => "<span class="elsevierStyleItalic">AKTIP</span>"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Obesity is a chronic disease caused by both environmental and genetic factors&#46; Epidemiological studies have documented that increased energy intake and sedentary lifestyle&#44; as well as a genetic contribution&#44; are forces behind the obesity epidemic&#46; Knowledge about the interaction between genetic and environmental components can facilitate the choice of the most effective and specific measures for the prevention of obesity&#46; The aim of this study was to assess the association between the <span class="elsevierStyleItalic">FTO</span>&#44; <span class="elsevierStyleItalic">AKT1</span>&#44; and <span class="elsevierStyleItalic">AKTIP</span> genes and childhood obesity and insulin resistance&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This was a case&#8211;control study in which SNPs in the <span class="elsevierStyleItalic">FTO</span> &#40;rs99396096&#41;&#44; <span class="elsevierStyleItalic">AKT1</span>&#44; and <span class="elsevierStyleItalic">AKTIP</span> genes were genotyped in groups of controls and obese&#47;overweight children&#46; The study included 195 obese&#47;overweight children and 153 control subjects&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">As expected&#44; the obese&#47;overweight group subjects had higher body mass index&#44; higher fasting glucose&#44; HOMA&#8208;IR index&#44; total cholesterol&#44; low&#8208;density lipoprotein&#44; and triglycerides&#46; However&#44; no significant differences were observed in genes polymorphisms genotype or allele frequencies&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The present results suggest that <span class="elsevierStyleItalic">AKT1</span>&#44; <span class="elsevierStyleItalic">FTO</span>&#44; and <span class="elsevierStyleItalic">AKTIP</span> polymorphisms were not associated with obesity&#47;overweight in Brazilians children&#46; Future studies on the genetics of obesity in Brazilian children and their environment interactions are needed&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objective"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusion"
          ]
        ]
      ]
      "pt" => array:3 [
        "titulo" => "Resumo"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A obesidade &#233; uma doen&#231;a cr&#244;nica sustentada por fatores ambientais e gen&#233;ticos&#46; Estudos epidemiol&#243;gicos documentaram que maior ingest&#227;o de energia e um estilo de vida sedent&#225;rio&#44; bem como a contribui&#231;&#227;o gen&#233;tica&#44; s&#227;o for&#231;as por tr&#225;s da epidemia de obesidade&#46; O conhecimento sobre a intera&#231;&#227;o entre os componentes gen&#233;ticos e ambientais pode facilitar a escolha das medidas mais efetivas e espec&#237;ficas para a preven&#231;&#227;o da obesidade&#46; O objetivo deste estudo foi avaliar a rela&#231;&#227;o entre os genes associado &#224; massa de gordura e &#224; obesidade &#40;<span class="elsevierStyleItalic">FTO</span>&#41;&#44; hom&#243;logo 1 do oncogene viral v&#8208;akt de timoma murino &#40;<span class="elsevierStyleItalic">AKT1</span>&#41; e de liga&#231;&#227;o <span class="elsevierStyleItalic">AKT1</span> &#40;<span class="elsevierStyleItalic">AKTIP</span>&#41; e a obesidade infantil e a resist&#234;ncia &#224; insulina&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudo de caso&#8208;controle no qual os polimorfismos de nucleot&#237;deo simples &#40;SNPs&#41; nos genes <span class="elsevierStyleItalic">FTO</span> &#40;rs99396096&#41;&#44; <span class="elsevierStyleItalic">AKT1</span> e <span class="elsevierStyleItalic">AKTIP</span> foram genotipados em grupos de controle e de crian&#231;as obesas&#47;acima do peso&#46; Foram recrutadas 195 crian&#231;as obesas&#47;acima do peso e 153 indiv&#237;duos controle&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Como esperado&#44; os indiv&#237;duos do grupo obeso&#47;acima do peso apresentaram maior &#237;ndice de massa corporal&#44; maior glicemia de jejum&#44; &#237;ndice do modelo de avalia&#231;&#227;o de homeostase &#40;HOMA&#8208;IR&#41;&#44; colesterol total&#44; lipoprote&#237;na de baixa densidade e triglicer&#237;deos&#46; Contudo&#44; n&#227;o encontramos diferen&#231;as significativas no gen&#243;tipo de polimorfismos g&#234;nicos ou nas frequ&#234;ncias al&#233;licas&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclus&#227;o</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Nossos resultados sugerem que os polimorfismos <span class="elsevierStyleItalic">AKT1</span>&#44; <span class="elsevierStyleItalic">FTO</span> e <span class="elsevierStyleItalic">AKTIP</span> n&#227;o estavam associados &#224; obesidade&#47;sobrepeso em crian&#231;as brasileiras&#46; S&#227;o necess&#225;rios estudos futuros sobre a gen&#233;tica da obesidade em crian&#231;as brasileiras e suas intera&#231;&#245;es ambientais&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclus&#227;o"
          ]
        ]
      ]
    ]
    "NotaPie" => array:2 [
      0 => array:3 [
        "etiqueta" => "1"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Ambos os autores contribu&#237;ram igualmente para este manuscrito&#46;</p>"
        "identificador" => "fn0005"
      ]
      1 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Como citar este artigo&#58; Pereira PA&#44; Alvim&#8208;Soares AM&#44; Sandrim VC&#44; Lanna CM&#44; Souza&#8208;Costa DC&#44; Belo VA&#44; et al&#46; Lack of association between genetic polymorphism of <span class="elsevierStyleItalic">FTO</span>&#44; <span class="elsevierStyleItalic">AKT1</span> and <span class="elsevierStyleItalic">AKTIP</span> in childhood overweight and obesity&#46; J Pediatr &#40;Rio J&#41;&#46; 2016&#59;92&#58;521&#8211;7&#46;</p>"
      ]
    ]
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 675
            "Ancho" => 1671
            "Tamanyo" => 38040
