Letter to the Editor
Genetic diversity of human adenovirus in hospitalized children with severe acute lower respiratory infections in Paraguay

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Funding

This work was funded in part by a fellowship to Daniel Benítez from the Consejo Nacional de Ciencia y Tecnología (CONACyT), Paraguay.

Competing interests

There are no competing interests.

Ethical approval

This protocol was approved by the Ethical Committee of the Instituto de Investigaciones en Ciencias de la Salud, under the following number: C45/2011.

Acknowledgements

We would like to thank Dr. Angilberto Paredes and Dr. Pio Alfieri (Directors of the Hospital General Pediátrico Niños de Acosta Ñu), and the following personnel from this institution: Dra. Viviana Pavlicich, Dra. Gloria Martínez, Dra. Carlos Caballero, Dra. Amalia Duarte, Dr. Héctor Castro, and Dr. Carolina Aquino, for the encouragement and support throughout the study.

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    In São Paulo, Brazil, Thomazelli et al.21 reported an overall positivity rate of 55.6% (187/336), with RSV in 24.1% and ADV in 6.8% of cases investigated by PCR for some of the same eight respiratory viruses analyzed in the present study, but in children up to 5 years of age hospitalized for suspected ARI. The high positivity for ADV observed in the present study could be the result of a convergence of different factors: the large number of hospitalized cases included, perhaps due to a broader range of acceptable diagnoses as inclusion criteria; the younger age group, likely to coincide with a peak incidence of disease associated with ADV;7,8,19 or the exclusive analysis of NPA samples collected in the first 24 hours of admission, which contain higher viral titers. ADV screening test by qualitative PCR is difficult to interpret, as it does not necessarily indicate it as the causative agent of the disease under investigation.

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