Compartilhar
Informação da revista
Vol. 89. Núm. 6.
Páginas 531-543 (Novembro - Dezembro 2013)
Compartilhar
Compartilhar
Baixar PDF
Mais opções do artigo
Vol. 89. Núm. 6.
Páginas 531-543 (Novembro - Dezembro 2013)
ARTIGO DE REVISÃO
Open Access
Epidemiological and genetic characteristics associated with the severity of acute viral bronchiolitis by respiratory syncytial virus
Características epidemiológicas e genéticas associadas à gravidade da bronquiolite viral aguda pelo vírus sincicial respiratório
Visitas
...
Alfonso E. Alvareza, Fernando A.L. Marsona,
Autor para correspondência
fernandolimamarson@hotmail.com

Corresponding author.
, Carmen S. Bertuzzob, Clarice W. Arnsc, José D. Ribeiroa
a Departamento de Pediatria, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil
b Departamento de Genética Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil
c Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil
Informação do artigo
Abstract
Objective

to assess the epidemiological and genetic factors associated with severity of acute viral bronchiolitis (AVB) by respiratory syncytial virus (RSV).

Data source

: the key words “bronchiolitis”, “risk factor”, “genetics” and “respiratory syn-cytial virus”, and all combinations among them were used to perform a search in the PubMed,SciELO, and Lilacs databases, of articles published after the year 2000 that included individualsyounger than 2 years of age.

Data synthesis

: a total of 1,259 articles were found, and their respective summaries were read. Of these, 81 were selected, which assessed risk factors for the severity of AVB, and were read in full; the 60 most relevant studies were included. The epidemiologic factors associated with AVB severity by RSV were prematurity, passive smoking, young age, lack of breastfeeding, chronic lung disease, congenital heart disease, male gender, ethnicity, viral coinfection, low weight at admission, maternal smoking during pregnancy, atopic dermatitis, mechanical ventilation in the neonatal period, maternal history of atopy and/or asthma during pregnancy, season of birth, low socioeconomic status, Down syndrome, environmental pollution, living at an altitude > 2,500 meters above sea level, and cesarean section birth. Conversely, some children with severe AVB did not present any of these risk factors. In this regard, recent studies have verified the influence of genetic factors on the severity of AVB by RSV. Polymorphisms of the TLRs, RANTES, JUN, IFNA5, NOS2, CX3CR1, ILs, and VDR genes have been shown to be associated with more severe evolution of AVB by RSV.

Conclusion

the severity of AVB by RSV is a phenomenon that depends on the varying degrees of interaction among epidemiological, environmental, and genetic variables.

Keywords:
Bronchiolitis
Risk factors
Respiratory syncytial virus
Genetics
Resumo
Objetivo

: avaliar os fatores epidemiológicos e genéticos associados à gravidade da Bronquiolite Viral Aguda (BVA) pelo Vírus Sincicial Respiratório (VSR).

Fonte dos dados

: foram utilizados descritores “bronchiolitis”, “risk factor”, “genetics” e “respiratory syncytial virus” e todas as combinações entre eles, nas bases de dados PubMed, SciELO e Lilacs publicados após o ano de 2000 e que incluíram indivíduos menores de dois anos de idade.

Síntese dos dados

: foram encontrados 1.259 artigos e lidos seus respectivos resumos. Destes foram selecionados 81 que avaliaram fatores de risco para a gravidade da BVA para leitura na íntegra, e foram incluídos os 60 estudos mais relevantes. Os fatores epidemiológicos associados com a gravidade da BVA pelo VSR foram: prematuridade, tabagismo passivo, baixa idade, ausência de aleitamento materno, doença pulmonar crônica, cardiopatia congênita, sexo masculino, etnia, coinfecção viral, baixo peso na admissão hospitalar, tabagismo materno na gestação, dermatite atópica, ventilação mecânica no período neonatal, antecedente materno de atopia e/ou asma na gestação, estação do nascimento, baixo nível socioeconômico, síndrome de Down, poluição ambiental, morar em altitude acima de 2.500 metros do nível do mar e parto cesariana. Em contrapartida, algumas crianças com BVA grave não apresentam nenhum desses fatores de risco. Neste sentido, estudos recentes têm verificado a influência de fatores genéticos relacionados à gravidade da BVA pelo VSR. Polimorfismos dos genes TLRs, RANTES, JUN, IFNA5, NOS2, CX3CR1, ILs e VDR têm-se mostrado associados com a evolução mais grave da BVA pelo VSR.