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Dendrograma da intera&#231;&#227;o g&#234;nica de pacientes obesos e controles&#46; As cores da legenda incluem um espectro que representa a transi&#231;&#227;o do sinergismo &#40;preto&#41; para redund&#226;ncia &#40;cinza&#41;&#46; Observe as seguintes intera&#231;&#245;es&#58; sinergismo entre o <span class="elsevierStyleItalic">FTO</span> rs9939609 e o <span class="elsevierStyleItalic">AKT1</span> rs10149779 e redund&#226;ncia entre estes e <span class="elsevierStyleItalic">AKTIP</span> rs9302648&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabela 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">HDL&#44; lipoprote&#237;na de alta densidade &#40;mg&#47;dL&#41;&#59; HOMA&#8208;IR&#44; modelo de avalia&#231;&#227;o da homeostase &#8211; resist&#234;ncia &#224; insulina&#59; IMC&#44; &#237;ndice de massa corporal &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&#59; LDL&#44; lipoprote&#237;na de baixa densidade &#40;mg&#47;dL&#41;&#59; PAS&#44; press&#227;o arterial sist&#243;lica &#40;mmHg&#41;&#59; PAD&#44; press&#227;o arterial diast&#243;lica &#40;mmHg&#41;&#46;</p><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Valores apresentados como m&#233;dia<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DP&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Sexo e hipertens&#227;o s&#227;o n&#250;meros de amostras &#40;&#37;&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Controle<br>n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>153 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Obesidade<br>n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>195 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sexo feminino&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">91 &#40;59&#44;47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">104 &#40;53&#44;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Idade&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&#44;9 &#177;3&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11 &#177;3&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">IMC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#44;9 &#177;2&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26&#44;7 &#177;4&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PAS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">105&#44;3 &#177;12&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">118&#44;7 &#177;15&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PAD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&#44;2 &#177;9&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73&#44;8 &#177;9&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hipertens&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5 &#40;3&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61 &#40;31&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Glicose &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80&#44;8 &#177;10&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">86 &#40;&#177;8&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HOMA&#8208;IR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;17 &#177;2&#44;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;68 &#177;3&#44;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Colesterol total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">142 &#177;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">145 &#177;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">LDL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#44;5 &#177;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">84&#44;8 &#177;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">HDL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44 &#177;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#177;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Triglicer&#237;deos &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&#44;3 &#177;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">88&#44;2 &#177;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1207369.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas demogr&#225;ficas dos participantes do estudo</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabela 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">gl&#58; grau de liberdade&#59; gl<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1 entre 2 alelos&#59; gl<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2 entre 3 gen&#243;tipos&#59; RC&#44; raz&#227;o de chance&#59; uma associa&#231;&#227;o significativa &#233; indicada em negrito it&#225;lico &#40;&#60; 0&#44;05&#41;&#59; valor de p ajustado pelo teste de permuta&#231;&#227;o&#58; 0&#44;2 &#40;alelo&#41;&#59; valor de p ajustado pelo teste de permuta&#231;&#227;o&#58; 0&#44;09 &#40;genot&#237;pico&#41;&#59; valor de p ajustado pelo teste de 1&#46;000 permuta&#231;&#245;es &#40;m&#250;ltiplo teste &#8211; sem fase&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Obesidade n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>195 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Controle n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>153 &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">RC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">90&#37; Baixo 95&#37; Alto&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">X</span><span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">gl&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Valor de <span class="elsevierStyleItalic">p</span> &#40;1&#46;000 permuta&#231;&#245;es&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">AKT1</span></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">rs2494738</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>G&#47;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">150 &#40;76&#44;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">126 &#40;82&#44;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>A&#47;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">30 &#40;15&#44;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 &#40;11&#44;76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;73&#8208;2&#44;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>A&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;0&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;0&#44;65&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;05&#8208;13&#44;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>G<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">330 &#40;84&#44;62&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">270 &#40;88&#44;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32 &#40;8&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">20 &#40;6&#44;54&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;73&#8208;2&#44;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">rs3730358</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>G&#47;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">116 &#40;59&#44;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">90 &#40;58&#44;82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>A&#47;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">54 &#40;27&#44;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48 &#40;31&#44;37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;87&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;54&#8208;1&#44;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>A&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;5&#44;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4 &#40;2&#44;61&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;65&#8208;6&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>G<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">286 &#40;73&#44;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">228 &#40;74&#44;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76 &#40;19&#44;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;18&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;73&#8208;1&#44;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">rs10149779</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>G&#47;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">94 &#40;48&#44;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55 &#40;35&#44;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;04 &#40;0&#44;09&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>G&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">73 &#40;37&#44;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76 &#40;49&#44;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;35 &#8208; 0&#44;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>A&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">18 &#40;9&#44;23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17 &#40;11&#44;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;29 &#8208;1&#44;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>G<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">261 &#40;37&#44;83&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">186 &#40;60&#44;78&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#44;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;03 &#40;0&#44;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">109 &#40;27&#44;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">110 &#40;35&#44;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;51&#8208;0&#44;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">AKTIP</span></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">rs9302648</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>T&#47;T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76 &#40;38&#44;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46 &#40;30&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;02 &#40;0&#44;09&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>G&#47;T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">76 &#40;38&#44;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82 &#40;53&#44;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;34&#8208;0&#44;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>G&#47;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36 &#40;18&#44;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21 &#40;13&#44;73&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;54&#8208;1&#44;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>T<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">228 &#40;58&#44;46&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">174 &#40;56&#44;86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">148 &#40;37&#44;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">124 &#40;40&#44;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;66&#8208;1&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic">rs7189819</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>C&#47;C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67 &#40;34&#44;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61 &#40;39&#44;87&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>C&#47;T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">84 &#40;43&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65 &#40;42&#44;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;73&#8208;1&#44;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>T&#47;T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">34 &#40;17&#44;44&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;15&#44;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;71&#8208;2&#44;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>C<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">218 &#40;55&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">187 &#40;61&#44;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">152 &#40;38&#44;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">111 &#40;36&#44;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;85 &#8208;1&#44;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="8" align="left" valign="top"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">FTO</span></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">rs9939609</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">rs9939609</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>A&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">44 &#40;22&#44;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">34 &#40;22&#44;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4&#44;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>T&#47;A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">45 &#40;23&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">71 &#40;46&#44;41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;66&#8208;1&#44;96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>T&#47;T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39 &#40;20&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">46 &#40;30&#44;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;35&#8208;1&#44;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>A<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">193 &#40;49&#44;49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">139 &#40;45&#44;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1 &#40;ref&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">183 &#40;46&#44;92&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">163 &#40;53&#44;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;59&#8208;1&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1207367.png"
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tblfn0015"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Alelo ancestral&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Gen&#243;tipo e frequ&#234;ncias de alelos dos seis SNPs marcados dos polimorfismos <span class="elsevierStyleItalic">FTO</span>&#47;<span class="elsevierStyleItalic">AKT1</span>&#47;<span class="elsevierStyleItalic">AKTIP</span> nas amostras</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabela 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabela "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Beta pad&#46;&#44; coeficiente de regress&#227;o padronizado&#59; HOMA&#44; &#237;ndice do modelo de avalia&#231;&#227;o da homeostase&#59; IMC&#44; &#237;ndice de massa corporal&#59; R<span class="elsevierStyleSup">2</span> ajus&#46;&#44; R<span class="elsevierStyleSup">2</span> ajustado&#46;</p>"
