TY - JOUR T1 - Systematic review on fecal calprotectin in cystic fibrosis JO - Jornal de Pediatria (English Edition) T2 - AU - Lazzarotto,Eduarda Sampaio AU - Vasco,Jannaina Ferreira de Melo AU - Führ,Fabiane AU - Riedi,Carlos Antônio AU - Filho,Nelson Augusto Rosário SN - 00217557 M3 - 10.1016/j.jped.2022.01.006 DO - 10.1016/j.jped.2022.01.006 UR - https://jped.elsevier.es/en-systematic-review-on-fecal-calprotectin-articulo-S0021755722000456 AB - ObjectivesFecal calprotectin is an inflammatory marker used for monitoring intestinal diseases. It has been studied as a marker of intestinal inflammation in cystic fibrosis (CF), a multi-systemic genetic disease caused by alterations to the CFTR gene. Manifestations of the disease favor a systemic inflammation not limited to the respiratory tract, therefore, calprotectin is a non-invasive and effective diagnostic method. The aim of the study was to perform a systematic review of the literature with a qualitative synthesis of studies. SourcesThe articles were selected from PubMed, Web of Science, Scielo and Lilacs. Summary of the findingsNine studies were selected for that qualitative synthesis, one was a randomized clinical trial, and eight were case-control or cohort designs. Most studies have indicated that calprotectin is a marker of systemic inflammation in CF and not just intestinal inflammation. Calprotectin is an aid in monitoring inflammatory bowel conditions in patients with cystic fibrosis. ConclusionFurther studies should be conducted to investigate the role of this marker in the systemic inflammation of CF. ER -