TY - JOUR T1 - Human parainfluenza virus surveillance in pediatric patients with lower respiratory tract infections: a special view of parainfluenza type 4 JO - Jornal de Pediatria (English Edition) T2 - AU - Thomazelli,Luciano M. AU - Oliveira,Danielle B. L. de AU - Durigon,Giuliana S. AU - Whitaker,Brett AU - Kamili,Shifaq AU - Berezin,Eitan N. AU - Durigon,Edison L. SN - 00217557 M3 - 10.1016/j.jped.2017.07.017 DO - 10.1016/j.jped.2017.07.017 UR - https://jped.elsevier.es/en-human-parainfluenza-virus-surveillance-in-articulo-S0021755717303522 AB - ObjectiveCharacterize the role of human parainfluenza virus and its clinical features in Brazilian children under 2 years of age presenting with acute lower respiratory tract infections. MethodsReal-time assays were used to identify strains of human parainfluenza virus and other common respiratory viruses in nasopharyngeal aspirates. One thousand and two children presenting with acute lower respiratory tract illnesses were enrolled from February 2008 to August 2010. ResultsOne hundred and four (10.4%) patients were human parainfluenza virus positive, of whom 60 (57.7%) were positive for human parainfluenza virus-3, 30 (28.8%) for human parainfluenza virus-4, 12 (11.5%) for human parainfluenza virus-1, and two (1.9%) for human parainfluenza virus-2. Seven (6.7%) patients had more than one strain of human parainfluenza virus detected. The most frequent symptoms were tachypnea and cough, similar to other viral respiratory infections. Clinical manifestations did not differ significantly between human parainfluenza virus-1, -2, -3, and -4 infections. Human parainfluenza virus-1, -3, and -4 were present in the population studied throughout the three years of surveillance, with human parainfluenza virus-3 being the predominant type identified in the first two years. ConclusionHuman parainfluenza viruses contribute substantially to pediatric acute respiratory illness (ARI) in Brazil, with nearly 30% of this contribution attributable to human parainfluenza virus-4. ER -