Conclusão

: a gravidade da BVA pelo VSR é um fenômeno dependente da interação entre variáveis epidemiológicas, ambientais e genéticas em seus diferentes graus de interação.

Palavras-chave:
Bronquiolite
Fatores de risco
Vírus sincicial respiratório
Genética
O texto completo está disponível em PDF
Referências
[1]
S. Chávez-Bueno, A. Mejías, R.C. Welliver.
Respiratory syncytial virus bronchiolitis: current and future strategies for treatment and prophylaxis.
Treat Respir Med., 5 (2006), pp. 483-494
[2]
P.L. Ogra.
Respiratory syncytial virus: the virus, the disease and the immune response.
Paediatr Respir Rev., 5 (2004), pp. S119-S126
[3]
L.J. Stockman, A.T. Curns, L.J. Anderson, G. Fischer-Langley.
Respiratory Syncytial Virus-associated Hospitalizations Among Infants and Young Children in the United States, 1997-2006.
Pediatr Infect Dis J., 31 (2012), pp. 5-9
[4]
S. Leader, K. Kohlhase.
Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997 to 2000.
J Pediatr., 143 (2003), pp. S127-S132
[5]
G. Ranmuthugala, L. Brown, B.A. Lidbury.
Respiratory syncytial virus – the unrecognised cause of health and economic burden among young children in Australia.
Commun Dis Intell., 35 (2011), pp. 177-184
[6]
E.A. Simões, X. Carbonell-Estrany.
Impact of severe disease caused by respiratory syncytial virus in children living in developed countries.
Pediatr Infect Dis J., 22 (2003), pp. S13-S18
[7]
E.P. Albernaz, A.M. Menezes, J.A. César, C.G. Victora, F.C. Barros, R. Halpern.
Risk factors associated with hospitalization for bronchiolitis in the post-neonatal period.
Rev Saude Publica., 37 (2003), pp. 485-493
[8]
S.A. Deshpande, V. Northern.
The clinical and health economic burden of respiratory syncytial virus disease among children under 2 years of age in a defined geographical area.
Arch Dis Child., 88 (2003), pp. 1065-1069
[9]
J.P. Fryzek, W.J. Martone, J.R. Groothuis.
Trends in chronologic age and infant respiratory syncytial virus hospitalization: an 8-year cohort study.
Adv Ther., 28 (2011), pp. 195-201
[10]
C.C. Sung, H. Chi, N.C. Chiu, D.T. Huang, L.C. Weng, N.Y. Wang, et al.
Viral etiology of acute lower respiratory tract infections in hospitalized young children in Northern Taiwan.
J Microbiol Immunol Infect., 44 (2011), pp. 184-190
[11]
M.L. García, M. Ordobás Gabin, C. Calvo Reya, M. González Alvarez, J. Aguilar Ruiz, A. Arregui Sierra, et al.
Viral infection of the lower respiratory tract in hospitalized infants: etiology, clinical features and risk factors.
An Esp Pediatr., 55 (2001), pp. 101-107
[12]
A.G. Riccetto, J.D. Ribeiro, M.T. Silva, R.S. Almeida, C.W. Arns, E.C. Baracat.
Respiratory syncytial virus (RSV) in infants hospitalized for acute lower respiratory tract disease: incidence and associated risks.
Braz J Infect Dis., 10 (2006), pp. 357-361
[13]
J.B. Salomão Junior, L.G. Gardinassi, P.V. Simas, C.O. Bittar, F.P. Souza, P. Rahal, et al.
Human respiratory syncytial virus in children hospitalized for acute lower respiratory infection.
J Pediatr (Rio J)., 87 (2011), pp. 219-224
[14]
P.D. Sly, C.M. Jones.
Viral co-detection in infants hospitalized with respiratory disease: is it important to detect?.
J Pediatr (Rio J)., 87 (2011), pp. 277-280
[15]
E.K. Miller, J.V. Williams, T. Gebretsadik, K.N. Carroll, W.D. Dupont, Y.A. Mohamed, et al.
Host and viral factors associated with severity of human rhinovirus-associated infant respiratory tract illness.
J Allergy Clin Immunol., 127 (2011), pp. 883-891