          "tablatextoimagen" => array:2 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " colspan="6" align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">Modelos de regress&#227;o linear do HOMA</span></th></tr><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Vari&#225;vel preditora&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">R<span class="elsevierStyleSup">2</span> ajus&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Beta padr&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">t&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">AKT1</span> rs2191738 HEX&#47;FAM A&#47;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;983&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">AKT1</span> rs3730358 HEX&#47;FAM A&#47;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;725&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">AKT1</span> rs10119779 HEX&#47;FAM A&#47;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;880&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FTO</span> rs9939309 HEX&#47;FAM A&#47;T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;971&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">AKTIP</span> rs9302318 HEX&#47;FAM G&#47;T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;421&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">AKTIP</span> rs7189819 HEX&#47;FAM C&#47;T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;567&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1207368.png"
              ]
            ]
            1 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " colspan="6" align="center" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">Modelos de regress&#227;o linear do IMC</span></th></tr><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Vari&#225;vel preditora&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">R<span class="elsevierStyleSup">2</span> ajus&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Beta padr&#227;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">t&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">AKT1</span> rs2191738 HEX&#47;FAM A&#47;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;919&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">AKT1</span> rs3730358 HEX&#47;FAM A&#47;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;802&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">AKT1</span> rs10119779 HEX&#47;FAM A&#47;G&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;137&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;1&#44;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">FTO</span> rs9939309 HEX&#47;FAM A&#47;T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;080&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">AKTIP</span> rs9302318 HEX&#47;FAM G&#47;T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;05&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;816&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">AKTIP</span> rs7189819 HEX&#47;FAM C&#47;T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;240&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;0&#44;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#8722;1&#44;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1207370.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "pt" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Modelo de regress&#227;o linear que aborda as contribui&#231;&#245;es de cada SNP para o HOMA&#8208;IR e o IMC em nossa amostra</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Refer&#234;ncias"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:40 [
            0 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Childhood maltreatment and obesity&#58; systematic review and meta&#8208;analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Danese"
                            1 => "M&#46; Tan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/mp.2013.54"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Psychiatry"
                        "fecha" => "2014"
                        "volumen" => "19"
                        "paginaInicial" => "544"
                        "paginaFinal" => "554"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23689533"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetics and epigenetics of obesity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;M&#46; Herrera"
                            1 => "S&#46; Keildson"
                            2 => "C&#46;M&#46; Lindgren"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.maturitas.2011.02.018"
                      "Revista" => array:7 [
                        "tituloSerie" => "Maturitas"
                        "fecha" => "2011"
                        "volumen" => "69"
                        "paginaInicial" => "41"
                        "paginaFinal" => "49"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21466928"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510711015136"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variability in the heritability of body mass index&#58; a systematic review and meta&#8208;regression"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;E&#46; Elks"
                            1 => "M&#46; den Hoed"
                            2 => "J&#46;H&#46; Zhao"
                            3 => "S&#46;J&#46; Sharp"
                            4 => "N&#46;J&#46; Wareham"
                            5 => "R&#46;J&#46; Loos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Front Endocrinol &#40;Lausanne&#41;"
                        "fecha" => "2012"
                        "volumen" => "3"
                        "paginaInicial" => "29"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differences in the prevalence of metabolic syndrome in boys and girls based on various definitions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "N&#46; Sarrafzadegan"
                            1 => "M&#46; Gharipour"
                            2 => "M&#46; Sadeghi"
                            3 => "F&#46; Nouri"
                            4 => "S&#46; Asgary"
                            5 => "S&#46; Zarfeshani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "ARYA Atheroscler"
                        "fecha" => "2013"
                        "volumen" => "9"
                        "paginaInicial" => "70"
                        "paginaFinal" => "76"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23696762"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1542356509008349"
