Original ArticleGeneral Movements in Full-Term Infants with Perinatal Asphyxia Are Related to Basal Ganglia and Thalamic Lesions
Section snippets
Methods
The study group comprised term infants born at or referred to the University Hospital of Modena, Italy between 2003 and 2006, who were prospectively enrolled after informed parental consent for a research project on the diagnostic and prognostic value of spontaneous motility in infants with HIE. Ethical permission for this retrospective review of general movements and MRI was provided by the Ethical Committee of Modena Province. Inclusion criteria were birth at ≥37 weeks’ gestational age,
Perinatal Data
During the study period, 43 term-born infants fulfilled the inclusion criteria; 9 infants were not studied (5 due to loss to follow-up, 1 due to neonatal death, and 3 due to insufficient clinical data). Thus the study group comprised 34 infants (20 males, 14 females), with a mean gestational age of 40.4 ± 1.2 weeks. Cardiotocographic abnormalities were present in 25 infants, and a clearly identifiable sentinel event was seen in 6 infants (2 with placental abruption, 3 with umbilical cord
Discussion
Our comparison of early MRI brain findings and general movement assessments in term infants with HIE provides evidence of close correlations between the individual site, severity, and pattern of brain lesions and the quality of general movements. Few previous studies have examined the relationship between brain lesions and quality of general movements in term-born infants.
In full-term infants affected by neonatal cerebral infarction, Guzzetta et al27 detected movement asymmetries as early as 3
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2024, European Journal of Paediatric NeurologyTherapeutic hypothermia is associated with changes in prognostic value of general movements
2023, European Journal of Paediatric NeurologyCitation Excerpt :Data on the predictors of outcomes after HIE between cooled and non-cooled infants [10,11] have clearly shown that the predictive power of the majority of outcome predictors, including Apgar score, lactate level, Sarnat score stages I-III, abnormal amplitude of integrated electroencephalography features, cranial ultrasound findings, and brain magnetic resonance spectroscopy findings, changed in the cooling era, whereas only neonatal neurologic examination and MRI findings at day 8 maintained the same predictive value as in the precooling era. Over the last three decades, a number of studies have assessed the predictive value of general movements (GMs), considered either singly or together with MRI findings, in at-risk newborn infants [12–19]. But few data are currently available regarding the possible effects of TH on GMs [20–23].
Neurological and developmental outcomes following neonatal encephalopathy treated with therapeutic hypothermia
2021, Seminars in Fetal and Neonatal Medicine
The authors declare no conflicts of interest.