Food, drug, insect sting allergy, and anaphylaxisComponent-resolved diagnosis of baker's allergy based on specific IgE to recombinant wheat flour proteins∗
Section snippets
Patients and sera
The 40 German bakers with work-related complaints were the same as described previously9 and were selected based on physician-diagnosed occupational disease and wheat allergy. The 24 Spanish bakers had work-related asthma and rhinitis and a positive inhalation challenge test result to wheat or rye flour. All consecutive bakers attending La Paz Hospital in 2005 to 2008 who were given a diagnosis of baker's asthma caused by wheat flour were selected. The 37 Dutch bakers were selected during the
Results
Of 101 bakers with work-related asthma, rhinitis and wheat flour sensitization, or both, 86 also had increased total IgE concentrations (>100 kUA/L), all had sIgE to rye flour, and 75 had sIgE to grass pollen (Fig 1). Bakers from the different countries were not significantly different concerning age or total and sIgE levels to wheat and rye flour or grass pollen. The same was true for control subjects from the different countries. Control subjects had significantly higher sIgE values to grass
Discussion
Several single wheat flour allergens relevant to baker's asthma have been identified in the last 30 years, and a number of them have been characterized on a molecular level. The current allergen nomenclature list of the World Health Organization/International Union of Immunological Societies comprises 20 wheat allergens (www.allergen.org). The Triticum aestivum allergen numbers start with Tri a 12 (profilin) and end with Tri a 39 (SPILA), leaving a place for wheat pollen allergens homologous to
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Cited by (0)
Supported by the DGUV (German Social Accident Insurance).
Disclosure of potential conflict of interest: H.-P. Rihs delivered recombinant wheat proteins to EUROIMMUN AG for testing the effects in their diagnostic system and will receive nonstatutory stock options due in 2016 for his work as a Scientific Advisory Board Member for Yulex Corporation, Phoenix, Arizona. The rest of the authors declare that they have no relevant conflicts of interest.
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Allergen names, including isoallergen and variant numbers, used in this study were approved by the International Union of Immunological Societies (IUIS) Allergen Nomenclature Sub-Committee.