Southwestern Surgical CongressCore needle biopsy is a safe and accurate initial diagnostic procedure for suspected lymphoma
Section snippets
Methods
Institutional review board approval was obtained before the initiation of this study. All patients that were referred to the outpatient general surgical service at Harbor-UCLA Medical Center between April 2008 and January 2014 for biopsy of cervical, axillary, or groin lymph nodes for suspected lymphoma were included in this study. Patients with mediastinal or intra-abdominal lymphadenopathy were excluded, as these areas were inaccessible to an ultrasound-guided core needle approach. Patients
Results
A total of 73 ultrasound-guided core needle biopsies were performed in 71 consecutive patients after the standardized protocol. The mean age of the group was 43.1 years (range, 18 to 71 years) and 40 (56%) were female. The number of biopsies per site were as follows: 46 in the axilla, 19 in the groin, and 8 in the supraclavicular or cervical region. Two additional patients evaluated with ultrasound were determined to be unsuitable candidates for image-guided core needle biopsy because of the
Comment
The results of this study further confirm that image-guided core needle biopsy provides sufficient tissue for the diagnostic evaluation of lymphadenopathy suspicious for lymphoma when a standard protocol is used. All diagnoses of lymphoma were made on the initial core biopsy specimens, and definitive therapy was initiated based on these results. Further excisional biopsy was requested by the primary provider and/or consulting hematologist in 4 patients whose needle biopsy results were not
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Cited by (23)
Lymph node excisions provide more precise lymphoma diagnoses than core biopsies: a French Lymphopath network survey
2022, BloodCitation Excerpt :Based on this largest multicenter survey to date, within the Lymphopath network, CNB seems to be a reliable diagnostic approach for patients with suspected lymphoma, providing a definitive diagnosis in 92.3% of cases after expert review. The high diagnostic accuracy of CNB in diagnosing lymphoma has been previously reported in the literature.11-39,42 However, most of these studies did not assess the percentage of CNB cases accurately ranked according to the WHO classification criteria.4
Sensitivity of fine-needle aspiration biopsy for diagnosing and grading follicular lymphomas using a multiparameter approach in a cancer center
2017, Journal of the American Society of CytopathologyCitation Excerpt :Technologic advances associated with diagnostic imaging, diagnostic markers, and molecular profiling, as well as an increased number of experts in the acquisition of the small needle biopsies and diagnosis of lymphoproliferative disorders, have contributed to this trend.8,9 Subclassifying lymphomas on small needle biopsies has been the focus of several studies, and CNB has been effective for this subclassification.3-5,10-12 In a few of these studies, a concurrent FNAB with ancillary studies contributed to the diagnosis, but the diagnostic accuracy of FNAB was not assessed.11
Overview of conventional imaging-based intervention in clinical practice
2016, PET ClinicsCitation Excerpt :Image-guided biopsies are performed with a variety of different sized needles, which tend to be smaller (25–20 G) for fine-needle aspiration biopsies (FNABs), and larger (20–11 G) for core biopsies (Table 1). Core biopsies have the advantage of providing a greater amount of cellular material for analysis, and also allow the cellular architecture of the tumor to be examined, which may be critical in the diagnosis of lymphoma and certain sarcomas.15–17 In addition, the greater amount of material obtained by core biopsy permits additional molecular testing, as may be necessary in both clinical and research settings.15,16
Pediatric abdominal non-Hodgkin's lymphoma: diagnosis through surgical and non-surgical procedures
2019, Jornal de PediatriaCitation Excerpt :The same conclusion applies to patients of the elective surgery group when compared with the urgent surgery group (p < 0.001; Table 4). Although similar studies exist, none of them exclusively analyzed patients under 18 years in a single center,4–7,12,13 with such a large sample.3,14,15 Furthermore, the authors also addressed some aspects not always emphasized by other studies, as the stratification of complications, lower-grade complications, and length of time before starting chemotherapy in association to the diagnostic method.
The authors declare no conflicts of interest.
This manuscript has been seen and approved by all the authors, and the material presented in this manuscript is previously unpublished.