                          "estado" => "S300"
                          "issn" => "15423565"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The metabolic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;A&#46; Cornier"
                            1 => "D&#46; Dabelea"
                            2 => "T&#46;L&#46; Hernandez"
                            3 => "R&#46;C&#46; Lindstrom"
                            4 => "A&#46;J&#46; Steig"
                            5 => "N&#46;R&#46; Stob"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1210/er.2008-0024"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocr Rev"
                        "fecha" => "2008"
                        "volumen" => "29"
                        "paginaInicial" => "777"
                        "paginaFinal" => "822"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18971485"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Weight status in childhood as a predictor of becoming overweight or hypertensive in early adulthood"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;E&#46; Field"
                            1 => "N&#46;R&#46; Cook"
                            2 => "M&#46;W&#46; Gillman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/oby.2005.21"
                      "Revista" => array:6 [
                        "tituloSerie" => "Obes Res"
                        "fecha" => "2005"
                        "volumen" => "13"
                        "paginaInicial" => "163"
                        "paginaFinal" => "169"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15761176"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of Fto&#47;Ftm gene expression in mice and humans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Stratigopoulos"
                            1 => "S&#46;L&#46; Padilla"
                            2 => "C&#46;A&#46; LeDuc"
                            3 => "E&#46; Watson"
                            4 => "A&#46;T&#46; Hattersley"
                            5 => "M&#46;I&#46; McCarthy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1152/ajpregu.00839.2007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Physiol Regul Integr Comp Physiol"
                        "fecha" => "2008"
                        "volumen" => "294"
                        "paginaInicial" => "R1185"
                        "paginaFinal" => "R1196"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18256137"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association analyses of 249&#44;796 individuals reveal 18 new loci associated with body mass index"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;K&#46; Speliotes"
                            1 => "C&#46;J&#46; Willer"
                            2 => "S&#46;I&#46; Berndt"
                            3 => "K&#46;L&#46; Monda"
                            4 => "G&#46; Thorleifsson"
                            5 => "A&#46;U&#46; Jackson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng.686"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2010"
                        "volumen" => "42"
                        "paginaInicial" => "937"
                        "paginaFinal" => "948"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20935630"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genome&#8208;wide association scan shows genetic variants in the FTO gene are associated with obesity&#8208;related traits"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Scuteri"
                            1 => "S&#46; Sanna"
                            2 => "W&#46;M&#46; Chen"
                            3 => "M&#46; Uda"
                            4 => "G&#46; Albai"
                            5 => "J&#46; Strait"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pgen.0030115"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS Genet"
                        "fecha" => "2007"
                        "volumen" => "3"
                        "paginaInicial" => "e115"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17658951"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variants in the FTO gene are associated with common obesity in the Belgian population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Peeters"
                            1 => "S&#46; Beckers"
                            2 => "A&#46; Verrijken"
                            3 => "P&#46; Roevens"
                            4 => "P&#46; Peeters"
                            5 => "L&#46; Van Gaal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ymgme.2007.10.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Genet Metab"
                        "fecha" => "2008"
                        "volumen" => "93"
                        "paginaInicial" => "481"
                        "paginaFinal" => "484"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18055244"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The FTO gene is associated with adulthood obesity in the Mexican population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Villalobos-Compar&#225;n"
                            1 => "M&#46; Teresa Flores-Dorantes"
                            2 => "M&#46; Teresa Villarreal-Molina"
                            3 => "M&#46; Rodr&#237;guez-Cruz"
                            4 => "A&#46;C&#46; Garc&#237;a-Ulloa"
                            5 => "L&#46; Robles"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Obesity &#40;Silver Spring&#41;"
                        "fecha" => "2008"
                        "volumen" => "16"
                        "paginaInicial" => "2296"
                        "paginaFinal" => "2301"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PI3 K&#58; downstream AKTion blocks apoptosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;F&#46; Franke"
                            1 => "D&#46;R&#46; Kaplan"
                            2 => "L&#46;C&#46; Cantley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "1997"
                        "volumen" => "88"
                        "paginaInicial" => "435"
                        "paginaFinal" => "437"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9038334"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Akt signaling&#58; linking membrane events to life and death decisions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46;A&#46; Hemmings"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "1997"
                        "volumen" => "275"
                        "paginaInicial" => "628"
                        "paginaFinal" => "630"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9019819"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "AKT&#47;PKB signaling&#58; navigating downstream"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "B&#46;D&#46; Manning"
