Original ArticleInflammation, insulin, and endothelial function in overweight children and adolescents: The role of exercise
Section snippets
Subjects
Twenty-five healthy, overweight children and adolescents (body mass index [BMI] >85th percentile for age and gender) were recruited from the greater Minneapolis/St. Paul, Minnesota, metropolitan area to participate in this study. Baseline characteristics for all participants are provided in Table I. Following baseline testing, 20 of the subjects were randomized to either the exercise or the control group. All participants and parents/guardians gave written informed assent and consent. The study
Discussion
The baseline association between CRP and fasting insulin is consistent with previous work in adults showing an independent association between chronic, subclinical inflammation and markers of insulin resistance.5., 7. Data from the present study confirm these previous findings in adults and extend the associations between inflammation and fasting insulin, a marker of insulin resistance, to children.
Children make a unique and valuable model for assessing the complex relationship between
References (24)
- et al.
C-reactive protein and body mass index in children: findings from the Third National Health and Nutrition Examination Survey, 1988-1994
J Pediatr
(2001) - et al.
C-reactive protein concentration in children: relationship to adiposity and other cardiovascular risk factors
Atherosclerosis
(2000) - et al.
Insulin resistance syndrome in childhood: associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors
J Pediatr
(2001) - et al.
Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study
Lancet
(2001) - et al.
Exercise training enhances endothelial function in young men
J Am Coll Cardiol
(1999) - et al.
Non-invasive detection of endothelial dysfunction in children and adults at risk for atherosclerosis
Lancet
(1992) - et al.
Impaired brachial artery endothelium-dependent and -independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease
J Am Coll Cardiol
(2004) - et al.
Effects of exercise training on vascular function in obese children
J Pediatr
(2004) - et al.
Exercise training normalizes vascular dysfunction and improves central adiposity in obese adolescents
J Am Coll Cardiol
(2004) - et al.
Assessing obesity: classification and epidemiology
Br Med Bull
(1997)
Metabolic prescursors and effects of obesity in children: a decade of progress, 1990-1999
Am J Clin Nutr
Obesity accelerates the progression of coronary atherosclerosis in young men
Circulation
Cited by (0)
Supported in part by Minnesota Obesity Center Grant #: 1 P30 DK 50456-08 (D.R.K.), American Heart Association Pre-Doctoral Grant #: 0315213Z (A.S.K.), and GCRC: M01-RR00400, General Clinical Research Center Program, NCRR/NIH.
Data presented in this manuscript appear in a dissertation titled “The effects of aerobic exercise training on vascular structure and function in obese children” that was completed at the University of Minnesota in February 2004.