[16]
M.S. Nascimento, A.V. Souza, A.V. Ferreira, J.C. Rodrigues, S. Abramovici, L.V. Silva Filho.
High rate of viral identification and coinfections in infants with acute bronchiolitis.
Clinics (São Paulo)., 65 (2010), pp. 1133-1137
[17]
J.R. Groothuis, J.P. Fryzek, D. Makari, D. Steffey, W.J. Martone.
Respiratory syncytial virus hospitalization trends in infants with chronic lung disease of infancy, 1998-2008.
Clin Epidemiol., 3 (2011), pp. 245-250
[18]
J.B. Gouyon, J.C. Rozé, C. Guillermet-Fromentin, I. Glorieux, L. Adamon, D.I.M. Maio.
Hospitalizations for respiratory syncytial virus bronchiolitis in preterm infants at <33 weeks gestation without bronchopulmonary dysplasia: the CASTOR study.
Epidemiol Infect., 15 (2012), pp. 1-11
[19]
M.G. Semple, D.C. Taylor-Robinson, S. Lane, R.L. Smyth.
Household tobacco smoke and admission weight predict severe bronchiolitis in infants independent of deprivation: prospective cohort study.
[20]
M. Koehoorn, C.J. Karr, P.A. Demers, C. Lencar, L. Tamburic, M. Brauer.
Descriptive epidemiological features of bronchiolitis in a population-based cohort.
Pediatrics., 122 (2008), pp. 1196-1203
[21]
C. Ochoa Sangrador, J. González de Dios.
Grupo de Revisión del Proyecto aBREVIADo (BRonquiolitis-Estudio de Variabilidad Idoneidad y Adecuación). [Consensus conference on acute bronchiolitis (VI): prognosis of acute bronchiolitis. Review of scientific evidence].
An Pediatr (Barc)., 354 (2010), pp. e1-e34
[22]
K. Grimwood, C. Cohet, F.J. Rich, S. Cheng, C. Wood, N. Redshaw, et al.
Risk factors for respiratory syncytial virus bronchiolitis hospital admission in New Zealand.
Epidemiol Infect., 136 (2008), pp. 1333-1341
[23]
A. López Guinea, J. Casado Flores, M.A. Martín Sobrino, B. Espínola Docio, T. de la Calle Cabrera, A. Serrano, M.A. García Teresa.
Severe bronchiolitis. Epidemiology and clinical course of 284 patients.
An Pediatr (Barc)., 67 (2007), pp. 116-122
[24]
P.W. Chan, F.Y. Lok, S.B. Khatijah.
Risk factors for hypoxemia and respiratory failure in respiratory syncytial virus bronchiolitis.
Southeast Asian J Trop Med Public Health., 33 (2002), pp. 806-810
[25]
C.G. Garcia, R. Bhore, A. Soriano-Fallas, M. Trost, R. Chason, O. Ramilo, A. Mejias.
Risk factors in children hospitalized with RSV bronchiolitis versus non-RSV bronchiolitis.
Pediatrics., 126 (2010), pp. e1453-e1460
[26]
A. Chatzimichael, A. Tsalkidis, D. Cassimos, S. Gardikis, G. Tripsianis, S. Deftereos, et al.
The role of breastfeeding and passive smoking on the development of severe bronchiolitis in infants.
Minerva Pediatr., 59 (2007), pp. 199-206
[27]
L.L. Jones, A. Hashim, T. McKeever, D.G. Cook, J. Britton, J. Leonardi- Bee.
Parental and household smoking and the increased risk of bronchitis, bronchiolitis and other lower respiratory infections in infancy: systematic review and meta-analysis.
Respir Res., 12 (2011), pp. 5
[28]
J.P. Bradley, L.B. Bacharier, J. Bonfiglio, K.B. Schechtman, R. Strunk, G. Storch, et al.
Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy.
Pediatrics., 115 (2005), pp. e7-e14
[29]
D. Hervás, J. Reina, A. Yañez, J.M. Del Valle, J. Figuerola, J.A. Hervás.
Epidemiology of hospitalization for acute bronchiolitis in children: differences between RSV and non-RSV bronchiolitis.
Eur J Clin Microbiol Infect Dis., 31 (2012), pp. 1975-1981
[30]
G. Oñoro, E. Pérez Suárez, M.I. Iglesias Bouzas, A. Serrano, A. Martínez De Azagra, et al.
