Food, drug, insect sting allergy, and anaphylaxisGene polymorphisms, breast-feeding, and development of food sensitization in early childhood
Section snippets
Study population
This study included 970 children from the Boston Birth Cohort, a cohort consisting of multiethnic mother-infant pairs (predominantly African American) enrolled 24 to 72 hours after delivery and followed prospectively from birth onward, as detailed in a previous publication.26 The information collected at birth includes comprehensive prenatal and perinatal epidemiologic and clinical variables. Since 2004, infants who obtained primary or specialist care at Boston University Medical Center have
Results
Nine hundred seventy children who have been followed for an average of 2.5 ± 2.2 years were included in this study. Three hundred sixty-one (37.2%) children had FS. Seven hundred thirty-nine (76.2%) children were ever breast-fed, and 200 children were exclusively breast-fed for 4 or more months. Ever breast-fed children were more likely to have a nonsmoking mother who was Hispanic, was older at delivery, and had a higher education level than never breast-fed children (P < .05, Table I). The
Discussion
In our inner-city US prospective birth cohort (predominantly African American), we found that breast-feeding was independently associated with an increased risk of FS in the total population, especially in children aged 2 or more years. Most importantly, we are the first to report that this positive association was dependent on functional genetic variants in the IL12RB1, TLR9, and TSLP genes, suggesting significant gene–breast-feeding interactions on FS. Our study underscores the importance of
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IL12RB1 allele bias in human T<inf>H</inf> cells is regulated by functional SNPs in its 3′UTR
2022, CytokineCitation Excerpt :Across multiple ethnicities and in otherwise immunocompetent individuals, IL12RB1 exhibits a high degree of polymorphism in translated and untranslated regions (UTRs) which can impact IL12RB1 function [8]. These polymorphisms primarily comprise single nucleotide polymorphisms (SNPs) and associate with a range of disease conditions, including those caused by infections [15–20] and non-infectious etiologies such as cancer [21–23], asthma [24] and allergy [25,26]. SNP-containing alleles (i.e. minor alleles) of IL12RB1 are common and carried by ≤ 25 % of individuals depending on their ethnicity [8].
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The parent study was supported in part by March of Dimes PERI grants (20-FY02-56), the National Institute of Environmental Health Sciences (R21 ES011666), and the National Institute of Child Health and Development (R01 HD041702). The follow-up study was supported in part by the Food Allergy Initiative and the National Institute of Allergy and Infectious Diseases (NIAID; R21AI079872; U01AI090727) and the Department of Defense (W81XWH-10-1-0123). R. K. is supported by the National Heart, Lung, and Blood Institute (K23HL093023). X. L. and L. A. are supported by a career development award from the National Institutes of Health/Clinical and Translational Science Awards Program, Northwestern University (KL2RR025740). X. L. also is supported by the NIAID (R21AI087888).
Disclosure of potential conflict of interest: R. Kumar has received research support from the National Heart, Lung, and Blood Institute. The rest of the authors have declared that they have no conflict of interest.