Immunity
Volume 52, Issue 5, 19 May 2020, Pages 731-733
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COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome

https://doi.org/10.1016/j.immuni.2020.04.003Get rights and content
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Summary

Zhou et al. (Nature) and Hoffmann et al. (Cell) identify ACE2 as a SARS-CoV-2 receptor, and the latter show its entry mechanism depends on cellular serine protease TMPRSS2. These results may explain proinflammatory cytokine release via the associated angiotestin II pathway and a possible therapeutic target via the IL-6-STAT3 axis.

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