Severe bronchiolitis Changes in epidemiology and respiratory support.
An Pediatr (Barc)., 74 (2011), pp. 371-376
[31]
D. Damore, J.M. Mansbach, S. Clark, M. Ramundo, C.A. Camargo Jr..
Prospective multicenter bronchiolitis study: predicting intensive care unit admissions.
Acad Emerg Med., 15 (2008), pp. 887-894
[32]
P. Papoff, C. Moretti, G. Cangiano, E. Bonci, M. Roggini, A. Pierangeli, et al.
Incidence and predisposing factors for severe disease in previously healthy term infants experiencing their first episode of bronchiolitis.
Acta Paediatr., 100 (2011), pp. e17-e23
[33]
S.M. Vidaurreta, D.N. Marcone, A. Ellis, J. Ekstrom, D. Cukier, C. Videla.
Acute viral respiratory infection in children under 5 years: Epidemiological study in two centers in Buenos Aires.
Argentina. Arch Argent Pediatr., 109 (2011), pp. 296-304
[34]
C.T. Dornelles, J.P. Piva, P.J. Marostica.
Nutritional status, breastfeeding, and evolution of Infants with acute viral bronchiolitis.
J Health Popul Nutr., 25 (2007), pp. 336-343
[35]
M.A. Al-Shehri, A. Sadeq, K. Quli.
Bronchiolitis in Abha Southwest Saudi Arabia: viral etiology and predictors for hospital admission.
West Afr J Med., 24 (2005), pp. 299-304
[36]
D. Che, J. Nicolau, J. Bergounioux, T. Perez, D. Bitar.
Bronchiolitis among infants under 1 year of age in France: Epidemiology and factors associated with mortality.
Arch Pediatr., 19 (2012), pp. 700-706
[37]
H.O. Fjaerli, T. Farstad, D. Bratlid.
Hospitalisations for respiratory syncytial virus bronchiolitis in Akershus Norway, 1993-2000: a population-based retrospective study.
BMC Pediatr., 4 (2004), pp. 25
[38]
H.C. Meissner.
Selected populations at increased risk from respiratory syncytial virus infection.
Pediatr Infect Dis J., 22 (2003), pp. S40-S45
[39]
A.G. Riccetto, L.H. Silva, F.R. Spilki, A.M. Morcillo, C.W. Arns, E.C. Baracat.
Genotypes and clinical data of respiratory syncytial virus and metapneumovirus in brazilian infants: a new perspective.
Braz J Infect Dis., 13 (2009), pp. 35-39
[40]
C. D’Elia, M.M. Siqueira, S.A. Portes, C.C. Sant’Anna.
Respiratory syncytial virus – associated lower respiratory tract infections in hospitalized infants.
Rev Soc Bras Med Trop., 38 (2005), pp. 7-10
[41]
J.A. Weigl, W. Puppe, H.J. Schmitt.
Variables explaining the duration of hospitalization in children under two years of age admitted with acute airway infections: does respiratory syncytial virus have a direct impact?.
Klin Padiatr., 216 (2004), pp. 7-15
[42]
H.K. Brand, R. de Groot, J.M. Galama, M.L. Brouwer, K. Teuwen, P.W. Hermans, et al.
Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis.
Pediatr Pulmonol., 47 (2012), pp. 393-400
[43]
M. De Paulis, A.E. Gilio, A.A. Ferraro, A.E. Ferronato, P.R. do Sacramento, V.F. Botosso, et al.
Severity of viral coinfection in hospitalized infants with respiratory syncytial virus infection.
J Pediatr (Rio J)., 87 (2011), pp. 307-313
[44]
T. Jartti, M. Söderlund-Venermo, K. Hedman, O. Ruuskanen, M.J. Mäkelä.
New molecular virus detection methods and their clinical value in lower respiratory tract infections in children.
Paediatr Respir Rev., 14 (2013), pp. 38-45
[45]
K.N. Carroll, T. Gebretsadik, M.R. Griffin, W.D. Dupont, E.F. Mitchel, P. Wu, et al.
Maternal asthma and maternal smoking are associated with increased risk of bronchiolitis during infancy.
Pediatrics., 119 (2007), pp. 1104-1112
[46]
B.L. Bloemers, A.M. van Furth, M.E. Weijerman, R.J. Gemke, C.J. Broers, K. van den Ende, et al.
