Original ArticleNeonatal Magnetic Resonance Imaging and Outcome at Age 30 Months in Extremely Preterm Infants
Section snippets
Methods
The Regional Ethics Committee in Stockholm approved the study and informed consent was obtained from all parents of the participating infants. All infants born in Stockholm with a gestational age (GA) of <27 weeks 0 days were included in the study. During the 3-year study period from January 1, 2004, to March 31, 2007, 192 infants were born alive and 129 (69%) survived to term age (mean GA, 25 weeks 4 days ± 1 day; mean birth weight, 808 ± 160 g). Children with malformations, chromosome
MRI
The incidence rates of white matter abnormalities in this cohort have been published previously.19 Moderate-severe white matter abnormalities were present in 14%; thus, 86% of the infants had no-mild white matter abnormalities on MRI at term equivalent age. DEHSI were seen in 56%, in infants with all grades of white matter abnormalities.
Neurodevelopmental Follow-Up
At age 30 months corrected, 91 of the 117 children (78%) attended follow-up. Of the 107 extremely preterm infants who underwent MRI, 85 (79%) attended follow-up
Discussion
We have reported neurodevelopmental outcomes at age 30 months corrected in a population-based cohort of extremely preterm infants. In this cohort, 7% had CP, only 2% had severe cognitive delay, and 5% had severe language delay. As a group, the preterm infants demonstrated performance within the normal range for age on all 3 BSID-III scales. These promising findings should be interpreted with caution, however.
Previous studies have shown an overall decline in CP rates over the last several
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Cited by (99)
Management of Encephalopathy of Prematurity
2023, Principles of NeonatologyRisk Assessment and Neurodevelopmental Outcomes
2023, Avery's Diseases of the NewbornPredictors of long-term neurodevelopmental outcomes of children born extremely preterm
2021, Seminars in Perinatology
Supported by the Swedish Medical Research Council (grant 2006-6151), a regional agreement for medical training and clinical research (ALF 20090177) between the Stockholm County Council and the Karolinska Institute, the Linnea and Josef Carlsson Foundation, the Swedish Order of Freemasons, the Swedish Medical Society, the Jerring Foundation, and Sällskapet Barnavård. B.V. was supported by a Marie Curie Individual Intra-European Fellowship within the EU FP6 Framework Program. The authors declare no conflicts of interest.