                            1 => "L&#46;C&#46; Cantley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cell.2007.06.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cell"
                        "fecha" => "2007"
                        "volumen" => "129"
                        "paginaInicial" => "1261"
                        "paginaFinal" => "1274"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17604717"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ft1 a novel gene related to ubiquitin&#8208;conjugating enzymes&#44; is deleted in the Fused toes mouse mutation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Lesche"
                            1 => "A&#46; Peetz"
                            2 => "F&#46; van der Hoeven"
                            3 => "U&#46; R&#252;ther"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mamm Genome"
                        "fecha" => "1997"
                        "volumen" => "8"
                        "paginaInicial" => "879"
                        "paginaFinal" => "883"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9383278"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A 680 kb duplication at the FTO locus in a kindred with obesity and a distinct body fat distribution"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;W&#46; Davies"
                            1 => "P&#46; Lau"
                            2 => "T&#46; Naing"
                            3 => "M&#46; Nikpay"
                            4 => "H&#46; Doelle"
                            5 => "M&#46;E&#46; Harper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ejhg.2013.63"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Hum Genet"
                        "fecha" => "2013"
                        "volumen" => "21"
                        "paginaInicial" => "1417"
                        "paginaFinal" => "1422"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23591406"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of apoptosis by the Ft1 protein&#44; a new modulator of protein kinase B&#47;Akt"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I&#46; Remy"
                            1 => "S&#46;W&#46; Michnick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Cell Biol"
                        "fecha" => "2004"
                        "volumen" => "24"
                        "paginaInicial" => "1493"
                        "paginaFinal" => "1504"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14749367"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Joint WHO&#47;FAO Expert Consultation on Diet&#44; Nutrition and the Prevention of Chronic Diseases &#40;2002&#58; Geneva&#44; Switzerland&#41;&#46; Diet&#44; nutrition and the prevention of chronic diseases&#58; report of a joint WHO&#47;FAO expert consultation&#44; Geneva&#44; 28 January&#8211;1 February 2002&#46;"
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CDC growth charts&#58; United States"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;J&#46; Kuczmarski"
                            1 => "C&#46;L&#46; Ogden"
                            2 => "L&#46;M&#46; Grummer-Strawn"
                            3 => "K&#46;M&#46; Flegal"
                            4 => "S&#46;S&#46; Guo"
                            5 => "R&#46; Wei"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Adv Data"
                        "fecha" => "2000"
                        "numero" => "314"
                        "paginaInicial" => "1"
                        "paginaFinal" => "27"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17784725"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents&#58; a working group report from the National High Blood Pressure Education Program"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Pediatrics"
                        "fecha" => "1996"
                        "volumen" => "98"
                        "paginaInicial" => "649"
                        "paginaFinal" => "658"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8885941"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016508512011572"
                          "estado" => "S300"
                          "issn" => "00165085"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use and abuse of HOMA modeling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "T&#46;M&#46; Wallace"
                            1 => "J&#46;C&#46; Levy"
                            2 => "D&#46;R&#46; Matthews"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes Care"
                        "fecha" => "2004"
                        "volumen" => "27"
                        "paginaInicial" => "1487"
                        "paginaFinal" => "1495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15161807"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "eNOS haplotype associated with hypertension in obese children and adolescents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;C&#46; Souza-Costa"
                            1 => "V&#46;A&#46; Belo"
                            2 => "P&#46;S&#46; Silva"
                            3 => "J&#46;T&#46; Sertorio"
                            4 => "I&#46;F&#46; Metzger"
                            5 => "C&#46;M&#46; Lanna"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes &#40;Lond&#41;"
                        "fecha" => "2011"
                        "volumen" => "35"
                        "paginaInicial" => "387"
                        "paginaFinal" => "392"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0315"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effects of endothelial nitric oxide synthase tagSNPs on nitrite levels and risk of hypertension and obesity in children and adolescents"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; de Miranda"
                            1 => "R&#46; Lacchini"
                            2 => "V&#46;A&#46; Belo"
                            3 => "C&#46;M&#46; Lanna"
                            4 => "J&#46;T&#46; Sertorio"
                            5 => "M&#46;R&#46; Luizon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/jhh.2014.48"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hum Hypertens"
                        "fecha" => "2015"
                        "volumen" => "29"
                        "paginaInicial" => "109"
                        "paginaFinal" => "114"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24943287"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0320"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A rapid non&#8208;enzymatic method for the preparation of HMW DNA from blood for RFLP studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;K&#46; Lahiri"