Down syndrome: a novel risk factor for respiratory syncytial virus bronchiolitis – a prospective birth-cohort study.
Pediatrics., 120 (2007), pp. e1076-e1081
[47]
C. Karr, T. Lumley, A. Schreuder, R. Davis, T. Larson, B. Ritz, et al.
Effects of subchronic and chronic exposure to ambient air pollutants on infant bronchiolitis.
Am J Epidemiol., 165 (2007), pp. 553-560
[48]
J.A. Choudhuri, L.G. Ogden, A.J. Ruttenber, D.S. Thomas, J.K. Todd, E.A. Simoes.
Effect of altitude on hospitalizations for respiratory syncytial virus infection.
Pediatrics., 117 (2006), pp. 349-356
[49]
H.C. Moore, N. de Klerk, P. Holt, P.C. Richmond, D. Lehmann.
Hospitalisation for bronchiolitis in infants is more common after elective caesarean delivery.
Arch Dis Child., 97 (2012), pp. 410-414
[50]
S.F. Thomsen, L.G. Stensballe, A. Skytthe, K.O. Kyvic, V. Backer, H. Bisgaard.
Increased concordance of severe respiratory syncytial virus infection in identical twins.
Pediatrics., 121 (2008), pp. 493-496
[51]
G. Tal, A. Mandelberg, I. Dalal, K. Cesar, E. Somekh, A. Tal, et al.
Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus disease.
J Infect Dis., 189 (2004), pp. 2057-2063
[52]
R.N. Douville, Y. Lissitsyn, A.F. Hirschfeld, A.B. Becker, A.L. Kozyrskyj, J. Liem, et al.
TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus.
[53]
J. Löfgren, R. Marttila, M. Renko, M. Rämet, M. Hallman.
Toll-like receptor 4 Asp299Gly polymorphism in respiratory syncytial virus epidemics.
Pediatr Pulmonol., 45 (2010), pp. 687-692
[54]
A. Mandelberg, G. Tal, L. Naugolny, K. Cesar, A. Oron, S. Houri, et al.
Lipopolysaccharide hyporesponsiveness as a risk factor for intensive care unit hospitalization in infants with respiratory syncitial virus bronchiolitis.
Clin Exp Immunol., 144 (2006), pp. 48-52
[55]
B. Puthothu, J. Forster, A. Heinzmann, M. Krueger.
TLR-4 and CD14 polymorphisms in respiratory syncytial virus associated disease.
Dis Markers., 22 (2006), pp. 303-308
[56]
B. Mailaparambil, M. Krueger, J. Heinze, J. Forster, A. Heinzmann.
Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases.
Dis Markers., 25 (2008), pp. 59-65
[57]
V. Amanatidou, G. Sourvinos, S. Apostolakis, P. Neonaki, A. Tsilimigaki, E. Krambovitis, et al.
RANTES promoter gene polymorphisms and susceptibility to severe respiratory syncytial virus-induced bronchiolitis.
Pediatr Infect Dis J., 27 (2008), pp. 38-42
[58]
T.L. Kresfelder, R. Janssen, L. Bont, M. Venter.
Confirmation of an association between single nucleotide polymorphisms in the VDR gene with respiratory syncytial virus related disease in South African children.
J Med Virol., 83 (2011), pp. 1834-1840
[59]
R. Janssen, L. Bont, C.L. Siezen, H.M. Hodemaekers, M.J. Ermers, G. Doornbos, et al.
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
J Infect Dis., 196 (2007), pp. 826-834
[60]
V. Amanatidou, G. Sourvinos, S. Apostolakis, A. Tsilimigaki, D.A. Spandidos.
T280M variation of the CX3C receptor gene is associated with increased risk for severe respiratory syncytial virus bronchiolitis.
Pediatr Infect Dis J., 25 (2006), pp. 410-414
[61]
S. Ampuero, V. Luchsinger, L. Tapia, M.A. Palomino, C.E. Larrañaga.
SP-A1 SP-A2 and SP-D gene polymorphisms in severe acute respiratory syncytial infection in Chilean infants.
Infect Genet Evol., 11 (2011), pp. 1368-1377
[62]
J.F. Mulet, B.O. Rodríguez de Torres.
Viral induced bronchiolitis and genetics.
An Pediatr (Barc)., 73 (2010), pp. 159-161

