Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura
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Highlights
► Matrix metalloproteinases (MMP) are involved in migraine attacks. ► Genetic polymorphisms may affect MMP-2 levels in patients with migraine. ► We showed that the C− 1306T and C− 735T affect MMP-2 levels in patients with migraine. ► Patients with high MMP-2 levels may be exposed increased cardiovascular risk. ► Those patients may benefit from the use of MMP inhibitors.
Abbreviations
MMPs
Matrix metalloproteinases
BBB
Blood–brain barrier
TIMPs
Tissue inhibitor of MMPs
CSD
Cortical spreading depression
MWA
Migraine without aura
MA
Migraine with aura
RT-PCR
Real time-polymerase chain reaction
ELISA
Enzyme-linked immunosorbent assay
Keywords
Migraine
Matrix metalloproteinase-2
Polymorphisms
Haplotype
TIMP-2
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