Original ArticlesPrevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis
Section snippets
Methods
The Cochrane Library, PubMed, and Embase databases were searched from 2006 (the year the Rome III criteria were published) up to September 2017. The protocol including the full search strategy is provided in Appendix 1 (available at www.jpeds.com). To identify additional studies, reference lists of review articles and included studies were searched manually. No language limits were used. This systematic review was not registered.
Articles were eligible for inclusion if they met the following
Results
A total of 4146 search results were identified (Figure). After we screened titles and abstracts, 218 full-text articles were assessed for eligibility and finally 37 articles were included.18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54 Reasons for exclusion are presented in the Figure. Of the 37 articles included in the qualitative analysis, 35 studies were included in the meta-analysis. One birth
Discussion
Our systematic review provides a meta-analysis that revealed a pooled functional constipation prevalence of 9.5% and a pooled FNRFI prevalence of 0.4% in children worldwide according to the Rome III criteria. No epidemiological stuies using the Rome IV criteria were identified. Pooled data analysis did not reveal a sex-related or age-related predominance for functional constipation; for FNRFI, this analysis was not performed because of scarcity of data. Significant geographic differences were
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Cited by (0)
M.V. received financial support from the Catharine van Tussenbroek fund (Nell Ongerboer Fund). The other authors declare no conflicts of interest.
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Contributed equally.