                            1 => "J&#46;I&#46; Nurnberger Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nucleic Acids Res"
                        "fecha" => "1991"
                        "volumen" => "19"
                        "paginaInicial" => "5444"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1681511"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0325"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Likelihood&#8208;based association analysis for nuclear families and unrelated subjects with missing genotype data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "F&#46; Dudbridge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1159/000119108"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hum Hered"
                        "fecha" => "2008"
                        "volumen" => "66"
                        "paginaInicial" => "87"
                        "paginaFinal" => "98"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18382088"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016510709024249"
                          "estado" => "S300"
                          "issn" => "00165107"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0330"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Haploview&#58; analysis and visualization of LD and haplotype maps"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;C&#46; Barrett"
                            1 => "B&#46; Fry"
                            2 => "J&#46; Maller"
                            3 => "M&#46;J&#46; Daly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/bioinformatics/bth457"
                      "Revista" => array:6 [
                        "tituloSerie" => "Bioinformatics"
                        "fecha" => "2005"
                        "volumen" => "21"
                        "paginaInicial" => "263"
                        "paginaFinal" => "265"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15297300"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0335"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multifactor dimensionality reduction&#58; an analysis strategy for modelling and detecting gene&#8211;gene interactions in human genetics and pharmacogenomics studies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;A&#46; Motsinger"
                            1 => "M&#46;D&#46; Ritchie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Genomics"
                        "fecha" => "2006"
                        "volumen" => "2"
                        "paginaInicial" => "318"
                        "paginaFinal" => "328"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16595076"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0340"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An obesity&#8208;associated FTO gene variant and increased energy intake in children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;E&#46; Cecil"
                            1 => "R&#46; Tavendale"
                            2 => "P&#46; Watt"
                            3 => "M&#46;M&#46; Hetherington"
                            4 => "C&#46;N&#46; Palmer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa0803839"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2008"
                        "volumen" => "359"
                        "paginaInicial" => "2558"
                        "paginaFinal" => "2566"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19073975"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A genome&#8208;wide association study of type 2 diabetes in Finns detects multiple susceptibility variants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;J&#46; Scott"
                            1 => "K&#46;L&#46; Mohlke"
                            2 => "L&#46;L&#46; Bonnycastle"
                            3 => "C&#46;J&#46; Willer"
                            4 => "Y&#46; Li"
                            5 => "W&#46;L&#46; Duren"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1126/science.1142382"
                      "Revista" => array:6 [
                        "tituloSerie" => "Science"
                        "fecha" => "2007"
                        "volumen" => "316"
                        "paginaInicial" => "1341"
                        "paginaFinal" => "1345"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17463248"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Meta&#8208;analysis identifies common variants associated with body mass index in east Asians"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46; Wen"
                            1 => "Y&#46;S&#46; Cho"
                            2 => "W&#46; Zheng"
                            3 => "R&#46; Dorajoo"
                            4 => "N&#46; Kato"
                            5 => "L&#46; Qi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng.1087"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2012"
                        "volumen" => "44"
                        "paginaInicial" => "307"
                        "paginaFinal" => "311"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22344219"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genome&#8208;wide association study for early&#8208;onset and morbid adult obesity identifies three new risk loci in European populations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Meyre"
                            1 => "J&#46; Delplanque"
                            2 => "J&#46;C&#46; Ch&#232;vre"
                            3 => "C&#46; Lecoeur"
                            4 => "S&#46; Lobbens"
                            5 => "S&#46; Gallina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng.301"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2009"
                        "volumen" => "41"
                        "paginaInicial" => "157"
                        "paginaFinal" => "159"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19151714"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Associations of six single nucleotide polymorphisms in obesity&#8208;related genes with BMI and risk of obesity in Chinese children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Wu"
                            1 => "B&#46; Xi"
                            2 => "M&#46; Zhang"
                            3 => "Y&#46; Shen"
                            4 => "X&#46; Zhao"
                            5 => "H&#46; Cheng"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2337/db10-0273"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes"
                        "fecha" => "2010"
                        "volumen" => "59"
