TY - JOUR T1 - Irritable bowel syndrome in Indonesian adolescents JO - Jornal de Pediatria (English Edition) T2 - AU - Kesuma,Yudianita AU - Sekartini,Rini AU - Timan,Ina S. AU - Kurniawan,Agnes AU - Bardosono,Saptawati AU - Firmansyah,Agus AU - Vandenplas,Yvan SN - 00217557 M3 - 10.1016/j.jped.2020.02.001 DO - 10.1016/j.jped.2020.02.001 UR - https://jped.elsevier.es/en-irritable-bowel-syndrome-in-indonesian-articulo-S0021755719305881 AB - ObjectiveIrritable bowel syndrome is a frequent functional gastrointestinal disorder. The aims of this study were to investigate its epidemiology, focusing on the role of intestinal mucosal integrity and to evaluate the impact on the quality of life. MethodsA community-based survey applying a comparative cross sectional approach was conducted in six high schools in Palembang. Subjects were recruited using multistage random sampling divided in two groups. Rome III criteria were used to establish a diagnosis of IBS in combination with a questionnaire to determine risk factors. Determination of fecal alpha-1-antitrypsin and calprotectin levels was performed to determine impaired intestinal mucosal integrity. A questionnaire was used to evaluate how quality of life was affected by irritable bowel syndrome. ResultsThe survey was performed in 454 14−18years old adolescents, of whom 30.2% fulfilled the Rome III criteria for IBS, with the following subtypes: 36.5% diarrhea, 18.9% constipation, 21.9% mixed, and 22.6% unclassified. Major risk factors were female gender, bullying, age 14–16 years, history of constipation and diarrhea, eating nuts, and drinking coffee, tea, and soft drinks. There was a significant association with intestinal inflammation (p=0.013). A significantly impaired quality of life was found (p=0.001). ConclusionsThe prevalence of irritable bowel syndrome in adolescents was high, with bullying, female gender, age 14–16 years, constipation and diarrhea, and dietary consumption of soft drinks, coffee, and tea as risk factors. A significant association with intestinal inflammation was found. ER -