TY - JOUR T1 - High-resolution CT pulmonary findings in children with severe asthma JO - Jornal de Pediatria (English Edition) T2 - AU - Silva,Thiago Krieger Bento da AU - Zanon,Matheus AU - Altmayer,Stephan AU - Pacini,Gabriel Sartori AU - Watte,Guilherme AU - Stein,Renato AU - Pitrez,Paulo Márcio AU - Hochhegger,Bruno SN - 00217557 M3 - 10.1016/j.jped.2019.10.011 DO - 10.1016/j.jped.2019.10.011 UR - https://jped.elsevier.es/en-high-resolution-ct-pulmonary-findings-in-articulo-S0021755719305352 AB - ObjectiveTo compare quantitative CT parameters between children with severe asthma and healthy subjects, correlating to their clinical features. MethodsWe retrospectively analyzed CT data from 19 school-aged children (5–17 years) with severe asthma and 19 control school-aged children with pectus excavatum. The following CT parameters were evaluated: total lung volume (TLV), mean lung density (MLD), CT air trapping index (AT%) (attenuation ≤856 HU), airway wall thickness (AWT), and percentage of airway wall thickness (AWT%). Multi-detector computed tomography (MDCT) data were correlated to the following clinical parameters: forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), forced expiratory flow at 25–75% (FEF 25–75%), FEV1/FVC ratio, sputum and bronchoalveolar lavage analysis, serum IgE levels, and previous hospitalizations due to asthma. ResultsAsthma patients presented higher mean values of AT% (23.8 ± 6.7% vs. controls, 9.7 ± 3.2%), AWT (1.46 ± 0.22 mm vs. controls, 0.47 ± −735 ± 28 HU vs. controls, −666 ± 19 HU). Mean AT% was 29.0 ± 4.7% in subjects with previous hospitalization against 19.2 ± 5.0% in those with no prior hospitalization (p < 0.001). AT% presented very strong negative correlations with FVC (r = −0.933, p < 0.001) and FEV1 (r = −0.841, p < 0.001) and a moderate correlation with FEF 25–75% (r = −0.608, p = 0.007). AT% correlation with FEV1/FVC ratio and serum IgE was weak (r = −0.184, p = 0.452, and r = −0.363, p = 0.202) ConclusionChildren with severe asthma present differences in quantitative chest CT scans compared to healthy controls with strong correlations with pulmonary function tests and previous hospitalizations due to asthma. ER -