                        "paginaInicial" => "3085"
                        "paginaFinal" => "3089"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20843981"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;F&#46; Grant"
                            1 => "M&#46; Li"
                            2 => "J&#46;P&#46; Bradfield"
                            3 => "C&#46;E&#46; Kim"
                            4 => "K&#46; Annaiah"
                            5 => "E&#46; Santa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pone.0001746"
                      "Revista" => array:6 [
                        "tituloSerie" => "PLoS ONE"
                        "fecha" => "2008"
                        "volumen" => "3"
                        "paginaInicial" => "e1746"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18335027"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0016508508002485"
                          "estado" => "S300"
                          "issn" => "00165085"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;F&#46; da Silva"
                            1 => "M&#46;R&#46; Zandon&#225;"
                            2 => "M&#46;R&#46; Vitolo"
                            3 => "P&#46;D&#46; Campagnolo"
                            4 => "L&#46;N&#46; Rotta"
                            5 => "S&#46; Almeida"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2350-14-34"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMC Med Genet"
                        "fecha" => "2013"
                        "volumen" => "14"
                        "paginaInicial" => "34"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23497514"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1542356509000032"
                          "estado" => "S300"
                          "issn" => "15423565"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ACTION Study Team&#46; FTO genotype&#44; vitamin D status&#44; and weight gain during childhood"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46;H&#46; Louren&#231;o"
                            1 => "L&#46; Qi"
                            2 => "W&#46;C&#46; Willett"
                            3 => "M&#46;A&#46; Cardoso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2337/db13-1290"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diabetes"
                        "fecha" => "2014"
                        "volumen" => "63"
                        "paginaInicial" => "808"
                        "paginaFinal" => "814"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24130335"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "AKT1 polymorphisms are associated with risk for metabolic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Devaney"
                            1 => "H&#46; Gordish-Dressman"
                            2 => "B&#46;T&#46; Harmon"
                            3 => "M&#46;K&#46; Bradbury"
                            4 => "S&#46;A&#46; Devaney"
                            5 => "T&#46;B&#46; Harris"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00439-010-0910-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Genet"
                        "fecha" => "2011"
                        "volumen" => "129"
                        "paginaInicial" => "129"
                        "paginaFinal" => "139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21061022"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epistasis&#58; too often neglected in complex trait studies&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Carlborg"
                            1 => "C&#46;S&#46; Haley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nrg1407"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Rev Genet"
                        "fecha" => "2004"
                        "volumen" => "5"
                        "paginaInicial" => "618"
                        "paginaFinal" => "625"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15266344"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epistasis among genes is a universal phenomenon in obesity&#58; evidence from rodent models"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;H&#46; Warden"
                            1 => "N&#46; Yi"
                            2 => "J&#46; Fisler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Nutrition"
                        "fecha" => "2004"
                        "volumen" => "20"
                        "paginaInicial" => "74"
                        "paginaFinal" => "77"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14698018"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity&#8208;susceptibility loci and the tails of the pediatric BMI distribution"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;A&#46; Mitchell"
                            1 => "H&#46; Hakonarson"
                            2 => "T&#46;R&#46; Rebbeck"
                            3 => "S&#46;F&#46; Grant"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Obesity &#40;Silver Spring&#41;"
                        "fecha" => "2013"
                        "volumen" => "21"
                        "paginaInicial" => "1256"
                        "paginaFinal" => "1260"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lack of association between DRD2 and OPRM1 genotypes and adiposity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;A&#46; Hardman"
                            1 => "P&#46;J&#46; Rogers"
                            2 => "N&#46;J&#46; Timpson"
                            3 => "M&#46;R&#46; Munaf&#242;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes &#40;Lond&#41;"
                        "fecha" => "2014"
                        "volumen" => "38"
                        "paginaInicial" => "730"
                        "paginaFinal" => "736"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:3 [
        "titulo" => "Agradecimentos"
        "texto" => "<p id="par0145" class="elsevierStylePara elsevierViewall">Este estudo foi financiado por CAPES&#44; FAPESP&#44; CNPq &#40;FAPEMIG&#58;CBB&#8208;APQ&#8208;00075&#8208;09&#47;CNPq 573646&#47;2008&#8208;2&#41;&#44; e FAPEMIG&#58;CDS&#8208;BPD&#8208;00296&#8208;14&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "pt"
  "url" => "/22555536/0000009200000005/v1_201609200029/S2255553616300787/v1_201609200029/pt/main.assets"
  "Apartado" => array:4 [
    "identificador" => "16682"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Artigos originais"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/22555536/0000009200000005/v1_201609200029/S2255553616300787/v1_201609200029/pt/main.pdf?idApp=UINPBA000049&text.app=https://jped.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2255553616300787?idApp=UINPBA000049"
]