Como citar este artigo: Alvarez AE, Marson FA, Bertuzzo CS, Arns CW, Ribeiro JD. Epidemiological and genetic characteristics associated with the severity of acute viral bronchiolitis by respiratory syncytial virus. J Pediatr (Rio J). 2013;89:531-43.

Copyright © 2013. Brasileira de Pediatria
Idiomas
Jornal de Pediatria

Receba a nossa Newsletter

Opções de artigo
Ferramentas
en pt
Taxa de publicaçao Publication fee
Os artigos submetidos a partir de 1º de setembro de 2018, que forem aceitos para publicação no Jornal de Pediatria, estarão sujeitos a uma taxa para que tenham sua publicação garantida. O artigo aceito somente será publicado após a comprovação do pagamento da taxa de publicação. Ao submeterem o manuscrito a este jornal, os autores concordam com esses termos. A submissão dos manuscritos continua gratuita. Para mais informações, contate assessoria@jped.com.br. Articles submitted as of September 1, 2018, which are accepted for publication in the Jornal de Pediatria, will be subject to a fee to have their publication guaranteed. The accepted article will only be published after proof of the publication fee payment. By submitting the manuscript to this journal, the authors agree to these terms. Manuscript submission remains free of charge. For more information, contact assessoria@jped.com.br.
Cookies policy Política de cookies
To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here. Utilizamos cookies próprios e de terceiros para melhorar nossos serviços e mostrar publicidade relacionada às suas preferências, analisando seus hábitos de navegação. Se continuar a navegar, consideramos que aceita o seu uso. Você pode alterar a configuração ou obter mais informações aqui.