Original ArticleHealth-Related Quality of Life in Pediatric Patients with Functional and Organic Gastrointestinal Diseases
Section snippets
Methods
Pediatric patients aged 5-18 years and parents of pediatric patients aged 2-18 years with a physician-diagnosed GI disorder using International Classification of Disease, Ninth Revision, Clinical Modification diagnosis codes and/or Rome III criteria for FGIDs for 7 GI diagnostic groups, including both functional (chronic constipation [CC], functional abdominal pain [FAP], irritable bowel syndrome [IBS], and functional dyspepsia [FD]) and organic diseases (Crohn's disease [CD], ulcerative
Results
A total of 689 patient families (584 children aged 5-18 years and 682 parents of children aged 2-18 years) participated in the field test study. The average age of the 318 boys (46.2%) and 371 girls (53.8%) was 11.43 years (SD, 4.58; range, 2.0-18.9). The racial/ethnic distribution was 517 (75.0%) white non-Hispanic, 68 (9.9%) Hispanic, 63 (9.1%) black non-Hispanic, 13 (1.9%) Asian/Pacific Islander, 1 Native American (0.1%), and 27 (3.9%) other. With respect to parent education, 6.1% of mothers
Discussion
The results of this multicenter study demonstrate that pediatric patients with FGIDs and organic GI diseases have significantly lower generic HRQOL compared with healthy children, with the majority of effects sizes in the medium to large range. In addition, these children missed more days from school, had more days in bed/too ill to play, and required greater healthcare utilization, and their parents reported more days missed from work and a greater impact on their daily work routine and
References (30)
- et al.
Health-related quality of life across pediatric chronic conditions
J Pediatr
(2010) - et al.
The PedsQL 4.0 as a pediatric population health measure: feasibility, reliability, and validity
Ambul Pediatr
(2003) - et al.
Fatigue and health-related quality of life in pediatric inflammatory bowel disease
Clin Gastroenterol Hepatol
(2009) - et al.
Health-related quality of life in children and adolescents with cyclic vomiting syndrome: a comparison with published data on youth with irritable bowel syndrome and organic gastrointestinal disorders
J Pediatr
(2013) - et al.
Childhood functional gastrointestinal disorders: child/adolescent
Gastroenterology
(2006) - et al.
Cross-sectional analysis of health-related quality of life in pediatric liver transplant recipients
J Pediatr
(2010) - et al.
Health-related quality of life in children and adolescents with Duchenne muscular dystrophy
Pediatrics
(2012) Constitution of the World Health Organization: Basic document
(1948)Guidance for industry. Patient-reported outcome measures: Use in medical product development to support labeling claims
(2009)- et al.
The Pediatric Quality of Life Inventory: measuring pediatric health-related quality of life from the perspective of children and their parents
Pediatr Clin North Am
(2009)
Assessment of abdominal pain through global outcomes and recent FDA recommendations in children: are we ready for change?
J Pediatr Gastroenterol Nutr
Gastroenterology Regulatory Endpoints and the Advancement of Therapeutics (GREAT) Workshop
Impaired health-related quality of life in children and adolescents with chronic conditions: a comparative analysis of 10 disease clusters and 33 disease categories/severities utilizing the PedsQL 4.0 Generic Core Scales
Health Qual Life Outcomes
The PedsQL 4.0 as a school population health measure: feasibility, reliability, and validity
Qual Life Res
The PedsQL: measurement model for the Pediatric Quality of Life Inventory
Med Care
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J.F. is currently at the Division of Gastroenterology, Hepatology, and Nutrition, Nemours Children's Hospital, Orlando, FL.
J.V. holds the copyright and the trademark for the PedsQL and receives financial compensation from the Mapi Research Trust, a nonprofit research institute that charges distribution fees to for-profit companies that use the PedsQL. The other authors declare no conflicts of interest.
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A list of PedsQL Gastrointestinal Symptoms Module Testing Study Consortium sites is available at www.jpeds.com (Appendix).