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Vol. 89. Núm. 1.
Páginas 64-69 (Janeiro - Fevereiro 2013)
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Vol. 89. Núm. 1.
Páginas 64-69 (Janeiro - Fevereiro 2013)
Original article
Open Access
Acute lymphoblastic leukemia in infants: 20 years of experience
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Amanda Ibagya,
Autor para correspondência
amanda_ibagy@hotmail.com

Corresponding author.
, Denise B. Silvab, Jackline Seibenc, Ana P.F.F. Winneshofferd, Tatiana E.J.B. Costad, Juliana S. Dacoregiod, Imaruí Costad, Daniel Faracod
a MD. Pediatric Oncologist. Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil
b MSc. Pediatric Hematologist. Hospital Infantil Joana de Gusmão, Florianópolis, SC, Brazil
c Medical Student, UFSC, Florianópolis, SC, Brazil
d MD. Pediatric Oncologist, Hospital Infantil Joana de Gusmão, Florianópolis, SC, Brazil
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Estatísticas
Abstract
Objective

To analyze patients younger than 2 years with acute lymphoblastic leukemia, treated in the period between 1990 and 2010 in a state reference center.

Methods

This was a clinical-epidemiological, cross-sectional, observational, and descriptive study. It included patients younger than 2 years with acute lymphoblastic leukemia, treated in the period of 1990 to 2010 in a pediatric oncology unit of a state reference center, totaling 41 cases.

Results

All patients were white ethnicity, and 60.9% were females. Regarding age, 24.38% were younger than 6 months, 17.07% were between 6 months and 1 year, and 58.53% were older than 1 year. The age of 6 months was statistically significant for the outcome of death. Predominant signs and symptoms were fever, bruising, and petechiae. A leukocyte count > 100,000 was found in 34.14% of cases, hemoglobin count < 11 in 95.13%, and platelet count < 100,000 in 75.61. Infiltration of central nervous system was present in 12.91% of patients. According to the lineage, B-cell lineage predominated (73%), but the T-cell line was statistically significant for death. 39% of patients had disease recurrence. In relation to vital status, 70.73% of the patients died; septic shock was the main cause.

Conclusions

Acute lymphoblastic leukemia in infants has a high mortality rate, especially in children under 1 year and those with T-cell derived lineage.

Keywords:
Infant
Leukemia
classification
Precursor cell lymphoblastic leukemia-lymphoma
Resumo
Objetivo

Analisar pacientes com menos de dois anos de idade com leucemia linfoblásti- ca aguda atendidos no período de 1990 a 2010, em um centro de referência estadual.

Métodos

Estudo clínico, epidemiológico, transversal, descritivo e observacional. Pacientes incluídos tinham menos de dois anos de idade, com leucemia linfoblástica aguda, tratados no período de 1990 a 2010 na unidade de oncologia pediátrica de um centro de referência estadual, totalizando 41 casos.

Resultados

Todos os pacientes eram Caucasianos e 60,9% eram do sexo feminino. Com relação à idade, 24,38% tinham menos de seis meses, 17,07% tinham entre seis meses e um ano e 58,53% mais do que um ano de idade. A idade de seis meses foi estatisticamente significante para o desfecho de óbito. Os sinais e sintomas predominantes foram febre, hematomas e petéquias. Uma contagem de leucócitos superior a 100.000 foi observada em 34,14% dos casos; hemoglobina inferior a 11 em 95,13% e contagem de plaquetas inferior a 100.000, em 75,61% dos casos. Infiltração do sistema nervoso central estava presente em 12,91% dos pacientes. Em relação à linhagem, a linhagem B predominou (73%), mas a linhagem de células T foi estatisticamente significativa para o óbito. Trinta e nove por cento dos pacientes tiveram recorrência da doença. Em relação ao estado vital, 70,73% dos pacientes morreram, sendo choque séptico a principal causa.

Conclusões

: leucemia linfoblástica aguda em crianças tem uma alta taxa de mortalidade, principalmente em crianças menores de um ano e linhagem derivada de células T.

Palavras-chave:
Crianças
Leucemia
classificação
Leucemia-linfoma linfoblástica precursora de células
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Please, cite this article as: Ibagy A, Silva DB, Seiben J, Winneshoffer AP, Costa TE, Dacoregio JS, et al. Acute lymphoblastic leukemia in infants: 20 years of experience. J Pediatr (Rio J). 2013;89:64-69.

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