TY - JOUR T1 - Glucose alteration and insulin resistance in asymptomatic obese children and adolescents JO - Jornal de Pediatria (English Edition) T2 - AU - Assunção,Silvana Neves Ferraz de AU - Boa Sorte,Ney Christian Amaral AU - Alves,Crésio de Aragão Dantas AU - Mendes,Patricia S. Almeida AU - Alves,Carlos Roberto Brites AU - Silva,Luciana Rodrigues SN - 00217557 M3 - 10.1016/j.jped.2017.06.008 DO - 10.1016/j.jped.2017.06.008 UR - https://jped.elsevier.es/en-glucose-alteration-insulin-resistance-in-articulo-S0021755716303229 AB - ObjectiveObesity is associated with the abnormal glucose metabolism preceding type 2 diabetes mellitus. Thus, further investigation on the prediction of this lethal outcome must be sought. The objective was the profile glycemic assessment of asymptomatic obese children and adolescents from Salvador, Brazil. MethodA fasting venous blood sample was obtained from 90 consecutive obese individuals aged 8–18 years, of both sexes, for laboratory determinations of glycated hemoglobin, basal insulin, and the Homeostasis Model Assessment Insulin Resistance index. The clinical evaluation included weight, height, waist circumference, assessment of pubertal development, and acanthosis nigricans research. The body mass index/age indicator was used for the severity of overweight assessment. ResultsGlycemic alterations were evidenced clinically and biochemically, although these individuals had no complaints or symptoms related to blood sugar levels. Quantitative and qualitative variables were respectively expressed measures of central tendency/dispersion and simple/relative frequency, using the SPSS, version 20.0. A p-value <0.05 was considered significant. ConclusionNotably, this study found a high prevalence of glucose and insulin disorders in asymptomatic obese children and adolescents. ER -