Original ArticleVolumetric Capnography in Infants with Bronchopulmonary Dysplasia
Section snippets
Methods
This cross-sectional observational study was based on previously-collected lung function data from healthy term and preterm infants with and without BPD, matched for a post-conceptional age of 44 weeks and recruited from 1999-2007 within the region of Bern, Switzerland. The study protocol was approved by the Bernese Cantonal Ethics Committee and written informed parental consent was obtained for each subject prior to enrollment.
Term-born participants were infants without postnatal respiratory
Results
Term-born infants (n = 102), healthy preterm infants (n = 52), and infants with BPD (n = 77) fulfilled the inclusion criteria. Therefore, data from 231 infants (129 preterm; 77 with BPD) were included in the final analysis. All subjects had complete tidal breathing, MBW, and volume-based capnographic measurements. After application of quality control criteria, all capnographic series were suitable for further analysis with an available number of breaths between 82 and 95 (88 ± 3 in average). No
Discussion
Volumetric capnography has not been extensively studied in spontaneously breathing infants. Previous reports on sidestream time-based measurements have suggested the existence of an ‘immature’ capnographic pattern in preterm neonates26 and outlined the differences in capnographic shapes between infants with and without BPD.27 Volume-based capnographic data from unsedated infants are sparse and derived solely from studies aiming to estimate deadspace ventilation.20, 23 We present volume-based
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Neonatal Pulmonary Physiology
2023, Avery's Diseases of the NewbornVolumetric Capnography at 36 Weeks Postmenstrual Age and Bronchopulmonary Dysplasia in Very Preterm Infants
2022, Journal of PediatricsCitation Excerpt :We examined the influence of the following explanatory variables on SnII, SnIII, and KPIv using univariable linear regression analysis: demographic factors (sex, gestational age, birth weight z-score, weight z-score at test), markers of lung disease (duration of respiratory support, duration of mechanical ventilation, duration of supplemental oxygen, mild BPD, BPD36), and breathing pattern (RR, VT per kilogram of body weight [VT/kg] and VD,aw/VT). For the multivariable models, we considered the following explanatory variables: (1) factors known from literature to influence respiratory outcomes of very preterm infants (gestational age, sex, and birth weight z-score), (2) factors identified from our previous study at 44 weeks PMA to be associated with the dependent variables (VT, RR, BPD36), and (3) those potentially influencing the outcome variable as identified in univariable regression analysis (P < .10).10,18 To avoid collinearity, we decided to explore only birth weight z-scores in the multivariable model and omit weight z-score at the time of the test.
Lung Protection During Mechanical Ventilation in the Premature Infant
2021, Clinics in PerinatologyAnatomical deadspace during resuscitation of infants with congenital diaphragmatic hernia
2020, Early Human DevelopmentCitation Excerpt :Traces were of sufficient quality for analysis if they had five continuous breaths with no artefact interference and allowed for reconstruction of volumetric capnograms with adequate slope definition. The CO2 and volume signals were synchronised by alignment of maximal EtCO2 with the end of expiration [22]. The reconstructed volumetric capnograms comprise of three phases [23].
Variability of Tidal Breathing Parameters in Preterm Infants and Associations with Respiratory Morbidity during Infancy: A Cohort Study
2019, Journal of PediatricsCitation Excerpt :The CO2 elimination per minute (MVCO2) was calculated as VE,CO2 × RR. Details regarding correction for CO2 signal delay and quality control criteria for the capnography parameters have been published previously.17 Short-term variability in VE,CO2, VT, and RR was calculated using the coefficient of variation (CV) as CV (%) = SD/mean × 100, and is reported as CVVE,CO2, CVVT, and CVRR, respectively.
S.F. is the recipient of the European Respiratory Society Fellowship (STRTF 53-2012). The authors declare no conflicts of interest.
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Contributed equally.