TY - JOUR T1 - Acute kidney injury in HIV-infected children: comparison of patients according to the use of highly active antiretroviral therapy JO - Jornal de Pediatria (English Edition) T2 - AU - Soares,Douglas de Sousa AU - Cavalcante,Malena Gadelha AU - Ribeiro,Samille Maria Vasconcelos AU - Leitão,Rayana Café AU - Vieira,Ana Patrícia Freitas AU - Pires Neto,Roberto da Justa AU - Silva Junior,Geraldo Bezerra da AU - Daher,Elizabeth de Francesco SN - 00217557 M3 - 10.1016/j.jped.2016.03.009 DO - 10.1016/j.jped.2016.03.009 UR - https://jped.elsevier.es/en-acute-kidney-injury-in-hiv-infected-articulo-S0021755716301036 AB - ObjectiveTo assess clinical and laboratory data, and acute kidney injury (AKI) in HIV-infected children using and not using highly active antiretroviral therapy (HAART) prior to admission. MethodsA retrospective study was conducted with HIV-infected pediatric patients (<16 years). Children who were using and not using HAART prior to admission were compared. ResultsSixty-three patients were included. Mean age was 5.3±4.27 years; 55.6% were females. AKI was observed in 33 (52.3%) children. Patients on HAART presented lower levels of potassium (3.9±0.8 vs. 4.5±0.7mEq/L, p=0.019) and bicarbonate (19.1±4.9 vs. 23.5±2.2mEq/L, p=0.013) and had a higher estimated glomerular filtration rate (102.2±36.7 vs. 77.0±32.8mL/min/1.73m2, p=0.011) than those not on HAART. In the multivariate analysis, the use of HAART prior to the admission was a protective factor for AKI (p=0.036; OR=0.30; 95% CI=0.097–0.926). ConclusionAKI is a common complication of pediatric HIV infection. Use of HAART prior to the admission preserved glomerular filtration and was a protective factor for AKI, but increased medication side effects, such as hypokalemia and renal metabolic acidosis. ER -